中医药辨证治疗慢性肾小球肾炎的疗效及安全性评价

中医药辨证治疗慢性肾小球肾炎的疗效及安全性评价
孟祥磊
【期刊名称】《中国生化药物杂志》
【年(卷),期】2017(000)005
【摘要】ObjectiveTo explore the efficacy and safety of traditional Chinese medicine in the treatment of chronic glomerulonephritis.Methods146 cases of chronic renal glomerulonephritis were randomly divided into two groups.The control group was given oral administration of valsartan 80mg on the basis of routine treatment.On the basis of the control group, Oral, two groups were treated for 12 weeks.The levels of LKN-1, TNF-α, T-PA and renal function were observed before and after treatment.The clinical efficacy and clinical efficacy of the two groups were observed.Adverse reactions.Results The levels of LKN-1 and TNF-α in group two were significantly lower than those before treatment (P<0.05), and the study group was significantly lower than the control group (P<0.05).Compared with the control group, the rats in the study group were significantly higher than those in the control group (P<0.05).After treatment, the levels of SCr, 24h urinary protein, BUN, UCr (P<0.05), and the clinical efficacy of the study group was significantly lower than that of the control group (P<0.05).The clinical curative effect of the study group was higher than that of the control group (P<0.05) There was no significant difference between the control group and the control group.Conclusion TCM
treatment of chronic glomerulonephritis can increase the clinical effect, safe and reliable.%目的探讨中医药辨证治疗慢性肾小球肾炎的疗效及安全性.方法将146例肺肾气虚型慢性肾小球肾炎随机分为2组,对照组在常规治疗的基础上给以缬沙坦80mg口服,研究组在对照组的基础上给以益气化肾汤口服,2组均治疗12个周.观察2组治疗前后白细胞诱导素1(LKN-1)、肿瘤坏死因子-α(TNF-α)、组织型纤溶酶原激活物(t-PA)及肾功能水平,统计2组临床疗效和不良反应.结果 2组治疗后LKN-1、TNF-α水平与治疗前相比较均显著降低(P<0.05),且研究组与同期对照组相比较均显著降低(P<0.05);2组治疗后t-PA与治疗前相比较均显著升高(P<0.05),且研究组与同期对照组相比较均显著升高(P<0.05);2组治疗后SCr、24h尿蛋白定量、BUN、UCr水平与治疗前相比较均显著降低(P<0.05),且研究组与同期对照组相比较均显著降低(P<0.05);研究组临床疗效高于对照组(P<0.05),不良反应发生率与对照组相比较差异无统计学意义.结论中医药辨证治疗慢性肾小球肾炎可增加临床效果,安全可靠.
【总页数】3页(P191-193)
【作者】孟祥磊
【作者单位】浙江省杭州萧山第一人民医院,浙江杭州311200
【正文语种】中文
【中图分类】R692.3
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