肺腺癌组织中Cripto-1、ZEB-1和E-cadherin的表达及意义

肺腺癌组织中Cripto-1、ZEB-1和E-cadherin的表达及意
义
肖高芳;丁宇;高双全;杜日昌;李静;黄伟;王林辉;徐彤
【期刊名称】《海南医学》
【年(卷),期】2015(000)016
【摘要】Objective To investigate the expression levels of Cripto-l, ZEB-1 and E-cadherin proteins in lung adenocarcinoma tissues, and to explore the correlation between these three proteins. Methods The expressions of Cripto-1, ZEB-1 and E-cadherin proteins were examined by immunohistochemistry in 72 samples of lung adeno-carcinoma tissues. And the correlation between Cripto-1, ZEB-1 and E-cadherin expression was also analyzed by clin-ical and pathological data. Results The positive expression rate of Cripto-l, ZEB-1 and E-cadherin were 54.17%, 58.33%, 36.11%respectively in lung adenocarcinoma tissues, and 20.0%, 22.5%, 92.5%respectively in adjacent tis-sues, with statistically significant differences between two groups (P<0.01). The expression of Cripto-1, ZEB-1 and E-cadherin showed significant correlation with the differentiation, clinical stage and lymph node metastasis (P<0.05). The expression of Cripto-1 showed a positive correlation with ZEB-1 (P<0.05), while the expression of Cripto-1 and ZEB-1 showed a negative correlation with E-cadherin in the lung adenocarcinoma tissues (P<0.05). Conclusion Ex-pressions of Cripto-1, ZEB-1 and E-cadherin may be involved in the
progression, invasion and metastasis of lung ade-nocarcinoma. A combined examination of these three proteins may help evaluate the prognosis of lung adenocarcinoma.%目的：探讨Cripto-1、ZEB-1和E-cadherin蛋白在肺腺癌组织中的表达及三者之间的关系。

方法采用免疫组化S-P
法检测72例肺腺癌组织中Cripto-1、ZEB-1和E-cadherin蛋白的表达情况，并结合临床病理资料分析Cripto-1、ZEB-1和E-cadherin表达的相关性。

结果(1)
肺腺癌组织中Cripto-1、ZEB-l和E-cadherin的表达率分别为54.17%、58.33%、36.11%，癌旁肺组织分别为20.00%、22.50%、92.50%，三种蛋白在肺腺癌组
织和癌旁肺组织中的表达差异均具有统计学意义(P<0.01)。

(2)肺腺癌组织中Cripto-l、ZEB-1和E-cadherin蛋白的表达与肺腺癌肿瘤分化程度、临床分期及
淋巴结转移有相关性(P<0.05)。

(3)肺腺癌组织中Cripto-1的表达与ZEB-1的表
达呈正相关(P<0.05)，Cripto-1、ZEB-1的表达与E-cadherin的表达呈负相关(P<0.05)。

结论 Cripto-1、ZEB-1和E-cadherin在肺腺癌发展、浸润和转移中发挥重要作用，联合检测三者能更好地评估肺腺癌患者的预后。

【总页数】4页(P2351-2354)
【作者】肖高芳;丁宇;高双全;杜日昌;李静;黄伟;王林辉;徐彤
【作者单位】韶关市粤北人民医院病理科，广东韶关 512026;韶关市粤北人民医
院病理科，广东韶关 512026;韶关市粤北人民医院病理科，广东韶关 512026;韶关市粤北人民医院病理科，广东韶关 512026;韶关市粤北人民医院病理科，广东
韶关 512026;韶关市粤北人民医院病理科，广东韶关 512026;韶关市粤北人民医
院病理科，广东韶关 512026;韶关市粤北人民医院病理科，广东韶关 512026【正文语种】中文
【中图分类】R734.2
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