DGAT-1 inhibitor 2_942999-61-3_DataSheet_MedChemExpress

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DGAT-1_inhibitor_2_LCMS_09258_MedChemExpress

=====================================================================Acq. Operator : Li Shan(LCMS-02) Seq. Line : 89Acq. Instrument : HY-LCMS-02 Location : P1-C-01Injection Date : 7/14/2015 5:25:04 PM Inj : 1Inj Volume : 3.000 µlAcq. Method : D:\AGLIENT 1260\DATA\20150714\20150714 2015-07-14 08-52-30\100-1000MS+3MIN- 1.5_(0.02%FA).MLast changed : 7/14/2015 8:52:30 AM by Li Shan(LCMS-02)Analysis Method : D:\AGLIENT 1260\DATA\20150709\20150709 2015-07-09 09-04-13\100-1000MS+3MIN- 1.5_(0.02%FA).M (Sequence Method)Last changed : 7/15/2015 5:09:42 PM by Li Shan(LCMS-02) (modified after loading)Method Info : Postive,MS:100-1000,Column ID:A-RP-132,40℃Catalog No : HY-50670 Batch#09258 A-RP-134Additional Info : Peak(s) manually integratedmin0.511.522.53mAU 0500100015002000 DAD1 B, Sig=214,4 Ref=off (D:\AGLIENT...0\DATA\20150714\20150714 2015-07-14 08-52-30\CPK2015-714-09258.D) 2.0972.179 2.4102.701 2.777===================================================================== Area Percent Report =====================================================================Sorted By : Signal Multiplier : 1.0000Dilution : 1.0000Do not use Multiplier & Dilution Factor with ISTDsSignal 1: DAD1 B, Sig=214,4 Ref=offPeak RetTime Type Width Area Height Area # [min] [min] [mAU*s] [mAU] %----|-------|----|-------|----------|----------|--------| 1 2.097 MF 0.0451 28.44566 10.50576 1.6073 2 2.179 FM 0.0458 1681.63904 611.79480 95.0188 3 2.410 MM 0.0424 17.73072 6.97320 1.0019 4 2.701 MM 0.0410 31.76068 12.92092 1.7946 5 2.777 MM 0.0385 10.22086 4.42166 0.5775Totals : 1769.79697 646.61634===================================================================== *** End of Report ***=====================================================================Acq. Operator : Li Shan(LCMS-02) Seq. Line : 89Acq. Instrument : HY-LCMS-02 Location : P1-C-01Injection Date : 7/14/2015 5:25:04 PM Inj : 1Inj Volume : 3.000 µlAcq. Method : D:\AGLIENT 1260\DATA\20150714\20150714 2015-07-14 08-52-30\100-1000MS+3MIN- 1.5_(0.02%FA).MLast changed : 7/14/2015 8:52:30 AM by Li Shan(LCMS-02)Analysis Method : D:\AGLIENT 1260\DATA\20150709\20150709 2015-07-09 09-04-13\100-1000MS+3MIN- 1.5_(0.02%FA).M (Sequence Method)Last changed : 7/15/2015 10:08:18 AM by Li Shan(LCMS-02) (modified after loading)Method Info : Postive,MS:100-1000,Column ID:A-RP-132,40℃Catalog No : HY-50670 Batch#09258 A-RP-134Additional Info : Peak(s) manually integratedmin0.511.522.5350000100000150000200000250000300000350000400000 MSD1 TIC, MS File (D:\AGLIENT 1260\DATA\20150714\20150714 2015-07-14 08-52-30\CPK2015-714-09258.D) ES-API, Pos, Sc0.5242.184MS Signal: MSD1 TIC, MS File, ES-API, Pos, Scan, Frag: 50 Spectra averaged over upper half of peaks. Noise Cutoff: 1000 counts.Reportable Ion Abundance: > 10%.Retention Mol. Weight Time (MS) MS Area or Ion0.524 3024535 157.00 I2.184 711059 422.20 I 421.20 Im/z10020030040050060070080020406080100*MSD1 SPC, time=0.486:0.578 of D:\AGLIENT 1260\DATA\20150714\20150714 2015-07-14 08-52-30\CPK2015-714-09258.D ES-API Max: 249931158.0157.0m/z1002003004005006007008005101520253035*MSD1 SPC, time=2.163:2.199 of D:\AGLIENT 1260\DATA\20150714\20150714 2015-07-14 08-52-30\CPK2015-714-09258.D ES-API 422.2 421.2*** End of Report ***。

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References: [1]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-1568. [2]. [ ] Matsuda D, Tomoda H. DGAT inhibitors for obesity. y Curr Opin p Investig g Drugs. g 2007 Oct;8(10):836-41. [3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29. [4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.
Caution: Not fully tested. For research purposes only Medchemexpress LLC

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Product Data SS No.: Cat. No.: MWt: Formula: Purity :
DGAT-1 inhibitor 2 942999-61-3 HY-50670 420.50 C24H28N4O3 >98%
Solubility:
DMSO
Mechanisms: Pathways:Metabolism/Protease; Target:DGAT g y Biological Activity: DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents. IC50 value: Target: DGAT-1 Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is a promising strategy for the treatment of obesity and type 2 diabetes.