蓝灵组织胶水--2015更新版

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PARTS GUIDE MANUAL APRIL 2005bizhub 162INFORMATION FOR PARTS GUIDE MANUALTo find correct Parts No., refer to the “HOW TO MAKE THE BEST USE OF THIS MANUAL” in the following page.HOW TO MAKE THE BEST USE OF THIS MANUAL1When you order, please check the proper figures beforehand that are on Our Parts Guide Manual, and order with the appropriate figures.2For screws, Nuts, Washers, retaining rings and Pins which are used in this model, one letter is shown on the Standard parts column of Parts list and exploded diagrams.3In order to maintain safety of the product, some specific parts composed of this product are set up as "essential safety parts".4The assigned parts number for the "essential safety parts" is indicated as "SP00-****".When replacing these parts, follow precautions for disassembling and installing which are listed in the Service Manual.Do not use any parts that are not set up as5 means that there are exclusive parts for each destination.Please check the appropriate destination when you order.6Revision MarkMarked as on the illustration shows that the revision has been made. 7All rights reserved. (any reprints or quotations are prohibited.)Use of this parts guide manual should be strictly supervised to avoid dis-closure of confidential information.パーツガイドマニュアルのご案内サービス部品をご発注の際には、下記に示す “パーツガイドマニュアルの活用にあたって”をご参照の上、正しい部品番号にてお願い致します。

神奇胶水“蓝灵”一分钟内可粘合伤口

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BS EN71-1-2011中文版玩具安全-第一部分机械和物理性能(翻译稿)

说明：本标准是对照BS EN 71-1：2011英文版标准翻译稿，出于版权原因，我们去掉了标准上的所有图片，全部用文字代替，需要大家对照原标准查看参考，为此给大家带去的不便，请谅解，
欧洲标准

BS EN 71-1:2011
2011 年 6 月
玩具安全－第 1 部分: 机械和物理性能
CEN 于 2011 年 5 月 25 日批准本欧洲标准。 CEN 的成员应遵守 CEN/CENELEC 的内部规定，将本欧洲标准视为其国家标准，并且不得作任何修改。上述国家标准的最新目录及参考书目可向 CEN-CENELEC 管理中心或任何一个CEN 成员申请索取。本欧洲标准有 3 个正式版本：英文1、法文、德文。CEN 的成员负责将其翻译成各自国家的语言，此类版本报 CEN-CENELEC 管理中心后，也视为正式版本。 CEN 的成员包括下列国家的标准化组织：奥地利、比利时、保加利亚、克罗地亚、塞浦路斯、捷克共和国、丹麦、爱沙尼亚、芬兰、法国、德国、希腊、匈牙利、冰岛、爱尔兰、意大利、拉脱维亚、立陶宛、卢森堡、马耳他、荷兰、挪威、波兰、葡萄牙、罗马尼亚、斯洛伐克、斯洛文尼亚、西班牙、瑞典、瑞士、英国。
EN 71-1:2011
目录
前言.................................................................................................................................................. 10 介绍....................................................................................................

msd sulfo-tag nhs-ester-说明书

MSD GOLD™ SULFO-TAG NHS-EsterMSD GOLD SULFO-TAG™ NHS-Ester 150 nmol (sufficient for conjugating 1 mg of IgG) R91AO-12 µmol (sufficient for conjugating 10 mg of IgG) R91AO-2MSD GOLD SULFO-TAG NHS-Ester Conjugation Packs Pack 1 (sufficient for conjugating 5 x 200 µg of IgG) R31AA-1 Pack 2 (sufficient for conjugating 5 x 1 mg of IgG) R31AA-2MSD Labeling ReagentsMSD GOLD SULFO-TAG NHS-EsterFor labeling aminesNote:150 nmol size of MSD GOLD SULFO-TAG NHS-Ester is sufficient for conjugating 1 mg of IgG and the 2 µmol size is sufficient for conjugating 10 mg of IgG at a challenge ratio of 20.Each MSD GOLD SULFO-TAG NHS-Ester Conjugation Pack contains enough material for 5 reactions. At a challenge ratio of 20, Pack 1 is sufficient for conjugating 200 µg of IgG per reaction, and Pack 2 is sufficient for conjugating 1 mg of IgG per reaction.This package insert must be read in its entirety before using this product.FOR RESEARCH USE ONLY.NOT FOR USE IN DIAGNOSTIC PROCEDURES.MESO SCALE DISCOVERY®A division of Meso Scale Diagnostics, LLC.1601 Research BoulevardRockville, MD 20850-3173 USAMESO SCALE DISCOVERY, MESO SCALE DIAGNOSTICS, MSD, MSD GOLD, DISCOVERY WORKBENCH, MULTI-ARRAY, MULTI-SPOT, QUICKPLEX, SECTOR, SECTOR PR, SECTOR HTS, SULFO-TAG, U-PLEX, V-PLEX, S-PLEX, STREPTAVIDIN GOLD, MESO, , SMALL SPOT (design), 96 WELL 1, 4, 7, & 10-SPOT (designs), 384 WELL 1 & 4-SPOT (designs), MSD (design), U-PLEX (design), V-PLEX (design), S-PLEX (design), and SPOT THE DIFFERENCE are trademarks and/or service marks of Meso Scale Diagnostics, LLC. ©2015 Me s o Scale Diagnostics, LLC. All rights reservedTable of ContentsIntroduction (4)Preparation of MSD GOLD SULFO-TAG Conjugates (5)MSD GOLD SULFO-TAG NHS-Ester Conjugation Packs (6)Additional Materials and Equipment (6)Protocol (8)Storage, Handling, and Stability (10)FAQs (11)Worksheet (14)Ordering InformationMSD Customer ServicePhone: 1-240-314-2795Fax: 1-301-990-2776Email: CustomerService@MSD Scientific SupportPhone: 1-240-314-2798Fax: 1-240-632-2219 attn: Scientific SupportEmail: ScientificSupport@IntroductionThis protocol details the conjugation procedure for proteins of molecular weight (MW) > 40,000 D altons using MSD GOLD SULFO-TAG NHS-Ester label. The straightforward procedure involves an optional buffer exchange step, a 2-hour incubation step, and a mandatory buffer exchange step to quickly isolate the conjugated protein using a spin column. MSD GOLD SULFO-TAG NHS-Ester (Figure 1) is an amine reactive, N-hydroxysuccinimide ester which readily couples to primary amine groups of proteins under mildly basic conditions to form a stable amide bond.MSD GOLD SULFO-TAG conjugates are stable and may be used at low concentrations. These features minimize time, cost, and labor as large batches of a stable conjugate can be prepared, validated, and used for long periods of time. Its excellent performance characteristics and simple conjugation procedure make MSD GOLD SULFO-TAG NHS-Ester the product of choice for molecules that contain primary amines (e.g., lysine-containing proteins). MSD GOLD SULFO-TAG offers low non-specific binding, resulting in highly sensitive detection when used in conjunction with MSD instruments.Figure 1: MSD GOLD SULFO-TAG NHS-EsterPreparation of MSD GOLD SULFO-TAG ConjugatesGeneral NotesIn order to minimize hydrolysis of MSD GOLD SULFO-TAG NHS-Ester, the reagent should be dissolved in cold distilled water just prior to its addition to the protein solution. If necessary, the stock MSD GOLD SULFO-TAG NHS-Ester solution can be kept on ice for up to 10 minutes. The reconstituted solution is unstable and any unused material should be discarded. Consider conjugating more than one protein at the same time to maximize the use of the MSD GOLD SULFO-TAG NHS-Ester reagent. Generally, 150 nmol of MSD GOLD SULFO-TAG NHS-Ester is sufficient for conjugation of up to 1 mg of IgG.The labeling ratio is the number of molecules of MSD GOLD SULFO-TAG conjugated to each molecule of protein. Optimal conjugation ratios for a MSD GOLD SULFO-TAG conjugated protein should be determined empirically for each specific application. For most applications using IgG antibodies (MW ~150,000), optimal performance is obtained with conjugation ratios between 2:1 and 20:1. In this range, assay signals typically show a linear dependence on conjugation ratio. Conjugation ratios significantly higher than 10:1 can be counterproductive and may lead to elevated background signals or loss of binding activity. For proteins that are significantly smaller than IgGs, lower conjugation ratios (between 1:1 and 5:1) may provide better assay performance.The challenge ratio is the number of moles of MSD GOLD SULFO-TAG per mole of protein in the conjugation reaction mixture. The challenge ratio required to achieve a specific conjugation ratio depends on a number of factors including pH, temperature, protein concentration, protein size, and the number of lysines available for coupling. Conjugating a 2 mg/mL IgG solution using the standard conditions described in this protocol will typically result in a label incorporation of approximately 50% (i.e., a challenge ratio of 10:1 will result in a conjugation ratio of about 5:1). Conjugation efficiencies for other proteins may be different. In general, conjugating with high protein concentrations of 1–2 mg/mL in slightly alkaline PBS (pH 7.9) in the absence of preservatives yields the best conjugation efficiencies. Maintaining consistent conjugation conditions (protein concentration, buffer type, MSD GOLD SULFO-TAG NHS-Ester concentration, incubation time, and temperature) is important when preparing multiple batches of conjugated protein in order to achieve consistent assay results.When developing immunoassays, MSD recommends conjugating antibodies using the standard conditions outlined in this document and challenge ratios of 6:1, 12:1, and 20:1 to identify optimal conjugation conditions. If evaluating different conditions is not possible due to limited reagent quantities, a challenge ratio of 20:1 will generally provide good performance. For immunogenicity applications where an antibody drug or protein therapeutic is used, the suggested challenge ratios are 12:1 and 6:1 MSD GOLD SULFO-TAG:drug. If only one ratio is tested, a 10:1 challenge ratio is recommended. For details on building immunogenicity assays, please refer to the Bridging Immunogenicity Guidelines for Assay Development at . The protocol describes the MSD GOLD SULFO-TAG conjugation procedure for proteins with a MW > 40,000 D a. Smaller proteins/polypeptides may also be conjugated using MSD GOLD SULFO-TAG NHS-Ester as long as they have an accessible lysine or the N-terminal amino group; however, alternative separation methods may be needed to remove unconjugated label. MSD offers a variety of services for the custom conjugation of reagents including proteins, peptides, and non-proteinaceous molecules.MSD GOLD SULFO-TAG NHS-Ester Conjugation PacksMSD offers all-inclusive conjugation packs that include the components and guidance that may be necessary for conjugating and purifying detection reagents with MSD GOLD SULFO-TAG label. Two sizes of conjugation packs are offered: MSD GOLD SULFO-TAG Conjugation Pack 1 and Pack 2. The two packs enable the conjugation of different amounts of IgG. MSD GOLD SULFO-TAG NHS-Ester Conjugation Pack 1 contains materials for conjugation and purification of up to 200 µg of IgG per reaction, and MSD GOLD SULFO-TAG NHS-Ester Conjugation Pack 2 allows conjugation of up to 1 mg of IgG per reaction. Each pack contains enough material for 5 reactions (i.e., 5 vials of MSD GOLD SULFO-TAG NHS-Ester).Table 1. Components of MSD GOLD SULFO-TAG Conjugation Packs*MSD GOLD SULFO-TAG Conjugation Pack 1 includes 10 columns of 0.5 mL capacity and 10 syringes of 1 mL size, and MSD GOLD SULFO-TAG Conjugation Pack 2 includes 10 columns of 5 mL capacity and 10 syringes of 3 mL size.**The pH of Conjugation Buffer is stable for up to 2 weeks after opening the bottle. For long term use, it is recommended to readjust the pH of the solution.Additional Materials and EquipmentThe following additional materials may be required. Some items (denoted with a *) are included in the MSD GOLD SULFO-TAG Conjugation Packs.1.Conjugation Buffer* (Phosphate-buffered saline (PBS), pH 7.9, preservative-free)2.Conjugate Storage Buffer* (PBS pH 7.4 + 0.05% Sodium Azide)3.Polypropylene microfuge tubes4.Spin columns.* MSD recommends the use of Zeba Spin Desalting Columns, 40K MWCO of various sizes from ThermoScientific, Catalog # 87766–877735.15 mL conical tubes for use with Zeba Spin Desalting Columns, 40K MWCO, 2 mL column size6.Protein assay such as BCA, Bradford, or Lowry7.MSD Blocker A (optional), Catalog # R93AA-2 (250 mL) and R93AA-1 (1 L)8.Spectrophotometer capable of an OD455 measurementReagent Storage Size Quantity DescriptionMSD GOLD SULFO-TAG NHS-Ester ≤-70°C 150 nmol 5 vials MSD GOLD SULFO-TAG NHS-Ester label forcoupling to antibodies and other proteinsZeba Spin Desalting Column, 40K MWCO* 2–8°C 0.5 mL or5 mL10 columns Size exclusion chromatography columns for thepurification of proteins larger than 40,000 DaFilter, 0.22 µm RT N/A 10 each Filter for use during purification Syringe * RT N/A 10 each Syringe for use during purificationConjugation Buffer** 2–8°C 40 mL 1 bottle Phosphate-buffered saline (PBS), pH 7.9, preservative-freeConjugate Storage Buffer RT 40 mL 1 bottle PBS pH 7.4 + 0.05% Sodium Azide9. 0.2 µm filter* (optional) Table 2. Suggestions for 0.2 µm filter10. Concentrator (optional) Table 3. Suggestions for concentratorsNoteThe following table lists the catalog numbers of the Zeba Spin Desalting Columns, 40K MWCO, from Thermo Scientific and the recommended sample volume for each column.Table 4. Catalog numbers of Zeba Spin Desalting Columns from Thermo ScientificVendorCatalog # Volume of Conjugated ProteinWhatmanAV125EAQU ≥ 2.0 mL Millipore or Fisher Scientific (MILLEX-GV)SLGV004SL0.2–1.0 mLVendorCatalog # Range Millipore BIOMAX-50 concentrator, 50 MWCO UFV5BQK25 0.05–0.5 mL AMICON Ultra-4 concentrator, PLQK Ultracel-PL Membrane, 50 MWCOUFC805008 0.5–4.0 mL AMICON Ultra-15 concentrator, PLQK Ultracel-PL Membrane, 50 MWCOUFC9050240.5–15.0 mLThermo ScientificCatalog #Number of Columns/packZEBA Spin Desalting Column VolumeRecommended Volume of the Conjugation Reaction87766 25 0.5 mL 70–100 µL 87767 50 0.5 mL 70–100 µL 87768 5 2 mL 200–450 µL 87769 25 2 mL 200–450 µL 87770 5 5 mL 300–1,000 µL 87771 25 5 mL 300–1,000 µL 87772 5 10 mL 1,000–2,000 µL 877732510 mL1,000–2,000 µLProtocol1.Prepare a 1–2 mg/mL solution of the protein to be conjugated in Conjugation Buffer. Antibodies in a storage buffer withpreservatives such as sodium azide or EDTA must be buffer exchanged before the conjugation reaction. It is recommended that dilute protein solutions be concentrated to at least 1 mg/mL. Protein solutions should be concentrated and/or buffer exchanged using the spin columns described above or an alternative centrifugal filtration/concentration unit that has been equilibrated with preservative-free PBS, pH 7.9. (Use Conjugation Buffer when using MSD GOLD SULFO-TAG NHS-Ester Conjugation Pack.) Filter the protein using a 0.2 µm filter. The concentration of the protein solution to be conjugated should be confirmed prior to beginning the conjugation reaction.Note: Conjugation buffer, 0.2 µm filter, and syringes are included in the MSD GOLD SULFO-TAG NHS-Ester Conjugation Packs.2.Equilibrate the protein to be conjugated with MSD GOLD SULFO-TAG NHS-Ester at the conjugation temperature of 23°C.A temperature range of 20°C to 25°C is acceptable. The equilibration can take between 10-30 minutes depending on thevolume of protein.3.Calculate the amount of MSD GOLD SULFO-TAG NHS-Ester stock solution required for the conjugation reaction using theformula depicted below and on the attached worksheet.EXAMPLE❑500 µL of 2 mg/mL antibody❑12:1 challenge ratio❑MSD GOLD SULFO-TAG stock = 3 nmol/µL1000 x 2 mg/mL x 12 x 500 µL = 80 nmol of MSD GOLD SULFO-TAG reagent required150,000 Da80 nmol of SULFO-TAG reagent = 26.7 µL of SULFO-TAG stock solution required for conjugation reaction3 nmol/µL SULFO-TAG stock solution4.Centrifuge the MSD GOLD SULFO-TAG NHS-Ester vial by pulse spinning for 1 minute or gently tap on a soft surface inorder to collect lyophilized material at the bottom of the vial. Reconstitute MSD GOLD SULFO-TAG NHS-Ester immediately prior to use with cold distilled water. For the 2 µmol and 150 nmol sizes of MSD GOLD SULFO-TAG NHS-Ester, dissolve with 200 µL and 50 µL, respectively to generate stock solutions of 10 and 3 nmol/µL. Gently vortex the vial to ensure complete dissolution of all lyophilized material.Note: Reconstituted MSD GOLD SULFO-TAG NHS-Ester may be kept for up to 10 minutes on ice prior to use.5.Add the calculated volume (from Step 3) of reconstituted MSD GOLD SULFO-TAG NHS-Ester to the protein solution andvortex immediately. Discard any remaining unused MSD GOLD SULFO-TAG NHS-Ester.6.Incubate at 23°C for 2 hours; a temperature range of 20°C to 25°C is acceptable. Shield the reaction from light bycovering the tube with aluminum foil or placing it in a dark area (e.g., a closed drawer). Take care to maintain consistent conjugation conditions between multiple preparation lots to ensure conjugation reproducibility.7.Prepare Zeba Spin D esalting Columns, 40K MWCO, towards the end of the incubation period. Remove the column'sbottom closure and loosen the cap. Do not remove the cap. Place the column in a collection tube to remove the storage buffer and wash the column 3 times with Conjugate Storage Buffer. Each preparation step should be carried out by centrifuging the columns, and their respective collection tubes, in a centrifuge with a swinging bucket rotor at 2–8°C.Refer to Table 5 below for the recommended sample volume, wash buffer volumes, collection tube sizes, and centrifugation times for each preparation step.Note: Reaction volumes larger than the capacity of a Zeba column should be distributed over multiple Zeba columns.8.Apply the conjugation reaction to the Zeba column in a dropwise manner following the recommendations in Table 2. Usinga swinging bucket rotor, centrifuge the columns in clean new collection tubes to purify the MSD GOLD SULFO-TAGconjugated protein. The MSD GOLD SULFO-TAG conjugated protein will be captured in the conical tubes. Retain the conjugated material in the conical tubes, and discard the columns.Note: The unconjugated MSD GOLD SULFO-TAG reagent will appear as yellow in the spin column.Table 5: Specifications for Zeba Spin Desalting Columns, 40K MWCOSize of Column (mL) 0.5 2 5 10 Sample Volume Range (µL) 70–100 200–450 300–1,000 1,000–2,000 Wash Buffer Volume 300 µL 1 mL 2.5 mL 5 mL Sample Volumes to use a stacker1N/A <350 µL <750 µL <1,500 µL Optional Stacker Volume N/A 40 µL 100 µL 200 µL Centrifugation Speed 1,500 x g1,000 x g1,000 x g1,000 x gCentrifugation Time(Min) Storage Solution Removal 1 2 2 2 Wash 1 1 4–8 4–8 4–8 Wash 2 1 2–8 2–8 2–8 Wash 32 3 5–8 5–8 5–8 Sample Recovery33–4 6–8 6–8 6–8addition of the protein to the column.2 If column is not mostly white after the third wash, the column may be spun for an additional 1–3 minutes.3 Additional sample recovery spin time is allowed if needed to ensure maximum recovery of sample. Overdrying the resin at this stage will not harm the protein; therefore, spinning for up to 8 minutes is allowed.9.It is recommended to filter the conjugated protein using a 0.2 µm filter. Filtration may cause some loss of the protein.Please refer to page 7 for the recommended filter units.10.Determine the molar protein concentration of the conjugated protein using a standard colorimetric protein assay such asBCA, Bradford, or Lowry.absorbance reading as MSD GOLD SULFO-TAG will absorb light at this wavelength.Note: Do not use an OD28011.Measure the absorbance of the MSD GOLD SULFO-TAG protein conjugate at 455 nm using a spectrophotometer. Dividethe measured value by the path length in cm, and then divide by the extinction coefficient of the label (15,400 M-1cm-1) to obtain the MSD GOLD SULFO-TAG label concentration in moles per liter. For reference, a formula calculation worksheet page is attached.12.To calculate the MSD GOLD SULFO-TAG label:protein conjugation ratio, divide the MSD GOLD SULFO-TAG labelconcentration value determined in step 11 by the molar protein concentration value determined in step 10.13.Antibody conjugates are usually stable for at least 2 years at 2–8°C at a concentration of 1–2 mg/mL; stability of otherprotein types should be determined. Conjugated proteins may be stored frozen at ≤-20°C or ≤-70°C, as long as the protein is stable to freeze-thaw cycles or stored in single-use aliquots. MSD GOLD SULFO-TAG conjugated proteins may be sensitive to extended exposure to light and should be stored in the dark or in amber or opaque vials. Short-term exposure of conjugates to light when carrying out assays is not a concern. If the protein concentration is low (< 0.1 mg/mL), consider adding a carrier protein such as 0.1% MSD Blocker A.Storage, Handling, and StabilityMSD GOLD SULFO-TAG NHS-Ester is supplied as a dry orange-red lyophilized solid. The vials should be stored at ≤-70°C. The expiration date of the product is indicated on the label. Following reconstitution, any remaining unused material should be discarded.FAQs1)What chemicals interfere with MSD GOLD SULFO-TAG conjugation?Primary amines and strong nucleophiles interfere with MSD GOLD SULFO-TAG NHS-Ester conjugation. Common reagents that can interfere with the amine coupling of NHS chemistry are:a)Trisb)Glycinec)Histidined)Azidee)Imidazolef)Glutathioneg)Ammonium ionsh)Glycerol2)What are typical carrier proteins in antibody solutions?a)BSAb)GelatinAntibodies should be obtained in carrier protein-free formulations for labeling with MSD GOLD SULFO-TAG NHS-Ester.Carrier proteins will interfere with MSD GOLD SULFO-TAG NHS-Ester conjugation and cannot be removed with desalting columns.3)What is the minimum amount of material that can be conjugated?Generally, 50-100 µg can be conjugated in PBS (without interfering buffer components) if the protein concentration is high enough (1–2 mg/mL). Otherwise, microconcentrators may be used to concentrate the antibody solution following equilibration of the microconcentrator with PBS.4)Are there alternatives to using Thermo Scientific Zeba Spin D esalting Columns for purifying the MSD GOLDSULFO-TAG conjugated antibody after conjugation?a)Users may purchase commercially available G-50 SEPHADEX columns or prepare G-50 SEPHADEX columns atthe bench. However, some G-50 columns may not be efficient in complete removal of unconjugated material. TheSEPHADEX grade is important. MSD recommends using fine grade SEPHADEX for preparing self-packed gelfiltration columns. Medium Grade SEPHADEX does not provide suitable separations and Superfine SEPHADEXdoes not allow an adequate flow rate without use of a pump. It is not recommended to use PD10 columns or G-25 SEPHADEX spin columns for purification of MSD GOLD SULFO-TAG-conjugated protein as these are notable to separate free MSD GOLD SULFO-TAG reagent from labeled conjugates.b)Alternatively, CENTRICON concentrators or similar microconcentrator products with adequate MWCO (forconcentrator information please refer to page 7) can be used to remove unbound label. Resuspend theconjugation mixture in a larger volume of PBS-0.05% azide, concentrate to a smaller volume, and then repeat theprocess as per the product instructions for desalting applications.c)Post-conjugation purification of proteins with MW < 40,000 Da will require alternative procedures (such as high-resolution size exclusion chromatography, HPLC, FPLC, etc.) because ZEBA Spin Desalting Columns or G-50columns will not provide adequate separation in this size range.5)What is the molecular weight of MSD GOLD SULFO-TAG?Unreacted MSD GOLD SULFO-TAG NHS-Ester has a molecular weight of 1,141 g/mol. After the conjugation reaction, each conjugated MSD GOLD SULFO-TAG adds 1,027 g/mol to the protein.6)What types of material can be conjugated?MSD GOLD SULFO-TAG NHS-Ester is reactive with primary amines. Proteins and large peptides are easily labeled. Fab fragments have also been conjugated successfully.MSD Conjugation Services may be used to conjugate small molecules and peptides. Please contact MSD Scientific Support (Phone: 1-240-314-2798, Email: ScientificSupport@) or your local MSD Application Scientist for details.7)What conjugation ratio is recommended for an IgM?A challenge ratio range from 8:1 to 12:1 may be used for conjugating IgM antibodies. The molecular weight of an IgM is inthe order of 900,000 Da. IgMs can be unstable at higher pHs, therefore conjugation at pH 7.0 to 7.2 may be better than the standard labeling buffer of pH 7.9 used for IgG.8)Are there alternatives to using Conjugation Buffer for the conjugation reaction?For best results, it is recommended to use Conjugation Buffer. However, other buffers can be used for the conjugation reaction provided they are free of amine-containing molecules (i.e., no Tris- or glycine-containing buffers) and preservatives. Affinity-purified antibodies are commonly eluted with high molarity glycine solutions; therefore, it is important that they are properly desalted prior to conjugation. Using alternative conjugation buffers may result in lower incorporation efficiencies.9)What should I do if my application requires the conjugated protein to be in a different buffer?The desalting columns may be equilibrated in a buffer other than PBS if the end application requires storage of the conjugated protein in a non-PBS buffer.10)Will my antibody retain activity after labeling?MSD GOLD SULFO-TAG is a small hydrophilic molecule and generally does not affect the function of its conjugation partner, especially when labeling large proteins such as antibodies. With small molecule or peptide labeling, the addition of MSD GOLD SULFO-TAG may have an effect on binding affinities.11)What is the stability of MSD GOLD SULFO-TAG NHS-Ester?The shelf life of MSD GOLD SULFO-TAG NHS-Ester is 3 years at ≤-70°C. The reagent can be stored for up to 2 years at ≤-10°C with minimal loss of activity. Reagent stability is lower at room temperature or at 2–8°C. At room temperature, there may be a 1/3 to 1/2 loss of active material in a month. Once the reagent is reconstituted, it should be used as soon as possible since the NHS-ester hydrolyzes in water. After reconstitution, the solution may be kept up to 10 minutes on ice with minimal loss of activity.12)What if the protein to be conjugated does not have any primary amine groups?Alternative linking chemistry options are available from MSD which allow non-amine containing molecules to be successfully labeled. These include Thiol-Reactive linker (SULFO-TAG Iodoacetamide), Carboxyl (-COOH) Reactive linker (SULFO-TAG Amine) and Carbohydrate Reactive SULFO-TAG. Please contact MSD Scientific Support (Phone: 1-240-314-2798, Email: ScientificSupport@) or your local MSD Application Scientist for details.13)I have an IgG purified antibody from my protein production group which has been eluted into PBS. Should Idesalt before conjugation?Yes. Tris-glycine is a major component of antibody elution buffers used in the purification procedure. On many occasions,a single desalting into PBS is insufficient. It is recommended to repeat the desalting step into PBS to remove any tracequantities of Tris-glycine that can hinder conjugation with MSD GOLD SULFO-TAG.14)How do I conjugate a high concentration protein solution with MSD GOLD SULFO-TAG?The conjugation reaction will be more efficient at high protein concentrations. It is recommended to use a lower challenge ratio for conjugation to compensate for the increased efficiency.15)How do I conjugate a low concentration protein solution with MSD GOLD SULFO-TAG?MSD recommends the protein concentration to be at least 0.5 mg/mL. If concentrating the protein solution is not feasible, conjugation can be done at a lower concentration, which may result in lower conjugation efficiency. Therefore, the conjugation reaction should be performed at a challenge ratio of 20:1 or higher.16)How do I conjugate small proteins with MSD GOLD SULFO-TAG?Proteins with MW < 40,000 Da can be conjugated by the same chemistry as antibodies; lower challenge ratios may be required for MSD GOLD SULFO-TAG conjugation of small proteins and peptides than for IgGs. The NHS-Ester will react with primary amines such as lysine residues and the N-terminus of proteins and peptides. If there is no primary amine available, a different chemistry will be necessary. Post-conjugation purification of small proteins will require alternative procedures (such as HPLC, FPLC, etc.) because small proteins are not resolved by G-50 columns.17)Why can't I use a spectrophotometer at 280 nm to determine conjugated protein concentration?MSD GOLD SULFO-TAG strongly absorbs at 280 nm and will interfere with any measurement of protein concentration at this wavelength.18)What is the stability of MSD GOLD SULFO-TAG conjugated proteins?MSD GOLD SULFO-TAG conjugated protein is generally as stable as the unconjugated protein if it is stored in the appropriate buffer, concentration, and storage temperature. The conjugated protein should be stored in the dark, either at 2–8°C or frozen in aliquots. Azide should be added for long term storage at 2–8°C to prevent any microbial growth. If the protein concentration is low, consider adding a carrier protein, such as 0.1% MSD Blocker A.19)My antibody did not conjugate very well. What are the possible reasons?The presence of preservatives, carrier protein or residual Tris-glycine or other interfering substances in the conjugation buffer (see FAQ 1 and 2) can reduce conjugation efficiency of the protein. Very low concentrations of the starting material (below 0.5 mg/mL) may also reduce conjugation ratios. It has also been observed that some IgGs label more efficiently than others.20)What components can be removed by buffer exchange or dialysis?Salt, azide, glycerol, buffering agent (e.g., Tris), carbohydrates (e.g., trehalose), and amino acids (e.g., histidine, glycine) can be successfully removed by buffer exchange method.21)Who should I contact if I have any questions on MSD GOLD SULFO-TAG conjugation?Please contact MSD Scientific Support (Phone: 1-240-314-2798, Email: ScientificSupport@) or your local MSD Application Scientist for details.WorksheetDate:MaterialsProtein to be conjugatedConcentration: Vendor:Catalog number: Lot number:Sample PreparationMethod: Buffer:Lot number: Date:Columns/Concentrators: Lot number:MSD GOLD SULFO-TAG NHS-Ester ReconstitutionSize: Lot number:Distilled water:Lot number: Date:Volume of water added to vial: Stock concentration (nmol/µL):Separation and CalculationsBuffer:Lot number: Date:Columns: Lot number:Protein assay kit:Type: Lot number:Pre-Conjugation Calculations1,000 x Protein conc. (mg/mL) x Challenge ratio x Volume of protein solution (µL) = nmol of SULFO-TAG reagent required Protein MW (Da)nmol of SULFO-TAG reagent required = µL of SULFO-TAG stock solution required for conjugation reaction Conc. of SULFO-TAG stock solution (nmol/µL)。

斯茹林Quantum Neo 中文操作手册V1.6

斯茹林
Rockingham Drive, Linford Wood East, Milton Keynes MK14 6LY, England Tele 电话 +44 (0) 1908 233 833 传真: +44 (0) 1908 235 333
CERULEAN
版本控制
版次
时间
所做变更
程序设计者
打开仪器，给它 30 分钟使其稳定到环境条件。
电脑里的本地日期和时间必须设置正确。Quantum Neo 使用此信息作为结果。
规格说明
Quantum Neo 的仪器规格和各种测量参数，请参阅来自当地斯茹林销售经理、斯茹林办公室的数据表，或通过斯茹林官方网站。
P 新增自动取样器和重复模式的改变
BSW
手册范围用户手册就是为如何配置仪器、校准、加载并运行样本，以及获得仪器结果提供相关信息。更多帮助斯茹林可以提供更深入的技术知识、故障查找、诊断以及维护和仪器上的培训课程。对于这些选项，请联系您所在地区的斯茹林销售或服务经理。
斯茹林还提供全面的安装、备件、修理、故障维修、年度维护以及合约服务。对于这些选项，请联系您所在地区的斯茹林销售或服务经理。
如需仪器的进一步技术支持，请联系 technical.support@ 或您所在地区的斯茹林办公室。调试客户必须在第一次使用前对 Quantum Neo 进行风险评估。
按钮使用的图标 .................................................................................................................................................................. 5 启动......................................................................................................................................................................................... 6

LORD Chemlok 253H 高浓度一剂性胶合剂说明书

DescriptionLORD Chemlok ® 253H adhesive is a high solids, one-coat adhesive designed to bond compounds based on natural rubber (NR), polyisoprene (IR), styrene-butadiene (SBR), polybutadiene (BR), polychloroprene (CR),nitrile (NBR), butyl (IIR) and EPDM polymers to metals. These metals include carbon and alloy steels, stainless steel, aluminum, magnesium, zinc, copper and copper alloys. It is composed of a mixture of polymers, organic compounds and mineral ﬁ llers dissolved or dispersed in an organic solvent system.Features and Beneﬁ tsConvenient – requires only a single coat for most appli-cations, reducing labor, solvent usage, inventory and shipping costs.Non-Chlorinated Solvent System – suitable for solvent incineration, saving cost of recovery equipment.Environmentally Resistant – provides superior resis-tance to heat, oils and salt spray.ApplicationSurface Preparation – Thoroughly clean metal surfaces prior to adhesive application. Remove protective oils,Chemlok ®253H Adhesivecutting oils and greases by solvent degreasing oralkaline cleaning. Remove rust, scale or oxide coatings by suitable chemical or mechanical cleaning methods.•Chemical CleaningChemical treatments are readily adapted to auto-mated metal treatment and adhesive application lines. Chemical treatments are also used on metal parts that would be distorted by blast cleaning or where tight tolerances must be maintained. Phos-phatizing is a commonly used chemical treatment for steel, while conversion coatings are commonly used for aluminum.•Mechanical CleaningGrit blasting is the most widely used method ofmechanical cleaning. However machining, grinding or wire brushing can be used. Use steel grit to blast clean steel, cast iron and other ferrous metals. Use aluminum oxide, sand or other nonferrous grit to blast clean stainless steel, aluminum, brass, zinc and other nonferrous metals.For further detailed information on surface preparation of speciﬁ c substrates, refer to Chemlok Adhesives appli-cation guide. Handle clean metal surfaces with clean gloves to avoid contamination with skin oils.Typical Properties*Appearance Black Liquid Viscositycps @ 25°C (77°F)300-2000 Brookﬁ eld VT Spindle 2, 30 rpmseconds20-70Zahn Cup #4Density kg/m 3 982.6-1030.5 (lb/gal)(8.2-8.6)Solids Content by Weight, % 25-30Flash Point, °C (°F) 9 (48)SolventsToluene*Data is typical and not to be used for speciﬁcation purposes.LORD provides valuable expertise in adhesives and coatings, vibration and motion control, and magnetically responsive technologies. Ourpeople work in collaboration with our customers to help them increase the value of their products. Innovative and responsive in an ever-changing marketplace, we are focused on providing solutions for our customers worldwide ... Ask Us How.LORD Corporation World Headquarters 111 Lord DriveCary, NC 27511-7923 USACustomer Support Center (in United States & Canada)+1 877 ASK LORD (275 5673)For a listing of our worldwide locations, visit .©2010 LORD Corporation OD DS3128 (Rev.4 7/10)Mixing – Thoroughly stir Chemlok 253H adhesive beforeuse, and agitate sufﬁ ciently during use to keep dispersed solids uniformly suspended. Mix drums for 8 hours orlonger at 30-60 rpm before using.Applying – Apply Chemlok 253H adhesive by spray, dip or brush methods. Chemlok 253H adhesive is best suited for dip application.When using Chemlok 253H adhesive as a one-coatadhesive, the dry ﬁ lm thickness should be maintained at17.8-27.9 micron (0.7-1.1 mil), particularly if the bonded assembly is likely to be exposed to severe environments. When used as a covercoat over a primer, the dry ﬁ lm thickness of Chemlok 253H adhesive should be 15.2-20.3 micron (0.6-0.8 mil).• SprayingDilute Chemlok 253H adhesive to a Zahn Cup #2viscosity of approximately 21 seconds. Use a ratio of approximately 50 parts adhesive to 50 parts xylene ortoluene. Tip sizes of 1.07-1.4 mm (0.042-0.055 in) are appropriate. Maintain atomization pressures at 0.345-0.379 MPa (50-55 psi).• D ippingUse full strength. As a one-coat adhesive, a single dipapplication of Chemlok 253H adhesive usually resultsin a dry ﬁ lm thickness of approximately 25.4 micron(1.0 mil).• Brushing Apply full strength.Curing – Chemlok 253H adhesive can be used incompression, transfer and injection molding procedures.Ideal bonding conditions involve a minimum amount of time between loading the adhesive coated parts andelastomer vulcanization. However, Chemlok 253H adhe-sive will resist moderate prebake times without affectingbond performance.Cleanup – Use solvents such as xylene and methyl ethyl ketone (MEK) to remove adhesive before heat is applied.Shelf Life/StorageShelf life is six months from date of shipment when stored in a well ventilated area at 21-27°C (70-80°F) in original, unopened container. Do not store or use near heat, sparks or open ﬂame.Cautionary Information Before using this or any LORD product, refer to the Mate-rial Safety Data Sheet (MSDS) and label for safe use and handling instructions.For industrial/commercial use only. Must be applied bytrained personnel only. Not to be used in householdapplications. Not for consumer use.Values stated in this technical data sheet represent typical values as not all tests are run on each lot of material produced. For formalized product speciﬁ cations for speciﬁ c product end uses, contact the Customer Support rmation provided herein is based upon tests believed to be reliable. In as much as LORD Corporation has no control over the manner in which others may use this information, it does not guarantee the results to be obtained. In addition, LORD Corporation does not guarantee the perfor-mance of the product or the results obtained from the use of the product or this information where the product has been repackaged by any third party, including but not limited to any product end-user. Nor does the company make any express or implied warranty of merchantability or ﬁ tness for a particular purpose concerning the effects or results of such use.Chemlok and “Ask Us How” are trademarks of LORD Corporation or one of its subsidiaries.。

组织胶水介绍(2011-10.19)

快速封闭伤口抗菌抑菌

防水透气
安全美容减轻疼痛
Heart In Hands
Win In Future
防菌和广谱抑菌
可以有效阻挡与伤口感染的有关的金葡菌和表皮葡萄球菌对所有革兰阳性微生物的生长和繁殖均有抑制作用
金黄色葡萄球菌
表皮葡萄球菌
Heart In Hands
Win In Future
聚合过程
单体
血液中含有水份水份由H+ 和 OH多个单体连接形成
组成
单体（液体）＋
OH-
聚合物 (多分子)
聚合物(固体) 10-20 秒
产品及其特性 •产品的优点及益处 •产品的使用方法 •产品使用的注意事项 •产品的临床应用
Heart In Hands
Win In Future
HISTOACRYL® 蓝灵组织胶水的作用
蓝灵组织胶水抑菌实验
放大
在蓝灵组织胶水封闭区域上植入丌同菌株进行培养。
Heart In Hands
Win In Future
蓝灵组织胶水抑菌实验
在蓝灵组织胶水封闭区域内没有细菌生长；其周围有明显菌群繁殖。
产品及其特性 •产品优点及益处 •产品的使用方法 •产品使用的注意事项
•产品的临床应用
Heart In Hands
Histoacryl®
病人伤口护理指南
Heart In Hands
Win In Future
蓝灵－创口闭合的蓝色精灵！
Heart In Hands
Win In Future
Thank you for your attention! Question Time

LEICA CM1850-中文版

3
目录
1.
1.1 1.2 1.3 1.4
重要信息 ...................................................................................................................................................6
Leica Biosystems Nussloch GmbH Heidelbergery 电话：+49 (62 24) 143-0 传真：+49 (62 24) 143-268 网址： Leica C M 1850 – 冷冻切片机
保证特征仅由我们和我们的客户之间达成的合同条款确定。徕卡公司保留更改技术规格和制造工艺的权利，恕不另行通知。只有这样，才有可能不断提高我们的产品采用的技术和制造技艺。本文档受著作权法保护。本文档一切版权均属 Leica Biosystems Nussloch GmbH 所有。以印刷、影印、缩影、网络摄像或其它方法 – 包括任何电子系统和媒介 – 复制本文档的文本和插图 (或其任何部分) 需要事先征得 Leica Biosystems Nussloch GmbH 的明确书面许可。仪器序列号和制造年份请参见仪器背面的铭牌。 © Leica Biosystems Nussloch GmbH
选址要求 ..................................................................................................................................................... 14 搬运到所需地点 ....................................................................................................................................... 14 标准配置 ..................................................................................................................................................... 15 安装手轮 ..................................................................................................................................................... 16 连接电源 ..................................................................................................................................................... 17 操作前 ......................................................................................................................................................... 17 Leica CM1850 — 概述 .......................................................................................................................... 18 电源开关和自动主电源保险丝 ............................................................................................................ 20 开启仪器 ..................................................................................................................................................... 20 控制面板 1 .................................................................................................................................................. 21 设定目标值 ................................................................................................................................................ 21 设置时间 ..................................................................................................................................................... 21 设置自动除霜时间 (冷冻箱) .................................................................................................................. 22 选择冷冻箱温度 ....................................................................................................................................... 22 启动 Peltier 元件 ....................................................................................................................................... 23 速冻架的手动除霜 ................................................................................................................................... 23 冷冻箱手动除霜 ....................................................................................................................................... 24 显示锁定 ..................................................................................................................................................... 24 控制面板 2 — 电动粗进 ..................................................................................................................... 25

Chemlok 8007蓝色水溶液粘合剂技术数据表说明书

Chemlok® 8007 Blue Primer Technical Data SheetChemlok® 8007 Blue water-based primer is designed to bond elastomers to metals and other substrates when used with Chemlok water-based covercoat adhesives, including Chemlok 8560S-1, Chemlok 8560D-1 and Chemlok 8210 adhesives. It is composed of a mixture of dispersed mineral fillers, organic compounds, resins and polymer latices in an aqueous medium. Features and Benefits:Environmentally Preferred – provides reduced VOC emissions, allowing for a safer work environment. Versatile – functions as an effective primer for many materials such as steel, phosphated steel, nylon, aluminum and brass.Environmentally Resistant – provides excellent resistance to water, salt spray, glycol, oil and heat. Excellent Appearance – provides a smooth coating for use by dip or spray applications. The blue color affords good contrast with black covercoats and prepared metals. Easy to Use – easily redispersed within 5 to 15 minutes of stirring; ready to use directly out of the container without dilution.Application:Surface Preparation – Thoroughly clean metal surfaces prior to application. Remove protective oils, cutting oils and greases by solvent degreasing or alkaline cleaning. Remove rust, scale or oxide coatings by suitable chemical or mechanical cleaning methods.For further detailed information on surface preparationof specific substrates, refer to Chemlok Adhesives application guide.Mixing – Thoroughly mix primer before using to disperse any soft settling which may have occurred during storage. Do not shake. To prevent foaming, mechanical mixing should not exceed 30 rpm. The addition of anti-foaming agents is not recommended.In most cases, dilution is not required. Deionized wateris suggested if dilution is necessary. Add water gradually while stirring either by hand or by using another low-shear mixing method.Applying – Preheat substrates to 49-65°C (120-150°F) prior to spray application of primer. This heat and spray method prevents runs and sags and gives a dry coating ready for covercoat application. Use contaminant-freeair for spraying. All spray equipment, including pressure pots, hoses, guns and nozzles, should be stainless steel or plastic.Dry film thickness of Chemlok 8007 Blue primer should be5.1-12.7 micron (0.2-0.5 mil).Chemlok 8007 Blue Primer — Technical Data SheetParker LordEngineered Materials Group 111 LORD DriveCary, NC 27511-7923USAphone +1 877 ASK LORD (275 5673)Values stated in this document represent typical values as not all tests are run on each lot of material produced. For formalized product specifications for specific product end uses, contact the Customer Support Center.Information provided herein is based upon tests believed to be reliable. In as much as Parker Lord has no control over the manner in which others may use this information, it does not guarantee the results to be obtained. In addition, Parker Lord does not guarantee the performance of the product or the results obtained from the use of the product or this information where the product has been repackaged by any third party, including but not limited to any product end-user. Nor does the company make any express or implied warranty of merchantability or fitness for a particular purpose concerning the effects or results of such use.WARNING — USER RESPONSIBILITY . FAILURE OR IMPROPER SELECTION OR IMPROPER USE OF THE PRODUCTS DESCRIBED HEREIN OR RELATED ITEMS CAN CAUSE DEATH, PERSONAL INJURY AND PROPERTY DAMAGE.This document and other information from Parker-Hannifin Corporation, its subsidiaries and authorized distributors provide product or system options for further investigation by users having technical expertise.The user, through its own analysis and testing, is solely responsible for making the final selection of the system and components and assuring that all performance, endurance, maintenance, safety and warning requirements of theapplication are met. The user must analyze all aspects of the application, follow applicable industry standards, and follow the information concerning the product in the current product catalog and in any other materials provided from Parker or its subsidiaries or authorized distributors.To the extent that Parker or its subsidiaries or authorized distributors provide component or system options based upon data or specifications provided by the user, the user is responsible for determining that such data and specifications are suitable and sufficient for all applications and reasonably foreseeable uses of the components or systems.©2022 Parker Hannifin - All Rights ReservedInformation and specifications subject to change without notice and without liability therefor. Trademarks used herein are the property of their respective owners.OD DS4175 11/22 Rev.3Drying/Curing – If no preheat is employed, parts will dry in 30 minutes to one hour at room temperature.When used in combination with Chemlok covercoat adhesives, Chemlok 8007 Blue primer can be used to bond rubber by compression, transfer and injection molding procedures.Cleanup – Use soap and water to remove wet primer. Dried primer is not water-soluble and must be removed with a ketone-type solvent.Shelf Life/Storage:Shelf life is three months from date of shipment when stored by the recipient at 21-27°C (70-80°F) in original, unopened container. Do not freeze product. Storage below 4°C (40°F) may be detrimental to the adhesive’s properties.Cautionary Information:Before using this or any Parker Lord product, refer to the Safety Data Sheet (SDS) and label for safe use and handling instructions.For industrial/commercial use only. Must be applied by trained personnel only. Not to be used in household applications. Not for consumer use.。

5070管理员说明书

Microsoft、Windows、Windows NT、Windows Server、Windows Vista、Internet Explorer和 Microsoft Network是Microsoft Corporation在美国及其他国家的商标或注册商标。 Novell、NetWare和NDS是Novell, Inc.在美国及其他国家的商标。 Adobe、Acrobat、PostScript和Adobe PostScript 3是Adobe Systems Incorporated的商标。 AppleTalk、EtherTalk、Macintosh、Mac oS是Apple Inc.的商标。 PCL、HP-GL和HP-GL/2是Hewlett-Packard Corporation的注册商标。 ThinPrint是ThinPrint GmbH在德国及其他国家的注册商标。 Unicode是Unicode, Inc.的注册商标。所有产品/品牌是各公司的商标或注册商标。 Microsoft产品画面的使用已获得美国Microsoft Corporation的许可。有关许可证的详情，请参照《使用说明书》中的 “有关许可证”。
2 纸张和其他介质 ...........................................................33 纸张类型 ................................................................. 34 所支持纸张的可放置数量和重量 .......................................... 34 支持的纸张类型 ............................. 36 放置纸张 ................................................................. 40 在纸盘1-4 （纸盘3和4(双纸盘模块)）（选装）中放置纸张 ................... 40 在纸盘3(复合纸盘模块) （选装）中放置纸张............................... 41 在纸盘4(复合纸盘模块) （选装）中放置纸张............................... 42 在纸盘5(手送纸盘)中放置纸张 ........................................... 42 在纸盘6(大容量纸盘) （选装）中放置纸张................................. 44 更改纸张尺寸 ............................................................. 45 更改纸盘1-4 （纸盘3和4(双纸盘模块)）（选装）的纸张尺寸 ................. 45 更改纸盘3(复合纸盘模块) （选装）的纸张尺寸............................. 46 更改纸盘4(复合纸盘模块) （选装）的纸张尺寸............................. 47 更改纸盘6(大容量纸盘) （选装）的纸张尺寸............................... 48 更改纸张设定 ............................................................. 50

吉尔特（Gillette）持久不败清洁凝胶说明书

SAFETY DATA SHEETIssuing Date: 17-Mar-2015Revision Date: 17-Mar-2015Version 11. IDENTIFICATIONProduct Name Gillette Endurance Undefeated Clear Gel Product ID:96723114_RET_NGProduct Type:Finished Product - Consumer (Retail) Use Only Recommended Use Personal Beauty Care ProductSynonymsGillette Endurance Cool Wave Clear Gel (96723107_RET_NG)Gillette Endurance Arctic Ice Clear Gel (96723105_RET_NG)Gillette Endurance Brisa Tropical Clear Gel (96671406_RET_NG)Gillette Sport High Performance Sport Triumph Clear Gel (96723100_RET_NG)Gillette Sport High Performance Power Rush Clear Gel (96723098_RET_NG)Gillette Sport with Power Beads Cool Wave Clear Gel (96671416_RET_NG)ManufacturerThe Procter & Gamble Company Sharon Woods Innovation Center 11510 Reed Hartman Highway Cincinnati OH 45241+1 513 626-2500E-mail Address Emergency TelephoneTransportation (24 HR)CHEMTREC - 1-800-424-9300(U.S./ Canada) or 1-703-527-3887Mexico toll free in country: 800-681-95312. HAZARD IDENTIFICATION"Consumer Products", as defined by the US Consumer Product Safety Act and which are used as intended (typical consumer duration and frequency), are exempt from the OSHA Hazard Communication Standard (29 CFR 1910.1200). This SDS is being provided as a courtesy to help assist in the safe handling and proper use of the product.This product is classifed under 29CFR 1910.1200(d) and the Canadian Hazardous Products Regulation as follows:.Eye Damage / Irritation Category 2B Flammable Liquids Category 2Signal Word DANGERHazard StatementsCauses eye irritationHighly flammable liquid and vaporHazard pictograms3. COMPOSITION/INFORMATION ON INGREDIENTSIngredients are listed according to 29CFR 1910.1200 Appendix D and the Canadian Hazardous Products Regulation 4. FIRST AID MEASURESFirst aid measures for different exposure routes Eye contactIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.Skin contact None under normal use.Ingestion Not an expected route of exposure. If swallowed:. Clean mouth with water and afterwards drink plenty of water.InhalationNone under normal use.Most important symptoms/effects,acute and delayedMay cause eye irritation.Indication of immediate medical attention and special treatment needed, if necessary Notes to PhysicianTreat symptomatically.5. FIRE-FIGHTING MEASURESPrecautionary Statements -PreventionKeep container tightly closed K e e p a w a y f r o m h e a t /s p a r k s /o p e n f l a m e s /h o t s u r f a c e s . — N o s m o k i n g Wash hands thoroughly after handlingPrecautionary Statements -ResponseIn case of fire: Use water, CO2, dry chemical, or foam for extinctionIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIf eye irritation persists: Get medical advice/attention Precautionary Statements -StorageNonePrecautionary Statements -DisposalDispose of contents/container in accordance with local regulation Hazards not otherwise classified (HNOC)NoneChemical NameSynonymsTrade SecretCAS-No Weight %Ethanol -No 64-17-510 - 15Isopropanol-No 67-63-0 1 - 5Calcium chloride (CaCl2), dihydrate -No 10035-04-8 1 - 5Octamethylcyclotetrasiloxane-No556-67-20.1 - 1.0Flammable properties Flammable liquid and vaporSuitable extinguishing media Water. Dry chemical. Alcohol-resistant foam. Carbon dioxide (CO 2). Unsuitable Extinguishing Media Do not use a solid water stream as it may scatter and spread fire. Special hazard Fumes may catch fire.Special protective equipment for fire-fighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.Specific hazards arising from thechemicalNone.6. ACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency proceduresPersonal precautions None under normal use conditions.Advice for emergency responders Use personal protective equipment as required.Environmental precautions Do not discharge product into natural waters without pre-treatment or adequate dilution. Methods and materials for containment and cleaning upMethods for containment Prevent product from entering drains. Prevent further leakage or spillage if safe to do so.Methods for cleaning up Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand,earth, diatomaceous earth, vermiculite) and place in container for disposal according tolocal / national regulations (see section 13).7. HANDLING AND STORAGEPrecautions for safe handlingAdvice on safe handling Keep container closed when not in use. Keep away from open flames, hot surfaces andsources of ignition. Never return spills in original containers for re-use. Use personalprotective equipment as required. Keep out of the reach of children.Conditions for safe storage, including any incompatibilitiesTechnical measures/Storage conditions Keep away from open flames, hot surfaces and sources of ignition. Store away from other materials.Storage Conditions Keep containers tightly closed in a dry, cool and well-ventilated place. Store in acool/low-temperature, well-ventilated, dry place away from heat and ignition sources. Incompatible products None known.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONControl parametersExposure Guidelines Exposure guidelines are not relevant when product is used as intended in a householdsetting.Exposure controlsEngineering Measures Manufacturing Sites:Ensure adequate ventilationDistribution, Workplace and Household Settings:Not applicablePersonal Protective EquipmentEye Protection Manufacturing Sites:Safety glasses with side-shieldsDistribution, Workplace and Household Settings:No special protective equipment requiredHand Protection No special protective equipment requiredSkin and Body Protection No special protective equipment requiredRespiratory Protection No special protective equipment required9. PHYSICAL AND CHEMICAL PROPERTIESPhysical State @20°C liquidAppearance clearOdor characteristicOdor threshold No information availableProperty Values NotepH value 3.0 - 5.0Melting/freezing point No information availableBoiling point/boiling range No information availableFlash point 30.5 °C / 86.9 °F Does not sustain combustion Evaporation rate No information availableFlammability (solid, gas)No information availableFlammability Limits in AirUpper flammability limit No information availableLower Flammability Limit No information availableVapor pressure No information availableVapor density No information availableRelative density 1.13Water solubility slightly solubleSolubility in other solvents No information availablePartition coefficient: n-octanol/water No information availableAutoignition temperature No information available.Decomposition temperature No information available.Viscosity of Product No information availableVOC Content (%)Products comply with US state and federal regulations for VOC content in consumerproducts.10. STABILITY AND REACTIVITYReactivity None under normal use conditions.Stability Stable under normal conditions.Hazardous polymerization Hazardous polymerization does not occur.Hazardous Reactions None under normal processing.Conditions to Avoid Keep away from open flames, hot surfaces and sources of ignition.Materials to avoid None in particular.Hazardous Decomposition Products None under normal use.11. TOXICOLOGICAL INFORMATION Product InformationInformation on likely routes of exposureInhalation No known effect.Skin contact No known effect.Ingestion No known effect.Eye contact Avoid contact with eyes. Irritating to eyes.Delayed and immediate effects as well as chronic effects from short and long-term exposure Acute toxicity No known effect.Skin corrosion/irritation No known effect.Serious eye damage/eye irritation Irritating to eyes.Skin sensitization No known effect.Respiratory sensitization No known effect.Germ cell mutagenicity No known effect.Neurological Effects No known effect.Reproductive toxicity No known effect.Developmental toxicity No known effect.Teratogenicity No known effect.STOT - single exposure No known effect.STOT - repeated exposure No known effect.Target Organ Effects No known effect.Aspiration hazard No known effect.Carcinogenicity No known effect.12. ECOLOGICAL INFORMATION EcotoxicityThe product is not expected to be hazardous to the environment.Persistence and degradability No information available.Bioaccumulative potential No information available.Mobility No information available.Other adverse effects No information available.13. DISPOSAL CONSIDERATIONSWaste treatmentWaste from Residues / Unused Products Disposal should be in accordance with applicable regional, national and local laws and regulations.Contaminated packaging Disposal should be in accordance with applicable regional, national and local laws andregulations.California Hazardous Waste Codes(non-household setting)331Disposal recommendations Products covered by this MSDS, in their original form, when disposed from a commercialfacility as waste, are ignitable hazardous waste, D001, according to Federal RCRAregulations(40 CFR 261). Disposal should be in accordance with Local, State and Federalregulations.14. TRANSPORT INFORMATIONDOTUN no UN1993UN Proper shipping name Flammable liquid, n.o.sDescription UN1993, Flammable liquid, n.o.s (Ethanol, Isopropanol), 3, IIIHazard Class3Packing Group III128Emergency Response GuideNumberIMDGUN Number UN1993UN Proper shipping name Flammable liquid, n.o.s.Description UN1993, Flammable liquid, n.o.s. (Ethanol, Isopropanol), 3, IIITransport hazard class(es)3Packing Group IIIEmS-No F-E, S-EIATAUN no UN1993UN Proper shipping name Flammable liquid, n.o.s.Description UN1993, Flammable liquid, n.o.s. (Ethanol, Isopropanol), 3, IIIHazard Class3Packing Group IIIERG Code3L15. REGULATORY INFORMATIONU.S. Federal RegulationsSARA 313Not applicable for consumer useCERCLANot applicable for consumer useFood and Drug Administration (FDA)The product described in this Material Safety Data Sheet is regulated under the Federal Food, Drug, and Cosmetics Act and is safe to use as per directions on container, box or accompanying literature (where applicable)Clean Air Act, Section 112 Hazardous Air Pollutants (HAPs) (see 40 CFR 61)Not applicable for consumer useClean Water ActNot applicable for consumer useCalifornia Proposition 65This product is not subject to warning labeling under California Proposition 65.U.S. State Regulations (RTK)Not applicable for consumer useInternational InventoriesUnited StatesProduct is a personal care product and regulated under FDA.CanadaThis product is in compliance with CEPA for import by P&G.LegendTSCA - United States Toxic Substances Control Act Section 8(b) InventoryCEPA - Canadian Environmental Protection ActPerfumes contained with the products comply with appropriate IFRA guidance.16. OTHER INFORMATIONIssuing Date:17-Mar-2015Revision Date:17-Mar-2015Reason for revision Initial Release.DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the textEnd of SDS。

LORD P-1291红色基础胶说明书

USA SAFETY DATA SHEET3000000035871. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name: LORD P-1291 RED PRIMER Product Use/Class:SiliconeLORD Corporation 111 LORD DriveCary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No.800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE: 12/18/20202. HAZARDS IDENTIFICATIONGHS CLASSIFICATION:Flammable liquids Category 2Skin corrosion/irritation Category 2Serious eye damage/eye irritation Category 2A Carcinogenicity Category 2Reproductive toxicity Category 2Specific target organ systemic toxicity (single exposure) Category 3Specific target organ systemic toxicity (single exposure) Category 1 Central nervous system, Kidney, Liver, Respiratory system, Systemic toxicity, Hematopoietic SystemSpecific target organ systemic toxicity (repeated exposure) Category 2 Liver, spleen, KidneySpecific target organ systemic toxicity (repeated exposure) Category 1 Nervous system, Respiratory system, Hematopoietic System, Central nervous system, Digestive organs, Ears Aspiration hazard Category 1Hazardous to the aquatic environment - acute hazard Category 2GHS LABEL ELEMENTS: Symbol(s)Signal WordD ANGERHazard StatementsHighly flammable liquid and vapor. Causes skin irritation.Causes serious eye irritation. Suspected of causing cancer.Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause respiratory irritation.Causes damage to organs.(Central nervous system, Kidney, Liver, Respiratory system, Systemic toxicity, Hematopoietic System)May cause damage to organs through prolonged or repeated exposure.(Liver, spleen, Kidney)Causes damage to organs through prolonged or repeated exposure.(Nervous system, Respiratory system, Hematopoietic System, Central nervous system, Digestive organs, Ears) May be fatal if swallowed and enters airways. Toxic to aquatic life.Precautionary StatementsPreventionKeep away from heat/sparks/open flames/hot surfaces. - No smoking.Ground/Bond container and receiving equipment.Use explosion-proof electrical/ventilating/lighting equipment.Use only non-sparking tools.Take precautionary measures against static discharge.Obtain special instructions before use.Do not handle until all safety precautions have been read and understood.Wear protective gloves/protective clothing/eye protection/face protection.Use personal protective equipment as required.Do not breathe dust/fume/gas/mist/vapors/spray.Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Use only outdoors or in a well-ventilated area.Avoid release to the environment.ResponseIn case of fire: refer to section 5 of SDS for extinguishing media.Call a POISON CENTER or doctor/physician if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatment (see supplemental first aid instructions on this label).IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.If skin irritation occurs: Get medical advice/attention.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.Continue rinsing.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Do NOT induce vomiting.StorageStore in a well-ventilated place. Keep cool.Store in a well-ventilated place. Keep container tightly closed.Store locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Vapor harmful; may affect the brain or nervous system causing dizziness, headache or nausea. Harmful if absorbed through skin. Possible irritation of the respiratory system can occur causing a variety of symptoms such as dryness of the throat, tightness of the chest, and shortness of breath. May cause central nervous system depression characterized by the following progressive steps: headache, dizziness, staggering gait, confusion, unconsciousness or coma.May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.Chronic: May affect the gastrointestinal system. Ethylbenzene has been classified by IARC as a possible human carcinogen (Group 2B) and reported by NTP to show clear evidence for carcinogenicity in animals.3. COMPOSITION/INFORMATION ON INGREDIENTSChemical Name CAS Number RangeXylene1330-20-725 - 30%Isopropanol67-63-025 - 30%Acetone67-64-120 - 25%Ethyl benzene100-41-4 5 - 10%Alkyl silicate PROPRIETARY 1 - 5%N-Butanol71-36-3 1 - 5%Any "PROPRIETARY" component(s) in the above table is considered trade secret, thus the specific chemical and its exact concentration is being withheld.4. FIRST AID MEASURESFIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult, give oxygen. Get immediate medical attention.FIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediately for further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.5. FIRE-FIGHTING MEASURESSUITABLE EXTINGUISHING MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUISHING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM THE CHEMICAL: Extremely flammable liquid and vapor. Keep containers tightly closed. Isolate from heat, electrical equipment, sparks, open flame, and other sources of ignition. Closed containers may rupture when exposed to extreme heat. Use water spray to keep fire exposed containers cool. During a fire, irritating and/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIRE-FIGHTERS: Wear full firefighting protective clothing, including self-contained breathing apparatus (SCBA). Water spray may be ineffective. If water is used, fog nozzles are preferable.6. ACCIDENTAL RELEASE MEASURESPERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES: Remove all sources of ignition (flame, hot surfaces, and electrical, static or frictional sparks). Avoid breathing vapors. Use self-contained breathing equipment. Avoid contact.ENVIRONMENTAL PRECAUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIALS FOR CONTAINMENT AND CLEANUP: Keep non-essential personnel away from spill area. Notify appropriate authorities if necessary. Contain and remove with inert absorbent material and non-sparking tools. Avoid contact. Before attempting cleanup, refer to hazard caution information in other sections of the SDS form.7. HANDLING AND STORAGEHANDLING: Keep closure tight and container upright to prevent leakage. Ground and bond containers when transferring material. Avoid skin and eye contact. Wash thoroughly after handling. Avoid breathing of vapor or spray mists. Do not handle until all safety precautions have been read and understood. Empty containers should not be re-used. Use with adequate ventilation. Because empty containers may retain product residue and flammable vapors, keep away from heat, sparks and flame; do not cut, puncture or weld on or near the empty container. Do not smoke where this product is used or stored.STORAGE: Do not store or use near heat, sparks, or open flame. Store only in well-ventilated areas. Do not puncture, drag, or slide container. Keep container closed when not in use. Refer to OSHA 29CFR Part 1910.106 "Flammable and Combustible Liquids" for specific storage requirements.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.8. EXPOSURE CONTROLS/PERSONAL PROTECTION COMPONENT EXPOSURE LIMITChemical Name ACGIH TLV-TWA ACGIH TLV-STELOSHA PEL-TWAOSHA PEL-CEILINGSkinXylene100 ppm150 ppm435 mg/m3100 ppmN.E.N.A.Isopropanol200 ppm400 ppm980 mg/m3400 ppmN.E.N.A.Acetone500 ppm750 ppm2,400 mg/m31,000 ppmN.E.N.A.Ethyl benzene20 ppm N.E.435 mg/m3100 ppmN.E.N.A.Alkyl silicate10 ppm N.E.850 mg/m3100 ppmN.E.N.A.N-Butanol20 ppm N.E.300 mg/m3100 ppmN.E.SN.A. - Not Applicable, N.E. - Not Established, S - Skin DesignationEngineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain air contaminant levels below recommended exposure limits. Caution: Solvent vapors are heavier than air and collect in lower levels of the work area. Sufficient ventilation (using explosion-proof equipment) should be provided to prevent flammable vapor/air mixtures from accumulating.PERSONAL PROTECTION MEASURES/EQUIPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed toremove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined space use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance with applicable laws and regulations of your country or particular locality.SKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Use disposable or impervious clothing if work clothing contamination is likely. Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in anychemical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.9. PHYSICAL AND CHEMICAL PROPERTIESTypical values, not to be used for specification purposes.ODOR: Pungent VAPOR PRESSURE: N.D.APPEARANCE: Red VAPOR DENSITY: Heavier than Air PHYSICAL STATE: Liquid LOWER EXPLOSIVE LIMIT: 1 %(V)FLASH POINT: 17 °F, -8 °C SetaflashClosed CupUPPER EXPLOSIVE LIMIT: 13 %(V)BOILING RANGE: 56 - 168 °C EVAPORATION RATE: Faster than n-butyl-acetate.AUTOIGNITION TEMPERATURE:N.D.DENSITY: 0.88 g/cm3 (7.32 lb/gal) DECOMPOSITION TEMPERATURE:N.D. VISCOSITY, DYNAMIC: N.D.ODOR THRESHOLD: N.D.VISCOSITY, KINEMATIC: N.D.SOLUBILITY IN H2O: Insoluble VOLATILE BY WEIGHT: 76.00 %pH: N.A.VOLATILE BY VOLUME: 81.60 %FREEZE POINT: N.D. VOC CALCULATED: 5.27 lb/gal, 632 g/l COEFFICIENT OF WATER/OIL N.D.DISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not Determined10. STABILITY AND REACTIVITYHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions. STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures. Sources of ignition.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.HAZARDOUS DECOMPOSITION PRODUCTS: Carbon monoxide, carbon dioxide11. TOXICOLOGICAL INFORMATIONEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Chemical Name LD50/LC50Xylene Oral LD50: Rat3,500 mg/kgDermal LD50: Rabbit> 4,350 mg/kgInhalation LC50: Rat29.08 mg/l/4 hIsopropanol Oral LD50: Rat1,870 mg/kgDermal LD50: Rabbit4,059 mg/kgInhalation LC50: Rat72,600 mg/m3/4 hAcetone Oral LD50: Rat5,800 mg/kgDermal LD50: Rabbit> 15,700 mg/kgInhalation LC50: Rat50,100 mg/m3/8 hEthyl benzene Oral LD50: Rat3,500 mg/kgDermal LD50: Rabbit15,400 mg/kgInhalation LC50: Rat17.4 mg/l/4 hAlkyl silicate Oral LD50: Rat6,270 mg/kgDermal LD50: Rabbit6300 µL/kgDermal LD50: Rabbit5,878 mg/kgN-Butanol Oral LD50: Rat700 mg/kgDermal LD50: Rabbit3,402 mg/kgInhalation LC50: Rat>8000 ppm/4 hGerm cell mutagenicity: No classification proposedCarcinogenicity: Category 2 - Suspected of causing cancer.Components contributing to classification: Ethyl benzene.Reproductive toxicity: Category 2 - Suspected of damaging fertility or the unborn child.Components contributing to classification: Xylene. Isopropanol. Acetone. Ethyl benzene.12. ECOLOGICAL INFORMATIONECOTOXICITY:Chemical Name EcotoxicityXylene Fish: Pimephales promelas13.4 mg/l96 h flow-throughOncorhynchus mykiss2.661 - 4.093 mg/l96 h StaticOncorhynchus mykiss13.5 - 17.3 mg/l96 hLepomis macrochirus13.1 - 16.5 mg/l96 h flow-throughLepomis macrochirus19 mg/l96 hLepomis macrochirus7.711 - 9.591 mg/l96 h StaticPimephales promelas23.53 - 29.97 mg/l96 h StaticCyprinus carpio780 mg/l96 h semi-staticCyprinus carpio> 780 mg/l96 hPoecilia reticulata30.26 - 40.75 mg/l96 h StaticInvertebrates: water flea3.82 mg/l48 hGammarus lacustris0.6 mg/l48 hIsopropanol Fish: Pimephales promelas9,640 mg/l96 h flow-throughPimephales promelas11,130 mg/l96 h StaticLepomis macrochirus> 1,400,000 µg/l96 hInvertebrates: Daphnia magna13,299 mg/l48 hPlants: Desmodesmus subspicatus> 1,000 mg/l96 hDesmodesmus subspicatus> 1,000 mg/l72 hAcetone Fish: Pimephales promelas6,210 - 8,120 mg/l96 h StaticLepomis macrochirus8,300 mg/l96 hInvertebrates: Daphnia magna10,294 - 17,704 mg/l48 h StaticDaphnia magna12,600 - 12,700 mg/l48 hEthyl benzene Fish: Oncorhynchus mykiss11.0 - 18.0 mg/l96 h StaticOncorhynchus mykiss4.2 mg/l96 h semi-staticPimephales promelas7.55 - 11 mg/l96 h flow-throughLepomis macrochirus32 mg/l96 h StaticPimephales promelas9.1 - 15.6 mg/l96 h StaticPoecilia reticulata9.6 mg/l96 h StaticPlants: Pseudokirchneriella subcapitata4.6 mg/l72 hPseudokirchneriella subcapitata> 438 mg/l96 hAlkyl silicate Fish: Danio rerio> 245 mg/l96 h semi-staticN-Butanol Fish: Pimephales promelas1,730 - 1,910 mg/l96 h StaticPimephales promelas1,740 mg/l96 h flow-throughLepomis macrochirus100,000 - 500,000 µg/l96 h StaticPimephales promelas1,910,000 µg/l96 h StaticInvertebrates: Daphnia magna1,983 mg/l48 hDaphnia magna1,897 - 2,072 mg/l48 h StaticPlants: Desmodesmus subspicatus> 500 mg/l96 hDesmodesmus subspicatus> 500 mg/l72 hPERSISTENCE AND DEGRADABILITY:Not determined for this product.BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.13. DISPOSAL CONSIDERATIONSDISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and local environmental control regulations. If waste is determined to be hazardous, use licensed hazardous waste transporter and disposal facility.14. TRANSPORT INFORMATIONUS DOT RoadProper Shipping Name: Flammable liquids, n.o.s.Hazard Class: 3SECONDARY HAZARD: NoneUN/NA Number: 1993Packing Group: IIEmergency Response Guide Number: 128IATA CargoPROPER SHIPPING NAME: FLAMMABLE LIQUID, N.O.S.Hazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1993PACKING GROUP: IIEMS: 3LIMDGPROPER SHIPPING NAME: FLAMMABLE LIQUID, N.O.S.Hazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1993PACKING GROUP: IIEMS: F-EThe listed transportation classification applies to non-bulk shipments. It does not address regulatory variations due to changes in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your transportation/compliance department.15. REGULATORY INFORMATIONU.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.:Chemical Name CAS Number Weight % Less ThanXylene1330-20-730.0%Isopropanol67-63-030.0%Ethyl benzene100-41-410.0%N-Butanol71-36-3 5.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if exported from the United States:None16. OTHER INFORMATIONUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 3 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: Section 2, Section 11, Section 12Effective Date: 12/18/2020DISCLAIMERThe information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred by use of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。

单位对个人工作鉴定范文(三篇)

单位对个人工作鉴定范文工作以来，该实习生通过自身的不断努力，无论是思想上、学习上还是工作上，都取得了长足的发展和巨大的收获，yjbys先后在某某部门、某某科室、会计科等科室工作过，不管走到哪里，都严格要求自己目前已熟练掌握储蓄、会计、计划、信用卡、个贷等业务，成为____行业务的行家里手。

篇四：公务员工作单位对个人的工作鉴定____同志于____年____月抽调到____工作，在其工作的一年里，能协助组长、配合同事完成组内和办公室领导交办的所有工作，做到了学习勤奋上进、工作踏实肯干、作风正派严谨，在各方面都取得较好的成绩。

现对其鉴定如下：政治坚定。

该同志能以马列主义、____理论、“____”等重要思想为指导，认真贯彻落实科学发展观，坚决执行党的各项方针政策，政治立场坚定。

学习勤奋。

该同志能把学习作为自我完善和提高的重要途径，坚持经常学习政策理论文献和业务知识，做到勤学善思、学以致用，同时，在工作中善于总结好的做法，对涉及灾后重建的法规政策能熟练掌握。

工作务实。

该同志在工作中能坚持用心谋事、务实干事，做到勤勤恳恳、任劳任怨。

该同志作为重建组的工作人员，始终能做到服从领导及办公室主任的安排，认真履行岗位职责，与同事经常加班加点勤奋工作，较好地完成了各项工作任务。

一是积极协助办公室主任做好办公室日常事务处理、重建组与相关单位之间的协调工作，推进了工作整理合力的形成。

如：协助恢复重建项目单位办理开工前的相关手续、布置重建组工作会议事务安排和需各恢复重建项目单位通力合作的重点工作等。

二是发挥自身较丰富的基层工作经历和工作经验，积极向领导谏言献策，为办公室内部管理、重建组工作加快推进尽了一份力量。

成绩斐然。

该同志在抽调期间，用心草拟重建组及其办公室文件和相关材料，协助同事完成领导讲话、工作总结等其他材料的草拟撰写工作。

一年里，该同志草拟、协助草拟的文件就达____余个，材料数____个。

同时协助办公室主任完成重建资料的领取与发放、报表的收集与上报工作。

蓝胶说明书翻译

二乙基氨基乙基-亲和层析蓝胶使用说明书目录号码153-7307介绍二乙基氨基乙基亲和层析蓝胶是一种双功能基团离子交换/亲和层析介质，该介质是由同时偶联有Cibacron Blue F3GA和二乙基氨基乙基BIO-GEL A-5m的基团的琼脂糖。

Cibacron Blue F3GA是一种离子型的、憎水的基团，其空间活性结合位点对具有双核苷酸折叠的蛋白质具有吸附作用，如白蛋白。

二乙基氨基乙基通过阴离子交换，其结合等电点比流动相低的蛋白质。

通过这两种双功能基团制备成二乙基氨基乙基亲和层析蓝胶成为一种非常强有力纯化工具。

通过改变盐离子强度和流洗缓冲液的PH，可以从不同种类的血清中纯化出高纯度的IgG。

二乙基氨基乙基亲和层析蓝胶层析过程提供一种纯化血清蛋白的最简便方法。

免疫球蛋白被洗脱后，其它杂蛋白组分可以通过通过离子强度进行洗脱下来。

二乙基氨基乙基亲和层析蓝胶对血清白蛋白亲和层析能力比二乙基氨基乙基离子交换层析的能力更强，可以从混有白蛋白的血清中分离出其它组分的有效的方法。

产品描述填料Bio Gel A-5m 琼脂胶颗粒半径150-300纳米（50-100网孔）洗脱方法0.01MTris,pH8,0.15MNaCl,0.04%NaN3官能团Cibacron blue and diethylaminoethy1（亲和分离介质三嗪染料和DEAE）推荐流速范围15-25cm/hr压力限定15pis容量血清0.2-1ml血清/蓝胶IgG的收率＞55%白蛋白的收率＞90%蛋白酶的去除率100%稳定性pH 2-11有机溶剂酒精温度不耐高温高压存储在0.02% NaN3或其他防腐剂中，4℃保存，一年*使用1.5*20cm的柱子和流动相1：1的压力下，确定的流速。

**兔血清和人血清能力的结合能力有很大的批间差异性，应按照不同的批号，进行不同的选择。

没有提供的必须材料预洗缓冲液0.1M醋酸，pH为3，1.4M的NaCl,40%异丙醇流洗缓冲液参照表2再生缓冲液2M盐酸胍于＋流洗缓冲液中或1.5MNaSCN布氏漏斗层析柱概述1、利用表格1所给出的信息来准备适当的缓冲液，准备准确缓冲液对最适IgG的回收是必须的。

FL-2000系列精密流量计说明书

FL-2011FL-2012FL-2014FL-2015The FL-2000 Series offers a wide variety of precision flowmeters for use in medical, industrial, chemical, and laboratory applications at an economical price. Units are available with or without valves.Acrylic FlowmetersB-15aFL-2000 SeriesSpeciFicationSaccuracy:Models FL-2001–FL-2025: ±5% F.S. Models FL-2031–FL-2069: ±3% F.S. Models FL-2071–FL-2128: ±2% F.S.Float: Black glass stainless steel Body: Clear acrylicSeals: Buna “O” Rings with brass or PVC fittings FKM “O”-Rings with stainless steel fittingspressure: 100 psig max @ 21°C (70°F)temperature:65°C (150°F) max @ 0 psigFittings: Brass std; stainless steel optional except for FL-2071 through FL-2128, which have 1 NPT PVC fittings onlyValves: Models FL-2001 throughFL-2069: brass standard; stainless steel cartridge type (optional)FL-2071 through FL-2128: Optional plastic in-line gateU e asy-to-Read english or Metric Scales U W ater Ranges from 4 ccM to 20 GpM, air Ranges from 40 ccM to 4000 LpM U t hreaded Brass inserts for Quick installation U e asy Disassembly and assembly for Maintenance U D urable one-piece clear acrylic construction U S table, easy-to-Read Float U S uperior Quality appLicationS U a ir Sampling equipment U a quaculture U D esalinization equipment U G as analyzers U M edical Systems U p hoto processing equipment U W ater treatment andDistribution SystemsFL-2013 air, shownsmaller than actual size.FL-2066-nV Water, shownsmaller than actual size.B(13.5)B-15bFL-2091 through FL-2128 DimensionsTo order with plastic integral gate valve, add suffix “-V” to model number for additional cost for FL-2090 Series, and FL-2120 Series.For optional 10-point NIST certificate add suffix, “-NIST” to the model number, for additional cost and two weeks to the standard lead time.Ordering Example: FL-2095, rotameter, 100 to 1400 LPM Air FL-2127-V, rotameter, 4 to 36 LPM water, with valves.FL-2097, shown smaller than actual sizeUnits are standard without valves.To order with plastic integral gate valve, add suffix “-V” to model number for additional cost.For optional 10-point NIST certificate add suffix, “-NIST” to the model number for additional cost and two weeks to the standard lead time.Ordering Examples: FL-2075, rotameter valve, 100 to 1400 LPM air.FL-2080, rotameter valve, 2 to 19 LPM water.FL-2041-nV, shown smaller than actual size.FL-2053, Water,shown smaller thanactual size.FL-2066-nV, shown smaller than actual size.To order with stainless steel valve, add suffix “-SS” to model number for additional cost.To order without a valve, add suffix “-NV” to model number and subtract from cost.For optional 10-point NIST certificate add suffix, “-NIST” to the model number, for additional cost and two weeks to the standard lead time.Ordering Examples: FL-2036, economical rotameter, with brass valve, 14 to 150 SCFH Air.FL-2036-NV , economical rotameter,without brass valve, 14 to 150 SCFH Air.BFL-2060, air, shown smaller than actual size.Dual scales supplied std: SCFM/SCFH, GPM/GPH and LPM/LPH To order with stainless steel valve, add suffix “-SS” to model number for additional cost.To order without a valve, add suffix “-NV” to model number and subtract from cost.For optional 10-point NIST certificate add suffix, “-NIST” to the model number, for additional cost and two weeks to the standard lead time.Ordering Examples: FL-2060, rotameter with brass valve, 0.5 to 5 SCFM. FL-2069-NV , rotameter no valve 2 to 20 LPM.FL-2091, air, shown smaller thanactual size.B-15cFL-2021-nV, Water, shown larger than actual size.Units come standard with brass valves and operator’s manual.To order with stainless steel valves, add suffix “-SS” to model number for additional cost.To order without a valve, add suffix “-NV” to model number and subtract from cost.For optional 10-point NIST certificate add suffix, “-NIST” to the model number, for additional cost and two weeks to the standard lead time.Ordering Examples: FL-2005, economical rotameter with brass valve, 2 to 20 SCFH air.FL-2005-NV , economical rotameter without valve, 2 to 20 SCFH air.accuracy: ±5% Full Scale panel MountB-15dFL-2011FL-2012FL-2014FL-2015。

Chromaline Alpha E-50 敏感化紫外线胶水说明书

Chromaline Screen Print Products4832 Grand Ave. Duluth, Minnesota 55807 T el: 218-628-2217 Fax: 218-628-3245Web Site: E-mail:********************AN IKONICS COMPANY ISO 9001 CERTIFIED NASDAQ LISTED: IKNXM I C R O -L I N E E -50 D U A L C U R E E M U L S I O NUSER'S GUIDEAlpha E-50 emulsion at 200 x Magnification. Microphotography supplied by Chromaline Labs™. Chromaline's latest Alpha E-50 emulsion coated 1 x 3 on 325 stainless steel mesh.ALPHA ™ E-50 KEy fEAtURESCapable of 50-Micron lines and spacesSharper stencil edges and smoother stencil walls Outstanding abrasion resistance Superior humidity resistanceSPECIfICAtIONS Appearance: BlueExplosure: Fast (See Reverse)Solids: 37% (Sensitized)Viscosity: 4,900 cps (Sensitized)Other: Available upon requestStandard Sizes: Quart, Gallon, 3.5 Gal., 50 Gal. Drum SAfEty AND HANDLING Avoid contact with skin and eyes. Refer to SDS for further information.StORAGESensitized Alpha E-50 emulsion has a shelf life of 4 to 6 weeks at room temperature (60 to 80°F). To maximize sensitized shelf life use only distilled water to dissolve diazo sensitizer.Protect from freezing. Alpha E-50 is not freeze/thaw stable. Freezing during shipping may result in clear gel spots which may resemble pinholes or emulsion may appear lumpy.Coated, unexposed screens can be stored as long as one month in a clean, cool, dry and completely dark area.Expiration date. Always check the expiration date on sensitizer bottle to assure freshness.Work under yellow lights.INStRUCtIONSDEGREASEUsing Degreaser 260 mesh degreaser, work up a lather on both sides of mesh. Flood screen and frame thoroughly with water, then dry.MIXMix emulsion and sensitizer according to instructions on bottle. Let emulsion stand at least two hours before using. Always stir emulsion before use. Contents may settle over long periods oftime. Gentle stirring will ensure that the emulsion is properly mixed. COAtFill scoop coater with room temperature emulsion. Slowly apply first coat to print side. Then coat squeegee side with one to three coats depending upon thickness required. If thicker stencil is required, additional coats may be applied to print side after initial drying of stencil. Be sure to dry thoroughly between coats. DRyThoroughly dry screen in horizontal position, print side down, using a dark, clean drying cabinet. Temperature should not exceed 110°F (43°C).EXPOSEPlace emulsion side of photopositive in contact with print side of screen.DEVELOPGently spray both sides of screen with tepid water, wait 30 sec-onds then gently wash print side of the screen until image is fully open. Rinse both sides thoroughly. Dry screen completely and you are ready to print.RECLAIMApply Chroma/Strip™ screen reclaimer to both sides of screen. Scrub area to be reclaimed with a stiff nylon brush to ensure entire surface is wet and let it work a few moments until stencil begins to dissolve. Remove stencil residue with pressure washer, then rinse with water, thoroughly flooding screen and frame. EXPOSURE GUIDELINESRefer to the Chromaline Exposure Calculator to determine optimal exposure times. Individual exposure times may vary depending upon equipment used, bulb age, and other shop conditions. AVOID fAILURE: Dual cure emulsions have a very wide expo-sure latitude. Underexposed stencils often appear acceptable, but premature breakdown can occur on the press. When determining exposure speed, always overexpose your test stencil. Then, using the Chromaline exposure calculator, reduce exposure time until acceptable image quality is achieved. This will help assure good durability.130208fOR tECHNICAL SERVICE Call Toll Free: 1-800-328-4261Email: *******************(Outside North America Call +1-218-628-2217)。

Elmer's 色彩粘合剂蓝色 Elmer's 色彩粘合液说明书

Elmer's Color Glue Opaque BlueElmer's Color GlueLiquid.GHS product identifier Other means of identification Product type:::Relevant identified uses of the substance or mixture and uses advised against Not applicable.Product code :2022929, 2086199, 2109500, 2110101, 2119117SAFETY DATA SHEETCHEMTREC (U.S. and Canada) 1-800-424-9300CHEMTREC (Outside the U.S.) +1-703-527-0585Emergency telephone number (with hours of operation):Manufacturer:Newell Brands, Inc.6655 Peachtree Dunwoody Road Sandy Springs, GA 30328USA800-323-0749Material uses :Not available.Not classified.Classification of the substance or mixture :Signal word :No signal word.Hazard statements :No known significant effects or critical hazards.Precautionary statements Prevention :Not applicable.Response :Not applicable.Storage :Not applicable.Disposal:Not applicable.GHS label elementsHazards not otherwise classified:None known.OSHA/HCS status:While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200), this SDS contains valuable information critical to the safe handling and proper use of the product. This SDS should be retained and available for employees and other users of this product.Other means of identification :Elmer's Color GlueSubstance/mixture :MixtureThere are no additional ingredients present which, within the current knowledge of the supplier and in theconcentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.Occupational exposure limits, if available, are listed in Section 8.Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur.Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs.Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur.Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur.Eye contactSkin contact Inhalation Ingestion::::Protection of first-aiders:No action shall be taken involving any personal risk or without suitable training.Notes to physician :Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.Description of necessary first aid measures Specific treatments :No specific treatment.Most important symptoms/effects, acute and delayed Inhalation :No known significant effects or critical hazards.No known significant effects or critical hazards.:Ingestion Skin contact :No known significant effects or critical hazards.No known significant effects or critical hazards.:Eye contact Over-exposure signs/symptomsSkin contact IngestionInhalation No specific data.No specific data.No specific data.:::Eye contact :No specific data.Potential acute health effects See toxicological information (Section 11)Indication of immediate medical attention and special treatment needed, if necessary Hazardous thermaldecomposition productsSpecific hazards arising from the chemical Decomposition products may include the following materials:carbon dioxide carbon monoxideIn a fire or if heated, a pressure increase will occur and the container may e an extinguishing agent suitable for the surrounding fire.Extinguishing media ::None known.Suitable extinguishing media:Unsuitable extinguishing media:there is a fire. No action shall be taken involving any personal risk or without suitable training.Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.Special protectiveequipment for fire-fighters:for fire-fightersEnvironmental precautionsPersonal precautions, protective equipment and emergency procedures Stop leak if without risk. Move containers from spill area. Prevent entry into sewers,water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible,absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13). Dispose of via a licensed waste disposal contractor. Note: see Section 1 for emergency contact information and Section 13 for waste disposal.::No action shall be taken involving any personal risk or without suitable training.Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment.Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).Large spill:Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.Small spill:Methods and materials for containment and cleaning up For non-emergency personnelFor emergency responders :If specialized clothing is required to deal with the spillage, take note of any information inSection 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".Advice on general occupational hygieneConditions for safe storage,including any incompatibilitiesEating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating,drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. See Section 10 for incompatible materials before handling or use.::Protective measures Put on appropriate personal protective equipment (see Section 8).:Precautions for safe handlingHand protectionBased on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Respirators must be used according to arespiratory protection program to ensure proper fitting, training, and other important aspects of use.Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary.Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: safety glasses with side-shields.Eye/face protectionRespiratory protection:::Body protectionPersonal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.:Environmental exposure controls:Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.Appropriate engineering controls:Good general ventilation should be sufficient to control worker exposure to airborne contaminants.Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period.Appropriate techniques should be used to remove potentially contaminated clothing.Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.Hygiene measures:Control parametersIndividual protection measures Skin protection Other skin protection:Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.Physical state Melting point Liquid.Not available.Not available.OdorpHOpaque. Blue.Color 4.5 to 5.5Not available.Odor threshold ::::::Appearance Boiling point:Not available.Vapor pressure Relative density Vapor density SolubilityNot available.Not available.Not available.Not available.Evaporation rate Not available.Auto-ignition temperature Not available.Not available.ViscosityNot available.Partition coefficient: n-octanol/water::::::::Flammability (solid, gas):Not available.Lower and upper explosive (flammable) limits :Not available.Decomposition temperature :Not available.Solubility in water :Not available.Flow time (ISO 2431):Not available.Hazardous decomposition productsConditions to avoid No specific data.Under normal conditions of storage and use, hazardous decomposition products should not be produced.The product is stable.Chemical stability No specific data.:::Incompatible materials :Possibility of hazardous reactions:Under normal conditions of storage and use, hazardous reactions will not occur.Reactivity :No specific test data related to reactivity available for this product or its ingredients.Carcinogenicity Not available.Mutagenicity Not available.Sensitization Not rmation on toxicological effectsNot available.Teratogenicity Not available.Reproductive toxicity Not rmation on the likely routes of exposureInhalation :No known significant effects or critical hazards.No known significant effects or critical hazards.:IngestionSkin contact :No known significant effects or critical hazards.No known significant effects or critical hazards.:Eye contact No known significant effects or critical hazards.General :No known significant effects or critical hazards.Carcinogenicity :No known significant effects or critical hazards.Mutagenicity :No known significant effects or critical hazards.Teratogenicity :Developmental effects :No known significant effects or critical hazards.Fertility effects:No known significant effects or critical hazards.Symptoms related to the physical, chemical and toxicological characteristics Skin contact IngestionInhalation No specific data.No specific data.No specific data.:::Eye contact :No specific data.Potential chronic health effects Delayed and immediate effects and also chronic effects from short and long term exposure Specific target organ toxicity (single exposure)Specific target organ toxicity (repeated exposure)Not available.Not available.Numerical measures of toxicity Acute toxicity estimatesAspiration hazard Not available.:Not available.Potential acute health effects Potential immediate effects:Not available.Short term exposure Potential delayed effects :Not available.Potential immediate effects:Not available.Long term exposure Potential delayed effects:Not available.Other adverse effects:No known significant effects or critical hazards.Toxicity Not available.Persistence and degradability Soil/water partition coefficient (K OC ):Not available.Mobility in soil Not available.The generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and anyregional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Empty containers or liners may retain some product residues. Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers.:Disposal methodsSpecial precautions for user Transport within user’s premises: always transport in closed containers that areupright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.:Transport in bulk according to IMO instruments:Not available.U.S. Federal regulationsThe following components are listed: GLYCERINE MISTdefects or other reproductive harm. For more information go to .Massachusetts ::Clean Air Act Section 112(b) Hazardous Air Pollutants (HAPs):ListedClean Air Act Section 602 Class I Substances :Not listed Clean Air Act Section 602 Class II Substances :Not listed DEA List I Chemicals (Precursor Chemicals):Not listed DEA List II Chemicals (Essential Chemicals):Not listedNew York :None of the components are listed.New Jersey :The following components are listed: GLYCERIN; 1,2,3-PROPANETRIOL Pennsylvania :The following components are listed: 1,2,3-PROPANETRIOL State regulations TSCA 8(a) PAIR : glutaralTSCA 8(a) CDR Exempt/Partial exemption : Not determined SARA 302/304SARA 304 RQ :Not applicable.No products were position/information on ingredients International regulationsChemical Weapon Convention List Schedules I, II & III ChemicalsSARA 311/312Classification :Not applicable.Montreal Protocol Not listed.Stockholm Convention on Persistent Organic Pollutants Not listed.Rotterdam Convention on Prior Informed Consent (PIC)UNECE Aarhus Protocol on POPs and Heavy Metals Not listed.Inventory list Australia :At least one component is not listed.Canada :All components are listed or exempted.China :All components are listed or exempted.Europe :Not determined.Japan :Japan inventory (ENCS): At least one component is not listed.Japan inventory (ISHL): At least one component is not listed.Republic of Korea :At least one component is not listed.New Zealand :At least one component is not listed.Philippines :At least one component is not listed.Taiwan :At least one component is not listed.Turkey :Not determined.United States :All components are active or exempted.Thailand :All components are listed or exempted.Viet Nam:Not determined.Not listed.3National Fire Protection Association (U.S.A.)HealthSpecial hazardsInstability Flammability Caution: HMIS® ratings are based on a 0-4 rating scale, with 0 representing minimal hazards or risks, and 4 representing significant hazards or risks. Although HMIS® ratings and the associated label are not required on SDSs or products leaving a facility under 29 CFR 1910.1200, the preparer may choose to provide them. HMIS® ratings are to be used with a fully implemented HMIS® program. HMIS® is a registered trademark and service mark of the American Coatings Association, Inc.The customer is responsible for determining the PPE code for this material. For more information on HMIS® Personal Protective Equipment (PPE) codes, consult the HMIS® Implementation Manual.1/28/2021HistoryDate of printing Date of issue/Date of revisionVersionTo the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.Notice to readerDate of previous issue ::::References:Not available.Key to abbreviations:ATE = Acute Toxicity Estimate BCF = Bioconcentration FactorGHS = Globally Harmonized System of Classification and Labelling of Chemicals IATA = International Air Transport Association IBC = Intermediate Bulk ContainerIMDG = International Maritime Dangerous GoodsLogPow = logarithm of the octanol/water partition coefficientMARPOL = International Convention for the Prevention of Pollution From Ships, 1973 as modified by the Protocol of 1978. ("Marpol" = marine pollution)N/A = Not availableSGG = Segregation Group UN = United Nations 1/28/2021No previous validation 1。

求助文献

1. Nematotoxicity of drupacine and a Cephalotaxus alkaloid preparation against the plant-parasitic nematodes Meloidogyne incognita and Bursaphelenchus xylophilusBy Wen, Yanhua; Meyer, Susan L. F.; Masler, Edward P.; Zhang, Fengxian; Liao, Jinling; Wei, Xiaoyi; Chitwood, David J.From Pest Management Science (2013), 69(9), 1026-1033. Language: English, Database: CAPLUS,DOI:10.1002/ps.3548~0 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.2. Alkaloids from Cephalotaxus lanceolata and Their CytotoxicitiesBy He, Yi-Ren; Shen, Yun-Heng; Li, Bo; Li, Bo; Lu, Lu; Tian, Jun-Mian; Zhang, Wei-DongFrom Chemistry & Biodiversity (2013), 10(4), 584-595. Language: English, Database: CAPLUS,DOI:10.1002/cbdv.201200105~2 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.5. Completed preparative separation of alkaloids from Cephaltaxus fortunine by step-pH-gradient high-speed counter-current chromatographyBy Liu, Zhonghua; Du, Qizhen; Wang, Kuiwu; Xiu, Lili; Song, GuangleiFrom Journal of Chromatography A (2009), 1216(22), 4663-4667. Language: English, Database: CAPLUS,DOI:10.1016/j.chroma.2009.03.083~21 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.7. Convergency and Divergency as Strategic Elements in Total Synthesis: The Total Synthesis of (-)-Drupacine and the Formal Total Synthesis of (±)-Cephalotaxine, (-)-Cephalotaxine, and (+)-CephalotaxineBy Liu, Qi; Ferreira, Eric M.; Stoltz, Brian M.From Journal of Organic Chemistry (2007), 72(19), 7352-7358. Language: English, Database: CAPLUS,~27 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.12. New Alkaloids from Cephalotaxus fortuneiBy Bocar, Mamadou; Jossang, Akino; Bodo, BernardFrom Journal of Natural Products (2003), 66(1), 152-154. Language: English, Database: CAPLUS,DOI:10.1021/np0203178~9 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.14. Cephalezomines A-F, potent cytotoxic alkaloids from Cephalotaxus harringtonia var. nanaBy Morita, Hiroshi; Arisaka, Mika; Yoshida, Naotoshi; Kobayashi, Jun'ichiFrom Tetrahedron (2000), 56(19), 2929-2934. Language: English, Database: CAPLUS,DOI:10.1016/S0040-4020(00)00091-0~29 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.17. Synthesis via vinyl sulfones. 38. Total synthesis of the cephalotaxus alkaloids dl-cephalotaxine,dl-11-hydroxycephalotaxine, and dl-drupacineBy Burkholder, T. P.; Fuchs, Phillip L.From Journal of the American Chemical Society (1990), 112(26), 9601-13. Language: English, Database: CAPLUS,~39 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.21. The studies of chemical constituents of Cephalotaxus hainanensis LiBy Xue, Zhi; Sun, Nan Jun; Chen, Di Hua; Xu, Li Zhen; Chen, Wei Ming; Ren, Li Juan; Liang, Xiao Tian; Huang, Liang Edited By:Wang, YuFrom Chem. Nat. Prod., Proc. Sino-Am. Symp. (1982), 195-9. Language: English, Database: CAPLUS~2 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.25. Carbon-13 nuclear magnetic resonance spectroscopy of Cephalotaxus alkaloidsBy Weisleder, David; Powell, Richard G.; Smith, Cecil R., Jr.From Organic Magnetic Resonance (1980), 13(2), 114-15. Language: English, Database: CAPLUS,DOI:10.1002/mrc.1270130210~3 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.27. Alkaloid distribution and catabolism in Cephalotaxus harringtoniaBy Delfel, Norman E.From Phytochemistry (Elsevier) (1980), 19(3), 403-8. Language: English, Database: CAPLUS,DOI:10.1016/0031-9422(80)83189-X~5 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.From Journal of Organic Chemistry (1974), 39(5), 676-80. Language: English, Database: CAPLUS, DOI:10.1021/jo00919a020~13 CitingsCopyright © 2014 American Chemical Society (ACS). All Rights Reserved.。

组织粘合剂在1例PICC置管后伴大量淋巴漏中应用的护理体会

组织粘合剂在1例PICC置管后伴大量淋巴漏中应用的护理体会发布时间：2022-10-11T02:43:26.437Z 来源：《护理前沿》2022年14期作者：茆书兰吴祥凤丁小琴[导读] 总结1例PICC置管后伴大量淋巴漏患者，应用组织粘合剂处理后的护理经验茆书兰吴祥凤丁小琴扬州市江都人民医院江苏扬州 225200摘要：总结1例PICC置管后伴大量淋巴漏患者，应用组织粘合剂处理后的护理经验。

护理要点包括：护理过程、原因分析、预防措施、组织粘合剂作用机理。

组织粘合剂自然待干后患者穿刺点无渗液，效果即刻显现，患者顺利完成6个周期化疗。

关键词：组织粘合剂；PICC；淋巴漏；护理经外周静脉置入中心静脉导管(peripherally inserted central catheters,PICC)，因操作简单，使用时间可长达1年，保护患者静脉，为患者提供一个安全、方便、有效的静脉通路等优点，已成为各大医院化疗患者的普遍选择。

虽然PICC优点众多, 但广泛应用于临床中, 也会存在一些并发症，如置管后出现PICC穿刺点淋巴漏为其中之一[1]，主要是穿刺时损伤淋巴管造成, 临床上对于淋巴漏有很多处理方法比如：纱布压迫[2]、藻酸盐敷料外用+个性化换药与固定+改进局部加压方式等[3]。

护理过程比较复杂，对于大量淋巴漏患者效果并不理想，给患者带来不便，加重患者心理负担，甚至有些患者因不能忍受频繁来院换药而选择拔管[4]，同时护士工作量也大大增加。

虽然目前临床上淋巴漏无统一处理办法，但在2021INS提到组织粘合剂（TA）：一种医用级氰基丙烯酸胶，可以密封插入部位[5]。

我院PICC门诊2021年4月12日处理1例因PICC置管出现淋巴液外渗的患者, 通过组织粘合剂处理, 效果显著, 现汇报如下。

1.病例资料患者，男性，72岁，因小细胞肺癌于2021年04月02日收住入院, 本次住院主要行 EP 方案（依托泊苷加顺铂）化疗，4月10日在左侧肱静脉采用超声引导结合改良赛丁格技术置入巴德4Fr三向瓣膜导管，一次置管成功。

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7B. Brau
美观
早日洗澡
闭合张力牢固
快速伤口处理
避免二次疼痛刺激（拆线）
减少疼痛
8
预防感染操作简单节省时间
颌面部创口组织胶水处置实例
伤后第3天
伤后第7天
创伤外科 ● 武汉同济医院
伤后第14天，创口长达14cm, 愈合良好，患者及家属均十分满意
9
颌面部创口组织胶水处置实例
伤后3天
-- 清创止血,皮下减张缝合,再涂抹蓝灵
B. Braun Melsungen AG | Page 22
蓝灵组织胶水使用注意事项
蘸干伤口干纱布
闭合伤口紧密
表面涂抹 0.5厘米
固定伤口约30秒
7-10天愈合水接触
纱布覆盖干纱布
1
2
3
23
蓝灵组织胶水使用注意事项
1 • 彻底清创止血 2 • 减张缝合 3 • 严密对齐皮肤,勿进入皮内 4 • 只涂抹1层,超过伤口边缘0.5cm 5 • 固定约30秒
操作简单,省时省力主要用于骨科
• 有创闭合, 影响伤口愈合 • 易使皮肤受压形成疤痕 • 钉孔易造成感染 • 外观难看 • 需要拆钉,增加患者疼痛
6B. rau
皮肤伤口闭合方式—免缝胶带
操作简单,闭合快速无创闭合, 舒适度好价格便宜
• 张力强度弱,伤口易裂开 • 易脱落 • 伤口不可接触水
减少疤痕
20
蓝灵组织胶水临床意义
张力强
防菌抑菌胶膜粘度高
快速可靠
降低感染
减轻疼痛
减少疤痕
B. Braun Melsungen AG | Page 21
蓝灵组织胶水使用注意事项
1
新鲜,清洁,边缘光滑,无张力的小切口 -- 无需缝合,直接涂抹蓝灵
2
手术伤口或深入皮下的伤口
(宽度≥ 0.5cm; 长度≥3cm; 深度≥ 1cm)
英国及爱尔兰麻醉师联合会杂志 2008, 63, 页码1372-1386
有效阻挡与伤口感染相关的金葡菌和表皮葡萄球菌
金黄色葡萄球菌
表皮葡萄球菌
19
蓝灵组织胶水三大优势
优势三：胶膜表面粘度高
临床益处：只需涂抹1层，30s快速闭合伤口伤口表面形成致密防水胶膜,减少外界炎症刺激
少量流水
减轻疼痛
辛基
CH2– CH2– CH2– CH2– CH2– CH2–CH2– CH3
链越长：反应速度越慢，柔韧性越好，粘合力越差！
粘合力
-
柔韧性
+
16
氰基丙烯酸盐黏合剂特点
4个碳=强度＆柔韧度的最佳平衡
Episiotomy Closure Comparing Enbucrilate Tissue Adhesive with Conventional Sutures 组织胶水与传统缝合在会阴切开术中的比较
用于新鲜无污染、边缘光滑、无张力的皮肤伤口闭合。
14
蓝灵组织胶水作用机理
α-氰基丙烯酸正丁酯
CH2 – CH2 – CH2 – CH3
约30 秒
长链聚合物
OH-
牢固的伤口闭合胶膜
氰基丙烯酸盐黏合剂特点
链越短：反应速度越快，粘合力越强，柔韧性越差！
乙基
CH2– CH3
+-
丁基 (蓝灵)
CH2 – CH2 – CH2 – CH3
张力强,闭合可靠价格便宜
• 急诊伤口须先打麻药—疼痛 • 急诊伤口针线缝合过程—疼痛 • 面颈部伤口留下疤痕 • 需要回医院拆线—疼痛,费时,费力 • 需要回医院换药– 费时,费力 • 伤口愈合前不能接触水—影响正常生活 • 缝合时间长—耗费医生时间精力
5B. Brau
皮肤伤口闭合方式—皮肤钉
伤后14天
创伤外科 ● 武汉同济医院
10
颌面部创口组织胶水处置实例
整形外科 ● 广州中山大学附属第一医院
11
12
皮肤伤口闭合方式—蓝灵组织胶水
简单快速安全可靠减轻疼痛减少疤痕抗菌抑菌防水透气
• 不适合张力高的伤口 • 不适合大伤口 • 不适合感染伤口
13
蓝灵组织胶水适应症
英国北安普敦总院妇产科 M.L. Bowen 英国皇家巴克夏医院妇产科 M. Selingerb
“在一系列烷基长度不同的氰基丙烯酸盐组织黏合剂中, HISTOACRYL® 很好地取得了这个平衡. 闭合切口的胶水薄膜，既有很好的伸缩性，同时又具有很高的张力强度，并且发生聚合反应的速度适中。”
17
蓝灵组织胶水三大优势
优势一：张力强度高
临床益处：伤口闭合更牢固，不易裂开
Histoacryl® α-氰基丙烯酸脂辛基酯
贝朗实验室数据：根据ASTM F 2458-05标准对比实验
18
蓝灵组织胶水三大优势
优势二：防菌抑菌
临床益处：减少伤口感染对革兰阳性菌的生长和繁
殖均有特异性抑制作用
Histoacryl® 皮肤粘合剂的抗菌效用
囊性病手术、小儿纵膈肿瘤手术、先天性膈疝手术、先心手术小儿泌尿外科：包皮环切、泌尿系畸形的矫治和重建小儿骨科：制动部位的伤口小儿肿瘤外科新生儿外科
26
蓝灵组织胶水在儿外科的应用
组织胶水与缝合法在儿童撕裂伤修复中的随机对照研究
P BARNETT,FEC JARMAN,皇家儿童医院,急诊医学部,澳大利亚 Journal of Paediatr. Child Health (1998) 34, 548-550
蓝灵组织胶水简介
主要内容蓝灵组织胶水优势特性及使用要点蓝灵组织胶水临床应用
2014销售业绩领导品牌
2014 皮肤伤口闭合组织胶水市场 2.94亿元 (HP) DP: HP=1: 3.5
其他 25%
贝朗
45%
爱必肤 8%
强生 10% 康派特 12%
B. Braun Melsungen AG | 3 Page
B. Braun Melsungen AG | Page 24
主要内容蓝灵组织胶水优势特性及使用要点蓝灵组织胶水临床应用
蓝灵组织胶水在儿外科的应用
急诊创伤伤口闭合
开放手术的切口闭合
微创手术创口闭合
减少疤痕
减轻疼痛
避免二次疼痛刺激（拆线）
包括但不仅限于以下手术：急诊：颌面部撕裂伤小儿普外科：腹股沟疝小儿胸心外科：胸壁畸形矫治、先天性肺
TOP 1 PLAYER
Data source: industry insights data (2013) & dealer data (2014)
蓝灵组织胶水 -- 安全可靠
40 多年安全使用历史
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