萎缩性胃炎与胃癌的危险因素

1.胃蛋白酶原I、维生素B12

维生素B 12 预测采血样10年后非贲门区肿瘤风险早于胃蛋白酶原I

Miranti Eugenia H,Stolzenberg-Solomon Rachael,Weinstein Stephanie J et al. Low vitamin B12 increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer.[J] .Int. J. Cancer, 2017, 141(6): 1120-1129.

2.在血清学风险预测系统：指标阴性（包括抗HP抗体、胃蛋白酶原阴性）的患者，根据HP 感染的与否分为两组，发现感染HP的患者组特点：年龄大，分化型癌，内镜可视化慢性萎缩性胃炎、胃蛋白酶原（PG）I / II比低于未感染HP组。在未感染HP组中，凹陷型癌占优势，PG I / II比高于幽门螺杆菌感染的胃癌患者。

什么是ABC分类系统,减少胃癌风险的假阴性评估

Kiso Mariko,Yoshihara Masaharu,Ito Masanori et al. Characteristics of gastric cancer in negative test of serum anti-Helicobacter pylori antibody and pepsinogen test: a multicenter study.[J] .Gastric Cancer, 2016.

3.Chen Xin-Zu,Schöttker Ben,Castro Felipe Andres et al. Association of helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study.[J] .Oncotarget, 2016, 7(13): 17182-93.

大型队列研究没有观察到幽门螺杆菌感染或萎缩性胃炎与结肠癌或胰腺癌的关联，但强调绝大多数非贲门胃癌由慢性萎缩性胃炎和CagA +幽门螺杆菌菌株感染相关

4.从胃癌高发地区移民的患者应

virulence factors such as Cag A, Vac A, and Bab A

Kim Gwang Ha,Liang Peter S,Bang Sung Jo et al. Screening and surveillance for gastric cancer in the United States: Is it needed?[J] .Gastrointest. Endosc., 2016, 84(1): 18-28.

5.幽门螺杆菌诱导的COX-2 / PGE2途径对中国人群胃癌前病变的发展起着重要作用。用杀HP治疗和/或塞来昔布（一种非甾体类抗炎药）可以降低分级反应COX-2，Ki67

Miranti Eugenia H,Stolzenberg-Solomon Rachael,Weinstein Stephanie J et al. Low vitamin B12 increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer.[J] .Int. J. Cancer, 2017, 141(6): 1120-1129.

6.恶性贫血的患者显著增加胃癌腺癌及其他癌症的风险

7.Chen Hai-Ning,Wang Zhu,Li Xiao et al. Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis.[J] .Gastric Cancer, 2016, 19(1): 166-75.

meta证明根除HP不降低肠化和异性增生的患者胃癌的风险

8.目的：比较长期（6个月或更长时间）PPI维持治疗的患者胃萎缩性胃炎，肠化生，肠嗜铬细胞样（ECL）细胞增生和发育异常等胃恶性前病变的发展或进展：没有证据表明

Song Huan,Zhu Jianwei,Lu DongHao. Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions.[J] .Cochrane Database Syst Rev, 2014.

连续感染幽门螺杆菌16年的个体与清除感染并且在之后持续保持阴性的患者有

更高的进展为高级诊断的概率。不完全型肠化与完全型肠化相比，发展为癌症的风险更高。连续感染幽门螺杆菌的人群平均病理组织学评分上升了0.20单位/年。感染累积时间对组织病理学评分进展的影响：萎缩但无肠化的患者组显着高于有肠化组。

结论：长期接触幽门螺杆菌感染与癌前病变的进展有关。感染幽门螺杆菌的患者可能从根除中获益，特别是没有IM的萎缩性胃炎患者。不完全型IM可能是鉴定癌症风险较高的个体的有用标志物。

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12.Borrelli F,Capasso R,Russo A et al. Systematic review: green tea and gastrointestinal cancer risk.[J] .Aliment. Pharmacol. Ther., 2004, 19(5): 497-510.文献没找到

绿茶meta对胃肠道出血肿瘤有保护性看题作用怎么定义这个量

13.神药二甲双胍降低2型糖尿病患者胃癌发生率

he risk of GC among patients with T2DM is lower in patients receiving metformin therapy than in patients not receiving metformin therapy. 14.有文献报道糖尿病对胃癌发生率没啥区别

participants with DM had little or no change in the risk of gastric cancer, or gastric cancer mortality. There was no evidence of difference in the RR for gastric cancer between men and women.