固肾保胎汤治疗体外受精_胚胎移植早孕先兆流产合并宫腔积血临床研究_邵蓉_孙迎春

*基金项目：山东省中医管理局基金项目（2013-273）固肾保胎汤治疗体外受精-胚胎移植早孕

先兆流产合并宫腔积血临床研究

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邵蓉，孙迎春

青岛市妇女儿童医院，山东青岛266034

摘要：目的：观察固肾保胎汤对体外受精-胚胎移植（in vitro fertilization and embryo transfer ，IVF-ET ）早孕先兆流产合并宫腔积血的临床疗效。方法：将72例IVF-ET 早孕先兆流产合并宫腔积血患者随机分为对照组与治疗组，每组36例，对照组在IVF-ET 后常规给予黄体酮80mg 肌肉注射以支持黄体功能，绒毛膜促性腺激素2000U 肌肉注射，隔日1次；治疗组在对照组治疗基础上加用自拟固肾保胎汤治疗。两组均连续治疗2周，观察治疗前后阴道出血、腰酸胀痛、小腹坠痛、B 超、血孕酮值、宫腔积血减少及胚胎发育情况等，并随访2个月。结果：两组间有效率比较，差异无显著性意义（P ＞0.05）；随访2个月，治疗组继续妊娠率明显优于对照组，差异有统计学意义（P ＜0．05）；停药后孕11 12周，治疗组血孕酮值升高明显优于对照组，

差异有统计学意义（P ＜0．05）。两组患者在治疗后较治疗前宫腔积血面积减少，差异有统计学意义（P ＜0．05），胚胎发育良好。结论：固肾保胎汤在治疗IVF-ET 早期先兆流产合并宫腔积血临床疗效显著。文献引用：邵蓉，孙迎春．固肾保胎汤治疗体外受精-胚胎移植早孕先兆流产合并宫腔积血临床研究［J ］．中医学报，2016，31（1）：102－104．

关键词：体外受精-胚胎移植早孕先兆流产；宫腔积血；固肾保胎汤；黄体酮；绒毛膜促性腺激素DOI ：10．16368/j．issn．1674－8999．2016．01．029中图分类号：Ｒ271．14

文献标志码：A

文章编号：1674－8999（2016）01－0102－03

Clinical Effect of Gushenbaotai Tang for Threatened Abortion with Uterine Hemorrhage in

Early Pregnancy with in Vitro Fertilization and Embryo Transfer

SHAO Ｒong ，SUN Yingchun

Qingdao City Women and Children's Hospital ，

Qingdao Shandong China 266034Abstract ：Objective ：To observe the clinical effect of Gushenbaotai Tang for threatened abortion with uterine hemorrhage in early pregnancy with in vitro fertilization and embryo transfer （IVF-ET ）threatened abortion in early pregnancy uterine hemorrhage of consolidation．Methods ：72cases of patients were randomly divided into control group and treatment group ，with 36cases in each group．After IVF-ET ，intramuscular injection of 80mg of progesterone to support luteal and human chorionic gonadotropin 2000U intra-muscularly every other day were given routinely to the two groups ；while the treatment group were treated with Gushenbaotai Tang based on that．After 2weeks continuous treatment ，patients'vaginal bleeding ，backache ，pain ，abdominal pain ，result of B ul-trasound ，blood progesterone ，uterine hemorrhage reduction and embryo development before and after the treatment of the two groups were observed ，with months of follow-up visits paid by doctors．Ｒesults ：The differences between the two groups were not sig-nificant （P ＞0．05）in the effective rate．However ，after two-month follow-up ，the continued pregnancy rate of the treatment group was significantly higher than that in the control group （P ＜0．05）．After 11－12weeks of pregnancy without any treatment ，the continued pregnancy rate of treatment group increased significantly than that of the control group （P ＜0．05）．After treatment ，the uterine hemorrhage area of the two groups of patients reduced significantly （P ＜0．05），with good embryonic development．Conclu-

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