细胞外基质成分可影响周围神经损伤的修复与再生(精)

细胞外基质成分可影响周围神经损伤的修复与再生
瑞士洛桑联邦理工学院生物材料 -材料 -组织接口联合实验室 di Summa教授所带团队研究人员正在合作开发一种新型多功能促进周围神经损伤修复的再生导管,这种导管整合仿生材料,微细加工技术和细胞治疗技术。

在《中国神经再生研究(英文版》最新一期杂志中,作者介绍了他们在细胞外基质分子在周围神经损伤修复在的重要作用及试验应用结果,表明其可以成为人工导管的最佳选择。

周围神经损伤严重影响患者的生活。

人工导管是周围神经损伤修复的有效替代方法,能够为周围神经修复创造适宜微环境,并指引轴突生长方向。

好的生物材料需要具备良好的生物相容性,能够减轻炎症和瘢痕组织形成。

充填细胞外基质的神经组织能延长细胞的存活,促进移植细胞在损伤部位生长,减少所需的内源雪旺氏细胞的滞后时间,在修复神经缺损方面表现出较好的应用潜能。

“我们的最新研究成果显示出促进周围神经再生是有希望”,作者如此说。

“未来我们团队的研究将集中于导管内腔的完善,使其可以更好的与涂覆有的细胞外基质成分结合,以增强细胞表面的相互作用,从而更好的促进损伤神经的再生”。

Article: " Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration? " by Alba C. de Luca 1, Stephanie P. Lacour1, Wassim Raffoul2, Pietro G. di Summa2 (1 EPFL, Centre for Neuroprosthetics, Laboratory for Soft Bioelectronic Interfaces, Station 17, 1015 Lausanne, Switzerland; 2 Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne (CHUV, Lausanne, Switzerland
de Luca AC, Lacour SP, Raffoul W, di Summa PG. Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration? Neural Regen Res. 2014;9(22: 1943-1948.
欲获更多资讯:N eural Regen Res
Impact and effect of the ECM molecules in peripheral nerve repair and regeneration Peripheral nerve injury is a serious problem affecting significantly patients’ life. New advanced
strategies have been developed to improve the regeneration of the injured nerve, including artificial conduits. Biomimetic materials aim at simulating the native neural tissue, creating a friendly environment for cells and tissue to growth. This allows the regeneration of longer gaps and extending cell survival.
Researchers at the EPFL and at the CHUV in Lausanne, Switzerland, are working together to develop novel multifunctional regenerative conduits for peripheral nerve repair, integrating biomimetic materials, microfabrication techniques and cell therapy. In a recent review accepted for publication in Neural Regeneration Research, they report recent progresses in the fabrication of biomimetic materials for peripheral nerve peripheral. As suggested by the tile, the impact and the effect of extracellular matrix (ECM molecules in nerve regeneration is therefore presented and critically discussed, including future perspectives in the field.
ECM molecules can either be used for filling artificial nerve guidance conduits or for coating the inner lumens, resulting in the ability of repairing long injury gaps. Bio-fillers can provide a suitable and natural environment to support cell survival and proliferation inside the tube, shortening the delay that triggers and activates the nerve regeneration. In addition, it has been demonstrated that ECM molecules can provide binding sites for specific growth factors and neurotrophins, making them suitable to develop a drug delivery system localized at the injury site.
“The latest results achieved in the field of peripheral nerve regeneration are promising”, state the authors. As reported, future research will focus on more advanced modifica tions of the inner lumen, which can be then further “coated with ECM components, in order to enhance cell-surface interactions, hence promoting higher
regeneration of the injured tissue”. The perspective article is published in Neural Regeneration Research (Vol. 9, No. 22, 2014.
Article: " Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration? " by Alba C. de Luca 1, Stephanie P. Lacour1, Wassim Raffoul2, Pietro G. di Summa2 (1 EPFL, Centre for Neuroprosthetics, Laboratory for Soft Bioelectronic Interfaces, Station 17, 1015 Lausanne, Switzerland; 2 Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne (CHUV, Lausanne, Switzerland
de Luca AC, Lacour SP, Raffoul W, di Summa PG. Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration? Neural Regen Res. 2014;9(22: 1943-1948.。