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The liver graft was allocated to a 59-year-old female recipient suf fering from decompensated primary biliary cirrhosis. Four years later (in 2011), a tumor was detected in segment VIII of the liver graft and histologically proven to be donor-derived metastasized ER+ breast cancer.
3
2、CASE REPORT
The 53-year-old donor in this case had no relevant medical history and donated her kidneys, lungs, liver. The other 4 recipients developed donorderived breast cancer (proven by DNA microsatellite) within 16 months to 6 years after transplantation. Unfortunately, the double-lung recipient, leftkidney recipient, and liver recipient died due to the donor-derived breast cancer. The right-kidney recipient remains alive. After the diagnosis of breast cancer in the transplanted kidney, the patient underwent transplant nephrectomy, his immunosuppression was stopped, chemotherapy was initiated, and he achieved complete remission despite widely metastasized disease.
IF:6.493
Yvette A. H. Matser1 | Matty L. Terpstra2 | Silvio Nadalin3 | George D. Nossent4 | Jan de Boer5 | Barbara C. van Bemmel6 | Susanne van Eeden7 | Klemens Budde8 | Susanne Brakemeier8 | Frederike J. Bemelman2
LOGO
Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients
CASE REPORT
Literatures Source
American journal of transplantation
2
1、 INTRODUCTION
This case report describes the transmission of breast cancer from a single organ donor to 4 recipients many years after donation. At the time of donation, it was unknown that the donor suffered from a malignancy.
FIGURE 1
1
5
①、Double-lung recipient
The lungs were allocated to a 42-year-old female who suffered from endstage lung disease due to sarcoidosis with remitting pneumothoraces. In August 2008 (16 months after transplantation), the patient was admitted to the hospital because of transplant dys function. A chest X-ray showed mediastinal lymphadenopathy. A mediastinal lymph node biopsy showed estrogen receptor and progesterone-receptor positive (ER+, PR+) adenocarcinoma. The FESPET scan revealed abnormalities in the lungs and bones. The patient’s immunosuppression was reduced. In September, a CT scan showed lesions in the liver and bones that were compatible with metastases. Six months later, she presented with increasing thoracic pain, hypercalcemia, and renal insufficiency. In August 2009, palliative care was started, and after a few days, the patient passed away.
Extensive research with 5 independent DNA microsatellite markers revealed that this breast cancer was donor derived.
6
②、Left-kidney recipien
7
wenku.baidu.com、Liver recipient
3
2、CASE REPORT
The 53-year-old donor in this case had no relevant medical history and donated her kidneys, lungs, liver. The other 4 recipients developed donorderived breast cancer (proven by DNA microsatellite) within 16 months to 6 years after transplantation. Unfortunately, the double-lung recipient, leftkidney recipient, and liver recipient died due to the donor-derived breast cancer. The right-kidney recipient remains alive. After the diagnosis of breast cancer in the transplanted kidney, the patient underwent transplant nephrectomy, his immunosuppression was stopped, chemotherapy was initiated, and he achieved complete remission despite widely metastasized disease.
IF:6.493
Yvette A. H. Matser1 | Matty L. Terpstra2 | Silvio Nadalin3 | George D. Nossent4 | Jan de Boer5 | Barbara C. van Bemmel6 | Susanne van Eeden7 | Klemens Budde8 | Susanne Brakemeier8 | Frederike J. Bemelman2
LOGO
Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients
CASE REPORT
Literatures Source
American journal of transplantation
2
1、 INTRODUCTION
This case report describes the transmission of breast cancer from a single organ donor to 4 recipients many years after donation. At the time of donation, it was unknown that the donor suffered from a malignancy.
FIGURE 1
1
5
①、Double-lung recipient
The lungs were allocated to a 42-year-old female who suffered from endstage lung disease due to sarcoidosis with remitting pneumothoraces. In August 2008 (16 months after transplantation), the patient was admitted to the hospital because of transplant dys function. A chest X-ray showed mediastinal lymphadenopathy. A mediastinal lymph node biopsy showed estrogen receptor and progesterone-receptor positive (ER+, PR+) adenocarcinoma. The FESPET scan revealed abnormalities in the lungs and bones. The patient’s immunosuppression was reduced. In September, a CT scan showed lesions in the liver and bones that were compatible with metastases. Six months later, she presented with increasing thoracic pain, hypercalcemia, and renal insufficiency. In August 2009, palliative care was started, and after a few days, the patient passed away.
Extensive research with 5 independent DNA microsatellite markers revealed that this breast cancer was donor derived.
6
②、Left-kidney recipien
7
wenku.baidu.com、Liver recipient