周剂量多西他赛联合奥沙利铂治疗48例晚期胃癌

775

周剂量多西他赛联合奥沙利铂治疗

48例晚期胃癌

［摘要］　背景与目的：化学治疗可提高晚期胃癌患者的生活质量，延长生存期。对进展期及转移性胃癌目前还没有标准的化疗方案，而且缺乏有效率高、毒副反应小、安全的化疗方案。毒副反应是晚期胃癌化疗的限制性因素，影响患者的生活质量。本研究观察周剂量多西他赛(多西紫杉醇,DOC）联合奥沙利铂（OXA）方案治疗晚期胃癌的临床疗效及毒副反应，以期发现疗效高、毒副反应小、耐受性更好的化疗方案。方法：选择48例晚期胃癌患者，采用DOC 35 mg/m 2静脉滴注（第1天和第8天）; OXA 130 mg/m 2静脉滴注（第1天）,21 d为1个周期，至少2个周期后评价疗效。结果：全组48例均可评价疗效，按WHO标准评定近期疗效和毒副反应，以完全缓解+部分缓解合计为有效，其中完全缓解3例，部分缓解24例，稳定12例，进展9例，有效率56.25%，中位疾病进展时间为5.6个月，中位生存期为11.8个月。毒性反应主要是骨髓抑制、外周神经炎和胃肠道反应，均为可逆性。 结论：周剂量DOC联合OXA治疗晚期胃癌疗效确切，毒性反应轻，患者耐受性好，值得临床推广。 ［关键词］　晚期胃癌；　多西他赛；　奥沙利铂；　化疗

中图分类号：R735.2；R730.53 文献标识码：A 文章编号：1007-3639(2008)10-775-03

Weekly docetaxel combined with oxaliplatin in the treatment of advanced gastric cancer CHEN Shao-jun,HUANG Hai-xin,LI Gui-sheng (Department of Medical Oncology,The Fourth Affiliated

Hospital of Guangxi Medical University, Liuzhou Guangxi 545005,China)Correspondence to：LI Gui-sheng E-mail：liguisheng1010@

［Abstract ］ Background and purpose ：It has been shown that chemotherapy could improve the quality of life and prolongation of survival time of the patients with advanced gastric cancer. There is still no standard chemotherapy regimen for advanced and metastatic gastric cancer, and regimens with high efficacy and safety are scare. Toxicities are considered to be limiting factors and in fl uence the quality of life in the patients with advanced gastric cancer. The purpose of this study was to investigate the ef fi cacy and toxicity of docetaxel(DOC) in combination with oxaliplatin(OXA) as fi rst-line treatment in advanced gastric cancer and try to fi nd a regimen that would be more tolerable without deterioration of treatment response. Methods ：48 patients with advanced gastric cancer were treated with docetaxel 35 mg/m 2, ivgtt, d1,d8 combined with oxaliplatin 130 mg/ m 2,ivgtt,d1 ;repeated every 3 weeks (one cycle) ,The effect was evaluated after two cycles. The ef fi cacy and toxicity were evaluated according to WHO standard. Results ：48 patients could be evaluated for clinical response. Complete response in 3 pts and partial response in 24 pts were observed with an overall response rate of 56.25%, median time to progression (MTTP) was 5.6 months and median overall survival (MST) was 11.8 months. The most common toxicities were bone marrow suppression, peripheral neuritis, nausea and vomiting. All of them are reversible. Conclusion ：Combining weekly docetaxel and oxaliplatin is an effective and well tolerated alternative treatment in advanced gastric cancer and has yielded promising results.

　［Key words ］　advanced gastric cancer; docetaxel; oxaliplatin; chemotherapy

通讯作者：李桂生　E-mail:liguisheng1010@

《中国癌症杂志》2008年第18卷第10期 CHINA ONCOLOGY CHINA ONCOLOGY 2008 Vol.18 No.10

胃癌是我国常见的恶性肿瘤，由于确诊时大多处于晚期，手术切除往往已不可能。胃癌是相对化疗敏感性的肿瘤，对于无法手

术切除的胃癌或转移性胃癌，化疗是首要的治疗手段［1］。近年来开发新的药物和方案在胃癌的临床应用研究中成为热点并已取得成效，如何合理的联合应用这些药物，使其发挥最大疗效并避免其毒性反应是目前研究方向［2］。我