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Apaf1
AAAAA
Chk2
MDM 2
ATM
Apaf1
Casp 3
Caspase 3 Substrates
IR
Caspase targets in apoptosis
CARD CARD
C
Casp 9 Apaf1 Apaf1 Casp 9
CARD Casp 2
Casp10 Casp 8
Casp 7 Casp 6 Casp 3
C
C
C
C
Apaf1
Cathepsin
CARD
Ceramide
SMase Cathepsins
Lysosome
Bax
Bax
RYR
Casp 3
Caspase 3 Substrates
Mitochondria and ER in apoptosis
m-Calpain
Apaf1
CC
C
C C C CC
Bcl-XL
Gas2
Gelsolin FAK
CAD
Topoisomerase
Transglutaminase
Calpastatin
Rock-1
Cell cycle and other
MDM2 SREB1
p21 NuMA
hnRNP EMAP II
ROS
NECROSIS
TNF R1 Signaling in apoptosis
R1
R1 R1
TNTTNFNFF
SODD
TNF
R1 R1 R1
Death Domain
SODD
SODD SODD
DD
DD DD
CC
C C
C
C
C
C
C
CCC
C
CC
C
AIF EndoG
Diablo AIF
EndoG
DiablocIAP
C
C
C
C CC
BBBBaaaakxkx
C
C
C
Bcl-2
Diablo
Diablo C CC
Bid
Bax
CARD
C CC C
Bax
CC
Bcl-2
C PTP
CC
Bax
CC C
EndoG
EndoG AIF
DiablocIAP
EndoG AIF
Diablo
Casp 3
Caspase 3 Substrates
Cathepsin
Cytoskeleton Cell shape and membrane blebbing
Fodrin
Actin
Lamin A
DNA fragmentation and chromatin condensation
ICAD
EndoG
DNA-PK PARP
Presenelin2
-catenin
Keratin18
CARD
FADD
DISC Cas 10
Bcl-2
C
Bid
Casp 9 Apaf1 Apaf1 Casp 9
EndoG
C
C
CARD
Diablo
C EndoG
AIF
CARD
DiablocIAP Casp 3 Casp 6 Casp 7
Casp10
FADD
Casp 8
FADD
Cas
8
FLIP
BAP31 p20
ChK2 ATM
CARD
Apaf1 C
C
Casp 3
Caspase 3 Substrates
Genotoxic stress
ROS in apoptosis
O-, OH-, NO-
C C
C
C
Diablo C
C
C
C
p53
Bid
Bax
BBBBaaaakxkx
C
C C
C
C
C
Diablo
C Diablo
CC
TNFR1 and FAS signaling in necrosis
FAS-L
DDDDDD
TNF
R1 R1 R1
DDDDDD
Death Domains
FADD
RIP Kinase
TRADD
FADD
FADD
FADD
RIP Kinase
FADD
FADD
Phosphorylated Intermediate(s)
Casp 12
28S
eIF2
Ire-1 PERK
Bax Bax
RYR
DNA damage-induced apoptosis
p53
Bax
Bcl-2
Bid
CC C
C CC
CARD
Pin 1
p53
p53 S20 S15 PARC
FAS
AAAAA
Puma AAAAA
Bid
AAAAA
CARD
NOXA AAAAA Bax AAAAA
FAS-L Signaling in apoptosis FAFSA-FLSA-LS-L
FAS-L
FADD FADD
RAID
FAS-L
DD
DED
DD DD DD
DDDDDD
DDDDDD
FADD
FADD
FADD
FADD
RAID
EndoG
AIF EndoG
CC
C C
C
C
C
C
C
CCC
C
CC
C
FADD
CARD Casp 2
CC C
CARD
EndoG
EndoG AIF
Apaf1
FADD
FADD
DDDDDD
RAID
FADD
FADD
DISC Cas
Cas
10
8
CARD Casp 2
CARD
Bcl-2
C
BAP31 p20
Bid
Casp10
Casp 8
Casp 3 Casp 6 Casp 7
FLIP
Caspase Substrates
Caspase 3 Substrates
Role of p53 in apoptosis
O-, OH-, NO-
Bax
C
MDM 2
p53
PALeabharlann BaiduC
S15 S20
Pin 1
p53
FAS
AAAAA
Puma AAAAA NOXA AAAAA Bax AAAAA
CARD
Bid AAAAA
Apaf1 AAAAA