脑出血患者D_二聚体和纤维蛋白原降解产物的变化

神经损伤,减轻了面部凹陷畸形,并保留了腮腺的功能,而在术后复发方面无统计学差异〔12〕。W arthin′s瘤常为多发,故在术前术中要注意有无多发性肿瘤。该肿瘤术后复发率约为515%～1212%,可能与肿瘤的多中心性有关,但W arthin′s瘤极少发生恶变。

3　参考文献

1　Mai orano E,Lo Muzi o L,Favia G,et al11W arthin′s tumuor:a study of 78cases with e mphasis on bilaterality,multif ocality and ass ociati on with other malignancies〔J〕1O ral Oncol ogy,2002;38(1):352401

2　Yoo GH,W eisele D,A skin F B,et al1W arthin′s tumuor:a402year expe2 rience at The Johns Hopkins Hos p ital〔J〕1Laryngoscope,1994;104(7): 79928031

3　Kot w all C1S moking as an eti ol ogic fact or in the devel opment of W artin′s tumor of the par otid gland〔J〕1Am J Surg,1992;164:646271

4　de Ru JA,Plantinga RF,Maj oor MH,et al1W arthin′s tumour and s mok2 ing〔J〕1B2ENT,2005;1(2):63261

5　Peter Kluss mann J,W ittekindt C,Fl orian Preuss S,et al1H igh risk for bilateralW arthin tumor in heavy s mokers2review of185cases〔J〕1Acta O t olaryngol,2006;126(11):1213271

6　Gorgone S,D i Pietr o N,R izz o A,et al1W arthin′s tumour of the par otid

gland〔J〕1Chir Ital,2002;54(6):8692721

7　Park CK,Manning JT,Battifora H,et al1Follicle center ly mphoma and W arthin tumour involving the sa me anat om ic site1Report of t w o cases and revie w of the literature〔J〕1Am J Clin Pathol,2000;113:113291

8　Nagao T,Sugano I,Ishida Y,et al1Mucoep ider moid carcinoma arising in W arthin′s t omour of the par otid gland:report of t w o cases wtith his2 t opathol ogical,ultrastructural and i m munohist ochem ical studies〔J〕1H ist opathol ogy,1998;33:3792861

9　Tey moortash AY,Krasnewicz Y,W erner JA1Clinical features of cystade2 noly mphoma(W arthin′s tumor)of the par otid gland:A retr os pective com2 parative study of96cases〔J〕1O ral Oncol,2006;42(6):5692731

10　Ki m J,Ki m EK,Park CS,et al1Characteristic s onographic findings of W arthin′s tumor in the par otid gland〔J〕1J Clin U ltras ound,2004;32

(2):782811

11　元建鹏,黄穗乔,谢榜昆,等146例腮腺W arthin′s瘤的MR I诊断价值及病理基础〔J〕1影像诊断与介入放射学,2004;13:882901

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脑出血患者D2二聚体和纤维蛋白原降解产物的变化

田　力　刘晓丹1　滕伟禹2　(中国医科大学附属盛京医院干诊科,辽宁　沈阳　110004)

〔摘　要〕　目的　观察脑出血患者血浆D2二聚体(D2D)及纤维蛋白原降解产物(F DP)的动态变化和临床意义。方法　采用免疫比浊法测定D2D水平,采用乳胶凝聚法测定F DP。测定观察组68例脑出血患者发病后1、3、7d时静脉血D2D及F DP含量的变化,同时与正常对照组57例相比较。结果　观察组血浆D2D含量在发病后1、3d较对照组增高有显著性差异(P<0105);而观察组3、7d时血浆F DP含量增高(P<0105)。结论　脑出血急性期血浆D2D含量增加,亚急性期F DP含量增高,这可能是脑出血后脑组织损伤引起外周血中纤溶活性增高的一种代偿反应。

〔关键词〕　脑出血;D2二聚体;纤维蛋白原降解产物

〔中图分类号〕　R743134 〔文献标识码〕　A 〔文章编号〕　100529202(2008)1221091202

The changes i n D2d i poly m er and f i br i n ogen degrada ti on product of i n tracerebra l hem orrhage pa ti en ts

T I AN L i,L I U X i a o2Dan,TENG W e i2Y u1

D epart m en t of Cadre D i a gnosis and Trea t m en t,Shengji n g Hosp it a l Aff ili a ted to Ch i n a M ed i ca l Un i versity,Shenyang110004,L i a2 on i n g,Ch i n a

【Abstract】　O bjecti ve　To observe the dyna m ic changes of D2di poly mer(D2D)and fibrinogen degradati on p r oduct(F DP)of intrace2 rebral he morrhage(I CH)patients and their clinical significance1M ethods　The D2D level was deter m ined by i m munoturbidi m etry1F DP was detected by latex coacervati on1The changes in D2D and F DP contents1,3,7d after attack of68I CH patients were deter m ined t o com2 pare with those in57cases of contr ol gr oup1Results　D2D contents1,3d after attack in I CH gr oup were significantly higher than those in contr ol gr oup(P<0105);but F DP levels3,7d after attack in I CH gr oup were significantly higher than those in contr ol gr oup(P<0105)1 Conclusi on s　The increased D2D content in acute phase and increased F DP levles in subacute phase of I CH m ight be a compensati on re2 s ponse of increasing fibrinolysis activity in peri pheral bl ood induced by brain tissue injury1

【Key words】　I ntracerebral he morrhage;D2di poly mer(D2D);Fibrinogen degradati on p r oduct(F DP)

基金项目:辽宁省自然科学基金资助项目(20051095)

1　检验科　2　中国医科大学附属第一医院神经内科

作者简介:田　力(19682),女,主治医师,在读博士,主要从事脑出血及老年病机制方面的研究。

脑出血后血肿及其周围水肿带压迫脑组织引发一系列病理生理变化,其中血肿及周围受损伤脑组织释出血管活性物质,引起局部脑血流量改变和纤溶凝血系统变化直接影响脑出血患者病情发展的严重程度,从而最终影响患者的预后。本文通过对68例脑出血患者血浆D2二聚体(D2D)及纤维蛋白原降

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田　力等　脑出血患者D2二聚体和纤维蛋白原降解产物的变化　第12期