患者治疗前后血清性激素水平观察

第11卷　第12期中华男科学杂志Vol.11　No.12 2005年12月Nati onal Journal of Andr ol ogy Dec.2005

・论著・

男性甲亢患者治疗前后血清性激素水平观察

郑铁生1,叶立新2,吴志勇2

(1.江苏大学医学技术学院;2.江苏大学附属医院内分泌科,江苏镇江212001)

摘要:　目的:探讨男性甲亢患者治疗前后血清性激素水平的变化及其临床意义。　方法:采用化学发光免疫法测定68例男性甲亢患者治疗前后血清卵泡刺激素(FS H)、黄体生成素(LH)、睾酮(T)和雌二醇(E

2

)的水平,并与

对照组比较,进行统计学分析。　结果:男性甲亢患者治疗前血清T和E

2

的水平明显高于对照组,差异有显著性

(P<0.05);FSH、LH的水平与对照组相比差异无显著性(P>0.05)。男性甲亢患者治疗后血清FSH、LH、T和E

2的水平与对照组相比差异无显著性(P>0.05)。　结论:男性甲亢患者存在性激素代谢紊乱;患者血清T和E

2

水平的增高是机体为了适应高代谢环境,下丘脑2垂体2性腺轴所产生的适应性变化;随着甲亢得到控制,其水平恢复正常。

关键词:甲状腺功能亢进;性激素;高代谢;适应性;男性

中图分类号:R581;R697+.22 文献标识码:A 文章编号:100923591(2005)1220936203

The Observation of Serum Sexual Hormone Levels Before and After Treat ment

i n M ale Hyperthyroidis m s

Z HE NG Tie2sheng1,YE L i2xin2,WU Zhi2yong2

1.College of M edica l Science Technology,J iangsu U niversity,Zhenjiang,J iangsu212001,China;

2.D epart m ent of Endocrinology,the A ffiliated Hospital of J iangsu U niversity,Zhenjiang,J iangsu212001,Ch ina Correspondence to:ZHEN G Tie2Sheng,E2m ail:jsdxzts@16

3.co m

Abstract:　O bjective:T o exp l ore the changes of seru m sexual hor mone levels in male hyperthyr oidis m s before and after treat m ent.　M ethods:Compared with the contr ol gr oup,the seru m follicle2sti m ulating hor mone(FSH),leuteinizing hor mone(LH),test oster one

(T)and estradi ol(E

2

)of68cases of male hyperthyr oidis m s bef ore and after treat m entwere detected by che m ilu m inescence i m munoas2 say technique,and then statistical analysiswas perf or med.　R esu lts:The seru m T and E2levels of male hyperthyr oidis m s were signifi2 cantly higher than those of the contr ol gr oup bef ore treat m ent(P<0.05);while no significant difference in FS H and LH levels existed bet w een the patients and the contr ol gr oup(P>0.05).There was no difference in FSH,LH,T and E2levels bet w een patients and the contr ol gr oup after treat m ent(P>0.05).　C onclusion:There are sexual hor mone metabolis m dis order in hyperthyr oidis m men,and the increasing seru m T and E2levels are only t o adap t the high metabolis m envir on ment,and the changes of hypothala mus2p ituitary2go2 nadal axes.A l ong with the contr ol of hyperthyr oidis m,the sexual hor mone levels return t o nor mal.　N a tl J A ndrol,2005,11(12): 9362938

Key words:hyperthyr oidis m;sexual hor mone;high metabolis m;adap tability;male

性激素与自身免疫性疾病的关系一直受到人们的关注,且与多种疾病相关[125]。甲状腺功能亢进(hyperthyr oidis m)简称甲亢,患者常存在下丘脑2垂体2甲状腺、垂体2性腺轴功能紊乱,病情严重者可出现男性乳房发育、性功能障碍等临床症状。本文采用化学发光免疫分析技术(che m ilu m inescence i m mu2

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6

3

9

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收稿日期:2005207212;修回日期:2005209208

作者简介:郑铁生(19482),男,江苏镇江市人,副教授,从事生物化学的教学和科研工作。

通讯作者:郑铁生,E2mail:jsdxzts@