抗原修复研究进展 - 360文档中心

合集下载

相关主题

1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。

̯ ԓν BOUJHFO SFUSJFWBM UFDIOJRVF "3 ̅ Ԧ Ր< >Ḽ"3 Ѭ ̅ ˖ ̅ ǋ Ӊ Ѭ Б Ӑ Ḽ̯ ˿̯͛ Փѫ ǌ"3 ˝Б Ӑ < >ǌ(PXO ͈"3 Ԩ Ḽ Ѣþ ԜӠ Ḽ"3 Б Ӑ ѫ ˿ Ḽ΍ ѫ˝ ˓ ̼ "3ґˀ"3Ր ̼ǌ ˆ ̼ѹ"3 ˆ ˏ˓ ѫ ÿ< >ǌ

Ḽ"3 Ԧ ̅Ӧ˓ˆ ґ Ӑ ˀ Ӑ ԥ Й ̾Ԣ ԓν < >ǌ"3 ԢФ̴ ˬ̅ ԩḼФ Φ ӫ Ḽ ˿Б Ӑ ̅ Ӊ Ѭ ǌ ̅"3 ҩ Ԧ < >ǌ ґḼ"3ʿ̨ ̅Б Ӑ ǋБ ǋ ǋ < >Ḽ ˄ ˀ Ӑ ԥ Վ ˀ Ӑ ԥ ͪ < >Ḽ"3 ̅ ԓͮ ̓̾Ԣ̯ Ѭ ˖ Ԩ ̾ ѫ < >ǌ ̅"3 Ḽ "3 ѫ ҃ Ԩ ѹ < >

ǌ ͂ ̯̂"3 ͺ ͳ͗Ḽ ʼḼ Ѣ̬Ր"3 Փ̾Θԟ ǌ

ʶǋБ Ӑ

"3 ˓ ṊҪ ͇Ԣν Q)Ϙ< >ǌ ˿̾ʽ˝Ф Ṋ Ҫ ǌҪ ˀҪ ԥ Ḽ Ḽ Ҫ Ѷ ǌԥ˧ Ҫ ǌ Ե Ҫ ͇ ͪḼՉ Ҫ Ժ̖ ͪ < >ǌ ν Q)Ϙ˝Բʶ

ԓν

e e

Clive R. Taylor

üüüüüü

䞥乍Ⳃ˖National Institutes of Health Grant (1 R33 CA-103455-01)

԰㗙 ԡ: Department of Pathology, University of Southern California K eck School of Medicine, Los Angeles, California 90033, U S A (⷇ ⒊, Clive R. Taylor); Department of Pathology, Albert Einstein College of Medicine Long Island Jewish Medical Center, New Hyde Park, New York 11040, U S A (⷇ⷮ) 䗮 ԰㗙: ⷇ ⒊ (E-mail:sshi@)

ǌ ԓ ν < >ǌ"3

Ү˿ "3 Ԧ̾Ԣ"3 эӐǌ/BNJNBUTV < > Q) ͺ˝ν Ḽ ąҪ Ḽ NJO Ф ͳБ Ӑ ͕̅ Ḽ ώ ͺ˝ "3 ǌ ͂ Ԧ Ḽ ͳԺ ҁ Ḽ̮ͭ ͳʿ ǌ ̅ ѫ ԢФˀ ԥ Ḽ ҁ ̅Չ ԓν "3 ǌ˝˿"3Б Ӑ эӐḼ ͂ ʶ Φ þ ÿḼԀ ԓ ˓ Ҫ ą ą ą ʿՎν ǋ˖ǋ "3 ՐБ Ӑ Ḽ͕̾ ԓ ·"3 < >ǌ < > ԓ ·ν ͇ Ḽ ˿ ͪ ǌ ˿ʿՎ ԓ ФՉ ·ν ͇ḼӉ Ҫ ˀQ)Ϙǌ ʶ ԓ Ḽ ̅"3Б Ӑ эӐ ˝ < >ǌ

С̅"3Ҫ Ր ϛ Ḽ.JLJ < >

ԢФԺ Ḽͭ ̬ ǌ Ḽ ΍ ͉ʹ ͳ "3 Ḽ ̾ʽ ̾ Ժ Ԧ ϛ Ṋ ζ Ḽ˿ ͳˀФ ԓ ԢФ Ю ͮѫ ṋ ͳ чш Ѭ Б Ӑ ṋ ˖Ḽ Ӊ Վ"3 Ր Ѭ Ḽ̾ Б у ̼ ͳͺ˝ ṋ ѫ ͳ Ю ѫ ՠ Ջ ӐԢ˙ ǌΒ ḼQ Б Ӑ "3 Ր Ѭ ʼḼ Ѣ чшѬ ǌͭ Ḽ ̾ Ф Ṋ Ю ѫ Ḽˀ˙ ˧ ѫ ǌ ̅"3 Ю Ժ ѻ˝ Ḽ ʿ ˿ < >ǌ

"3 ʼ Ḽ ˝Б Ӑ ǌ ˿ Ӊ ґ "3 ΘԺ .*# Б Ӑ < >ǌ Ḽ "3 ՐḼ.*# Х ḼԺ̾ђ ˖ < >ǌ(POH < >̲ ˿ʿՎ

ˀ Ѭ ԩͳ ḼԦ "3Ժ̾ ζՁḼ΍ Վ Ѭ կՋ ҁ ͉ʹϛ ǌ

ˀ Ӑԥ Ḽ Ḽ ˶ ͺ˝ ԓν ǌΒ Ḽ ՐḼ Ӊ ̠ͳ Ḽ Ẏ Ӑ Ѭ Ẏ NJOḼԺ̾ < >ǌ Ҫ ˶Ժ̾Ջ Ҫ ̾ ΍ < >ǌ Џ< > ˿ Ҫ "3 ̠ͳ Б Ӑ Ḽ ˝"3 Ԧ ͺ ǌ Ջ Ҫ ˀҪ Ḽ"3 ҩ ̅Б Ḽν ˿ ǋ Ӊ Ѭ ˖ ԓǌЎ ̅ ʼ Ѭ Ḽ ˲ ˝ Ӑ ˖ NJOḼ ̅ ϟ ˖ Iǌв Й ˧ ν ˖ NJO̾ ҁν ԓ ǌ ՐḼ Ѣ ˿ʿ "3Б < >ǌ ԓѶ˝ Ѭ Ў Ӑ ḼҪ Ḽ Ẏ NJOԀԺǌ ˝ Ѭ Ԍ Ҫ ąẎ c$ Б ζՁ < >ǌ4BJUP < >̲ ˿ʿՎ Ҫ ͇Ԣ ν Ջ Ӊ Ѭ Ḽ ˝ 5SJT у Q) ·ν Ḽ ͯ ąҪ Ѭ IԺ ǌ Б Ӑ ḼҪ Ժ̾ ґʶ ԓ ͳԥ ̖ ՎՐ ҍ ̓ԡԥ Ḽ̯ ˿ ζՁ Ḽ ђ ˿ < >ǌ"3 ̅ ḼԺ̾ Ӑґ ՐՋ ΍ ̾ Ӊ ˖ %/"ѫ э Ḽ Џ ̾ ҁ < >ǌ "3 Б Ӑ ζՁ Վ Ḽ ђ Ḽ ն"3 Ѭ Ժ̾ Б Џ Ḽ ̅ < >ǌͭ ˀчшѬ ̾ ǌ Ḽ:BNBTIJUB 0LBEB< > "3 ̅ чшѬ ˿͕ Б Ӑ ǌ̴͂ ԺҪЙ NNPM -$B$M чшѬ NJO ̃ NJOǌˀ ˈ чшѬ ḼԦ ԓ Ԍ Ҫ c$ՐḼБ Ӑ ·Ḽ Ԣ ͕̅ˈ Ѭ ǌ ͂ Б ˖Ḽ˶Ԧ "3 ͕̅ ˈ ǌ ˈ ˲ Ր Ԝ ԓ Ḽͭ ՐҪ̾"3 ḼԺ̾ Б ǌ"3 чшѬ ʼ Ḽ Ѣ˿ʶ˓ ḼԀ ʹ ͈ͤ ͺ˝ э чшѬ Б Ӑ ˖ ͮǌ

̃ǋ ԓͮ ̓Ԣ Ḹ5E5ḹ̭ E651 ԯ Ḹ56/&-ḹ ̅"3Ҫ ԓѶ Ḽ ԓͮ ̓ 56/&-˧ґḼ Ѭ Ҫ Ԍ Ҫ c$̾ < >ǌ Ϸ ѫ ̲ ˿ͺ˝3/"ԓͮ ̓ґ Ҫ ˀ Ӑ ḼԦ Ҫ NJOԺ̾ ҁ чшѬ < >ǌ "3 ̅56/&- Ḽ ̅ ̒ Ḽ̾ Ҫ Ѭ ̅Q) ˝ Ջ ν ͇< >ǌͭ ʿ Ժ ̖ ϛ ǌ Ḽ Ջ Ў ̾ ν ͇ǌʻǋ эӐ

< > ѢḼ ҩ Б Ӑ С эӐḼͭ ʶ˓ Ḽ͉ ǌ эӐӉ ̯ ҁ ն К < >ǌФ˖ ф С ʹэ ͈ͤ ̅ ̾ʹ Ѭ ˧ ʿ Վ ԓˎ Ḽ̯ ҁ Б Ӑ < >ǌ Б Ӑ ̾ Ḽ ˽ ˖)FS С ҁ ՠ ͳ ф < >ǌ˝ фʿՎ ˧ Ḽ ˿Ӊ ˓ ˓ Ю Б Ӑ ͤ< >ǌ3IPEFT < > ѫѾ̼ ʿՎ )FS Ḽ Ӊ Ѭ Ḽ Ѵ ̅ ʼ̾ͺ˝ э ǌ ԟҪ Ӭͮ ˽ Ѭ Б Ӑ ḼҪ э Ф Ḽ э ː ҃Б Ӑ ͇ḼՉ ʶ ǌ Б Ӑ ͤ Ժ̾ ҁ ̯҃ эӐ ǌͭ Ḽʼ эӐ ̮ ф̾ ҁ Б Ӑ ǌ˝ Ḽ-FPOH< > ˝ ҁʶ ̅ Ѭ ˖ Ю ԓḼ ҃ ԓˎ Ḽ Β ԓ դ ǌՠѶḼ ґ Б Ӑ ն ͤ ǌͭ Ḽ̯ Ḽі˪ʿԺ Ժ̾ ̅ Ѭ Ю ԓǌ ЎḼՎʶ ԓ ʿՎ ˖ ѫ ʿ ՎǌΒ Ḽ ̅ʿՎ ˖ Ю Ḽ $% ǋ$% Ԣ Л С ԓ ͳ Б Ӑ ṊʿՎ ˖ Ю ʿՎ < >ǌФ Ḽ