生物信息学1 陈润生
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破译人类遗传密码就要读懂由30亿符号组成的100万 页的“天书”
1995
Bacteria, 1.6 Mb, ~1600 genes
[Science 269: 496]
1997
Eukaryote, 13 Mb,
~6K genes
[Nature 387: 1]
1998
Animal, ~100 Mb, ~20K genes
Jian Wang,1,2 Lihuang Zhu,3 † Longping Yuan,8 † Huanming Yang 1,2,3 †
它是一个学科领域，包含着基因组信息的获取、处理、存储、分 配 、分析和解释的所有方面。
(The U.S. Human Genome Project: The First Five Years FY 1991-1995, by NIH and DOE)
从美国的三个国家计划说起：曼哈顿计划；阿婆罗计 划；人类基因组计划。
Jianping Liu,1 Qiuhui Qi,1 Jinsong Liu,1 Li Li,1 Tao Li,1 Xuegang Wang,1 Hong Lu,1 Tingting Wu,1 Miao Zhu,1 Peixiang Ni,1 Hua Han,1 Wei Dong,1,3 Xiaoyu Ren,1 Xiaoli Feng,1,3 Peng Cui,1 Xianran Li,1 Hao Wang,1 Xin Xu,1 Wenxue Zhai,3 Zhao Xu,1 Jinsong Zhang,3 Sijie He,3 Jianguo Zhang,1 Jichen Xu,3 Kunlin Zhang,1,5 Xianwu Zheng,3 Jianhai Dong,2 Wanyong Zeng,3 Lin Tao,2 Jia Ye,2 Jun Tan,2 Xide Ren,1 Xuewei Chen,3 Jun He,2 Daofeng Liu,3 Wei Tian,2,6 Chaoguang Tian,1 Hongai Xia,1 Qiyu Bao,1 Gang Li,1 Hui Gao,1 Ting Cao,1 Juan Wang,1 Wenming Zhao,1 Ping Li,3 Wei Chen,1 Xudong Wang,3 Yong Zhang,1,5 Jianfei Hu,1,5 Jing Wang,1,5 Song Liu,1 Jian Yang,1 Guangyu Zhang,1 Yuqing Xiong,1 Zhijie Li,1 Long Mao,3 Chengshu Zhou,8 Zhen Zhu,3 Runsheng Chen,1,9 Bailin Hao,2,10 Weimou Zheng,1,10 Shouyi Chen,3 Wei Guo,11 Guojie Li,12 Siqi Liu,1,2 Ming Tao,1,2
L. ssp. indica)
Jun Yu,1,2,3,4 *Songnian Hu,1 *Jun Wang,1,2,5 * Gane Ka-Shu Wong,1,2,4 *Songgang Li,1,5 Bin Liu,1 Yajun Deng,1,6 Li Dai,1 Yan Zhou,2,7 Xiuqing Zhang,1,3 Mengliang Cao,8 Jing Liu,2
Jiandong Sun,1 Jiabin Tang,1,3 Yanjiong Chen,1,6 Xiaobing Huang,1 Wei Lin,2 Chen Ye,1 Wei Tong,1 Lijuan Cong,1 Jianing Geng,1 Yujun Han,1 Lin Li,1 Wei Li,1,9 Guangqiang Hu,1 Xiangang Huang,1 Wenjie Li,1 Jian Li,1 Zhanwei Liu,1 Long Li,1
Trisomy 13 Patau Syndrome
Patau Syndrome
Cleft lip and palate Extra fingers & toes
– polydactylism
Defects
– Heart – Braiwk.baidu.com – Kidney
Most abort Live span < 1 month
中国科学院生物物理研究所 北京朝阳区大屯路15号
背景
Normal Male
FISH
Different probes used to mark each chomosome
Computer identifies probe and give chromosome a false color
[Science 282: 1945]
2000?
Human, ~3 Gb, ~100K genes [???]
Genomes highlight
the Finiteness
of the “Parts” in Biology
real thing, Apr ‘00
‘98 spoof
A Draft Sequence of the Rice Genome (Oryza sativa
一. 什么是生物信息学？
Genome informatics is a scientific discipline that encompasses all aspects of genome information acquisition, processing, storage, distribution, analysis, and interpretation.
生物信息学现状和重要研究方向
陈润生
E-mail : crs@sun5.ibp.ac.cn runshengc@hotmail.com
Tel: 86-10-64888543 Fax: 86-10-64871293
凌伦奖
E-mail : ling@sun5.ibp.ac.cn Tel: 86-10-64888544
1995
Bacteria, 1.6 Mb, ~1600 genes
[Science 269: 496]
1997
Eukaryote, 13 Mb,
~6K genes
[Nature 387: 1]
1998
Animal, ~100 Mb, ~20K genes
Jian Wang,1,2 Lihuang Zhu,3 † Longping Yuan,8 † Huanming Yang 1,2,3 †
它是一个学科领域，包含着基因组信息的获取、处理、存储、分 配 、分析和解释的所有方面。
(The U.S. Human Genome Project: The First Five Years FY 1991-1995, by NIH and DOE)
从美国的三个国家计划说起：曼哈顿计划；阿婆罗计 划；人类基因组计划。
Jianping Liu,1 Qiuhui Qi,1 Jinsong Liu,1 Li Li,1 Tao Li,1 Xuegang Wang,1 Hong Lu,1 Tingting Wu,1 Miao Zhu,1 Peixiang Ni,1 Hua Han,1 Wei Dong,1,3 Xiaoyu Ren,1 Xiaoli Feng,1,3 Peng Cui,1 Xianran Li,1 Hao Wang,1 Xin Xu,1 Wenxue Zhai,3 Zhao Xu,1 Jinsong Zhang,3 Sijie He,3 Jianguo Zhang,1 Jichen Xu,3 Kunlin Zhang,1,5 Xianwu Zheng,3 Jianhai Dong,2 Wanyong Zeng,3 Lin Tao,2 Jia Ye,2 Jun Tan,2 Xide Ren,1 Xuewei Chen,3 Jun He,2 Daofeng Liu,3 Wei Tian,2,6 Chaoguang Tian,1 Hongai Xia,1 Qiyu Bao,1 Gang Li,1 Hui Gao,1 Ting Cao,1 Juan Wang,1 Wenming Zhao,1 Ping Li,3 Wei Chen,1 Xudong Wang,3 Yong Zhang,1,5 Jianfei Hu,1,5 Jing Wang,1,5 Song Liu,1 Jian Yang,1 Guangyu Zhang,1 Yuqing Xiong,1 Zhijie Li,1 Long Mao,3 Chengshu Zhou,8 Zhen Zhu,3 Runsheng Chen,1,9 Bailin Hao,2,10 Weimou Zheng,1,10 Shouyi Chen,3 Wei Guo,11 Guojie Li,12 Siqi Liu,1,2 Ming Tao,1,2
L. ssp. indica)
Jun Yu,1,2,3,4 *Songnian Hu,1 *Jun Wang,1,2,5 * Gane Ka-Shu Wong,1,2,4 *Songgang Li,1,5 Bin Liu,1 Yajun Deng,1,6 Li Dai,1 Yan Zhou,2,7 Xiuqing Zhang,1,3 Mengliang Cao,8 Jing Liu,2
Jiandong Sun,1 Jiabin Tang,1,3 Yanjiong Chen,1,6 Xiaobing Huang,1 Wei Lin,2 Chen Ye,1 Wei Tong,1 Lijuan Cong,1 Jianing Geng,1 Yujun Han,1 Lin Li,1 Wei Li,1,9 Guangqiang Hu,1 Xiangang Huang,1 Wenjie Li,1 Jian Li,1 Zhanwei Liu,1 Long Li,1
Trisomy 13 Patau Syndrome
Patau Syndrome
Cleft lip and palate Extra fingers & toes
– polydactylism
Defects
– Heart – Braiwk.baidu.com – Kidney
Most abort Live span < 1 month
中国科学院生物物理研究所 北京朝阳区大屯路15号
背景
Normal Male
FISH
Different probes used to mark each chomosome
Computer identifies probe and give chromosome a false color
[Science 282: 1945]
2000?
Human, ~3 Gb, ~100K genes [???]
Genomes highlight
the Finiteness
of the “Parts” in Biology
real thing, Apr ‘00
‘98 spoof
A Draft Sequence of the Rice Genome (Oryza sativa
一. 什么是生物信息学？
Genome informatics is a scientific discipline that encompasses all aspects of genome information acquisition, processing, storage, distribution, analysis, and interpretation.
生物信息学现状和重要研究方向
陈润生
E-mail : crs@sun5.ibp.ac.cn runshengc@hotmail.com
Tel: 86-10-64888543 Fax: 86-10-64871293
凌伦奖
E-mail : ling@sun5.ibp.ac.cn Tel: 86-10-64888544