Tin Mesoporphyrin IX (chloride)_血红素加氧酶(HO)活性的有效竞争性抑制剂_106344-20-1_Apexbio
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ApexBio Technology
参考文献:
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Others Heme oxygenase
Tin Mesoporphyrin IX is a potent and competitive inhibitor of heme oxygenase (HO) activity. Heme oxygenase or haem oxygenase (HO) is an enzyme catalyzing the degradation of heme. This produces biliverdin, ferrous iron, and carbon monoxide. There is limited evidence that levels of heme oxygenase are positive predictors of metabolic disease, insulin resistance, and metaflammation. In vitro: Previous study found that Tin Mesoporphyrin IX was a potent competitive in-vitro inhibitor of enzyme activity when it was incubated with rat splenic microsomal heme oxygenase, with a Ki of 0.014 microM [1]. In vivo: Animal study showed that Tin Mesoporphyrin IX at 1 pmol/kg body wt could inhibit hepatic, renal, and splenic heme oxygenase activity in adult animals for extended periods of time. Tin Mesoporphyrin IX at 1 pmol/kg body wt also prevented the transient increase in serum bilirubin 24 h after birth in the rat neonate and significantly reduced the levels of serum bilirubin in aminolevulinic acid induced hyperbilirubinemia in the 7-day-old suckling neonate. Moreover, it was found that the tissue heme oxygenase activity decreased in both animal models of hyperbilirubinemia. Tin Mesoporphyrin IX treatment resulted in a prolonged increase in the heme saturation of hepatic tryptophan pyrrolase [1]. Clinical trial: So far, no clinical study has been conducted.
Tin Mesoporphyrin IX (chloride)
106344-20-1 754.3
//struct//
C34H34Cl2N4O4Sn • 2H
NSC 267099,SnMP
(OC-6-13)-dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-por phine-2,18-dipropanoato(4-)-κN21,κN22,κN来自百度文库3,κN24]-stannate(2-), dihydrogen
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式: 别名: 化学名:
SMILES:
溶解性: 储存条件: 一般建议:
运输条件:
生物活性
靶点 : 信号通路: 产品描述: Ki = 14 nM
产品名: Tin Mesoporphyrin IX (chloride) 修订日期: 6/30/2016
[Cl-][Sn+4]123([N-]4C5=C(CCC([O-])=O)C(C)=C4C=C(C(CC)=C6C)[N]1= C6C=C(C(CC)=C7C)[N-]2C7=CC8=[N]3C(C(CCC([O-])=O)=C8C)=C5)[Cl-] .[H+].[H+]
Soluble in DMSO
参考文献:
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
Others Heme oxygenase
Tin Mesoporphyrin IX is a potent and competitive inhibitor of heme oxygenase (HO) activity. Heme oxygenase or haem oxygenase (HO) is an enzyme catalyzing the degradation of heme. This produces biliverdin, ferrous iron, and carbon monoxide. There is limited evidence that levels of heme oxygenase are positive predictors of metabolic disease, insulin resistance, and metaflammation. In vitro: Previous study found that Tin Mesoporphyrin IX was a potent competitive in-vitro inhibitor of enzyme activity when it was incubated with rat splenic microsomal heme oxygenase, with a Ki of 0.014 microM [1]. In vivo: Animal study showed that Tin Mesoporphyrin IX at 1 pmol/kg body wt could inhibit hepatic, renal, and splenic heme oxygenase activity in adult animals for extended periods of time. Tin Mesoporphyrin IX at 1 pmol/kg body wt also prevented the transient increase in serum bilirubin 24 h after birth in the rat neonate and significantly reduced the levels of serum bilirubin in aminolevulinic acid induced hyperbilirubinemia in the 7-day-old suckling neonate. Moreover, it was found that the tissue heme oxygenase activity decreased in both animal models of hyperbilirubinemia. Tin Mesoporphyrin IX treatment resulted in a prolonged increase in the heme saturation of hepatic tryptophan pyrrolase [1]. Clinical trial: So far, no clinical study has been conducted.
Tin Mesoporphyrin IX (chloride)
106344-20-1 754.3
//struct//
C34H34Cl2N4O4Sn • 2H
NSC 267099,SnMP
(OC-6-13)-dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-por phine-2,18-dipropanoato(4-)-κN21,κN22,κN来自百度文库3,κN24]-stannate(2-), dihydrogen
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式: 别名: 化学名:
SMILES:
溶解性: 储存条件: 一般建议:
运输条件:
生物活性
靶点 : 信号通路: 产品描述: Ki = 14 nM
产品名: Tin Mesoporphyrin IX (chloride) 修订日期: 6/30/2016
[Cl-][Sn+4]123([N-]4C5=C(CCC([O-])=O)C(C)=C4C=C(C(CC)=C6C)[N]1= C6C=C(C(CC)=C7C)[N-]2C7=CC8=[N]3C(C(CCC([O-])=O)=C8C)=C5)[Cl-] .[H+].[H+]
Soluble in DMSO