肺癌简介(英文版)
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Frankly Speaking About Lung Cancer
“What You Need to Know About Lung Cancer
& Its Treatment”
2
Frankly Speaking About Lung Cancer
Powerful facts: • 177,000 cases annually • Lung cancer is the #1 cause of cancer-
lung tissue and lymph nodes outside of the lung
distant spread (liver, adrenal glands, bone, brain, other sites)
7
Frankly Speaking About Lung Cancer
LUNG CANCER STAGING (TNM) T= Primary tumor size (T1-T4) N= Lymph node involvement (N1-N3) M= Distant metastasis (M0-M1)
smokers
6
Frankly Speaking About Lung Cancer
Stages of Non-Small Cell Lung Cancer
– Stage I – Stage II
– Stage III
– Stage IV
confined to lung tissue alone
lung tissue and lymph nodes in lung
promising • Adjuvant (given after surgery) chemotherapy
or radiation therapy show no improvement
12
Frankly Speaking About Lung Cancer
✓Acts synergistically with XRT to downstage NSCLC and make tumor-free margin surgery more likely
• Radiation Therapy ✓ “Sterilizes” surgical margins making local recurrence less likely
8
Frankly Speaking About Lung Cancer
Treatment of Stage I NSCLC
• Evaluate for surgery • Surgery alone is the standard of care • Pathologic stage I: 67% cure • Clinical trials are evaluating the value of
adjuvant (after surgery) therapy
10
Frankly Speaking About Lung Cancer
‘Theoretical’ Advantages of Combining Different Types of Cancer Therapies
• Chemotherapy: ✓Controls micro-metastases that may be responsible for systemic recurrence after “successful” surgery
11
Frankly Speaking About Lung Cancer
Summary: Treatment Stage I & II NSCLC
• Surgery is the standard of care • Neoadjuvant (given before surgery) therapy is
5ຫໍສະໝຸດ Baidu
Frankly Speaking About Lung Cancer
Small Cell Lung Cancer (SCLC)
• Comprises 15-20% of all lung cancers • Spreads more aggressively than NSCLC • Is more responsive to chemotherapy • Frequently found in smokers or former
cases)
• Occupational/environmental
4
Frankly Speaking About Lung Cancer
Non-Small Cell Lung Cancer (NSCLC) Comprises 85% of all lung cancers
Types of NSCLC: – Adenocarcinoma (most common) – Squamous cell – Bronchoalveolar Carcinoma – Large Cell Carcinoma – Adenosquamous
related deaths by far in the U.S. …more than breast, prostate, and colon cancer combined.
3
Frankly Speaking About Lung Cancer
Risk Factors: • Smoking (90% of all cases) • Second-hand smoke (25% of non-smoker
adjuvant (after surgery) therapy
9
Frankly Speaking About Lung Cancer
Treatment of Stage II NSCLC
• Evaluate for type of surgery • Surgery alone is the standard of care • Pathologic stage II: 40-50% cure • Clinical trials are evaluating the value of
“What You Need to Know About Lung Cancer
& Its Treatment”
2
Frankly Speaking About Lung Cancer
Powerful facts: • 177,000 cases annually • Lung cancer is the #1 cause of cancer-
lung tissue and lymph nodes outside of the lung
distant spread (liver, adrenal glands, bone, brain, other sites)
7
Frankly Speaking About Lung Cancer
LUNG CANCER STAGING (TNM) T= Primary tumor size (T1-T4) N= Lymph node involvement (N1-N3) M= Distant metastasis (M0-M1)
smokers
6
Frankly Speaking About Lung Cancer
Stages of Non-Small Cell Lung Cancer
– Stage I – Stage II
– Stage III
– Stage IV
confined to lung tissue alone
lung tissue and lymph nodes in lung
promising • Adjuvant (given after surgery) chemotherapy
or radiation therapy show no improvement
12
Frankly Speaking About Lung Cancer
✓Acts synergistically with XRT to downstage NSCLC and make tumor-free margin surgery more likely
• Radiation Therapy ✓ “Sterilizes” surgical margins making local recurrence less likely
8
Frankly Speaking About Lung Cancer
Treatment of Stage I NSCLC
• Evaluate for surgery • Surgery alone is the standard of care • Pathologic stage I: 67% cure • Clinical trials are evaluating the value of
adjuvant (after surgery) therapy
10
Frankly Speaking About Lung Cancer
‘Theoretical’ Advantages of Combining Different Types of Cancer Therapies
• Chemotherapy: ✓Controls micro-metastases that may be responsible for systemic recurrence after “successful” surgery
11
Frankly Speaking About Lung Cancer
Summary: Treatment Stage I & II NSCLC
• Surgery is the standard of care • Neoadjuvant (given before surgery) therapy is
5ຫໍສະໝຸດ Baidu
Frankly Speaking About Lung Cancer
Small Cell Lung Cancer (SCLC)
• Comprises 15-20% of all lung cancers • Spreads more aggressively than NSCLC • Is more responsive to chemotherapy • Frequently found in smokers or former
cases)
• Occupational/environmental
4
Frankly Speaking About Lung Cancer
Non-Small Cell Lung Cancer (NSCLC) Comprises 85% of all lung cancers
Types of NSCLC: – Adenocarcinoma (most common) – Squamous cell – Bronchoalveolar Carcinoma – Large Cell Carcinoma – Adenosquamous
related deaths by far in the U.S. …more than breast, prostate, and colon cancer combined.
3
Frankly Speaking About Lung Cancer
Risk Factors: • Smoking (90% of all cases) • Second-hand smoke (25% of non-smoker
adjuvant (after surgery) therapy
9
Frankly Speaking About Lung Cancer
Treatment of Stage II NSCLC
• Evaluate for type of surgery • Surgery alone is the standard of care • Pathologic stage II: 40-50% cure • Clinical trials are evaluating the value of