(R)-(-)-Phenylephrine hydrochloride_61-76-7_DataSheet_MedChemExpress

Product Name:

(R)-(-)-Phenylephrine hydrochloride CAS No.:

61-76-7

Product Data Sheet

Cat. No.:

HY-B0471MWt:

203.67Formula:

C9H14ClNO2Purity :

>98%

Solubility:Mechanisms:

Biological Activity:

Pathways:GPCR/G protein; Target:Adrenergic Receptor DMSO 40 mg/mL; Water 40 mg/mL

g y (R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist

Target: α1- Adrenergic Receptor Phenylephrine (PE), an alpha-adrenergic agonist and promoter of hypertrophic growth in the ventricular myocyte, to activate the three best-characterized mitogen-activated protein kinase

(MAPK) subfamilies, namely p38-MAPKs, SAPKs/JNKs (i.e. stress-activated protein kinases/c-Jun N-terminal kinases) and ERKs (extracellularly responsive kinases), in perfused contracting rat hearts

[1]. PE induced dose-dependent and fully reversible isometric contractions with a threshold concentration of 10 nM (n = 4), and an EC50of 1microM [2, 3]. References:

[1]. Lazou, A., P.H. Sugden, and A. Clerk, Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the

perfused rat heart. Biochem J, 1998. 332 ( Pt 2): p. 459-65.[2]. Eckert, R.E., et al., Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role ()[]

...

[]g y y p p

of voltage-gated calcium channels and intracellular calcium stores. Urol Res, 2000. 28(2): p. 122-7.[3]. Morton, J.S., et al., Alpha(1A)-adrenoceptors mediate contractions to phenylephrine in rabbit

penile arteries. Br J Pharmacol, 2007. 150(1): p. 112-20.Caution: Not fully tested. For research purposes only

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