CCT128930_COA_05054_MedChemExpress
低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用[
专利名称：低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用
专利类型：发明专利
发明人：管华诗,李春霞,李海花,胡婷,李全才,于广利
申请号：CN201210439029.0
申请日：20121106
公开号：CN102920729A
公开日：
20130213
专利内容由知识产权出版社提供
摘要：本发明提供了一种低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用。
在体外细胞实验中，低聚甘露糖醛酸能明显促进CFU-GM的形成，同时能促进骨髓基质细胞的增殖，促进骨髓基质细胞分泌GM-CSF，促进脾淋巴细胞分泌白介素-3。
体内实验进一步表明低聚甘露糖醛酸能明显抑制环磷酰胺所致的小鼠白细胞的减少，提高小鼠的骨髓有核细胞数量，提高CFU-GM的形成。
实验结果证明本发明提供的低聚甘露糖醛酸可以开发成为一种临床上有效的防治白细胞减少症的药物。
申请人：中国海洋大学
地址：266003 山东省青岛市市南区鱼山路5号
国籍：CN
代理机构：青岛联智专利商标事务所有限公司
代理人：崔滨生
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支气管肺泡灌洗液中生物标志物在特发性肺纤维化中的研究进展
-D 浓 度 高 于 结 节 病
断可能需要多个标志物。
骨膜蛋白是一种细胞外基质细 胞 蛋 白, 属
结节 病 组 [(
7 05±12 79)pg/g] 及 对 照 组 [(
1 84±
(
S100A9/MRP14) 水平升高,可为 IPF 的诊断提供依据。
黏蛋白是糖蛋白的一种,是由分泌 细 胞 分 泌
外表面 表 达 的 糖 蛋 白, 目 前 被 认 为 是 可 与 IPF 表 现 相 同 或 类 似。 急 性
IPF 诊断性生 物 标 志 物, 其 确 切 的 功 能 尚 不 清 楚。 作 为 一
诊断 IPF、监测 IPF 进 展、 判 断 IPF 预 后 的 生 物 标 志 物 受
程中,正常健康肺组 织 被 明 显 破 坏 的 肺 泡 结 构 和 改 变 的 细
胞外基质所取代。这 些 变 化 导 致 肺 气 体 交 换 中 断, 顺 应 性
降低,最终导致 呼 吸 衰 竭 和 死 亡 [2]。IPF 的 5 年 生 存 率 在
20%~40% 之间,死亡 率 高 于 结 肠 癌、 多 发 性 骨 髓 瘤 和 膀
6
和 SP
-D 相比,单 体 骨 膜 蛋 白 对 IPF 的 识 别 能 力 最 强。 传
广泛表 达, 分 别 为 MUC5AC 和 MUC5B, MUC5AC 主 要
在 一项对IPF 患者 BALF 的定量蛋白质组学的研究中发现,
气道上皮细胞在中性 粒 细 胞 弹 性 蛋 白 酶 和 活 化 的 嗜 酸 粒 细
和其他高危疾病 (特 应 性 皮 炎、 系 统 性 硬 皮 病 和 哮 喘 ) 患
由近端气 道 产 生, 而 MUC5B 主 要 表 达 于 远 端 呼 吸 道 [19]。
Calcipotriol_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Sep.-13-2017Print Date:Sep.-13-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :CalcipotriolCatalog No. :HY-10001CAS No. :112965-21-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MC 903; CalcipotrieneFormula:C27H40O3Molecular Weight:412.60CAS No. :112965-21-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. 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Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature: 4°C, protect from light, stored under nitrogenShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. 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PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. 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一种螺杂环类化合物、其制备方法及应用[发明专利]
![一种螺杂环类化合物、其制备方法及应用[发明专利]](https://img.taocdn.com/s3/m/0603462002d8ce2f0066f5335a8102d276a261fd.png)
专利名称：一种螺杂环类化合物、其制备方法及应用
专利类型：发明专利
发明人：王倩,张冰宾,石辰,舒思杰,霍国永,向志军,夏广新,吴国胜,梁涛,赵永新,李令文,柯樱
申请号：CN202111305935.7
申请日：20211105
公开号：CN114437096A
公开日：
20220506
专利内容由知识产权出版社提供
摘要：本发明提供了一种螺杂环类化合物、其制备方法及应用。
本发明的螺杂环类化合物如式I所示。
该类化合物对RORγt具有抑制活性，可有效抑制RORγt蛋白受体，从而调控Th17细胞的分化，抑制IL‑17的产生，进而治疗RORγt介导的相关自身免疫类疾病。
申请人：上海医药集团股份有限公司
地址：201203 上海市浦东新区张江路92号
国籍：CN
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顶空气相色谱法测定唑来膦酸中氯苯的残留量
顶空气相色谱法测定唑来膦酸中氯苯的残留量林生文【摘要】目的采用顶空气相色谱法测定唑来膦酸中氯苯的残留量.方法用DB-624毛细管柱,柱温:起始温度80 ℃,维持5 min,再以35 ℃·min-1的速率升温至220 ℃,维持5 min;进样口温度为250 ℃;氢火焰离子化检测器(FID);检测器温度为280 ℃.结果溶剂与氯苯的分离度良好,氯苯在所考察的质量浓度范围内线性关系良好,r=0.999 2,平均回收率为99.0%,检出限为0.007 μg·mL-1.结论该方法简单,结果准确,可用于唑来膦酸中有机溶剂的限度检查.【期刊名称】《西北药学杂志》【年(卷),期】2013(028)004【总页数】2页(P369-370)【关键词】顶空气相色谱法;氯苯;唑来膦酸【作者】林生文【作者单位】广东省食品药品检验所,广州,510180【正文语种】中文【中图分类】R927唑来膦酸是一种特异性地作用于骨的二磷酸化合物，它能抑制因破骨活性增加而导致的骨吸收，临床用于治疗恶性高钙血症，控制恶性肿瘤骨转移，能改善多发性骨髓瘤、前列腺癌、乳腺癌、肺癌等恶性肿瘤治疗的疗效，并且在治疗恶性肿瘤骨转移患者的过程中取得了较好的效果[1-3]。
目前主要有注射用唑来膦酸等制剂。
唑来膦酸的制备工艺比较复杂，各个厂家所用到的溶剂略有差异，但所有厂家的工艺中均采用了氯苯。
《中国药典》2010年版二部附录[4]规定氯苯的残留量限度为0.036%，氯苯对中枢神经系统有抑制和麻醉作用；对皮肤和黏膜有刺激性，毒性较大，其残留量应当得到有效控制。
本文建立了顶空毛细管气相色谱法测定唑来膦酸中的氯苯的残留量，方法快速，准确，灵敏度高。
1.1 仪器 Aglient 7890A气相色谱仪；Aglient G1888顶空进样器；氢火焰离子化检测器。
1.2 试药试剂均为分析纯；氯苯对照品(阿拉丁试剂，批号110503，质量分数≥99%)；二甲基亚砜(默克公司，顶空级)；唑来膦酸样品[山东新时代(批号：090901)，北京诺华制药(批号：C0001)，南京制药厂(批号：ZA20090801，ZA20090802，ZA20090803)]。