世界最杰出的生物医学论文

世界最杰出的生物医学论文千名生物学家（Faculty of 1000 Biology）和千名医学家（Faculty of 1000 Medicine）是英国BioMed Central出版集团，所建立的两个医学生物学论文数据库。

它是由美国哈佛大学和英国剑桥大学等近5000多名世界顶级生物医学同行专家，所推荐和评选出的世界医学和生物学的最新发表的论文所组成。

论文依据创新性、新理论、新发现、新技术、科学价值和实际应用前景等原则，从世界上几千种重要的医学生物学杂志，成千上万篇论文中，实时进行筛选和评定，评选出F1000因子，并进行分级排序，分为杰出(Exceptional 9分)、必读(Must Read 6分)和推荐(Recommend 3分)三个级别，并写有简短的评语。

再向医学生物学界进行推荐和发布，以提供世界上最重要、最优秀的生物医学论文信息和最新研究成果与发展趋势。

F1000只重视论文的实际科学价值和临床应用前景，不考虑期刊的状况和论文在何处发表，影响因子（I F）值也仅仅作为辅助参考指标。

被推荐出的论文不足SCI发表论文的千分之二，其中杰出的论文仅占所推荐论文的5%。

F1000还依据不同的科学领域，适时评选出最近和最受关注（Must-Viewed）的10篇最佳论文，称为“Top 10”，并不断更新。

此外还邀请世界上最知名和权威的领域科学家，编写生物医学最近的进展、评论和综述，刊登在“F1000 Reports上”。

F1000是一个新的医学生物学论文数据库，是一个新的生物医学论文评价工具，是一个新的医学论文评估的专家系统。

它不仅可以帮助我们来快速检索世界上最“杰出”、“必须阅读”和“值得推荐”的生物医学论文；还可以了解每篇发表论文的专家评价观点和意见，使我们可以节时、高效、全面认识和了解当今世界上生物医学最新研究成果和发展动向，引导和促进生物医学科学的发展。

研究论文能为F1000所收录和推荐，成为F1000“杰出”论文，代表着该论文的极高的科学水平和重要的科学价值。

目前我国每年被SCI收录的医学生物学论文已逾万篇，成为“论文大国”，但能为F1000收录为“杰出”的论文却寥寥。

以2009—2010年为例，在F1000收录和推荐出1017篇“杰出”论文中，中国只有11篇，其中还有4篇是台湾和香港的。

从2000—2010年F1000共评出近5000篇“杰出”论文，中国（包括台湾和香港）总共只有25有篇。

反应出我国现在医学生物学研究“跟”多“创”少，重“量”不重“质” ；一般资料性的工作多，有创新性、有实际应用价值、有重要理论和应用前景的论文少的潜在而深刻的危机。

我们必须在原始创新和实际应用上再上一层楼！我们要发表SCI论文，要发表高IF影响因子论文；我们更要多发表F1000“杰出”论文，发表创新性强，有重要理论价值和实际应用前景的科学论文，这才能成为真正的科技强国。

这里我们收集了2009－2010年心血管、肿瘤、细胞生物学、分子生物学、免疫学、神经科学等领域F1000的“杰出”论文供大家参考，更多的F1000论文，可在F1000Biology和F1000Medicine网站上搜索。

• Biochemistry• Bioinformatics• Biotechnology• Cancer Biology• Cardiovascular Biology• Cell Biology• Chemical Biology• Developmental Biology• Ecology• Evolutionary Biology• Gastrointestinal Biology• Genomics & Genetics• Immunology• Metabolic & Endocrine Science• Microbiology• Molecular Biology• Molecular Medicine• Neuroscience• Pharmacology & Drug Discovery• Physiology• Plant Biology• Renal Biology• Respiratory Biology• Structural Biology• Anesthesiology & Pain Management• Cardiovascular Disorders• Critical Care & Emergency Medicine• Dermatology• Diabetes & Endocrinology• Gastroenterology & Hepatology• Hematology• Infectious Diseases• Nephrology• Neurological Disorders• Oncology• Otolaryngology• Psychiatry• Public Health & Epidemiology• Research Methodology• Respiratory Disorders• Rheumatology & Clinical Immunology• Urology• Women's Health________________________________________F1000 Reportcell-A mover and a shaker'- 53BP1 allows DNA doublestrand breaks a chance to dance and unitecell-A virtual cycle- theory and experiment converge on the exit from mitosiscell-Aberrant mRNA transcripts and nonsense-mediated decaycell-Autophagy of intracellular microbes and mitochondria- two sides of the same coincell-Brd4 engagement from chromatin targeting to transcriptional regulation- selective contact with acetylated histone H3 and H4cell-Conformational changes in receptor tyrosine kinase signaling- an ErbB garden of delightscell-Destroy to create- E3 ubiquitin ligases in neurogenesiscell-Doing cell biology in embryos- regulated membrane traffic and its implications for cadherin biologycell-Epigenetic regulation of antigen receptor gene rearrangementcell-G-protein-coupled receptor structurecell-Induced pluripotent stem (iPS) cells- an up-to-the-minute reviewcell-Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancercell-Intracellular trafficking and signaling in developmentcell-LOV conquers (sm)All GTPasescell-Membrane deformation and 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stenosiscv-Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflexcv-Telemonitoring and self-management in the control of hypertension (TASMINH2)cv-Telmisartan, ramipril, or both in patients at high risk for vascular eventsecology-A global network of coexisting microbes from environmental and whole-genome sequence data ecology-Competition limits adaptation and productivity in a photosynthetic alga at elevated CO2ecology-Ecosystem response to elevated CO(2) levels limited by nitrogen-induced plant species shiftecology-Local adaptation and the evolution of species' ranges under climate changeecology-Parasite prevalence and the worldwide distribution of cognitive abilityecology-Promiscuity and the evolutionary transition to complex societiesecology-Statistical inference for noisy nonlinear ecological dynamic systemsecology-The quantitative genetics of phenotypic robustnessgenome-cell line misidentificationgenome-Chaperonin-dependent accelerated substitution rates in prokaryotesgenome-Chromosome size differences may affect meiosis and genome sizegenome-Common SNPs explain a large proportion of the heritability for human heightgenome-Dissecting cancer through mathematics- from the cell to the animal modelgenome-Global analysis of trans-splicing in Drosophilagenome-High-resolution analysis of parent-of-origin allelic expression in the mouse braingenome-Inaugural Article- Fast live simultaneous multiwavelength four-dimensional optical microscopy genome-Segregation of yeast nuclear poresgenome-Statistical design and analysis of RNA sequencing datagenome-The coevolution of human hands and feetgenome-The genetic landscape of a cellgenome-Trans-acting small RNA determines dominance relationships in Brassica self-incompatibilityimm-A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosisimm-Activation of a metabolic gene regulatory network downstream of mTOR complex 1imm-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosisimm-Duration of antibiotic therapy in hospitalised patients with community-acquired pneumoniaimm-Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapseimm-Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionimm-Evidence of dysregulation of dendritic cells in primary HIV infectionimm-Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceimm-Glutamine uptake and metabolism are coordinately regulated by ERK-MAPK during T lymphocyte activation imm-IgT, a primitive immunoglobulin class specialized in mucosal immunityimm-Immature Dengue Virusimm-Lipid accumulation and dendritic cell dysfunction in cancerimm-Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognitionimm-Naturally arising human CD4 T-cells that 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