肝炎后肝硬化患者D-二聚体、血小板相关免疫球蛋白G变化及临床意义

肝炎后肝硬化患者D-二聚体、血小板相关免疫球蛋白G变化
及临床意义
孙玉洁;吴兵;金雪琴;黄捷
【期刊名称】《中国血液流变学杂志》
【年(卷),期】2014(000)001
【摘要】Objective To investigate the changes and clinical significance of D-dimer (DD) and platelet-associated immunoglobulin G (PAIgG) in posthepatitic cirrhosis and the relationship between hemostatic changes in posthepatitic cirrosis patients with different degree of liver lesions. Methods Fifty-five patients with posthepatitic cirrhosis were divided into three subgroups (A, B, C) on the basis of Child-Pugh classification. Among the patients, 18 were classified as Child-Pugh class A, 17 were class B, 20 were class C. 20 healthy individuals served as controls. A series of tests including DD and PAIgG were performed on 55 patients and the 20 healthy controls. Furthermore, we divided the fifty-five patients with posthepatitic cirrhosis into two groups, 30 as bleeding group and 25 as non-bleeding group. The above tests were analyzed between the two groups. Results (1)DD was progressively increased form group A to group B and then to group C. In comparison to the controls there was a significant difference (P<0.05). (2)PAIgG was significantly higher in posthepatitic cirrhosis group than the control group (P<0.05). No significant differences of PAIgG were found between the group A and
group B (P>0.05). Also, PAIgG was significantly higher in group C than in the other three groups (P<0.05). (3)In posthepatitic cirrhosis patients, DD was significantly higher in bleeding group than non-bleeding group, while no significant differences of PAIgG was found between the two groups (P>0.05). Conclusion We found that there is a close relationship between the coagulation disorders and the severity of posthepatitic cirrhosis, classified on the basis of Child-Pugh classification.%目的：初步探讨肝炎后肝硬化患者D-二聚体（D-Dimer, DD）、血小板相关免疫球蛋白G（Platelet-associated Immunoglobulin G, PAIgG）变化及临床意义。

方法肝炎后肝硬化患者55例，并按Child-Pugh肝功能分级，A级18例、B级17例、C级20例，健康对照组20名，检测DD、PAIgG的水平变化。

另按有无出血现象对肝炎后肝硬化患者进行分组，出血组患者30例，无出血组患者25例，从而对上述指标进行两组间比较。

结果(1)肝炎后肝硬化患者A、B、C组与对照组比较，DD随肝炎后肝硬化的严重程度而升高，各组之间比较差异均有统计学意义（P＜0.05）；
(2)PAIgG在肝炎后肝硬化各组均明显高于对照组（P＜0.05），A组与B组之间差异无统计学意义（P＞0.05），C组则明显高于A组、B组及对照组（P＜
0.05）；(3)肝炎后肝硬化患者，DD在出血组明显高于无出血组，两组之间比较差异有统计学意义（P＜0.05），PAIgG则在出血组与无出血组之间差异无统计学意义（P＞0.05）。

结论肝炎后肝硬化患者存在明显的凝血、抗凝血以及纤溶机制的异常，且与肝炎后肝硬化肝功能Child-Pugh分级密切相关。

【总页数】4页(P66-69)
【作者】孙玉洁;吴兵;金雪琴;黄捷
【作者单位】苏州市吴中人民医院，江苏苏州215128;苏州市吴中人民医院，江
苏苏州215128;苏州市吴中人民医院，江苏苏州215128;苏州市吴中人民医院，
江苏苏州215128
【正文语种】中文
【中图分类】R575.2
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