Nitrofurazone_59-87-0_DataSheet_MedChemExpress

Product Name:
Nitrofurazone CAS No.:
59-87-0Cat. No.:
HY-B0226Product Data Sheet
MWt:
198.14Formula:
C6H6N4O4Purity :>98%
DMSO 40 mg/mL (201 mM); Water Solubility:Mechanisms:
Biological Activity:
Nit f l i b t i id l d d tibi ti t l i th f f i t t
Pathways:Anti-infection; Target:Antibacterial SO 0g/(0);ate <1 mg/mL (<1 mM)
Nitrofural is a bactericidal compound used as an antibiotic most commonly in the form of ointments.
Target: Antibacterial Nitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until now been
considered as activated in bacteria by nitroreductases. Its use in medicine has become less frequent as safer and more effective products have become available, and it has been discontinued in the
US.Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented
antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50%inhibitory concentration (IC50)for NF and NFOH presented values of 22.83±1.2M and 10.55References:
[1]. Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci
Rep. 2011;1:63.50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ± 1.2 μM and 10.55± 0.81 μM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory a...Caution: Not fully tested. For research purposes only
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