白藜芦醇抗氧化作用在神经保护中的研究进展_李燕玲

[16]Raidoo DM ,Sa want S,Mahabeer R ,et al.Kinin recep t ors

are exp ressed in human astr ocytic tumour cells.I m munop 2

har macol ogy,1999,43(223):2552263.

[17]B lack K L ,Cl oughesy T,Huang SC ,et al.

I ntracar otid infu 2

si on of RMP 27,a bradykinin anal og,and trans port of galli 2um 268ethylenedia m ine tetraacetic acid int o human gli omas.J Neur osurg,1997,86(4):6032609.

[18]刘云会,薛一雪,王荣耀,等.脑肿瘤细胞的B 2受体表

达水平决定缓激肽诱发之血脑屏障开放的程度.中华神经外科杂志,2003,1:25228.

[19]A rganaraz G A ,Silva JA J r,Per osa SR ,et al.The synthesis

and distributi on of the kinin B 1and B 2recep t ors are modified in the hi ppoca mpus of rats subm itted t o p il ocar p ine model of ep ilep sy.B rain Res,2004,1006(1):1142125.

[20]Ongali B ,Ca mpos MM ,B regola G ,et al.Aut oradi ographic

analysis of rat brain kinin B 1and B 2recep t ors:nor mal dis 2tributi on and alterati ons induced by ep ilep sy.J Comp Neur ol,2003,461(4):5062519.

[21]Per osa SR ,A rganaraz G A ,Got o E M ,et al.

Kinin B 1and

B 2recep t ors are overexp ressed in the hi ppoca mpus of humans with te mporal l obe ep ilep sy.H i ppoca mpus,2007,17(1):26233.

[22]Adolfo A rganaraz G ,Regina Per osa S,Cristina Lenci oni E ,

et al.Role of kinin B 1and B 2recep t ors in the devel opment of p il ocar p ine model of ep ilep sy.B rain Res,2004,1013(1):30239.

[23]B regola G ,Varani K ,Gessi S,et al.Changes in hi ppoca m 2

pal and cortical B 1bradykinin recep t or bi ol ogical activity in t w o experi m ental models of ep ilep sy.Neur oscience ,1999,

92(3):104321049.

[24]王琳,伍国锋,薛红,等.氯化锂毛果芸香碱癫痫鼠模

型B 1与B 2激肽受体表达研究.中华老年心脑血管病杂志,2007,9(9):6342636.

[25]鲍娟,杨期东.热休克蛋白70在阿尔茨海默病中作用

的研究进展.国际神经病学神经外科学杂志,2008,

35(3):2642267.

[26]Menendez 2Gonzalez M ,Castr o 2Sant os P ,Suarez A ,et al.

Value of measuring p las matic levels of neur osin in the diagno 2sis of A lzhei m er ’s disease.J A lzhei m ers D is,2008,14

(1):59267.

[27]Svenungss on E ,Jensen 2U rstad K ,Hei m burger M ,et al.

R isk fact ors for cardi ovascular disease in system ic lupus erythe 2mat osus.Circulati on ,2001,104(16):188721893.

[28]Dellalibera 2Joviliano R ,Dos Reis ML ,Cunha Fde Q ,et al.

Kinins and cyt okines in p las ma and cerebr os p inal fluid of pa 2tients with neur op sychiatric lupus.J Rheumat ol,2003,30(3):4852492.

[29]Shcherbakova I,Neshkova E ,Dotsenko V ,et al.The possi 2

ble r ole of p las ma kallikrein 2kinin syste m and leukocyte elas 2tase in pathogenesis of schiz ophrenia.I m munophar macol ogy,

1999,43(223):2732279.

收稿日期:2009-11-24;修回日期:2010-01-04作者简介:李燕玲(1979-),女,硕士在读。

白藜芦醇抗氧化作用在神经保护中的研究进展

李燕玲　综述 王文敏　审校

昆明医学院第一附属医院,云南省昆明市　650032

摘　要:白藜芦醇是一种含有菧类结构的非黄酮类多酚化合物,具有抗肿瘤、保护心血管、抗菌、抗病毒、免疫调节等多种生物活性和药理作用,对神经系统也有多种保护机制,其中抗氧化清除自由基的作用受到广泛关注,深入研究白藜芦醇抗氧化作用具有重要临床意义,本文就其抗氧化作用在神经保护中的研究进展做一综述。关键词:白藜芦醇;抗氧化;神经保护

白藜芦醇(resveratr ol,RES ),是一类主要存在于虎仗、葡萄皮中的非黄酮类多酚化合物,化学名为菧三酚,分子式3,4,52三羟基21,22二苯乙烯

(C12H 14O 3),分子量228.25,呈白色针状结晶,

难溶于水,易溶于有机溶剂。1940年首次从毛叶

藜芦(veratrum grandifl orum )的根部获得RES [1]

,天