内科学英文课件：Hemorrhagic Disorders
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Hereditary:
– Hereditary hemorrhagic telangiectasia（遗传性出 血性毛细血管扩张症）,
– hereditary disorders of connective tissue such as Ehlers-Danlos syndrome.
Secondary: infections, chemical factors or drugs,
Other purpuras: purpura simplex, senile purpura, mechanic purpura, paraproteinemia.
Classification: platelet disorders
Thrombocytopenia
Thrombocytosis
Thrombocytopathy
disorders of metabolism (Vitamin C deficiency), pathological changes of vascular wall (atherosclerosis), connective tissue diseases.
Allergy: allergic purpura.
TFPI
蛋白C系统
ATIII
肝素
Anticoagulation and fibrinolytic mechanism
Fibrinolysis system
– Plasminogen – Tissue-type plasminogen activator(t-PA) – Urokinase- type plasminogen activator(u-PA) – Inhibitors:α2-plasmin inhibitor(α2-PI),
chronic myelocytic leukemia, other myeloproliferative disorders (such as polycythemia vera 真性红细胞增多症）
Classification: platelet disorders
Functional abnormalities of platelets
red thrombus
Anticoagulation and fibrinolytic mechanism
Anticoagulation system
– AT-Ⅲ – Protein C system: PC, PS, TM – TFPI – Heparin
Anticoagulation system
plasminogen activator inhibitor-1(PAI-1)
Fibrinolysis system
An overview of endothelial function in coagulation
Classification
1
vascular disorders
2
platelet disorders
Hemorrhagic Disorders
Definition
When the normal hemostatic mechanism fails, major hemorrhage may follow minor trauma or may arise apparently spontaneously
Classification: platelet disorders
Classification: platelet disorBaidu Nhomakorabeaers
Thrombocytosis
– Primary: essential thrombocythemia – Secondary: infections, injury, post-splenectomy,
– Hereditary – Acquired: due to drugs, uremia, liver
diseases, dysproteinemias.
Inherited Disorders of Platelet Function
Giant platelet syndrome (Bernard-Soulier syndrome) 巨大血小板病 Glanzmann Thrombasthenia 血小板无力症
凝血酶
(纤维蛋白原缺乏症 纤维蛋白原
低纤维蛋白原血症)
XIII
纤维蛋白
XIIIa (FXIII缺乏症) 交联的纤维蛋白
Classification:
disorders of anticoagulation system and fibrinolytic system
Classification: disorders of blood coagulation
Hereditary
Acquired: Vitamin K deficiency, severe liver diseases, disseminated intravascular coagulation (DIC) etc.
3
disorders of
blood coagulation
4
disorders of anticoagulation system
and fibrinolytic
system
5
Complex disorders
of hemostatic mechanism
Classification: Vascular disorders
Inherited Disorders of blood coagulation
(FVII缺乏症) VII/TF
组织损伤 TF
IX
XII
XIIa
VIIa/TF
(FXI缺乏症) XI
XIa
IXa (血友病B)
(血友病A) VIII
VIIIa
(FX缺乏症) X （低凝血酶原血症） 凝血酶原
Xa
X
Va
V (FV缺乏症)
Mechanism of normal hemostasis
– Vascular mechanism – Platelet mechanism – Blood coagulation mechanism
Normal hemostasis
凝血瀑布反应
凝 第血 一活 阶酶 段生
成
第二阶段
第三阶段
– Hereditary hemorrhagic telangiectasia（遗传性出 血性毛细血管扩张症）,
– hereditary disorders of connective tissue such as Ehlers-Danlos syndrome.
Secondary: infections, chemical factors or drugs,
Other purpuras: purpura simplex, senile purpura, mechanic purpura, paraproteinemia.
Classification: platelet disorders
Thrombocytopenia
Thrombocytosis
Thrombocytopathy
disorders of metabolism (Vitamin C deficiency), pathological changes of vascular wall (atherosclerosis), connective tissue diseases.
Allergy: allergic purpura.
TFPI
蛋白C系统
ATIII
肝素
Anticoagulation and fibrinolytic mechanism
Fibrinolysis system
– Plasminogen – Tissue-type plasminogen activator(t-PA) – Urokinase- type plasminogen activator(u-PA) – Inhibitors:α2-plasmin inhibitor(α2-PI),
chronic myelocytic leukemia, other myeloproliferative disorders (such as polycythemia vera 真性红细胞增多症）
Classification: platelet disorders
Functional abnormalities of platelets
red thrombus
Anticoagulation and fibrinolytic mechanism
Anticoagulation system
– AT-Ⅲ – Protein C system: PC, PS, TM – TFPI – Heparin
Anticoagulation system
plasminogen activator inhibitor-1(PAI-1)
Fibrinolysis system
An overview of endothelial function in coagulation
Classification
1
vascular disorders
2
platelet disorders
Hemorrhagic Disorders
Definition
When the normal hemostatic mechanism fails, major hemorrhage may follow minor trauma or may arise apparently spontaneously
Classification: platelet disorders
Classification: platelet disorBaidu Nhomakorabeaers
Thrombocytosis
– Primary: essential thrombocythemia – Secondary: infections, injury, post-splenectomy,
– Hereditary – Acquired: due to drugs, uremia, liver
diseases, dysproteinemias.
Inherited Disorders of Platelet Function
Giant platelet syndrome (Bernard-Soulier syndrome) 巨大血小板病 Glanzmann Thrombasthenia 血小板无力症
凝血酶
(纤维蛋白原缺乏症 纤维蛋白原
低纤维蛋白原血症)
XIII
纤维蛋白
XIIIa (FXIII缺乏症) 交联的纤维蛋白
Classification:
disorders of anticoagulation system and fibrinolytic system
Classification: disorders of blood coagulation
Hereditary
Acquired: Vitamin K deficiency, severe liver diseases, disseminated intravascular coagulation (DIC) etc.
3
disorders of
blood coagulation
4
disorders of anticoagulation system
and fibrinolytic
system
5
Complex disorders
of hemostatic mechanism
Classification: Vascular disorders
Inherited Disorders of blood coagulation
(FVII缺乏症) VII/TF
组织损伤 TF
IX
XII
XIIa
VIIa/TF
(FXI缺乏症) XI
XIa
IXa (血友病B)
(血友病A) VIII
VIIIa
(FX缺乏症) X （低凝血酶原血症） 凝血酶原
Xa
X
Va
V (FV缺乏症)
Mechanism of normal hemostasis
– Vascular mechanism – Platelet mechanism – Blood coagulation mechanism
Normal hemostasis
凝血瀑布反应
凝 第血 一活 阶酶 段生
成
第二阶段
第三阶段