线粒体抑制剂和解偶联剂

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the
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competitive inhibitor of COX. Uncouplers
DNP FCCP CCCP Ion transport oligomycin valinomycin nigericin mersalyl N-ethylmaleimide 1 gmg-1 P 150 ngmg-1 P 27 pmolmg-1 P inhibition of H+ transport through ATPase. catalyzes electrogenic K+ transport electrochemical transmembrane gradient. catalyzes K+/H+ antiport. inhibition of Pi symporter. blocks endogenous Pi transport. Substrate transport carboxyatractyloside -cyanohydroxycinnamate phenylsuccinate 10 M 0.65 mM 20 mM inhibition of adenlyate translocase. inhibition of pyruvate transport. competitive inhibition of succinate transport.
The Power of Life
10-07-21
Inhibitors of mitochondrial electron and substrate transport, and agents acting on ion transport.
Inhibitor Conc. Effect
Complex I: NADH dehydrogenase, FMN, Fe/S centres rotenone amytal piericidine 5 M 10 M inhibition of NADH-DH. muscle fibers (Gellerich et al.). inhibition of NADH-DH; barbiturate drug. competitive inhibitor of NADH-DH, ubiquinone structure; antibiotic. Complex II: Succinate dehydrogenase, FAD, Fe/S, b-type haem malonate competitive inhibition of SDH. Complex III: Cytochrome bc1, Rieske Fe/S antimycin A myxothiazol 6.5 M blocks between cyt b to cyt c; antibiotic; for permeablized muscle fibers (Gellerich et al.). inhibits also Complex I (Lenaz) Complex IV: Cytochrome aa3 oxidase, Cu ions cyanide azide sulfide CO NO 1 mM