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• Constant renewal of a highly ordered structure accompanied by an increase in complexity of that structure
• Overcoming entropy requires energy • Life is self-replicating
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Range of sizes of objects studied by biochemists
and biologists
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Uses of Biochemistry
• Agriculture: Herbicides and pesticides • Medicine : Monocloning antibodies • Nutrition : Vitamines • Clinical Chemistry: transaminases and
bilirubin/Liver disease • Pharmacology: penicillin (inhibiting an
enzyme that synthesizes an essential polysaccharide of the bacterial cell wall) • Toxicology:
第8页/共10页
designer drugs
• If the target site for action of a drug is a protein enzyme or receptor, determining the detailed molecular structure of that target allows us to design inhibitors that bind to it with great selectivity.
第9页/共10页
End
第10页/共10页
第2页/共10页
Biochemistry as a Discipline
• Biochemistry as a Chemical Science • Amino acids
Sugars Lipids Nucleotides Vitamins Hormones
第3页/共10页
Chemical Elements of Living Matter
Biochemistry
Introduction
第1页/共Fra Baidu bibliotek0页
What is Biochemistry?
• Describe structure, organization, function of cells in molecular terms. Structural Chemistry Metabolism Molecular Genetics
第4页/共10页
Monomers/Polymers
• Sugar/Polysaccharide Nucleotide/Nucleic Acids Amino acid/Polypeptides
第5页/共10页
Biochemistry as a Biological Science
Distinguishing Characteristics of Living Matter
AZT was the first drug approved in the United States for the treatment of HIV infections. This nucleoside is anabolized to the corresponding 5' triphosphate, which acts as an inhibitor of viral reverse transcriptase in making DNA from the viral RNA
• Overcoming entropy requires energy • Life is self-replicating
第6页/共10页
Range of sizes of objects studied by biochemists
and biologists
第7页/共10页
Uses of Biochemistry
• Agriculture: Herbicides and pesticides • Medicine : Monocloning antibodies • Nutrition : Vitamines • Clinical Chemistry: transaminases and
bilirubin/Liver disease • Pharmacology: penicillin (inhibiting an
enzyme that synthesizes an essential polysaccharide of the bacterial cell wall) • Toxicology:
第8页/共10页
designer drugs
• If the target site for action of a drug is a protein enzyme or receptor, determining the detailed molecular structure of that target allows us to design inhibitors that bind to it with great selectivity.
第9页/共10页
End
第10页/共10页
第2页/共10页
Biochemistry as a Discipline
• Biochemistry as a Chemical Science • Amino acids
Sugars Lipids Nucleotides Vitamins Hormones
第3页/共10页
Chemical Elements of Living Matter
Biochemistry
Introduction
第1页/共Fra Baidu bibliotek0页
What is Biochemistry?
• Describe structure, organization, function of cells in molecular terms. Structural Chemistry Metabolism Molecular Genetics
第4页/共10页
Monomers/Polymers
• Sugar/Polysaccharide Nucleotide/Nucleic Acids Amino acid/Polypeptides
第5页/共10页
Biochemistry as a Biological Science
Distinguishing Characteristics of Living Matter
AZT was the first drug approved in the United States for the treatment of HIV infections. This nucleoside is anabolized to the corresponding 5' triphosphate, which acts as an inhibitor of viral reverse transcriptase in making DNA from the viral RNA