蛋白酶切位点

.
Xaa-Yaa-Pro-|-Zaa,if Zaa≠Pro
Peptidyl-depeptidaseA, or angiotensin-converting enzyme
.
Xaa-|-Yaa-Zaa,if Yaa≠Pro or Zaa≠
Asp or Glu
Carboxypeptidase A
.
Xaa-|-Yaaif Yaa ≠Asp,Glu,Arg,Lys or Pro
.
Ala-|-Xaa,andalsoGly-|-Xaa,
Val-|-Xaa, Ser-|-Xaa,
Thrombin(凝血酶)
.
Arg-|-Gly,
Plasmin(胞质素，胞浆素)
.
Lys-|-Xaa,>Arg-|-Xaa
Prolyl oligopeptidase,or prolylendopeptidase
Carboxypeptidase B,or protaminase
.
Xaa-|-ArgandXaa-|-Lys
Carboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶)
.
Xaa-|-Lys>> Xaa-|-Arg
.
Plasma kallikrein (血浆激肽释放酶)
.
Arg-|-Xaa, Lys-|-Xaa,including
Arg-|-Ser,Lys-|-Arg,
Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶)
.
Xaa-Yaa-|-Zaa,if Xaa≠ArgorLys,or
Yaa ≠Pro,orZaa≠Pro
Dipeptidyl-peptidase IV
.
Preferentially Xaa-Pro-|-Zaa,(but also Xaa-Ala-|-Yaa)withYaa ≠Pro or Hyp
Prolyl tripeptyl-peptidase
.
Xaa-|-Arg, Xaa-|-Ser,Xaa-|-Ile,
Xaa-|-Ala, Xaa-|-Gly,
Leucyl-aminopeptidase
.
Preferentially Leu-|-Xaa,but not
Arg-|-Xaa,andLys-|-Xaa,
Aminopeptidase M or N,or alanyl aminopeptidase,or membrane alanineaminopeptidase
Carboxypeptidase U or R
.
Xaa-|-Arg and Xaa-|-Lys
Glutamate CarboxypeptidaseII,or folate hydrolase
.
Xaa-|-Glu,preferentially with Xaa=
Asp or Glu
Enzymes
. Number
Cleavage sites
胰凝乳蛋白酶，糜
蛋白酶)
.
Tyr-|-Xaa,Trp-|-Xaa, Phe-|-Xaa, and
alsoLeu-|-Xaa,Met-|-Xaa,
Trypsin (胰朊酶，胰蛋白酶)
.
Arg-|-Xaa, Lys-|-Xaa,
Pancreatic elastase (胰弹性蛋白酶)
.
Arg-|-Xaa, Lys-|-Xaa,
AminopeptidaseA,or angiotensinase,or glutamyl-aminopeptidase
.
Glu-|-Xaa>>Asp-|-Xaa,
Dipeptidyl-peptidaseI,or cathepsin(组织蛋白酶)C or J
.
Preferentially Ala-|-Xaa,and Tyr-|-Xaa,if Yaa-Pro-|-Xaa interm with Yaa=Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released
Aminopeptidase B
And also Leu-|-Xaa,and Trp-|-Xaa, ideally with Xaa= Phe,Trp,orTyr
Cathepsin(组织蛋白酶)D
.
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
And also Leu-|-Xaa,ideally with Xaa
≠AlaorVal
脑啡肽酶),or enkephalinase(脑啡肽酶),or neutralendopeptidase
.
Xaa-|-Tyr,Xaa-|-Phe, Xaa-|-Trp,and
Xaa-|-Leu,
Thimet oligopeptidase(甲拌磷寡肽 酶),or endo-oligopeptidase A,or endopeptidase(肽链内切 酶),or pz-peptidease(肠促胰 酶素)
Lys-|-Xaa
Calpain(钙激活中性蛋白酶)-1,or μ-calpain
.
Met-|-Xaa,Tyr-|-Xaa and
Arg-|-Xaa(with LeuorVal as the P2 residue)
胃朊酶，胃蛋白酶)
.
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
.
Val-|-Xaa, Ala-|-Xaa,
B (源自文库织蛋白酶)
.
Arg-Arg-|-Xaa,and also Leu-|-Xaa,
Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa,
Clostripain(梭菌蛋白酶),orendoproteinase Arg-C
.
Arg-|-Xaa includingArg-|-Pro,but not