药理学留学生试题 山东大学

Pharmacology Exam for Grade 2003(A) Pakistan Students

(Exam 1) —Nov 10th,2005

Part ⅠChoice Questions （60 points）

Type A (only one answer is correct)

1. Which of the following statements is correct?

A.weak bases are absorbed efficiently across the epithelial cells of the

stomach

B.coadministration of atropine speeds the absorption of a second drug

C.drugs showing large V d can be efficiently removed by dialysis of the

plasma.

D.stressful emotions can lead to a slowing of drug absorption.

E.if the V d for a drug is small, most of the drug is in the extraplasmic space.

2. The drugs that can pass across the blood brain barrier are

A. small in molecular weight and ionized drugs

B. small in molecular weight and nonionized drugs

C. large in molecular weight and ionized drugs

D. large in molecular weight and nonionized drugs

E. all of above are not true

3. Which of the following statements is correct?

A.if 10mg of drug A produces the same response as 100mg of drug B, drug A

is more efficacious than drug B.

B.the greater the efficacy, the greater the potency of a drug

C.in selecting a drug, potency is usually more important than efficacy

D.a competitive antagonist increases ED50

E.variation in response to a drug among different individuals is most

likely to occur with a drug showing a large therapeutic index

4. Which of the following is true for a drug whose elimination from plasma shows

first-order kinetics?

A.the half-life of the drug is proportional to the drug concentration in

plasma

B.the amount eliminated per unit time is constant

C.the rate of elimination is proportional to the plasma concentration

D.elimination involves a rate-limiting enzyme reaction operating at its

maximal velocity

E. a plot of drug concentration versus time is a straight line

5. Which of the following drugs has the largest therapeutic index ?

A. Drug A LD50=150mg, ED50=100mg

B. Drug B LD50=100mg, ED50=50mg

C. Drug C LD50=250mg, ED50=100mg

D. Drug D LD50=300mg, ED50=50mg

E. Drug E LD50=300mg, ED50=150mg

6. A drug eliminated with first-order kinetics, the concentration of the drug in

plasma is 100mg/L at 9 am after administration of a single dose, and at 6 pm the drug plasma concentration is 12.5 mg/L. So, its t1/2 is

A. 4h

B. 5h

C. 6h

D. 3h

E. 12h

7. The maximal effect of a drug is called

A. potency

B. efficacy

C. affinity

D. toxic effect

E. margin of safety

8. Among the following drugs, which will be excreted most quickly in acidic

urine？

A. a weak acid drug with pKa of 5.5

B. a weak base drug with pKa of 7.5

C .a weak base drug with pKa of 4.5

D. a weak acid drug with pKa of 3.5

E. a weak base drug with pKa of 6.5

9. The mechanism of treating phenobarbital poisoning with bicarbonate sodium is that it

A. neutralizes Phenobarbital

B. stimulates Phenobarbital transference from the brain to the plasma