实验论文范文

沈阳药科大学毕业设计（论文）

苦参碱缓释微球的制备

学生姓名

指导教师

专业

学院

2011年0 月日

Graduation Project (Thesis)

Shenyang Pharmaceutical University

Preparation of Matrine Sustained-Release

Microspheres

Student

Supervisor

Specialty

School

2009-06- 01

毕业设计（论文）任务书

毕业设计（论文）审阅评语

毕业设计（论文）审阅评语

毕业设计（论文）答辩评语

摘要

利用海藻酸钠溶液与氯化钙溶液发生沉淀反应，采用滴制法制备海藻酸钠微球，可以提高药物的生物利用度,增强药物的稳定性及临床疗效,达到缓释作用和靶向作用,从而控释药物,实现靶向和定位给药,减少给药次数,减轻或消除毒副作用。以微球的基本药剂学性质（形态、粒径及其分布；药物的含量；药物的载药量与包封率；药物的释放速率）为指标，筛选出符合微球质量要求的最佳处方。采用紫外分光光度法建立了缓释微球中苦参碱含量测定的方法，方法操作简便，重复性好。同时建立了苦参碱缓释微球溶出度测定的方法。

关键词：苦参碱；海藻酸钠；微球；缓释制剂

Abstract

Ca-alginate gel microspheres were prepared by dropping Na-alginate solution into CaCl2 solution.It can enhance the bioavailability. The medicine's stability and the clinical effect were enhanced.It achieved the slow release function and the function of controlling the release of the medicine,which can realize the target to give the medicine with the localization, reduce the medicine of number of times, reduce or eliminate the poisonous side effect. The basic prescription and preparation was designed by the study about formulation screening and optimization, based on the pharmacy rule ( appearance, size and disposition, content, envelop rate of drug and drug release-rate )as indicator and the stability maintaining of Matrine Ultraviolet spectrophotometry was used in quality criteria research of Matrine which has simple method of operation and good reproducibility as well as the method to determine the dissolution of Matrine.

KEY WORDS :Matrine ；sodium polymannuronate；microspheres；sustained-release preparation

目录

摘要 ................................................................................................................................ I Abstract................................................................................................................................. II 1绪论.. (1)

1.1缓释制剂的研究与应用 (1)

1.2缓释制剂研究进展 (2)

1.2.1口服缓控释给药系统 (2)

1.3微球制剂进展 (6)

1.3.1制备方法多样 (6)

1.3.2局麻药实现长效缓释 (7)

1.3.3眼用微球制剂受肯定 (7)

1.3.4微球制剂抗癌研究进展迅速 (8)

1.4海藻酸钠概述 (8)

1.4.1海藻酸盐来源 (8)

1.4.2海藻酸钠的化学性质 (9)

1.4.3性状 (9)

1.4.4黏性 (9)

1.4.5溶解性 (10)

1.4.6稳定性 (10)

1.4.7缓释作用 (10)

1.5苦参碱概述 (10)

1.5.1来源 (10)

1.5.2理化性质 (11)

1.5.3药理作用 (11)

1.5.4临床应用 (11)

1.5.5展望 (11)

1.6本课题的来源及研究的目的意义 (12)

1.6.1本课题来源 (12)

1.6.2研究的目的意义 (12)

2实验部分 (13)

2.1药品与仪器 (13)

2.1.1实验药品 (13)

2.1.2实验仪器 (13)

2.1.3其他 (13)

2.2苦参碱缓释微球的制备 (13)

2.2.1苦参碱缓释微球的制备工艺过程 (14)

2.2.2讨论 (14)

2.3苦参碱缓释微球质量评价 (15)

2.3.1含量测定标准曲线的建立 (15)