青年乳腺癌与绝经后乳腺癌的病理特点对比

·基础医学·

中国当代医药2019年2月第26卷第6期

CHINA MODERN MEDICINE Vol.26No.6February 2019

乳腺癌是一种女性常见的恶性肿瘤,多发于绝经前中年女性[1]。近年来,随着生活习惯的改变、工作压力的增大等因素,乳腺癌的发病率逐年增高、发病年龄不断年轻化[2-3]。针对青年乳腺癌和绝经后乳腺癌的研究很少,现认为青年乳腺癌和绝经后乳腺癌具有较

为独特的生物学行为,比如青年乳腺癌表现出更高的侵袭性和复发率、较差的预后,相应地其治疗策略和预后也会有所不同[4]。总体而言,这两个年龄段患者的乳腺癌分型和病理特点尚不明确,有待研究。这种现状不利于制订有效的治疗方案和判断预后。本研究的目的是分析和比较青年乳腺癌和绝经后乳腺癌的病

理特点,现报道如下。1资料与方法1.1一般资料

选取2015年1月~2018年1月于我院收治的30例

青年乳腺癌患者(A 组)和30例绝经后乳腺癌患者

(B 组)。青年定义为≤35周岁,A 组中,年龄为25~35岁,平均(32.96±2.75)岁。B 组中,年龄为45~76岁,平均(62.96±4.87)岁。所有患者经活检诊断确认为乳腺癌,所有患者均接受术前化疗或放疗。本研究纳入对象均签署知情同意书,且本研究已经医院医学伦理委员会批准。

青年乳腺癌与绝经后乳腺癌的病理特点对比

何卫华

江西省上饶市立医院病理科,江西上饶

334000

[摘要]目的分析和比较青年乳腺癌和绝经后乳腺癌的病理特点。方法选取2015年1月~2018年1月我院收治的30例青年乳腺癌患者(A 组)和30例绝经后乳腺癌患者(B 组),观察并记录两组的肿瘤相关因子检测结果、乳腺癌分子分型、乳腺癌组织学分级和临床分期结果。结果A 组的孕激素受体(PR)及雌激素受体(ER)阳性率低于

B 组(P <0.05);A 组的人表皮生长因子受体(HER-2)阳性率及肿瘤细胞增殖相关核抗原(Ki-67)高表达率高于

B 组(P <0.05);A 组的Luminal A 型比例低于B 组,三阴型比例高于B 组(P <0.05);A 组的组织学Ⅰ级比例低于B 组(P <0.05),Ⅱ型比例低于B 组(P <0.05)。结论青年乳腺癌和绝经后乳腺癌的病理特点有较大不同,临床上制订治疗方案和判定疗效预后时要给予充分的重视。[关键词]青年;绝经后;乳腺癌;病理特点[中图分类号]R737.9

[文献标识码]A

[文章编号]1674-4721(2019)2(c)-0032-03

Comparison of pathological features between young breast cancer and postmenopausal breast cancer

HE Wei-hua

Department of Pathology,Shangrao Municipal Hospital,Jiangxi Province,Shangrao

334000,China

[Abstract]Objective To analyze and compare the pathological features of young breast cancer and postmenopausal breast cancer.Methods A total of 30cases of young breast cancer patients (group A)and 30cases of postmenopausal breast cancer patients (group B)admitted to our hospital from January 2015to January 2018were selected.The out⁃

comes of tumor-related factors,breast cancer molecular typing,breast cancer histological grade and clinical stage were observed and recorded in the two groups.Results The positive rates of progesterone receptor (PR)and estrogen receptor (ER)in group A were lower than those in group B (P <0.05).The positive rate of human epidermal growth factor recep⁃tor (HER-2)and high expression of related nuclear antigen in tumor cell proliferation (Ki-67)in group A were higher than those of group B (P <0.05).The proportion of Luminal A type in group A was lower than that in group B,and the

proportion of triple negative type in group A was higher than that in group B (P <0.05).In group A,the proportion of histological grade Ⅰwas lower than that of group B (P <0.05),the proportion of type Ⅱin group A was lower than that in group B (P <0.05).Conclusion The pathological characteristics of young breast cancer and postmenopausal breast

cancer are quite different.It is necessary to give full attention to the clinical development of treatment plan and the e⁃valuation of effect and prognosis.

[Key words]Young;Postmenopausal;Breast cancer;Pathological features

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