循证医学证据等级
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Oxford Centre for Evidence-based Medicine Levels of Evidence (May 2001)
Produced by Bob Phillips, Chris Ball, Dave Sackett, Doug Badenoch, Sharon Straus, Brian Haynes, Martin Dawes since November 1998.
Notes
Users can add a minus-sign "-" to denote the level of that fails to provide a conclusive answer because of:
∙EITHER a single result with a wide Confidence Interval (such that, for example, an ARR in an RCT is not statistically significant but whose confidence intervals fail to exclude clinically important benefit or harm)
∙OR a Systematic Review with troublesome (and statistically significant) heterogeneity.
∙Such evidence is inconclusive, and therefore can only generate Grade D recommendations.
Grades of Recommendation
"Extrapolations" are where data is used in a situation which has potentially clinically important differences than the original study situation.