蜂胶(翻译

天然产物巴西蜂胶加强吞噬细胞杀真菌的活性

Abstract

Natural product incorporation into microcarriers increases the bioavailability of these compounds, consequently improving their therapeutic properties. Natural products, particularly those from bees such as propolis, are widely used in popular medicine. Propolis is a powerful treatment for several diseases. In this context, the present study evaluated the effect of propolis Scaptotrigona sp. and its fractions, alone or adsorbed to polyethylene glycol (PEG) microspheres, on the activity of human phagocytes against Candida albicans.The results show that propolis exerts a stimulatory effect on these cells to assist in combating the fungus, especially as the crude extract is compared with the fractions. However, when incorporated into microspheres, these properties were significantly potentiated. These results suggest that propolis adsorbed onto PEG microspheres has immunostimulatory effects on phagocytes in human blood. Therefore, propolis may potentially be an additional natural product that can be used for a variety of therapies.

天然产物包埋在载体中能够增加这些化合物的生物药效，因此能够提高它们的治疗功效。天然产物，特别是些来自蜜蜂的，例如蜂胶，正被广泛的应用到流行药中。对于一些疾病，蜂胶具有非常好的治疗功效。鉴于此，现在研究评估Scaptotrigona sp.的蜂胶及其馏分在单独的或吸附到聚乙二醇微粒上时，对人类吞噬细胞作用白色念珠菌的效果。结果表明蜂胶对这些细胞对抗真菌具有辅助的促进作用，值得注意的是粗提物的效果要比馏分的促进效果更好。但是包埋到PEG微粒中的蜂胶的这些功效要更强。这些结果表明：吸附到PEG微粒上的蜂胶在人类血液中对吞噬细胞具有免疫调节功效。因此，蜂胶有可能作为一种天然产物添加，用在各种各样的治疗中。

前言

Th e current focus on natural products and alternative medicines has renewed interest in bee products such as honey, royal jelly, pollen, and propolis. Propolis is a sticky dark-coloured material collected by worker bees from the leaf buds or exuded from numerous tree species. Once collected, this material is enriched with salivary and enzy-matic secretions and used in the construction, adaptation, and protection of their nests [3,4]. In this way propolis chemical composition is a direct reflex of the vegetable flora and bee species [5,6].

目前关于天然产物和可替代性药品的研究又重新集中于像蜂蜜、蜂王浆、花粉、蜂胶等蜜蜂产品上，蜂王浆是一种黑色粘稠的物质，是由雄蜂采集自叶芽或许多树种的渗出液。一旦采集完，这种物质又富加以唾液和酶促分泌物，然后用来筑造、改建、和保护它们的蜂巢。这样一来，蜂胶的化学成分就能直接反映出蔬菜的种类和蜜蜂的种类。

In Brazil, besides wide variety of flora there are also several bees species, among which stand out those belonging to Apidae family and Meliponinae subfamily, better known as indigenous stingless bees, and which produce propolis from the resinous material of plants with wax and soil. In this group are found bees of the Scaptotrigona genus with twenty four species described and eight of which already identified in Brazil [4, 7–9].

在巴西，除了广泛种类的植物群，还有一些密封种类，他们中有代表性的属于蜜蜂科和Meliponinae亚科，比较有名的土著无刺蜂它们产的蜂胶来自于含蜡植物的树脂和土壤。在这个群体中，Scaptotrigona属的24个种的蜜蜂都有所描述，其中有8个种都已经在巴西发现了。