二苯基氯化碘盐DPI

Diphenyleneiodonium chloride Product Number D2926
Store at Room Temperature
Product Description
Molecular Formula: C12H8ICl
Molecular Weight: 314.6
CAS Number: 4673-26-1
Synonyms: DPI, dibenziodolium chloride1
This product is an inhibitor of nitric oxide synthase. It irreversibly inhibits endothelium-dependent vasodilations in a similar manner to the N G-substituted arginine analogs, but this pressor effect is attenuated or abolished by blockers of the sympathetic nervous system and does not lead to a sustained rise in blood pressure.2 This product also inhibits neutrophil NADPH oxidase.3 The K i for time-dependent inhibition of NADPH oxidase by DPI is 5.6 µM.3 These effects of DPI on NADPH oxidase (in the absence of enzyme turnover) was based on preincubating whole neutrophils in DPI at a concentration range of
1- 25 µM.
Precautions and Disclaimer
For Laboratory Use Only. Not for drug, household or other uses. Preparation Instructions
The product maximum solubility is in DMSO (10
mg/ml) with strong heating and is also easily soluble in DMSO (2.4 mg/ml), 0.1N NaOH (0.5 mg/ml), 0.1N HCl (0.2 mg/ml), ethanol (0.2 mg/ml) or water (0.2 mg/ml. Literature also indicates stock solutions can be prepared at 10 mM in DMSO3 or at 3 x 10-8 to
3 x 10-6 M in a 5% glucose solution.2
References
1. Dictionary of Organic Compounds, 5th ed.,
Buckingham, J., ed., Chapman and Hall (New
York, NY: 1982) p. 1593.
2. Wang, Y. X., et al., Inhibitory Actions of
Diphenyleneiodonium on Endothelium-dependent Vasodilatations In Vitro and In Vivo. Br. J.
Pharmacol., 110(3), 1232-1238 (1993).
3. O'Donnell, V. B., et al., Studies on the Inhibitory
Mechanism of Iodonium Compounds with Special Reference to Neutrophil NADPH Oxidase.
Biochem. J., 290(pt 1), 41-49 (1993).
CMH/RXR 6/08
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