英文文献汇报技巧

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1、研究背景及目的
· Backgroud: ① Damage to the hypothalamus-pituitary-thyroid axis may result in hypothyroidism, with overt symptoms including weight gain, dry skin, hair loss, cold intolerance, general weakness,mu-scle cramps, depression, irritability, and memory loss. ② As an organ situated in the anterior neck, the thyroid gland is often entirely or partially included in the high-dose region. Many related studies on lymphoma and head and neck cancers (HNC) have reported that high-dose radiation to the thyroid can induce primary hypothyroidism. ③ Radiation injury to the hypothalamic–pituitary (H–P) axis can result in dysfunction of the H–P axis followed by central hypothyroidism in NPC patients after RT.
可能原因：城市化程度越高，居民越容 易得到医疗资源
随着年龄的增加， 风险性降低
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4、讨论
① In this study, The risk was significantly higher among NPC patients after RT than among the matched cohort (adjusted HR = 14.35) and HNC patients who received RT without thyroidectomy (adjusted HR = 2.06). ② In the multivariable Cox model with competing risks, younger age,female sex, higher urbanization level, autoimmune disease, and receiving chemotherapy were risk factors for hypothyroidism a mong NPC patients after RT, but receiving radical excision of cervical lymph nodes was not.
④use of clinical hypothyroidism diagnoses defined according to
ICD-9-CM codes.
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Limitation(局限性):
① the NHIRD does not contain detailed information on potential confounding factors,such as family history of hypothyroidism, diet, smoking, alcohol consumption and NPC stage. ② the NHIRD provided no information on RT dose level, energy level, technique, distribution and treated volumes of RT to the thyroid, pituitary gland, and hippocampus. ③ Not collecting sufficient numbers of other NHC patients to be propensity score matched with the NPC patients according to sex and age.
（作者提出：鼻咽癌放疗与中枢性甲减的关系需进一步研究）
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Strengths(优势):
① include its large sample size； ② long-term follow-up period (12 years)； ③ adequate controls for comorbidities；
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1 研究背景及目的 2 研究方法 3 研究结果 4 讨论
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1、研究背景及目的
· Purpose: This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT).
Journal:Radiarion and ncology IF：4.36(医学二区) Publication: May 2017
Risk of hypothyroidism among patients with nasopharyngeal
carcinoma treated with radiation therapy: A Population-Based Cohort Study
subsequent risk of hypothyroidism until recently.
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2、研究方法
① Data source:the National Health Insurance Research Database (NHIRD) .The NHIRD includes the Registry of Catastrophic Illness Patient Database. ② the baseline comorbidity history for each participant: hypertension, diabetes, chronic obstructive pulmonary disease, alcohol-related illness, and autoimmune disease. Cancer treatments：including chemotherapy and radical excision of cervical lymph nodes among NPC and HNC cohorts, were also noted.
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· Backgroud: ④ Radiation-indwenku.baidu.comced hypothyroidism after RT for NPC has been reported in previous studies. However, there has been no nationwide epidemiological study of NPC patients after RT and the
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2、研究方法 • Inclusion and exclusion criteria:
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3、研究结果
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There were 213 patients (1.43%) that developed H–P dysfunction in the NPC cohort, significantly higher than the 56 patients (0.35%) in the HNC cohort (p < 0.0001). 10
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谢谢！ 请老师同学指正批评
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③ Radiation damage is a potent cause of H–P dysfunction and is highly dose-dependent [18]. Neuronal cell death and degeneration due to the direct effects of radiation appear to play a major role [19]. ④ Our results showed NPC patients after RT had significantly higher inci-dences of hypothyroidism as well as H–P dysfunction compared to HNC patients without thyroidectomy after RT. This can be partially explained by the effect of an H–P axis injury causing central hypothyroidism, bec-ause the H–P axis lies within the field of RT for NPC.