临床表现 中山大学精品课程.ppt
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Anti-HBs a protective antibody to HBsAg an indicaHale Waihona Puke Baiduor of past infection and immunity to HBV reinfection suggesting non-infectious
• HBeAg suggesting HBV replication and high infectivity negative when pre-C mutation but with high level of replication useful for evaluation of anti-HBV therapy
• Hepatitis A and E
Transmitted by fecal-oral route, present acute and self-limited course
• Hepatitis B ,C and D
Spread parenterally easily lead to chronic hepatitis
Viral Hepatitis
Dept. of Infectious Diseases SunYat-sen University
Q.F.XIE
Introduction
• Viral hepatitis are a group of diseases,
Caused by A、B、C、D and E 5 hepatitis virus
Anti HAV IgG current or previous infection a protective antibody, conferring immunity persist for life long time
Etiology-HBV
• Orthohepadnavirus, Dane particle • 4 open reading frame: S,C,P,X • 8 genotypes A-H, B and C
Hepatitis B Virus
Etiology-HCV
• RNA virus, 6genotypes, mainly 1b in the country
• Molecular heterogeneity driven by high mutation rate usually proceed to chronic course
Anti-HBe antibody to HBeAg
HBe seroconversion HBeAg(+) →(-)and anti-HBe(-) →(+)
• HBcAg existing in the core of virion a marker of replication and infectivity
Anti-HBc IgM a marker of acute primary HBV infection
Anti-HBc IgG appeared in almost all HBV present and past infection host body
• HBVDNA the genome of HBV suggesting active virus replication and infectivity useful for diagnosis and evaluation of anti-HBV therapy
Significance
Highly endemic Wide clinical spectrum High fatality rate in severe cases No specific pathogenic therapy available now Chronic hepatitis B and C very common,
predominantly in China • Strong ability against to environment • 3 antigen and antibody system
• HBsAg found in serum and other body fluid not infectious itself suggesting current infection and infectivity
• Anti-HCV IgM and IgG types antibody to HCV suggesting HCV infection
• HCVRNA the genome of HCV suggesting replication and infectivity of HCV useful for the diagnosis and evaluation of antivirus treatment
some may develop to cirrhosis even HCC Successful vaccination for HBV and HAV
Etiology-HAV
Heparnavirus Appeared in bile and feces, spreaded via feces No chronic carrier status observed
• Clinical characters including fatigue, intestinal symptoms tender and enlarged liver abnormal LFTs jaundice in some cases very variable in severity
Anti-HAV antibody to HAV Anti-HAV IgM
indicative of current or recent infection appeared very early, disappear in about 3months most useful for confirm the diagnosis
• HBeAg suggesting HBV replication and high infectivity negative when pre-C mutation but with high level of replication useful for evaluation of anti-HBV therapy
• Hepatitis A and E
Transmitted by fecal-oral route, present acute and self-limited course
• Hepatitis B ,C and D
Spread parenterally easily lead to chronic hepatitis
Viral Hepatitis
Dept. of Infectious Diseases SunYat-sen University
Q.F.XIE
Introduction
• Viral hepatitis are a group of diseases,
Caused by A、B、C、D and E 5 hepatitis virus
Anti HAV IgG current or previous infection a protective antibody, conferring immunity persist for life long time
Etiology-HBV
• Orthohepadnavirus, Dane particle • 4 open reading frame: S,C,P,X • 8 genotypes A-H, B and C
Hepatitis B Virus
Etiology-HCV
• RNA virus, 6genotypes, mainly 1b in the country
• Molecular heterogeneity driven by high mutation rate usually proceed to chronic course
Anti-HBe antibody to HBeAg
HBe seroconversion HBeAg(+) →(-)and anti-HBe(-) →(+)
• HBcAg existing in the core of virion a marker of replication and infectivity
Anti-HBc IgM a marker of acute primary HBV infection
Anti-HBc IgG appeared in almost all HBV present and past infection host body
• HBVDNA the genome of HBV suggesting active virus replication and infectivity useful for diagnosis and evaluation of anti-HBV therapy
Significance
Highly endemic Wide clinical spectrum High fatality rate in severe cases No specific pathogenic therapy available now Chronic hepatitis B and C very common,
predominantly in China • Strong ability against to environment • 3 antigen and antibody system
• HBsAg found in serum and other body fluid not infectious itself suggesting current infection and infectivity
• Anti-HCV IgM and IgG types antibody to HCV suggesting HCV infection
• HCVRNA the genome of HCV suggesting replication and infectivity of HCV useful for the diagnosis and evaluation of antivirus treatment
some may develop to cirrhosis even HCC Successful vaccination for HBV and HAV
Etiology-HAV
Heparnavirus Appeared in bile and feces, spreaded via feces No chronic carrier status observed
• Clinical characters including fatigue, intestinal symptoms tender and enlarged liver abnormal LFTs jaundice in some cases very variable in severity
Anti-HAV antibody to HAV Anti-HAV IgM
indicative of current or recent infection appeared very early, disappear in about 3months most useful for confirm the diagnosis