微针技术

Microneedle geometry
不给但渗分同药尖透析横针达型能：截形峰微矛力药面微时针形按物积针间最依三透的（没大次角皮大平有峰增形吸小型显浓强、收有和著度。梯跟关尖差最形微。型异高、针），。
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2019/10/28
Different approaches of drug delivery by hollow and solid microneedles
other methods
Approved microneedle products
• The first product was the Dermaroller®, which is a cylindrical roller covered on its surface with solid, metal microneedles that measure 0.2–2.5 mm in length. (http://dermaroller.com/)
• Soluvia® is a single hollow microneedle that is 1.5 mm long and is attached to a syringe.(http://www.bd.com/pharmaceuticals/products/ microinjection.asp)
经皮吸收过程
1
皮肤附属器通道
2
穿透角质层细胞到达活性表皮
3
通过角质层细胞间隙到达活性表皮
为什么发展微针技术
• 皮肤（特别是角质层）严重阻碍药物的透皮 吸收，即使在各种促渗剂的作用下，也仅能 使部分小分子药物穿过皮肤达到有效的药物 浓度，大多数药物，尤其是蛋白类大分子药 物，即便是一些剂量低、疗效高的药物，透 皮渗透速度也难以满足治疗的需要。
Applications of microneedles
• Delivery to the skin • Biotherapeutics • Vaccines • Blood and interstitialfluid
extraction • Combination of microneedles and
• MicroHyala® was developed as a patch coveredwith dissolving microneedles containing hyaluronic acid that is released in the skin to treat wrinkles. (http://www.cosmed-pharm.co.jp/)
现代促渗技术
离子导入
微针
经皮给药
超声导入
电穿孔
微针介绍
• 利用微针阵列改进皮肤的通透性，通过创造
• 优微点米：尺寸的通道（比分子尺寸大一个数量
级），使大分子可以透过皮肤。
• 避免了口服给药可能发生的肝脏首过效应及 肠胃灭活，提高了治疗效果。
• 避免因静脉注射而引起的痛楚和感染。 • 通过改变给药面积调节给药剂量，减少个体
差异。 • 且患者可以自主用药，也可以随时停止用药
微针促渗的原理
Abstract
Representation of the skin microanatomy
Microneedles made of different materials
Schematic representation of the manufacturing of in-plane (right) and out-ofplain (below) microneedles from silicon wafers (upper left)
Hollow microneedles made of silicon and polymers
advantages and disadvantages of each of these approaches
Examples of microneedle-based (trans)dermal delivery of model drugs into the skin
• Finally, MicronJet® recently received FDA clearance. (http://www. nanopass.com/content-c.asp?cid=22)
传未相统来关的的链疫疫接苗苗注注射射是是这这样个的样！子的！
• 微针疫苗
http://news.cntv.cn/china/20121214/100438.shtml
微针技术
LOGO
Contents
1
基础知识
2
文献解读
3
研究现状
4
相关链接
微针技术在经皮给药的应用（2012）
经皮给药系统----微针技术
• 经皮给药系统(transdermal drug delivery systems，简称 TDDS)是指经皮肤敷贴方式用药，
药物经由皮肤吸收进入全身血液循环并达到有效血 药浓度、实现疾病治疗或预防的一类制剂。
• 微针美容
SUCCESS
THANK YOU
2019/10/28
Biblioteka Baidu
Drug delivery methods via the skin by microneedles
Coated microneedles made of metal and polymer
Dissolving microneedles made of water-soluble polymers and biodegradable polymers