口腔白斑癌变率与癌变时间及其影响因素的回顾

病例，统计口腔白斑癌变率和癌变时间的基线资料，同时评价影响口腔白斑癌变的相关因素。 方法：使用 SAS6.12 软
件包对合适的病例资料进行生 存 分 析 （寿 命 表 法 和 乘 积 极 限 法 ）和 Cox 回 归 ，分 析 和 描 述 口 腔 白 斑 的 癌 变 率 和 影 响
因素。 结果： 576 例口腔白斑中，男 350 例，女 226 例， 66 例癌变，男女各 33 例，总癌变率为 11.46%。 适合生存分析
和 Cox 回归的病例 共 267 例 ，根 据 病 程 计 算 1 年 癌 变 率 （寿 命 表 法 、乘 积 极 限 法 ）为(0.40±0.40)%、(0.86±0.61)%，2 年
癌变率上升至(2.84±1.15)%、(2.93±1.18)%，5 年癌变率达(11.28±2.70)%、(11.31±2.71)%。在多因素分析得出的 Cox 回归
模型中，部位和年龄是影响口腔白斑癌变的主要因素。 结论：口腔白斑的癌变率与随Βιβλιοθήκη Baidu时间有关，影响癌变的主要因
素是发病部位和年龄。
[关键词] 口腔白斑；癌变率；癌变时间；影响因素；生存分析；Cox 回归分析
[中图分类号] R781.5
[文献标志码] A
A retrospective analysis on the malignant transformation rate, time and risk factors of oral leukoplakia WANG Yu -feng1, SHANG Shu2, ZHOU Zeng -tong1, TANG Guo -yao1. (1.Department of Oral Mucosa Disease, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011; 2.Department of Oral Medicine, Shanghai Stomatological Disease Center. Shanghai 200031, China) [Abstract] PURPOSE: A retrospective analysis was made on the oral leukoplakia(OLK) patients archived from 1978 to 2009 at the Department of Oral Medicine, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University, to analyze the malignant transformation of oral leukoplakia and its influential factors. METHODS: The data was studied with the SAS6.12 software package, using the methods of survival analysis and Cox regression to acquire malignant transformation rate(MTR) and malignant transformation time(MTT). RESULTS: According to the archived files, there were 576 cases of OLK with 350 males and 226 females. Among them, 66 cases (33 males and 33 females) developed OSCC, the total MTR was 11.46%. Two hundred and sixty-seven cases were suitable for survival analysis and Cox regression. The 1-year MTR was (0.40±0.40)%, (0.86±0.61)% (life-table method/product-limit method); the 2-year MTR went up to (2.84±1.15)%, (2.93±1.18)% and the 5-year MTR was as high as (11.28±2.70)%, (11.31±2.71)%. In Cox regression model, location of lesion and age were the main factors that affected OLK’s transformation to OSCC. CONCLUSIONS: The MTR of OLK is related to the follow -up time; The lesion site and age are the most important risk factors. Supported by Research Fund of Science and Technology Commission of Shanghai Municipality (08DZ2271100), Shanghai Leading
上海口腔医学 2011 年 2 月 第 20 卷 第 1 期 Shanghai Journal of Stomatology Vol．20 No．1 February,2011
·55·
［文章编号］1006-7248(2011)01-0055-07
·临床研究·
Clinical Study
口腔白斑癌变率与癌变时间及其影响因素的回顾分析
王宇峰 1，尚书 2，周曾同 1，唐国瑶 1 （1.上海交通大学医学院附属第九人民医院·口腔医学院 口腔黏膜科，
上海市口腔医学重点实验室，上海 200011； 2.上海市口腔病防治院 口腔内科，上海 200031）
[摘要]目的：回顾 1978 年—2009 年就诊于上海交通大学医学院附属第九人民医院口腔黏 膜 病 专 科 门 诊 的 口 腔 白 斑