碳纳米管在生物传感器中的应用
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HRTEM images of Fc@SWNTs (A) and Fc@SWNTs gel
Peptide nanotube-modified electrodes for enzyme-biosensor applications
The conductive properties of CNT– mediate electron transfer reactions with electroactive species in solution
Time dependence of source-drain current of the CNTFET
Anal. Chem. 2007, 79, 782-787
Future outlook
Improved methods for the synthesis of site- specific and
Although acid treated CNTs are watersoluble, the carbonyl (C=O), carboxyl (– COOH), and/or hydroxyl (–OH) groups on their surfaces might lead to higher toxicity.
Platinum nanoparticles with a diameter of 2-3 nm were prepared and used in combination with single-wall carbon nanotubes (SWCNTs) for fabricating electrochemical sensors with remarkably improved sensitivity toward hydrogen peroxide.
structurally-defined biomaterial-CNT hybrid
The ordered and controlled assembly of addressable
biomaterial-CNT systems on surfaces
The development of microscopic imaging techniques to
Applications
Bioelectrochemically functional nanohybrids through co-assembling of proteins and surfactants onto carbon nanotubes: facilitated electron transfer of assembled
Enzyme-functionalized CNTs as the biocatalytic amplifying tags with biorecognition units
An oligonucleotide for the electrochemical DNA sensing using the alkaline phosphatase-functionalized CNTs.
J. Am. Chem. Soc. 2004, 126, 3010-3011
Bioelectronic systems– field-effect-transistors
Schematic structure of the experimental setup for the detection of IgE using an aptamermodified CNT-FET device.
Applications of carbon nanotubes in biosensors
Outline
➢ Preface ➢ Functionalization of CNTs ➢ Novel applications ➢ Future outlook
Preface
CNT is a tubular form of carbon with diameter as small as 1 nm. Length: few nm to microns.
Enzyme sensing assembly of the SWCNT electrically-contacted glucose oxidase electrode.
molecule wire
Baidu Nhomakorabea
F. Patolsky, Y. Weizmann, I. Willner, Angew. Chem. 2004, 116, 2165 ± 2169; Angew. Chem. Int. Ed. 2004, 43, 2113± 2117.
characterize hybrid system
The structures and functions of the nanoscale devices.
proteins with enhanced faradic response
Biopolymer and Carbon Nanotubes Interface Prepared by
Self-Assembly Microperoxidase-11
Ferrocene Peapod Modified Electrodes
CNTs is insoluble in water, so functionalization of CNTs is necessary.
Functionalization of CNTs
✓ Assemble with small molecules
✓CNTs and polymer
✓ Mental nanoparticles and CNTs
✓ Fill CNTs with nanoparticles
Assemble CNTs with small molecules
Assemble CNTs with small molecules and proteins
Chitosan-grafted multi-walled carbon nanotubes
Selective attachment of gold nanoparticles to nitrogen-doped carbon nanotubes
Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes
Special structural features and properties of CNTs
The recognition or catalytic properties of the biomaterials Proteins/enzymes, antigens/antibodies, or DNA , et al.
Peptide nanotube-modified electrodes for enzyme-biosensor applications
The conductive properties of CNT– mediate electron transfer reactions with electroactive species in solution
Time dependence of source-drain current of the CNTFET
Anal. Chem. 2007, 79, 782-787
Future outlook
Improved methods for the synthesis of site- specific and
Although acid treated CNTs are watersoluble, the carbonyl (C=O), carboxyl (– COOH), and/or hydroxyl (–OH) groups on their surfaces might lead to higher toxicity.
Platinum nanoparticles with a diameter of 2-3 nm were prepared and used in combination with single-wall carbon nanotubes (SWCNTs) for fabricating electrochemical sensors with remarkably improved sensitivity toward hydrogen peroxide.
structurally-defined biomaterial-CNT hybrid
The ordered and controlled assembly of addressable
biomaterial-CNT systems on surfaces
The development of microscopic imaging techniques to
Applications
Bioelectrochemically functional nanohybrids through co-assembling of proteins and surfactants onto carbon nanotubes: facilitated electron transfer of assembled
Enzyme-functionalized CNTs as the biocatalytic amplifying tags with biorecognition units
An oligonucleotide for the electrochemical DNA sensing using the alkaline phosphatase-functionalized CNTs.
J. Am. Chem. Soc. 2004, 126, 3010-3011
Bioelectronic systems– field-effect-transistors
Schematic structure of the experimental setup for the detection of IgE using an aptamermodified CNT-FET device.
Applications of carbon nanotubes in biosensors
Outline
➢ Preface ➢ Functionalization of CNTs ➢ Novel applications ➢ Future outlook
Preface
CNT is a tubular form of carbon with diameter as small as 1 nm. Length: few nm to microns.
Enzyme sensing assembly of the SWCNT electrically-contacted glucose oxidase electrode.
molecule wire
Baidu Nhomakorabea
F. Patolsky, Y. Weizmann, I. Willner, Angew. Chem. 2004, 116, 2165 ± 2169; Angew. Chem. Int. Ed. 2004, 43, 2113± 2117.
characterize hybrid system
The structures and functions of the nanoscale devices.
proteins with enhanced faradic response
Biopolymer and Carbon Nanotubes Interface Prepared by
Self-Assembly Microperoxidase-11
Ferrocene Peapod Modified Electrodes
CNTs is insoluble in water, so functionalization of CNTs is necessary.
Functionalization of CNTs
✓ Assemble with small molecules
✓CNTs and polymer
✓ Mental nanoparticles and CNTs
✓ Fill CNTs with nanoparticles
Assemble CNTs with small molecules
Assemble CNTs with small molecules and proteins
Chitosan-grafted multi-walled carbon nanotubes
Selective attachment of gold nanoparticles to nitrogen-doped carbon nanotubes
Electrochemical biosensing platforms using platinum nanoparticles and carbon nanotubes
Special structural features and properties of CNTs
The recognition or catalytic properties of the biomaterials Proteins/enzymes, antigens/antibodies, or DNA , et al.