Non-Voigt Lyman-alpha absorption line profiles

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迎浪船舶参数横摇的理论研究

迎浪船舶参数横摇的理论研究
基于以上考虑,本文的研究旨在提出可以正确描述船舶此类非线性运动的数值 模型,并在正确模拟船舶参数横摇的行为的基础上,理解参数横摇的形成机理,分 析参数横摇的发生过程,研究参数横摇的作用因素,最终编制可应用于参数横摇模 拟计算和分析的整套程序,为参数横摇问题在工程上的研究应用提供方便友好的平 台。
1.2 参数横摇研究进展
long-crest waves,wave group
VII
上海交通大学硕士学位论文
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本人郑重声明:所呈交的学位论文,是本人在导师的指导下,独立 进行研究工作所取得的成果。除文中已经注明引用的内容外,本论文不 包含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究 做出重要贡献的个人和集体,均已在文中以明确方式标明。本人完全意 识到本声明的法律结果由本人承担。
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上海交通大学硕士学位论文
时也导致了船舶在波浪上的稳性特征值的变化。其中,船舶横摇恢复力矩作为保证 船舶安全的最为重要的参数受此变化影响最为严重。传统理论对船舶各个运动模态 的数值估计和预报是在船舶线性运动理论框架下进行的,适应于微幅运动,对于船 舶发生大幅度运动时所呈现强烈的非线性运动无法适用。参数横摇的存在揭示了船 舶海上客货安全和航行效率上存在的危险隐患.其影响强度是船舶频域幅值理念下 安全预报的盲区,因此正确预报船舶参数横摇的发生范围和危险程度势在必行。 1.1.2 研究目的
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上海交通大学硕士学位论文

非糖基化重链 英文

非糖基化重链 英文

非糖基化重链英文Non-glycosylated heavy chainNon-glycosylated heavy chain refers to the heavy chainof a protein that does not have any sugar moleculesattached to it. Glycosylation is a common post-translational modification in which sugar molecules are added to proteins, and it plays important roles in protein folding, stability, and function. However, there arecertain proteins whose heavy chains are not glycosylated, and this can have implications for their structure and function.One example of a non-glycosylated heavy chain protein is immunoglobulin M (IgM), which is a type of antibody. IgM antibodies have a pentameric structure, with each monomeric subunit consisting of two heavy chains and two light chains. The heavy chains in IgM antibodies are not glycosylated, unlike those in other types of antibodies such as IgG. This lack of glycosylation affects the ability of IgM antibodies to interact with other components of the immune system, and it may also influence their stability and half-life in the body.In addition to antibodies, non-glycosylated heavy chains are also found in other proteins such as some cytokines and growth factors. These proteins often have specific functions that are influenced by the absence of glycosylation on their heavy chains. For example, the lack of glycosylation on the heavy chain of a cytokine mayaffect its binding to receptors and signaling activity, leading to different biological effects compared to glycosylated forms of the same cytokine.The study of non-glycosylated heavy chain proteins is important for understanding the diversity of protein structures and functions in the body. It also has implications for the development of therapeutic proteins, as the presence or absence of glycosylation can impact the pharmacokinetics and immunogenicity of protein drugs.非糖基化重链非糖基化重链指的是蛋白质中的重链没有任何糖分子与其结合。

一种NO供体型他汀衍生物、制备方法和应用[发明专利]

一种NO供体型他汀衍生物、制备方法和应用[发明专利]

专利名称:一种NO供体型他汀衍生物、制备方法和应用专利类型:发明专利
发明人:陈宇瑛,罗刚,艾林,王式跃
申请号:CN201710206968.3
申请日:20170331
公开号:CN106938979A
公开日:
20170711
专利内容由知识产权出版社提供
摘要:本发明提供了一种具有通式(Ⅰ)所示结构式的化合物,该化合物具有较好的NO释放活性,具有较好的应用前景,可用于抗炎、抗血栓形成、抗血小板活性、降低胆固醇和甘油三酯水平和/或提高高密度脂蛋白水平、治疗外周局部缺血、糖尿病人的血管并发症或者动脉粥样硬化等方面。

本发明还提供了制备所述化合物的方法。

申请人:中国医药集团总公司四川抗菌素工业研究所,浙江海森药业有限公司
地址:610000 四川省成都市东三环路二段龙潭工业园区华冠路168号
国籍:CN
代理机构:成都玖和知识产权代理事务所(普通合伙)
代理人:黎祖琴
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阿韦艾利酰胺、斯特伐希丁B和其类似物的合成[发明专利]

阿韦艾利酰胺、斯特伐希丁B和其类似物的合成[发明专利]

专利名称:阿韦艾利酰胺、斯特伐希丁B和其类似物的合成专利类型:发明专利
发明人:安德鲁·G·迈尔斯,塞思·B·赫尔佐恩,杰里米·厄尔·伍尔夫,罗曼·西格里斯特,雅各布·什文达,马修·艾伦·扎亚

申请号:CN200680015727.0
申请日:20060317
公开号:CN101189229A
公开日:
20080528
专利内容由知识产权出版社提供
摘要:本发明提供天然产物阿韦艾利酰胺(avrainvillamide)和斯特伐希丁B(stephacidin B)的合成。

阿韦艾利酰胺和其3-亚烷基-3H-吲哚1-氧化物核的α,β-不饱和硝酮官能团展示与含杂原子的亲核基团以共价且可逆方式键结。

这种能力可允许这些分子与活性位点亲核基团结合并且可提供设计有效和选择性酶抑制剂的基础。

据报导,阿韦艾利酰胺与其二聚体斯特伐希丁B二者都展现出抗增生活性,并且据报导,阿韦艾利酰胺还展现出对抗多重耐药菌的抗菌活性。

已发现,阿韦艾利酰胺靶向细胞骨架连接膜蛋白(CLIMP-63),从而防止细胞进行有丝分裂。

本发明提供这些天然产物以及这些天然产物的类似物和其功能性核的合成。

本发明的化合物可用于治疗诸如癌症、自体免疫疾病和细菌感染等疾病。

申请人:哈佛大学校长及研究员协会
地址:美国马萨诸塞州
国籍:US
代理机构:北京律盟知识产权代理有限责任公司
代理人:刘国伟
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亚甲胺叶立德参与的催化不对称环化反应

亚甲胺叶立德参与的催化不对称环化反应

亚甲胺叶立德参与的催化不对称环化反应亚甲胺叶立德作为一种非常有用的合成中间体,被广泛应用于药物中间体以及天然产物的合成。

十几年来,关于亚甲胺叶立德参与的催化不对称反应特别是催化不对称[3+2]环化反应得到了广泛和深入的研究。

近几年,我们课题组也开展了很多关于亚甲胺叶立德参与的催化不对称环化反应。

为了更好的利用亚甲胺叶立德以及类似于其结构的合成子合成更多种类的手性杂环化合物,我们依据亚甲胺叶立德的结构特点设计了几种不同类型的催化不对称环化反应。

主要包括以下几个方面的研究:1)通过亚甲胺叶立德对(Z)-β-苯基砜基丙烯酸甲酯的催化不对称1,3-偶极[3+2]环化反应,研究了亚甲胺叶立德对α,β位含有不同吸电子基团的烯烃的区域选择性以及对映选择性。

利用实验室自己开发的AgOAc/(R)-TF-Biphamphos络合物作为手性催化剂,得到高产率(73-98%)、高endo/exo(>98:2)选择性以及高对映选择性(95-99%ee)的酯基控制区域选择性的产物。

尤其对于a-位含有取代基的氨基酸酯衍生的亚胺酯,也能够得到高选择性的含有季碳手性中心的四氢吡咯衍生物。

通过实验结果以及化学计算,提出了可能的过渡态模型和反应机理。

2)首次实现了叶立德之间(亚甲胺叶立德和吡唑烷3-酮叶立德)的催化不对称1,3-偶极[3+3]交叉环化反应,其可以高效的合成含有1,2,4-三嗪骨架的手性杂环化合物。

利用CuBF4/(S,Sp)-tBu-Phosferrox络合物作为手性催化剂,可以得到高产率(67-94%)、高exolendo(>20:1)选择性以及高对映选择性(74-98%ee)的交叉环加成产物。

对于亚甲胺叶立德和吡唑烷3-酮叶立德,该催化体系都有着非常广的底物适应性。

3)首次实现了取代吲哚对现场生成的氮杂二烯的反电子需求的氮杂Diels-Alder反应,其可以构建含有哒嗪并[3,4-b]吲哚的手性杂环化合物。

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Early attempts to model the Lyα absorption lines considered pressure-confined clouds (Sargent et al. 1980, Ostriker & Ikeuchi 1983) inside a hot intergalactic medium (IGM). Other ideas used dark matter mini-halos to gravitationally confine the Lyα clouds (Rees 1986). In these models a Voigt profile naturally arises from a Maxwellian thermal distribution, or Gaussian turbulent motion of the gas. This lead to the fitting of Voigt profiles to the data; a method now generally used to analyse the complex blended features seen in the high resolution Keck spectra (e.g. Kirkman & Tytler 1997).
arXiv:astro-ph/9912091v1 6 Dec 1999
Non-Voigt Lyman-alpha absorption line profiles
P. J. Outram1 and R. F. Carswell Institute of Astronomy, Madingley Road, Cambridge CB3 0HA, U.K.
and
T. Theuns Max-Planck-Institut fu¨r Astrophysik, Karl-Schwarzschild-Str. 1, D-85740 Garching bei
Mu¨nchen, Germany
ABSTRACT
Recent numerical simulations have lead to a paradigm shift in our understanding of the intergalactic medium, and the loss of a physical justification for Voigt profile fitting of the Lyman-alpha forest. Many individual lines seen in simulated spectra have significant departures from the Voigt profile, yet could be well fitted by a blend of two or more such lines. We discuss the expected effect on the line profiles due to ongoing gravitational structure formation and Hubble expansion. We develop a method to detect departures from Voigt profiles of the absorption lines in a statistical way and apply this method to simulated Lyα forest spectra, confirming that the profiles seen do statistically differ from Voigt profiles.
This change in our understanding of the IGM has called into question the justification behind Voigt profile fitting. In recent years, dramatic improvements in the resolution and signal-to-noise ratio (S/N) of data has lead to complex blends of Voigt profiles in order to fit the absorption features. Problems due to the somewhat arbitrary number of components, and the non-uniqueness of the fitted solutions have become apparent. Now the simulations have shown that the physical interpretation of the solutions themselves are in doubt. Despite this there is little direct evidence that the Lyα forest line profiles are significantly different from Voigt profiles. Many absorption lines appear to have remarkably Gaussian velocity distributions, especially at lower redshift where blending is less of a problem. On the other hand, non-Gaussian features could as well be attributed to blends of two or more Voigt profiles as to an intrinsically non-Voigt distribuing Non-Voigt Profiles
If the Lyα forest is now viewed as density fluctuations within the IGM, then what does this imply about the physical nature of Lyα absorbers? Typical systems have column densities of around 13.0 <log N (H I)< 14.0 (log cm−2). Observations of quasar pairs have shown that these systems can be very large; of the order of 500 kpc across (Dinshaw et al. 1994). They are therefore highly ionized, and hence contain a significant fraction of all the baryons at z = 3, yet they are only slightly overdense (ρ/ρ¯ ∼ 1 − 10) compared to the mean baryonic density. Although a large variety of structures are seen in the simulations, they tend to have a flattened geometry, in the form of “pancakes” or filamentary structures. They are unlikely to be virialized objects, and are probably transient density fluctuations undergoing gravitational collapse in one direction, whilst still expanding with the Hubble flow in others (Haehnelt 1996).
Subject headings: cosmology: theory – intergalactic medium – line: profiles – quasars: absorption lines
1. Introduction
Recent hydrodynamic simulations of large-scale structure formation in cold dark matter (CDM) dominated cosmologies (e.g. Cen et al. 1994, Zhang, Anninos & Norman 1995, Hernquist et al. 1996, Theuns et al. 1998) have been able to naturally reproduce the Lyman-alpha (Lyα) forest. These simulations have been remarkably accurate in reproducing
Outram et al. (1999) proposed a method to detect departures from Voigt profiles of the absorption lines in a statistical way. They applied it to the Lyα forest spectrum of GB1759+7539, but detected no significant evidence of non-Voigt profiles. In this letter we develop the method proposed by Outram et al.. In the next section we discuss the signature of non-Voigt profiles in Lyα forest spectra, and present details of the method to detect it. Then we apply this method to simulated forest spectra to show that the profiles seen in hydrodynamic simulations are indeed statistically non-Voigt, before finally discussing the implications of this result.
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