new gom3-supplement and exercise
雷帕霉素增强RSL3对睾丸癌细胞I-10的增殖、侵袭与迁移的抑制作用
睾丸癌是青年人群中最常见的恶性肿瘤[1]。
西方国家发病率在过去20年中上升,手术和以顺铂为基础的化学疗法的结合使得睾丸癌患者的治愈率大于90%[2]。
尽管如此,10%~20%患有转移性疾病的睾丸癌患者不能通过基于顺铂的化疗治愈[3]。
因此,探索治疗睾丸肿瘤的新方法具有研究价值。
铁死亡是一种铁依赖形式的非凋亡细胞死亡,其特征是脂质ROS 的积累[4]。
在细胞和小鼠中进行的遗传学研究确定硒酶谷胱甘肽过氧化物酶(GPX4)是这种形式的细胞死亡的关键调节因子。
GPX4将脂质氢过氧化物转化为脂质醇,这一过程阻止了铁(Fe 2+)依赖的有毒脂质活性氧(ROS )的形成。
GPX4功能的抑制导致脂质过氧化,并可诱导铁死亡[5,6]。
近年来,人们在设计和开发基于铁死亡诱导的抗癌药物方面做了大量工作,在癌症治疗中引入铁死亡具有很好的治疗潜力[7]。
RSL3是一种常用的铁死亡诱导剂,通过抑制谷胱甘肽Rapamycin enhances inhibitory effect of RSL3on proliferation,invasion and migration of testicular cancer I-10cells in vitroLI Bin,WANG Yue,HOU Fengwei,DU Jiaru,TONG XuhuiSchool of Pharmacy,Bengbu Medical College,Anhui Provincial Engineering Research Center for Biochemical Pharmaceuticals,Bengbu 233030,China摘要:目的探究雷帕霉素增强RSL3对睾丸癌细胞I-10的增殖、侵袭与迁移能力的抑制作用。
方法MTT 法检测RSL3(Type II )及合用雷帕霉素(RAPA )作用后I-10细胞的存活率。
将RSL3(0~16μmol/L )分别以及联合16μmol/L 雷帕霉素作用于睾丸癌细胞I-10,采用MTT 法检测I-10细胞增殖抑制情况,利用集落克隆形成实验检测细胞增殖能力,采用划痕实验和Transwell 小室检测I-10细胞的迁移与侵袭能力,采用流式细胞术检测I-10细胞的脂质活性氧水平,采用GSH 和MDA 检测试剂盒检测细胞中GSH 和MDA 含量,利用Western blot 检测细胞GPX4蛋白表达。
褪黑素调控MEG3
doi:10.3969/j.issn.1000-484X.2023.12.012褪黑素调控MEG3/miR-223/NLRP3轴对流感病毒感染小鼠模型肺损伤的影响①靳莉徐超张华李振华(郑州大学附属郑州中心医院呼吸与危重症医学科,郑州 450000)中图分类号R373 文献标志码 A 文章编号1000-484X(2023)12-2528-06[摘要]目的:探究褪黑素(MT)调控母体表达基因3(MEG3)/微小RNA-223(miR-223)/核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)轴对流感病毒感染小鼠模型肺损伤的保护情况。
方法:50只小鼠按随机数字法分为对照组、模型组、MT 低、中、高剂量组,每组10只。
除对照组外,其余各组以5×105 EID50剂量给予H7N9病毒悬浮液滴鼻,对照组给予等体积磷酸缓冲液滴鼻。
造模后当天MT低、中、高剂量组分别腹腔注射15、30、60 mg/kg MT,对照组、模型组腹腔注射等体积生理盐水。
末次给药24 h处死小鼠进行实验。
所有小鼠检测肺指数;苏木精-伊红(HE)染色观察肺组织形态;ELISA检测肺组织中IL-1β、IL-18、IL-6、TNF-α、IFN-β水平;实时荧光定量PCR(RT-qPCR)检测小鼠肺组织中MEG3 mRNA、miR-223水平;蛋白免疫印迹检测肺组织中NLRP3、凋亡相关斑点样蛋白(ASC)、半胱氨酸天冬氨酸蛋白水解酶1(caspase-1)、pro-caspase-1蛋白水平。
生物信息学预测和双荧光素酶实验检测MEG3与miR-223、miR-223与NLRP3的靶向关系。
结果:病理结果显示模型组小鼠肺组织肺泡壁充血明显、腔内出现明显的炎症渗出及炎症细胞浸润明显;MT(低、中、高)剂量组随着MT剂量的升高,小鼠肺组织肺泡壁充血现象、腔内炎症渗出及炎症细胞浸润现象均得到改善。
与对照组相比,模型组肺指数、肺组织中趋化因子、炎症因子、抗病毒因子、MEG3水平,NLRP3通路蛋白水平升高(P<0.05),miR-223水平降低(P<0.05);添加MT后抗病毒因子升高明显,其余指标均有所改善。
新标准大学英语综合教程3答案(全版)
新标准大学英语3Unit1Active reading(1)4.b c c d c a5.productive attendance resistance ambitious acceptance script impressive6.attendance ambitious productive impressive resistance script acceptance7.mortgage deck surf coastal;defy lengthy8.b a b b b a b bActive reading(2)4.triple cemetery rear biography cram budding finite elapse5.elapsed;cemetery rear;crammed triple budding;biography finite6.a b a a b b a a7.a b b a a b b b aLanguage in use6.(1)我们都觉得在校时间不多了,以后再也不会有这样的学习机会了,所以都下定决心不再虚度光阴。
当然,下一年四五月份的期末考试最为重要。
我们谁都不想考全班倒数第一,那也太丢人了,因此同学们之间的竞争压力特别大。
以前每天下午5点以后,图书馆就空无一人了,现在却要等到天快亮时才会有空座,小伙子们熬夜熬出了眼袋,他们脸色苍白,睡眼惺忪,却很自豪,好像这些都是表彰他们勤奋好学的奖章。
(2)明天行吗?明天只是个谎言;根本就没有什么明天,只有一张我们常常无法兑现的期票。
明天甚至压根儿就不存在。
你早上醒来时又是另一个今天了,同样的规则又可以全部套用。
明天只是现在的另一种说法,是一块空地,除非我们开始在那里播种,否则它永远都是空地。
你的时间会流逝(时间就在我们说话的当下滴答滴答地走着,每分钟顺时针走60秒,如果你不能很好地利用它,它就会走得更快些),而你没有取得任何成就来证明它的存在,唯独留下遗憾,留下一面后视镜,上面写满了“本可以做”“本应该做”“本来会做”的事情。
全国医护英语水平考试强化教程3
全国医护英语水平考试强化教程3 The National Medical English Proficiency Exam Intensive Tutorial 3。
Welcome to the third installment of our Intensive Tutorial series for the National Medical English Proficiency Exam. In this tutorial, we will delve deeper into essential topics and strategies to help you excel in the exam. Let's begin our journey towards mastering medical English.1. Building a Strong Foundation:To excel in the National Medical English Proficiency Exam, it's crucial to build a strong foundation in medical terminology, grammar, and vocabulary. Start by familiarizing yourself with common medical terms and their meanings. Understanding the root words, prefixes, and suffixes will help you decipher unfamiliar terms during the exam.2. Enhancing Communication Skills:Effective communication is essential for healthcare professionals. In the exam,you'll encounter tasks that assess your ability to communicate with patients, colleagues, and other healthcare professionals. Practice active listening, clear articulation, and empathy to convey information accurately and compassionately.3. Mastering Medical Writing:Medical writing requires precision and clarity. Whether you're writing patient notes, medical reports, or research papers, it's essential to communicate information accurately and concisely. Practice writing clear and organized documents, paying attention to grammar, punctuation, and formatting.4. Understanding Medical Ethics:Healthcare professionals must adhere to ethical standards in their practice. Familiarize yourself with medical ethics principles, such as patient confidentiality,informed consent, and beneficence. During the exam, you may encounter scenarios that test your understanding of ethical dilemmas in healthcare. Apply ethical reasoning to make informed decisions.5. Preparing for Clinical Scenarios:The exam may include clinical scenarios that require you to analyze patient symptoms, diagnose conditions, and recommend treatment plans. Practice interpreting medical charts, laboratory results, and imaging studies to develop your clinical reasoning skills. Pay attention to details and prioritize patient safety in your decision-making process.6. Staying Updated on Medical Advances:Healthcare is an ever-evolving field, with new research and advancements emerging regularly. Stay updated on current medical practices, guidelines, and breakthroughs in your specialty area. The exam may include questions on recent developments in healthcare, so staying informed is essential.7. Managing Time Effectively:Time management is crucial during the exam. Practice completing tasks within the allotted time frame to avoid rushing through questions or leaving them unanswered. Prioritize tasks based on their complexity and allocate time accordingly. Remember to review your answers for accuracy and completeness before submitting your exam.8. Seeking Feedback and Support:Don't hesitate to seek feedback from peers, instructors, or mentors to identify areas for improvement. Collaborate with study groups or participate in mock exams to simulate the exam environment and receive constructive criticism. Take advantage of resources such as textbooks, online courses, and practice exams to supplement your preparation.In conclusion, excelling in the National Medical English Proficiency Exam requires a combination of knowledge, skills, and practice. By building a strong foundation, enhancing communication skills, mastering medical writing, understanding medicalethics, preparing for clinical scenarios, staying updated on medical advances, managing time effectively, and seeking feedback and support, you can approach the exam with confidence and achieve success. Keep practicing and striving for excellence in your medical English proficiency journey.。
N-3多不饱和脂肪酸促进小鼠骨再生的实验研究
Journal of Molecular Imaging, 2018, 41(3): 287-290
doi 10.3969/j.issn.1674-4500.2018.03.01
· 287 ·Effe来自t of n-3 polyunsaturated fatty acids on accelerating bone regeneration in mice
INTRODUCTION Although improvements of internal fixations have
been developed rapidly in clinical area, the high rate (20%) of bone union of fracture is presented a severe clinical issue worldwide[1]. In past decades, numerous investigators focused their studies on vitamin D and calcium intake for the diet management of bone regeneration[2]. However, vast intake of either vitamin D or calcium did not accelerate bone regeneration in vivo due to the limited digestive as well as the whole body metabolic balance. Recently, the modulatory role of fatty acids (FAs) in bone regeneration process has been reported[3, 4, .5] In addition, past clinical reports suggested that saturated fatty acids might elevate the risk of fracture[6, .7] Recent investigations showed that the long-term supplementation of n-3 PUFAs promoted the long bone strength in mice[8], and, simultaneously, Fat-1 mice showed remarkable resistant to ovariectomy-induced bone loss through adipogenesis reduction in bone marrow[9]. Moreover, clinical data suggested that serum n-3 PUFAs levels were positively correlated with bone mass, as risk of fracture was supposed to be increased by saturated FAs intake[3, 6, . 10-12]
三期临床实验英文
三期临床实验英文Clinical Trials in Phase IIIIntroduction:Clinical trials play a vital role in the development of new drugs and medical treatments. These trials are conducted in different phases to ensure the safety and efficacy of the interventions. Phase III clinical trials are particularly important, as they involve a large number of participants and provide crucial data for regulatory approval. This article will discuss the key aspects of Phase III clinical trials and their significance in the drug development process.1. Purpose of Phase III Clinical Trials:Phase III clinical trials are conducted to evaluate the effectiveness and safety of the new intervention compared to existing treatments or placebos. These trials aim to gather sufficient evidence to support the submission for regulatory approval. The primary objectives include determining the intervention's benefits, risks, optimal dosage, and potential side effects.2. Design of Phase III Clinical Trials:Phase III clinical trials generally follow a randomized, controlled design to minimize bias and ensure reliable results. Participants are randomly assigned to either the intervention group or the control group, which may receive standard treatment or a placebo. The trial duration, sample size, and follow-up period are carefully planned to obtain statistically significant outcomes.3. Participant Selection:Phase III clinical trials involve a larger and more diverse population than earlier phases. Participants are recruited based on strict inclusion and exclusion criteria to ensure a representative sample. Factors such as age, gender, medical history, and disease severity are considered to gather comprehensive data on the intervention's effects across different patient populations.4. Data Collection and Analysis:Phase III trials collect a wide range of data, including clinical outcomes, biomarkers, and patient-reported outcomes. Standardized protocols and data collection forms are used to ensure uniformity and accuracy. Statistical analysis is conducted to compare the intervention group's outcomes with the control group, providing evidence of efficacy and safety profiles.5. Regulatory Approval:Successful Phase III trials provide the basis for regulatory submission and approval. The data obtained from these trials are crucial for demonstrating the intervention's efficacy, safety, and benefits over existing treatments. Regulatory agencies thoroughly assess the trial results before granting marketing authorization, considering the overall risk-benefit balance.6. Post-Marketing Surveillance:Even after regulatory approval, Phase III clinical trials continue to contribute to the evaluation of long-term safety and effectiveness. Post-marketing surveillance studies monitor the intervention's performance inlarger patient populations to detect any rare adverse events or unexpected outcomes.Conclusion:Phase III clinical trials are a crucial stage in the drug development process, providing strong evidence of an intervention's efficacy and safety. These trials involve a large number of participants and rigorous study designs to ensure reliable results. Successful Phase III trials play a significant role in obtaining regulatory approval and guiding medical practice. The insights gained from these trials contribute to improving patient care and advancing medical science.。
介绍新药(NewKindofMedicine)
介绍新药(New Kind of Medicine)武汉第三制药厂(medical nant)研制了一种新药,药品已被外商订购。
制药厂请你为该厂产品写一份说明书,请根据提示完成。
1.本药品为中药,对心脏病疗效显著。
2。
用量:每日三次,一次两粒(pi11);发病时可加服1~2粒。
可长期服用。
3.服药后如感身体不适请停服。
小孩和孕妇(pregnant)禁服。
4.本药品应放在阴凉干燥处。
5.使用本药品还应严格听从医生的指导。
注意:1.说明书必须包括以上所有要点,但不要逐条翻译。
2.词数100左右。
a new kind of medicinewuhan no.3 medical plant has invented a new kind of medicine.it is very good for heart trouble (disease). it should be taken three times a clay and two pills once. it can also be taken one or two more pills if needed. this kind of medicine can be used for a long time.it's dangerous for children and the pregnant. they mustn't take this medicine. if you are not feeling well after taking the medicine, you should stop taking it. this medicine should be kept in a cool and dry place. it's better to follow the doctor's advice before taking it.一种新药武汉第三制药厂研制了一种新药,对治疗心脏病有显著疗效。
现代质三联治疗共47页文档
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0 100 130 160 190 LDL - Cholesterol mg / dl
MRFIT (usual care) Incidence rate of CHD 12
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CASTELLI WP. Am J Cardiol 1998; 82:60-65
25 45 65 85
Incidence of cardiac events (per 1000 person-years)
Helsinki Heart Study
65 55 45 35
GORDON DJ et al. Circulation 1989; 79: 8 - 15.
Framingham Heart Study
CAD risk as a function of LDL-C and HDL-C in men (50 to 70 y)
3
2.5
2
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22% reduction in combined fatal
and non-fatal MI
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RUBINS HB et al. New Engl J Med 1999; 341:410
HDL - Cholesterol as Risk Factor for CHD
metc医学英语水平考试应试指南听力三级
metc医学英语水平考试应试指南听力三级Tips for Passing the METC Medical English Proficiency Exam Level 3 Listening SectionThe METC Medical English Proficiency Exam (MEPE) is known for being a challenging test, especially the listening section. However, with proper preparation and practice, you can increase your chances of passing with flying colors. In this guide, we will provide you with some tips on how to prepare for the Level 3 listening section of the exam.1. Familiarize yourself with the format of the exam:Before you start preparing for the listening section, it's essential to familiarize yourself with the format of the exam. The listening section of the Level 3 exam consists of multiple-choice questions based on audio recordings related to medical topics. Make sure you understand the instructions and know what to expect on the day of the exam.2. Practice regularly:One of the best ways to improve your listening skills is by practicing regularly. Set aside time each day to listen to English podcasts, watch medical documentaries, or even practice with sample audio recordings provided by the METC. This will helpyou get used to listening to English spoken at a natural pace and improve your comprehension skills.3. Take notes while listening:During the exam, you will be allowed to take notes while listening to the audio recordings. Make sure to jot down key points, main ideas, and any important details that you hear. This will help you remember the information better and answer the questions more accurately.4. Focus on understanding the context:When listening to the audio recordings, try to focus on understanding the context of the conversation or lecture. Pay attention to the speaker's tone, body language, and the overall theme of the recording. This will help you comprehend the information better and answer the questions correctly.5. Practice with past exam papers:To get a better idea of the types of questions you may encounter in the listening section, it's essential to practice with past exam papers. You can find sample questions and audio recordings on the METC website or ask your tutor for additional resources. By practicing with past papers, you can familiarize yourself with the exam format and improve your listening skills.6. Seek feedback from a tutor:If you're struggling with the listening section, consider seeking help from a tutor or language coach. They can provide you with valuable feedback on your listening skills and suggest areas for improvement. Working with a tutor can significantly enhance your chances of passing the exam and achieving a higher score.In conclusion, passing the listening section of the METC Medical English Proficiency Exam Level 3 requires practice, dedication, and focus. By following the tips mentioned above and putting in the effort to improve your listening skills, you can increase your chances of success on exam day. Good luck!。
结直肠癌病人口服营养补充依从性评估量表的构建
结直肠癌病人口服营养补充依从性评估量表的构建刘曼丽,林清然*,皮美娟,章淑贤,吴桂虹暨南大学附属第一医院,广东 510000Construction of oral nutritional supplements compliance assessment scale for patients with colorectal cancerLIU Manli, LIN Qingran, PI Meijuan, ZHANG Shuxian, WU GuihongThe First Affiliated Hospital of Jinan University, Guangdong 510000 ChinaCorresponding Author LINQingran,E⁃mail:******************Abstract Objective:To construct oral nutritional supplements(ONS) compliance assessment scale for patients with colorectal cancer. Methods:The theory of knowledge,attitude,practice was used as the structural framework of scale,relevant guidelines and literature were used as reference materials,and a pool of items of ONS compliance assessment scale for patients with colorectal cancer was formed. Then,ONS compliance assessment scale for patients with colorectal cancer was constructed by expert inquiry method.Results:Two rounds of expert inquiry were conducted, with questionnaire response rates of 90.91% and 100.00%,expert opinion submission rates of 45.00% and 25.00%, and expert authority coefficients of 0.878 and 0.893,respectively.In the second round of expert inquiry,the average score of importance of the dimensions were from 4.80 to 4.90,the full score ratio were from 85% to 90%,the coefficient of variation were from 0.06 to 0.11,and the Kendall harmony coefficient was 0.874 (P<0.001).The average score of importance of the items were from 4.30 to 4.95,the full score ratio were from 35% to 95%,the coefficient of variation were from 0.05 to 0.24,and the Kendall harmony coefficient was 0.410(P<0.001).Finally,ONS compliance assessment scale for patients with colorectal cancer was constructed,which included 3 dimensions and 33 items.Conclusions:The constructed ONS compliance assessment scale for patients with colorectal cancer has good scientific and reliable validity,and can be used as a tool for evaluating ONS compliance in patients with colorectal cancer. Keywords colorectal cancer; Delphi method; oral nutritional supplements; compliance; scale; nursing摘要目的:构建结直肠癌病人口服营养补充(ONS)依从性评估量表。
新通用大学英语第三册unit02
Lesson 1 Lesson 2 Extended Exercises Checkpoint
UNIT GOALS
1. Make an appointment to see a doctor
2. Discuss types of medical treatments 3. Get to know some diseases and medications 4. Write about health matters
Lesson 1
3
Lead-in Listening
3
Speaking Reading
3
Writing
Lead-in
Sitcom: Are You OK?
3
Exercise A Exercise B
Exercise A
Complete the sentences. Circle the correct answers.
C. trembling begins in one or both hands D. people do not take mental confusion seriously
Passage 2 Laughter Is the Best Medicine
Listen to the passage and fill in the blanks with what you hear.
Part 2 Describing Symptoms at a Doctor’s Office
Listen to the conversations. Check the symptoms each patient describes. if the patient has any pain, where is it?
老师教学打篮球的作文英语
Our school recently introduced a new physical education program, and it was none other than basketball. Our PE teacher, Mr. Johnson, is an experienced basketball player and a certified coach. He decided to teach us the basics of basketball to promote teamwork and physical fitness.The first day of basketball class was both exciting and a bit intimidating. Mr. Johnson started by explaining the importance of the sport and how it could benefit us in various ways. He emphasized the value of discipline, sportsmanship, and the joy of playing a team sport.We began with warmup exercises to prepare our bodies for the physical activity ahead. Mr. Johnson led us through a series of stretching and jogging exercises to increase our heart rate and loosen our muscles.Next, he taught us the fundamentals of dribbling. He demonstrated the correct way to hold the ball and how to bounce it rhythmically with one hand. We practiced dribbling around the court, trying to maintain control of the ball while moving at different speeds.After mastering the basics of dribbling, we moved on to passing. Mr. Johnson explained the different types of passes, such as chest pass, bounce pass, and overhead pass. He stressed the importance of accuracy and timing in passing the ball to teammates.We then learned how to shoot the ball. Mr. Johnson showed us the proper shooting technique, which involved bending our knees, aligning our arms, and following through with our wrist. We took turns shooting at the hoop, gradually improving our aim and form.Defensive skills were also a crucial part of the lesson. Mr. Johnson taught us how to position ourselves to block shots, steal the ball, and prevent opponents from scoring. We practiced defensive stances and learned to anticipate our opponents moves.Finally, we played a scrimmage game to put all our newly acquired skills into practice. It was a thrilling experience, as we applied what we had learned and worked together as a team. Mr. Johnson provided guidance and encouragement throughout the game, helping us improve our performance.The basketball lessons were not only fun but also educational. They taught us valuable life skills such as teamwork, communication, and perseverance. We look forward to more basketball classes and the opportunity to further develop our skills and enjoy the sport.。
美国运动医学会指南英语
美国运动医学会指南英语In the world of fitness and exercise, the American College of Sports Medicine (ACSM) guidelines serve as the gold standard for scientific and evidence-based recommendations. These guidelines are continually updated to reflect the latest research and scientific findings, ensuring that individuals can achieve optimal health and fitness outcomes through structured and safe exercise programs.The ACSM guidelines cover a wide range of topics, including the frequency, intensity, duration, and type of exercise required for various health outcomes. Whether you are aiming to lose weight, improve cardiovascular health, or simply maintain good overall health, the ACSM guidelines provide a roadmap to successful exercise programming.One of the key principles emphasized by the ACSM is the importance of personalized exercise programming. Everyone's fitness level, health status, and goals are unique, and the guidelines recognize that a one-size-fits-all approach is not effective. Instead, they recommend that individuals work with qualified health and fitness professionals todevelop a customized exercise plan that meets theirspecific needs.The guidelines also stress the importance of progressive overload in exercise programming. Thisprinciple involves gradually increasing the intensity, duration, or frequency of exercise over time to challenge the body and stimulate adaptive changes. By gradually pushing the body out of its comfort zone, individuals can achieve greater fitness gains and improved health outcomes. In addition to personalized programming and progressive overload, the ACSM guidelines also address the role of warm-up and cool-down in exercise. These important components help to prepare the body for exercise and promote recovery post-exercise, reducing the risk of injury and improving overall exercise performance.The ACSM guidelines also include recommendations for special populations, such as older adults, individuals with chronic health conditions, and those who are overweight or obese. These recommendations provide valuable guidance for ensuring that these individuals can safely and effectivelyparticipate in exercise programs that are tailored to their unique needs and challenges.The influence of the ACSM guidelines extends beyond the fitness industry, shaping public health policies and guidelines worldwide. Their recommendations are often referenced by governments, health organizations, and medical professionals as the foundation for evidence-based exercise advice.In conclusion, the American College of Sports Medicine guidelines are the cornerstone of scientific exercise programming. They provide a comprehensive framework for individuals and health professionals to develop safe, effective, and personalized exercise plans that lead to improved health and fitness outcomes. By following these guidelines, we can embark on a journey of optimal health and well-being through the power of structured andscientific exercise.**美国运动医学会指南:科学运动的黄金标准**在健身和运动领域,美国运动医学会(ACSM)指南被视为科学和基于证据建议的黄金标准。
晨梅梅《新发展英语综合教程(3)》学习指南【词汇短语+课文精解+全文翻译+练习答案】(Unit 12
Unit 12一、词汇短语babysit vi. 当临时保姆;代人承担照料责任vt. 为人临时照看;照顾婴儿【例句】Minna could babysit one night if your father has to work. 如果你的父亲得去工作,米娜可以看一晚上孩子。
【词组】babysit sb. 照顾某人【派生】babysitter n. 临时保姆ingredient [n. (混合物的)组成部分,配料;成份,要素【例句】Consideration and tolerance are the ingredients of a good marriage. 体谅和容忍是婚姻美满的主要因素。
【助记】ingr(=integr完整,进入)+edi(吃)+ent→进入吃的东西内的东西→(烹调的)原料campground n. 野营地;露营场所【例句】They have a large campground forested area and go for hikes throughout the day.他们有一个很大的可以散步的森林露营场所。
anthropology [n. 人类学【例句】Social anthropology is one of the social sciences. 社会人类学是社会科学之一。
【词组】cultural anthropology 文化人类学【派生】anthropological adj. 人类学的;人类学上的interpersonal adj. 人与人之间的;关于人与人之间关系的【例句】Training in interpersonal skills is essential. 各种人际交往技巧的训练是非常必要的。
aggressive [] adj. 侵略的,好斗的;敢做敢为的,有进取心的;强有力的;坚持己见的【例句】He is respected as a very aggressive and competitive executive. 他被尊认为一位十分好强好胜的主管。
新医疗模式的英文作文
新医疗模式的英文作文In today's fast-paced world, the healthcare industry is undergoing significant transformations, giving rise to a new medical model that promises to revolutionize the way we approach healthcare. This model, often referred to as the "new medical model," is not just a technological advancement but a comprehensive approach that addresses the physical, mental, and social well-being of individuals.在当今快节奏的世界中,医疗行业正在经历重大变革,催生了一种新的医疗模式,有望彻底改变我们对待医疗保健的方式。
这种模式通常被称为“新医疗模式”,它不仅仅是一项技术进步,更是一种全面的方法,旨在解决个人的身体、心理和社会福祉问题。
The cornerstone of the new medical model is the patient-centered approach. It shifts the focus from a disease-oriented mindset to a holistic view that takes into account the unique needs and preferences of each individual. This means that doctors and healthcare providers now spend more time understanding thepatient's lifestyle, genetic makeup, and environmental factors that may contribute to their health conditions.新医疗模式的核心是以患者为中心的方法。
新标准大学英语3unit3
新标准大学英语3unit3Unit 3。
Learning Objectives:Understand the main idea and specific information in spoken and written texts about social issues and human relationships。
Learn to use new vocabulary and expressions in the context of social issues and human relationships。
Develop the ability to express opinions and ideas on social issues and human relationships。
Key Vocabulary:discrimination。
stereotype。
gender equality。
social justice。
cultural diversity。
empathy。
mutual respect。
social responsibility。
Text 1: Breaking Stereotypes。
In this unit, we will explore the theme of breaking stereotypes. Stereotypes are oversimplified ideas about groups of people. They can be based on race, gender, age,religion, or other factors. Stereotypes often lead to discrimination and can have a negative impact on individuals and society as a whole. As we study this topic, we will learn about the harmful effects of stereotypes and how we can challenge and break them.Text 2: Gender Equality。
2021年全新版大学进阶英语综合教程3课件及答案Unit4EmergingAdulthood
2021年全新版大学进阶英语综合教程3课件及答案 Unit 4:Emerging Adulthood1. IntroductionIn this unit, we will explore the concept of emerging adulthood, which refers to the period between adolescence and adulthood. This is an important stage in a person’s life where individuals experience various changes and transitions. We will discuss the characteristics of emerging adulthood and its impact on personal development and relationships. Additionally, we will provide valuable resources such as course materials, lecture slides, and answer keys to help you better understand the content.2. Lesson Objectives•Understand the concept of emerging adulthood and its significance in today’s society.•Explore the different characteristics and challenges individuals face during this stage.•Analyze the impact of emerging adulthood on personal development and relationships.•Develop critical thinking skills through class discussions and activities.•Enhance English language proficiency through reading, writing, and speaking exercises.3. Course MaterialsLecture Slides•Lecture 1: Introducing Emerging Adulthood•Lecture 2: Characteristics and Challenges of Emerging Adulthood•Lecture 3: Impact on Personal Development•Lecture 4: Impact on RelationshipsAdditional Resources•Reading Materials on Emerging Adulthood•Case Studies of Emerging Adults•Research Articles on Emerging Adulthood4. Class ActivitiesThroughout this unit, we will engage in various class activities to deepen our understanding of emerging adulthood. Some of the activities include:•Group Discussions: Students will be divided into groups to discuss specific topics related to emergingadulthood. Each group will present their findings to theclass.•Case Studies: We will analyze real-life case studies of emerging adults and identify the challenges they face. This will help us understand the complexities of this stage of life.•Role-Playing: Students will participate in role-playing activities to empathize with the experiences andemotions of emerging adults.•Writing Assignments: Students will be given writing assignments to express their thoughts and reflections onthe topics covered in the unit.5. AssessmentTo assess your understanding of the content, there will be a final examination at the end of the unit. The examination will include multiple-choice questions, short answer questions, and an essay question. Additionally, your participation in class activities and completion of assignments will be taken into consideration for your final grade.ConclusionUnit 4 of the 2021 edition of the Advanced English Comprehensive Course focuses on the concept of emerging adulthood. By studying this stage of life, we hope to gain insight into the challenges faced by individuals during this transitional period. The course materials, lecture slides, and class activities provided will aid in facilitating a deeper understanding and appreciation of emerging adulthood. Remember to actively engage and participate in discussions and activities to maximize your learning experience.。
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Question An automobile manufacturer is considering a change in an assembly line that should save money due to a reduction in labor and material cost. The change involves the installation of four new robots that will automatically install windshields. The cost of the four robots, including installation and initial programming, is $400,000. Current practice is to amortize the initial cost of robots over two years on a straight-line basis. The process engineer estimates that one full-time technician will be needed to monitor, maintain, and reprogram the robots on an ongoing basis. This person will cost approximately $60,000 per year. Currently, the company uses four full-time employees on this job and they each make about $52,000 per year. One of these employees is a material handler, and this person will still be needed with the new process. To complicate matters, the process engineer estimates that the robots will apply the windshield sealing material in a manner that will result in a savings of $0.25 per windshield installed. How many automobiles need to be produced over the next two years to make the new robots an attractive investment? Due to the relatively short horizon, do not consider the time value of money.
10 5
Total Hourly Output
6 12
Efficiency (%)
47.5 76.0
6
7 8
9
10 11 12 13 14
Return to King for Using More Machines
Number of Type of next Machines machine
4 5 -C
Position rear wheel #1 and fasten hubcap. Position rear wheel #2 and fasten hubcap. Position front wheel #1 and fasten hubcap. Position front wheel #2 and fasten hubcap. Position wagon handle shaft on front axle assembly and hand fasten bolt and nut Tighten bolt and nut
Solution Day 1 Problem 1 Sales increase by 6% = $100M x 6% = $6M Benefits: Profits increase by 16% of the increased sales = $6M x 16% = $0.96M Cost: Increase product cost by 10% = ($100M x 63%) x 10% = $6.3M Because costs exceed benefits, the new feature should not be added.
Question: The model J Wagon is to be assembled on a conveyor belt. Five hundred wagons are required per day. Production time per day is 420 minutes, and the assembly steps and times for the wagon are given in the following Exhibit. Assignment: find the balance that minimizes the number of workstations, subject to cycle time and precedence constraints.
18 20
79.2
81.4 79.2
9
10 11 12 13 14
B
C D A C C
2
2 2 1.33 1.33 1.33
1.5
1.5 1.5 1.5 1.5 1.5
2.5
2 2 2 1.67 1.43
2
2 1 1 1 1
2.5
2 2 2 1.67 1.5
24
30 30 30 36 40
84.4
95.0 86.0 79.2 87.5 90.5
Solution: Cost of the current process over the next two years is just the cost of the four full-time employees. $52,000/employees x 4 employees x 2 years = $416,000 The cost of the new process over the next two years, assuming the robot is completely costed over that time, is the following: ($52,000/material handler + $60,000/technician) x 2 + $400,000/robots - $0.25 x autos Equating the two alternatives: $416,000 = $624,000 - $0.25 x autos Solving for the break-even point: -$208,000/-$0.25 = 832,000autos This indicates that to break even, 832,000 autos would need to be produced with the robots over the next two years.
D
WS2
E
WS4: G,H,I,J
T 195 Efficiency .77 or 77% N (5)(50.4)
4. Select assignment rules a. assign tasks in order of the largest number of following tasks b. assign tasks in order of longest task time 5. Make task assignments to form Workstation 1, Workstation 2….. 6. Calculate efficiency: assume 5 first? 7. Evaluate the solution. An efficiency of 77 percent indicates an imbalance or idle time of 27 percent across the entire line.
TASK
TASK TIME IN SECONDS 45
DESCRIPTION
TASKS THAT MUST PRECEDE --
A
Position rear axle support and hand fasten four screws to nuts.
B
C D
11
9 50
Insert rear axle
Machine Times (min)
A 4 4 B 3 3 C 10 5 D 2 2
Cycle Time (min)
10 5
Total Hourly Output
6 12
Efficiency (%)
47.5 76.0
6
7 8
C
A C
4
2 2
3
3 3
3.33
3.33 2.5
2
2 2
4
3.33 3
15
Tighten rear axle support screws to nuts Position front axle assembly and hand fasten with four screws to nuts
A
B --
E
F G H I J K
15
12 12 12 12 8 9 195
Tighten front axle assembly screws