几丁质结合蛋白介绍

A role for variable region-containing 包含多个结构域chitin-binding proteins 几丁质结合蛋白(VCBPs) in host gut–bacteria interactions宿主肠道细菌相互作用

A number of different classes of molecules许多不同种类的分子，function as structural matrices 起到结构矩阵的作用for effecting以影响innate and adaptive immunity. 先天和后天免疫

The most extensively最普遍的characterized 特征性mediators中介者of adaptive immunity获得性免疫are the immunoglobulins 免疫球蛋白and T-cell antigen receptors T细胞抗原受体found in jawed vertebrates. 有颚（颌类）脊椎动物

In both classes of molecules,在两种分子中unique receptor specificity特异性受体专一性is effected through somatic variation通过体细胞变异实现in the variable (V) 结构域structural domain.

V region-containing chitin-binding proteins 包含V结构域的几丁质结合蛋白(VCBPs) consist of 由...构成two tandem两个串联的Ig 免疫球蛋白V domains as well as a chitin-binding domain. 和一个几丁质结合结构域

VCBPs are encoded at four loci (i.e., VCBPA–VCBPD) in Ciona, a urochordate, and are expressed by distinct epithelial cells of the stomach and intestine, as well as by granular amoebocytes present in the lamina propria of the gut and in circulating blood.

VCBPs are secreted into the gut lumen, and direct binding to bacterial surfaces can be detected by immunogold analysis.

Affinity-purified native and recombinant VCBP-C, as well as a construct consisting only of the tandem V domains, enhance bacterial phagocytosis by granular amoebocytes in vitro.

Various aspects of VCBP expression and function suggest an early origin for the key elements that are central to the dialogue between the immune system of the host and gut microflora.

bacteria opsonization | bacteria phagocytosis | immunoglobulin variable

domains