Maxacalcitol_SDS_MedChemExpress

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大麦提取物抗氧化活性测定

大麦提取物抗氧化活性测定
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Ab s t r a c t : To e v a l u a t e t h e s c a v e n g i n g e f f e c t o n f r e e r a d i c a l DM PD , t h e p r o t e c t i o n e f f e c t o n p r o t e i n,
取 物 可有 效 清 除 DMP D‘ +自 由基 ,1 2 5 g ・ mL 时清除率超过 5 0 . 0 ,2 5 0 g ・ mL 时对 A AP H 引起 的蛋 白质 氧 化 损

Sigma-Aldrich是全世界领先的生命科学与高科技集团公司。

Sigma-Aldrich是全世界领先的生命科学与高科技集团公司。

Sigma-Aldrich 是全世界领先的生命科学与高科技集团公司。

我们的生物化学与有机化学产品与试剂盒被广泛地应用研究于生命科学研究、有机化学研究、材料科学研究、分析化学研究与其他高科技生产中。

我们的用户遍及生命科学研究公司、大学与政府研究机构与企业,超过一百万科学家与科研人员使用到我们的产品。

SIGMA 原装促销欢迎垂询!sigma 51370 Harmane 1G 现货sigma 222984 dl-Propranolol HCl 5G 现货sigma 284785 S-6-Methoxy-a-Methyl-2-Naphthaleneacetic acid 25G 现货sigma 857416 3-(3,4-Dihydroxyphenyl)-2-methyl-L-Alanine 5g 现货sigma 857440 Chloramphenicol 25G 现货sigma A4669 Acycloguanosine 500mg 现货sigma A5882 Antipyrine 500G 现货sigma A7655 Atenolol 25G 现货sigma A8523 Amoxicillin 25g 现货sigma B7283 Benserazide HCl 5G 现货sigma C2505 Corticosterone 500MG 现货sigma C4024 Carbamazepine 25G 现货sigma C4216 Coumarin 500G 现货sigma C4255 Creatinine 1KG 现货sigma C4522 Cimetidine 25G 现货sigma C5793 Ceftriaxone Na 1G 现货sigma C6022 Cyproheptadin HCl 1G 现货sigma D1756 Dexamethasone 500MG 现货sigma D2521 Diltiazem 10G 现货sigma D4007 Phenytoin 500G 现货sigma D6270 1-(2,6-dichlorobenzyl-ideneamino)guanidine 100MG 现货sigma D9628 l-3,4-Dihydroxyphenyl-alanine 100G 现货sigma E6888 Enalapril Maleat 5G 现货sigma F4381 Furosemide 25G 现货sigma F8514 Flurbiprofen 25G 现货sigma F9677 Felodipine 25MG 现货sigma H0888 Hydrocortisone 10G 现货sigma H4759 Hydrochlorothiazide 100G 现货sigma I0899 Imipramine HCl 25G 现货sigma K1751 Ketoprofen 100G 现货sigma M5391 Metoprolol x 1/2 Tartrate 10G 现货sigma N144 Nitrendipine 500MG 现货sigma N7758 Naloxone 1G 现货sigma N8280 Naproxen 5G 现货sigma N9890 Norfloxacin 25G 现货sigma P0847 Piroxicam 10G 现货sigma P7412 Pirenzepine 1G 现货sigma Q3625 Quinidine 25G 现货sigma R101 Ranitidine 5G 现货sigma S0883 Sulfasalazine 100G 现货sigma S8010 Sulpiride 100G 现货sigma T1500 Testosterone 25G 现货sigma T2528 Terbutaline x 1/2 Tartrate 5G 现货sigma T69809 Trimethoxybenzamide HCl 100G 现货sigma V4629 Verapamil 10G 现货sigma E3763 Ethoxyresorufin 5MG 现货sigma A2500 Phenacetin 100G 现货sigma UC175 S-(+)Mephenytoin 5MG 现货sigma T1912 Paclitaxel 25MG 现货sigma UC214 S-Warfarin 10MG 现货sigma D6899 Diclofenac sodium salt 10G 现货sigma O104 Omeprazole 500MG 现货sigma D9684 Dextromethorphan hydrobromide 5G 现货sigma UC168 (±)-Bufuralol hydrochloride 10MG 现货sigma C4397 Chlorzoxazone 25G 现货sigma H24003 Umbelliferone 10G 现货sigma A7085 Acetaminophen 100G 现货sigma UC126 4-hydroxymephenytoin 5MG 现货sigma T2573 Troglitazone 5MG 现货sigma UC211 7-hydroxywarfarin 5MG 现货sigma H3661 4'-hydroxydiclofenac 1VL 现货sigma UC179 (R)-(?)-Nirvanol 5MG 现货sigma H147 Hydroxybufuralol maleate 2MG 现货sigma C188 6-Hydroxychlorzoxazone 5MG 现货sigma H2898 6β-Hydroxytestosterone 5MG 现货sigma M3501 8-Methoxypsoralen 1G 现货sigma S0758 Sulfaphenazole 1G 现货sigma C1240 Clomethiazole 10MG 现货sigma K1003 Ketoconazole 100MG 现货sigma T6514 Oleandomycin triacetate 1G 现货sigma D127 Dextrorphan tartrate 500MG 现货sigma Merck 580559 6alpha-OH-paclitaxel 5 mg 现货sigma N6505 NADPH (reduced form) 100 mg 现货sigma o3639 Ondansetron (7, 8) 50 mg 现货sigma UC448 Paracetamol 5 mg 现货sigma T5648 Tamoxifen (N-demethylation) 1g 现货sigma M4267 Mefenamic acid (3-methyl) 50g 现货sigma R2625 Retinoic acid (Tretinoin) 1g 现货sigma T0909 Tenoxicam (5') 1g 现货sigma T0781 Trimethadione (N-demethylation) 1g 现货sigma A8676 Alprenolol (Ar hydrox) 5g 现货sigma A8404 Amitryptyline 10 g 现货sigma C1290 Chlorpropamide 25 g 现货sigma C5270 Cinnarizine (Ar hydrox) 10g 现货sigma C7291 Clomipramine 5 g 现货sigma C6305 Clozapine 100 mg 现货sigma C5901 Codeine 1g 现货sigma D1306 Debrisoquine (4) 100 mg 现货sigma F6777 Flecainide 25 mg 现货sigma F8257 Flunarizine (Ar hydrox) 1 g 现货sigma i2909 Indoramin 10 mg 现货sigma M9651 Maprotiline 1g 现货sigma M1641 Methoxyphenamine 5g 现货sigma M2727 Mexiletine 25 g 现货sigma M3157 Minaprine 1g 现货sigma N7261 Nortriptyline 10g 现货sigma p3028 Perhexiline 5g 现货sigma p6402 Perphenazine 5g 现货sigma p7045 Phenformin 10g 现货sigma p4670 Propafenone 5g 现货sigma T9025 Thioridazine 5g 现货sigma A8423 Amiodarone (N-deethylation) 1 g 现货sigma B7777 Budesonide (6?) 250mg 现货sigma 46158 Dapsone (N) 250mg 现货sigma D5878 Digitoxin (oxidation) 1 g 现货sigma L8533 Lansoprazole (sulfoxyde-oxidation) 250 mg 现货sigma L7757 Lidocaine (N-deethylation) 25 g 现货sigma M2147 Lovastatin 25 mg 7 现货sigma N7634 Nifedipine (dihydropyridine) 5g 现货sigma S7507 Sulfamethoxazole (N) 10g 现货sigma T9772 Triazolam 10 mg 现货sigma N6505 Nicotinamide adenine dinucleotide phosphate 100 mg 现货sigma F6889 Famotidine 现货sigma C0378 Chloramphenicol 现货sigma T1633 Theophylline 现货sigma T1500 testosterone 现货sigma B9300 benzoicacid 现货sigma L1011 Labetalol hydrochloride 现货sigma S7507 Sulfamethoxazole 现货sigma B4144 Bromazepam 现货sigma D0899 Diazepam 现货sigma T7883 Trimethoprim 现货sigma Q1125 Quinine HCl 现货sigma D6899 Diclofenac sodium salt 现货sigma S0883 Sulfasalazine 现货sigma N144 Nitrendipine 现货sigma T9652 Terfenadine 现货sigma F9677 Felodipine 现货sigma N3889 Nitrazepam 现货sigma C4024 Carbamazepine 现货sigma C0750 Caffeine 现货sigma F4381 Furosemide 现货sigma K1751 Ketoprofen 现货sigma N9890 Norfloxacin 现货sigma C3045 Cholesterol 现货sigma G2878 Glycocholic acid hydrate 现货sigma P3556 L-α-Phosphatidylcholine 现货sigma D221104 Dodecane 现货sigma M8389 MOPSO 现货sigma FOR P450 inhibition 现货sigma N0505 NADP+ 现货sigma G7250 Glucose-6-phosphate 现货sigma G6378 G6PDH 现货sigma F-124 furafylline 现货sigma p8511 tranylcypromine 现货sigma UC455 CEC (3-cyano-7-ethoxycoumarin) 现货sigma F6377 Fluorescein 现货sigma 28605 CHC (3-cyano-7-hydroxycoumarin) 现货sigma L8533 Lansoprazole 现货sigma C4740 Cisapride 现货sigma N5757 alpha-naphthoflavone 现货sigma S6319 sertraline hydrochloride 现货sigma T6654 Ticlopidine hydrochloride 现货sigma 74437 Nootkatone 现货sigma 30024 Cyclosporin A 现货sigma 22530 Quinacrine 现货sigma B5016 Bepridil 现货sigma N149 Nimodipine 现货sigma F132 Fluoxetine 现货sigma M8046 Mifepristone 现货sigma 10798 Apigenin 现货sigma 0 2644 7-ethoxycoumarin 现货sigma M3512 Miconazole 现货sigma I4883 Ibuprofen 现货sigma F8929 Fluconazole 现货sigma 62630 Lobeline 现货sigma H1512 Haloperidol 现货sigma M2727 Mexiletine 现货sigma C6628 chloroquine 现货sigma D1306 Debrisoquine sulfate 现货sigma Q0125 Quercetin 现货sigma T0891 Tolbutamide 现货sigma 67580 4-Methylimidazole 现货sigma 4-methylpyrazole 现货sigma C6019 Clotrimazole 现货sigma A6424 Astemizole 现货sigma N7510 Nicardipine hydrochloride 现货sigma M5441 Mibefradil dihydrochloride hydrate 现货sigma I6657 Itraconazole 现货sigma B5774 Benzbromarone 现货sigma Fluvoxamine 现货sigma E4876 17α-Ethynylestradiol 现货sigma 01338 Bergamottin 现货sigma UC431 4-OH-midazolam 现货sigma n4505 500mg 现货sigma n1511 1g 现货sigma c5275-5mg concanavalin a form canavalia ensiformis 5mg 现货sigma a0937-1g norepinephrine bitartrate salt 1g 现货sigma c7527-100g Choline chloride cell culture tested 100g 现货sigma I6504-500mg Isoproterenol hydrochloride 500mg 现货sigma M5379-250mg L Methionine sulfoximine 250mg 现货sigma L9634-1g Laminarin from Laminaria digitata 1g 现货sigma F7131-100mg N 3 2 Furyl acryloyl]-Phe-Gly-Gly 100mg 现货sigma L8754-5mg Lectin from Phaseolus vulgaris (red kidney bean) Phytohemaggluti 5mg 现货sigma T5910-5g 2,3,5-Triiodobenzoic acid 5g 现货sigma E1253-100mg E1253 Estriol 100mg 现货sigma D9891-1G Doxycycline hyclate 1g 现货sigma F2878-100g Ficoll PM70 100g 现货sigma D5879-100ml D5879 DMSO 100ml 现货sigma I5879-100mg Isobutyl 1 methylxanthine 100mg 现货sigma D1756-25mg Dexamethasone 25mg 现货sigma I5500-50mg Insulin from bovine pancreas 50mg 现货sigma N5764-5g Nisin from Lactococcus lactis 2.5% 5g 现货sigma H1384-1g Hypotaurine 1g 现货sigma C7352-25g L-Cysteine 25g 现货sigma H3506-1g Hyaluronidase from bovine testes Type I-S, lyophilized 1g 现货sigma L4263-100ml Sodium DL lactate solution syrup 100ml 现货sigma B2261-25mg bisBenzimide H 33342 trihydrochloride 25mg 现货sigma D4263-5VL Deoxyribonuclease I from bovine pancreas Standardized vial 5VL 现货sigma a3307-5mg Sialyllactose sodium salt 5mg 现货sigma C9210-5g Cyanogen bromide activated Agarose lyophilized powder 5g 现货sigma S1782-0.2mg 3 Sialyl Lewis X tetrasaccharide 0.2mg 现货sigma c4805-5g b Cyclodextrin powder 5g 现货sigma D0627-25mg Dibutyryl cAMP 25mg 现货sigma S5265-25KU streptolysin 25KU 现货sigma R7256-100ml R7256 RPMI1640 100ml 现货sigma c8518-10g Cesium hydroxide hydrate 10g 现货sigma d95204-100g 100g 现货sigma c9253 Cholesteryl oleate ≥98%1g 现货sigma e6005-5g 现货sigma 15139 Bisphenol F bis(3-chloro-2-hydroxypropyl) ether 250mg 现货sigma 299537 Trifluoroacetic acid 100g 现货sigma 545201 Cucurbit[7]uril 100mg 现货sigma 545228 Cucurbit[8]uril 100mg 现货sigma T8949 Telmisartan 10mg 现货sigma D141 DigitoninSigma BSA 牛血清白蛋白A3912-10gSigma Cholesterol 胆固醇C8667-5g Sigma Indomethacin 吲哚美辛I7378-5gSigma Dexamethasone 地塞米松D1756-100mgSigma L-Ascorbic acid维生素C A4544-25GSigma insulin 牛胰岛素I5500-100mg Sigma Oil Red O 油红O O0625-25g Sigma LPS 脂多糖L2880-25mgSigma MTT 噻唑兰M2128-100mgSigma BrDu 溴脱氧尿嘧啶核苷B5002-500mg Sigma Proteinase K蛋白酶K P6556-25mg/100mgSigma Trypan Blue台盼蓝T6146-5gSigma Uracil 尿嘧啶U0750-5gSigma Thymidine 胸苷T9250-1gSigma L-Cysteine hydrochloride 半胱氨酸盐酸盐C1276-10G Sigma Ethambutol dihydrochloride E4630-25GSigma Phenol Red 酚红P3532-5GSigma Ethambutol dihydrochloride 盐酸乙胺丁醇E4630-25G Sigma Sodium tripolyphosphate 三聚磷酸钠238503-25G sigma Palmitic acid棕榈酸P5585-10Gsigma Levofloxacin左氧氟沙星28266-10G-Fsigma L-Tryptophan L-色氨酸T0254-1G。

一甲基澳瑞他汀 e 化学结构-概述说明以及解释

一甲基澳瑞他汀 e 化学结构-概述说明以及解释

一甲基澳瑞他汀e 化学结构-概述说明以及解释1. 引言1.1 概述一甲基澳瑞他汀(Simvastatin)是一种广泛应用于临床治疗高胆固醇血症和心血管疾病的药物。

它属于被称为他汀类药物的一员,是一种竞争性抑制HMG-CoA还原酶的药物,通过降低胆固醇的合成来达到降低血浆胆固醇的效果。

随着现代生活方式的改变和不良饮食习惯的普遍存在,高胆固醇血症在全球范围内变得越来越普遍。

该疾病不仅与心血管疾病的发展密切相关,还可能导致其他严重的健康问题,如动脉粥样硬化和心肌梗死等。

一甲基澳瑞他汀由黄曲霉属真菌产生,即通过天然发酵法生产得到。

然而,为了提高其药代动力学性质和治疗效果,科学家们通过改进和优化合成方法,合成了合成一甲基澳瑞他汀。

现在,一甲基澳瑞他汀已经成为一种被广泛研究和临床使用的药物。

在本篇文章中,我们将介绍一甲基澳瑞他汀的化学结构、合成方法、性质与用途等方面的内容。

通过深入了解一甲基澳瑞他汀,我们可以更好地理解它在治疗高胆固醇血症和心血管疾病方面的作用机制,并有望对该药物的未来发展提供一定的启示。

在接下来的章节中,我们将详细介绍一甲基澳瑞他汀的化学结构、合成方法以及它在临床上的广泛用途。

最后,我们将总结这篇文章的主要观点,并对一甲基澳瑞他汀的未来进行展望。

通过本文的阅读,读者将能够全面了解一甲基澳瑞他汀,为今后的相关研究和临床实践提供有益的指导与参考。

文章结构部分的内容如下:1.2 文章结构本文主要包含以下几个部分:引言、正文和结论。

引言部分通过概述一甲基澳瑞他汀的化学结构和合成方法,介绍背景知识和研究意义。

此外,本部分还会明确文章的目的,即对一甲基澳瑞他汀进行全面的分析和探讨。

正文部分将围绕一甲基澳瑞他汀展开讨论。

首先,我们将介绍一甲基澳瑞他汀的化学结构,包括其分子式、分子量等信息,并通过图表等形式直观地展示其结构。

其次,我们将详细介绍一甲基澳瑞他汀的合成方法,包括起始原料的选择、反应步骤和条件等。

美国Medchemexpress化合物库(小分子库)_Medchemexpress_(MCE中国)

美国Medchemexpress化合物库(小分子库)_Medchemexpress_(MCE中国)

美国Medchemexpress化合物库(小分子库)-原装进口,现货供
应,提供组合定制服务
品牌:Medchemexpress (MCE)
保存条件:-20℃
供应商:MCE中国
数量:大量
保质期:2年
Size:
Pre-dissolved DMSO/Solid(Or dry solid)
100 uL/well (10 mM solution)
200 uL/well (10 mM solution)
MedChemExpress (MCE)专注于各种抑制剂、调节剂、API、天然产物及化合物库,总部位于美国新泽西。

MCE经过十年努力已成为全球生物活性小分子领域的一流供应商。

MedChemExpress(MCE)产品涵盖近20个热门研究领域,1000多个细分靶点,超过3000个现货抑制剂、拮抗剂和激动剂。

相关的应用成果已发表于Nature、Cell等国际知名杂志,在全球20余个国家地区设有代理机构。

上海皓元生物医药科技有限公司(MCE 中国) 是MedChemExpress (MCE) 亚洲总代理。

MCE化合物库涵盖20余种不同的类型,超过2500个化合物,进口原装,
现货供应,提供详实的生物活性信息、化学结构信息、质控图谱(NMR和HPLC 等)。

还可根据您的实际研究需要,为您度身定制任意组合、规格、布板的特殊化合物库。

/screening-libraries.html
现有特色化合物库有:。

Maxacalcitol-D6__DataSheet_MedChemExpress

Maxacalcitol-D6__DataSheet_MedChemExpress

Product Name:Maxacalcitol-D6CAS No.:Product Data SheetCat. No.:HY-15329MWt:424.65Formula:C26H36D6O4Purity :>98%Solubility:Mechanisms:Biological Activity:Pathways:Vitamin D Related; Target:VD/VDR DMSOg y Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemicvitamin D3 analog and VDR ligand of VDR-like receptors.IC50 value:Target: Maxacalcitol (22-Oxacalcitriol)suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Maxacalcitol exhibits similar effects to calcitriol in osteoblast-like cells. Maxacalcitol(22-Oxacalcitriol) inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.References:[1]. Monier-Faugere et al 22-Oxacalcitriol suppresses secondary hyperparathyroidism withoutinducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.[2]. Barroga et al Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci.p y(2000)68 79.[3]. Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, Kusunoki Y, Takabatake Y,Hirata M, Nishiyama A, Tsubakihara Y, Isaka Y, Rakugi H.Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to b Invest. 2012 Aug27.[4]. Karashima T, Hashikawa K, Ono F, Eguchi H, Hamada T, Ishii N, Dainichi T, Yasumoto S,Tsuruta D, Hashimoto T.Successful Treatment of Bowen's Disease with Topical Maxacalcitol.ActaD...Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。

用于治疗肥胖症的邻苯二酚丁烷的释放的方法和组合物[发明专利]

用于治疗肥胖症的邻苯二酚丁烷的释放的方法和组合物[发明专利]

专利名称:用于治疗肥胖症的邻苯二酚丁烷的释放的方法和组合物
专利类型:发明专利
发明人:乔纳森·赫勒,尼尔·弗雷泽,张智川,伊莱恩·林,茹智·C·黄
申请号:CN200480021054.0
申请日:20040520
公开号:CN1852705A
公开日:
20061025
专利内容由知识产权出版社提供
摘要:本发明提供了用于治疗肥胖症的试剂盒、方法和组合物。

此处的该组合物含有一种基本上纯的至少一种邻苯二酚丁烷,包括,例如在一种制药学上可接受的载体或赋形剂中的NDGA化合物的制剂。

该邻苯二酚丁烷诸如NDGA或其衍生物被给药至一名或多名需要治疗的受试者。

申请人:埃里莫斯医药品有限公司,约翰霍普金斯大学
地址:美国德克萨斯州
国籍:US
代理机构:北京邦信阳专利商标代理有限公司
更多信息请下载全文后查看。

代谢检测试剂盒指南

代谢检测试剂盒指南

检测法 带有近红外荧光读数、比色或荧光读数的In-Cell ELISA 蛋白质印迹抗体混合(Cocktail) ICC 抗体混合(Cocktail) 流式抗体混合(Cocktail)
检测试剂盒 ab110217, ab110216, ab140359
ab123545 ab170194 ab168540
JC-1:ab113850
酶标仪、显微镜、590/520-570) 在高浓度下形成红色聚集物(未聚 JC-10 (比
检测法
读数
细胞外耗氧量
细胞内氧水平 糖酵解活性(细 胞外酸化)
备注
检测试剂盒
随着细胞呼吸,氧气浓度降低,染料信号将增强。油层 ab197243
将细胞与空气隔离。
染料扩散到细胞中。染料荧光被胞内氧淬灭。
ab197245
糖酵解过程中产生乳酸,导致胞外基质酸化。染料荧光 ab197244
随酸化而增加。
脂肪酸氧化 (FAO) 乳酸
图 4.使用 In-Cell ELISA 试剂盒 ab110217 评估 COX-1(线粒体 DNA 编码) 和 SDH-A(细胞核 DNA 编码)的相对量,进而评估氯霉素对线粒体生物合 成的抑制作用。
“我正在使用该试剂盒 [ab110217] 进行 500 多种化合物的高通量筛查。该试剂盒具有很高的可重现性,而且我没有观 察到任何批间差异。强烈推荐该试剂盒。” - Analeeb Sajid 博士
abcam
工具指南
代谢 检测试剂盒指南
用于酶标仪、显微镜和流式细胞仪的简 易、精细检测试剂盒
代谢是一个复杂的过程,也是生物学的核心。代谢异常会引发从癌症到神经退行性病变等一系列 后果。 我们的简易检测试剂盒可以简化您代谢方面的研究。使用酶标仪、显微镜或流式细胞仪上的读数 来分析活细胞、裂解液和生物体液。 检查: - 糖、脂、氨基酸、糖酵解和柠檬酸循环过程中的酶等 - 耗氧量、乳酸产生以及 ATP、NADH 和类似分子 - 线粒体与线粒体功能 - 氧化应激、ROS、抗氧化剂和相关细胞损伤

艾美捷总胆汁酸(TBA)测定试剂盒(酶循环法)说明书

艾美捷总胆汁酸(TBA)测定试剂盒(酶循环法)说明书

总胆汁酸(TBA)测定试剂盒(酶循环法)说明书【产品名称】总胆汁酸(TBA)测定试剂盒(酶循环法)【包装规格】a)试剂1:2×45mL 试剂2:2×15mL b)试剂1:4×60mL 试剂2:4×20mL c)试剂1:2×60mL试剂2:2×20mL【预期用途】用于体外定量测定人体血清中总胆汁酸的含量。

血清中TBA 水平升高见于急性病毒性肝炎、肝硬化、胆汁淤积性胆管炎、慢性活动性肝炎、酒精性肝炎、阻塞性黄疸、肝囊性纤维变性[1]。

【检验原理】胆汁酸被3α-HSD 及THIO-NAD 特异性的氧化,生成3-酮类固及还原型硫代辅酶Ⅰ(THIO -NADH )。

此外,生成的3-酮类固醇在3α羟基类固醇脱氢酶及还原型硫代辅酶Ⅰ(THIO -NADH )存在下,生成胆汁酸及氧化型硫代辅酶Ⅰ(THIO -NAD )。

如上述,据循环酶而放大微量的胆汁酸量,测定在单位时间内生成的还原型硫代辅酶Ⅰ在405nm 处的吸光度变化,可求得样本中总胆汁酸的含量。

【主要组成成分】试剂1主要组分磷酸氢二钠-柠檬酸缓冲液100mmol/L 氧化型硫代辅酶Ⅰ(THIO-NAD)950mg/L还原型辅酶(NADH)6g/L 聚氧乙烯油醇醚适量试剂2主要组分Tris 缓冲液100mmol/L 3α-羟基类固醇脱氢酶(3α-HSDH)12.5KU/L聚氧乙烯油醇醚适量注:不同批号试剂盒中各组分未经试验不可互换。

【储存条件及有效期】贮存于2~8℃,有效期为18个月,生产日期、有效期见标签。

【适用仪器】艾威德AS-420/AS-660/AS-1200;日立HITACHI 7020型/7060型/7180型/7600型/LABOSPECT 008AS 型;贝克曼AU400/AU480/AU640/AU680/AU2700/AU5400/AU5800/AU5811/AU5821;佳能TBA-FX8/TBA-120FR /TBA-2000FR ;罗氏cobas 8000c 702/cobas 8000c 701/cobas 8000c 502;西门子SIEMENS ADVIA 1800/ADVIA 2400;雅培ABBOTT ARCHITECT c8000/ARCHITECT c16000/ARCHITECT ci8200;西森美康SYSMEX BM6010/C ;科华KHB 卓越310/卓越330/卓越400/卓越450/ZY-1200/ZY-1280;迪瑞CS-240/CS-T300/CS-300B/CS-380/CS-400A/CS-400B/CS-600A/CS-600B/CS-800A/CS-800B/CS-1200/CS-1200ISE/CS-1300B/CS-1400;迈瑞MINDRAY BS-220/BS-330/BS-350E/BS-380/BS-390/BS-400/BS-430/BS-600/BS-800/BS-2000M ;颐兰贝ES-200/ES-380/ES-480;赛诺迈德SUNMATIK-9050型;雷杜Chemray 420;英诺华D280;特康TC6010L ;锦瑞GS400;普康6066。

Maxquant使用说明

Maxquant使用说明
包含修饰位点的多肽序列,修饰位点会标记在被修饰的氨基酸前面,修饰方式会以缩写的形式呈现出来,一般情况下,多肽会被下划线标记
Carbamidomethyl (C) Probabilities
半胱氨酸被烷基化的可能性:包含翻译后修饰的多肽可能出现修饰的可能性,其中概率为0—1其中1为最大,该列表示半胱氨酸烷基化的可能性
Label free norm param
用于label-free实验当中测定峰强度值的标准因素
Evidence
名称
分隔
描述说明
Sequence
鉴定出来的多肽的序列
Length
保存在sequence框内的序列长度
Modifications
在被鉴定的多肽上的转录后修饰
Modified sequence
Oxidation (M) Score Diffs
通过计算PTM添加到的那个位置以及没有PTM位点之间的差异计算,如果值为负,则说明其修饰的可能性近乎没有
Acetyl (Protein N-term)
发生在蛋白质N末端的乙酰化的数量
Carbamidomethyl (C)
发生在半胱氨酸上的烷基化修饰的数量
被二级质谱(测序)鉴定到的同位素序列的总数量
Isotope Patterns Sequenced (z>1)
被二级质谱(测序)鉴定到的同位素序列的总数量(电荷数>1)
Isotope Patterns Sequenced[%]
被二级质谱(测序)鉴定到的同位素序列的比例
Isotope Patterns Sequenced (z>1)[%]
Retention time calibration
Match time difference

Alda-1_DataSheet_MedChemExpress

Alda-1_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:Alda–1 is a potent ALDH2 agonist, which significantly improves ALDH2 activity.In Vivo: Alda–1 treatment results in a significant decrease of 4–HNE–protein content in the plasma of apoE -/- mice. Alda–1administration leads to a slight increase in gene expression related to neurogenesis (Nog ), mitochondrial biogenesis (CYTB , ND1),and apoptosis (Bax , Gsk3b ) in the Hp of apoE -/- mice. Alda–1 administration leads to 2 and 10 differentially expressed proteins in theFCx and Hp of apoE -/- mice, respectively [1]. Alda–1 (1.5 mg/kg, b.w., i.p.) administration significantly increases the climbing time,tends to reduce the immobility time and increases the swimming time of the prenatally stressed rats in the forced swim test.Moreover, treatment of prenatally stressed rats with Alda–1 significantly increases number of entries into the open arms of the maze and the time spent therein, as assessed by elevated plus–maze test [2]. Alda–1 (8.5 mg/kg, i.p.) with glucose significantly lowers 4–HNE and FJB–positive cells in the cerebral cortex of Alda–1–treated rats than in DMSO–treated rats 24 h after glucose administration [3]. Alda–1 (10 mg/kg per day) treatment prevents aldehydic overload, mitochondrial dysfunction and improves ventricular function in post–MI cardiomyopathy rats [4].PROTOCOL (Extracted from published papers and Only for reference)Cell Assay:[2]Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96–well plates at final volume of 0.2mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]–thymidine per well at 16 h before the end of the incubation.The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillationcounter.Animal Administration: Alda–1 is dissolved in 1 mL/kg b.w. DMSO/water 50/50.[2]After behavioral verification at three months of age,the animals are divided into the following four groups: control, control + Alda–1, prenatally stressed and prenatally stressed + Alda–1(6 animals per group). Alda–1 injections are given intraperitoneally (i.p.) once daily at a dose of 1.5 mg/kg b.w. (dissolved in 1 mL/kg b.w. DMSO/water 50/50) for 14 days. At the same time, the control and prenatally stressed rats receive 1 mL/kg b.w. DMSO/water 50/50. The injections of Alda–1 and vehicle are given between 10 a.m and 11 a.m. In the last five days of Alda–1 treatment the behavioral parameters in the elevated plus maze test and then in the forced swim test are measured.References:[1]. Stachowicz A, et al. Proteomic Analysis of Mitochondria–Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda–1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci.[2]. Stachowicz A, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda–1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016 Jan;51:144–53.Product Name:Alda–1Cat. No.:HY-18936CAS No.:349438-38-6Molecular Formula:C 15H 11Cl 2NO 3Molecular Weight:324.16Target:Aldehyde Dehydrogenase (ALDH)Pathway:Metabolic Enzyme/Protease Solubility:DMSO: ≥ 51 mg/mL[3]. Ikeda T, et al. Effects of Alda–1, an Aldehyde Dehydrogenase–2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e0128844.[4]. Gomes KM, et al. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post–myocardial infarction cardiomyopathy: benefits of Alda–1. Int J Cardiol. 2015 Jan 20;179:129–138.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

一种耐万古霉素肠球菌的多重荧光定量PCR检测试剂盒及其检测方法[发明专利]

一种耐万古霉素肠球菌的多重荧光定量PCR检测试剂盒及其检测方法[发明专利]

专利名称:一种耐万古霉素肠球菌的多重荧光定量PCR检测试剂盒及其检测方法
专利类型:发明专利
发明人:程伟,金大智
申请号:CN201410228321.7
申请日:20140527
公开号:CN103993089A
公开日:
20140820
专利内容由知识产权出版社提供
摘要:本发明涉及一种耐万古霉素肠球菌的多重荧光定量PCR检测试剂盒,所述试剂盒包括VanA 特异性引物、VanB特异性引物、VanA荧光探针、VanB荧光探针、PCR缓冲液、脱氧三磷酸核苷混合物、DNA聚合酶、VanA基因标准品序列、VanB基因标准品序列。

本发明的有益效果为:由于采用了PCR检测方法,能够做到准确、快速、定量的检测。

申请人:北京信科奥达科技有限公司
地址:100083 北京市海淀区清华东路东王庄39号院
国籍:CN
代理机构:北京同辉知识产权代理事务所(普通合伙)
代理人:赵慧
更多信息请下载全文后查看。

科研平台仪器介绍3

科研平台仪器介绍3

主要参数,
温度范围:(10)20℃-1000℃ 升温与降温速率:0-100K/min 冷却时间:10min(1000℃-100℃)
热重分析仪

号:Applied
Biosystems Stepone

地:新加坡
单价(万元):16.89
实时PCR扩增仪
突变检测分析系统

号:Bio-Rad Dcodel

地:美国
单价(万元):7.80
单通道电化学工作站

号:AutoLAB PGSTAT302N

地:荷兰
单价(万元):29.48
主要参数,
循环伏安最大扫速:250V/s 施加电位精度:设定±2mV±0.2% 施加电流分辨率:电流范围的0.03% 测量电流分辨率:电流范围的0.0003% 响应时间:<250ns 交流阻抗频率范围:10μHz-1MHz
扫描电子显微镜

号:Carl Zeiss EVO LS10

地:德国
单价(万元):167.00

号: TurboMatrix 16

地:美国
单价(万元):16.3 加热温度范围:35-210℃
顶空进样器

号:耐驰 TG209F1

地:德国
单价(万元):27.86

号:Biotek

地:美国
单价(万元):31.45
多功能酶标仪
全自动固相萃取仪

号:戴安AutoTrace 280

地:美国
单价(万元):40.24
快速溶剂萃取仪

号:戴安ASE 150

macrolactin a结构式 -回复

macrolactin a结构式 -回复

macrolactin a结构式-回复Macrolactin A是一种天然产物,它是由细菌Streptomyces sp. JCM3145产生的。

这种化合物具有复杂的结构,并在药物研究领域展示出巨大的潜力。

在这篇文章中,我将详细介绍macrolactin A的结构和合成过程,并探讨其在生物医学领域中的应用。

首先,让我们来研究一下macrolactin A的结构。

它是一种具有环状结构的大分子化合物,由多个亚基组成。

这些亚基主要包括糖部分、脂肪酸部分和稠合的内酯部分。

这种复杂的结构为其展现出一系列的生物活性奠定了基础。

接下来,让我们来探讨macrolactin A的合成过程。

由于其复杂的结构,这个化合物的合成过程并不简单。

然而,许多研究人员已经提出了一些有效的合成策略。

其中一种方法是利用天然存在的Streptomyces sp. JCM3145菌株通过发酵过程来产生macrolactin A。

这种方法相对简单并且能够得到高产量的产物。

另一种方法是通过化学合成来获得macrolactin A。

这个方法需要进行多步反应,但可以通过调节反应条件和反应物来获得所需的目标产物。

macrolactin A在生物医学领域中展示出广泛的应用潜力。

首先,它被发现具有抗菌和抗炎作用。

这使得它成为新型抗生素和抗炎药物的候选化合物。

其次,macrolactin A还具有抗肿瘤活性。

研究发现,它可以通过抑制肿瘤细胞的增殖和诱导细胞凋亡来抗击癌症。

这表明macrolactin A可能作为治疗癌症的新型药物。

此外,macrolactin A还被发现具有抗病毒和抗真菌的活性,这为研发新型抗感染药物提供了新思路。

然而,尽管macrolactin A具有如此多的生物活性和应用潜力,其合成成本和产量仍然是一个挑战。

因此,研究人员需要进一步改进其合成策略和提高产量,以满足其在临床应用中的需求。

总的来说,macrolactin A是一种具有复杂结构和广泛生物活性的天然产物。

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Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jun.-28-2017Print Date:Jun.-28-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MaxacalcitolCatalog No. :HY-32339CAS No. :103909-75-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:22–OxacalcitriolFormula:C26H42O4Molecular Weight:418.61CAS No. :103909-75-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

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