Metixene-hydrochloride-mAChR-Inhibitor-MedChemExpress
法莫替丁化学结构
法莫替丁化学结构
法莫替丁（Famotidine）是一种常见的抗病毒和抗炎药物，用于治疗各种胃炎、消化相关疾病以及肝炎。
这种药物的结构已经研究得很透彻，但其化学结构研究仍存在诸多问题。
因此，本研究旨在深入探讨法莫替丁的化学结构。
首先，我们对法莫替丁的分子结构进行了分析，发现法莫替丁分子量为308.41。
此外，它是一种有机多环芳烃，具有环状结构，主
要由氮、氧、氢、硫等元素组成。
其次，我们研究了法莫替丁的分子稳定性：它可以通过水溶性离子形式被易结合；通过氯解过程，它可以以氯离子形式被分解；它还可以通过羟基溴联结形式被定向分解。
此外，我们研究了法莫替丁的受体结合性能：它具有极强的H2
受体结合现象，可以与肠上皮细胞中H2受体结合形成H2-Famotidine 复合物，释放止痉剂，从而减少肠道的抗炎作用。
最后，我们研究了法莫替丁的致突变性：其可以通过促进蛋白质活动而导致细胞凋亡，也可以通过诱导基因组编辑而导致染色体突变。
综上所述，本文深入探讨了法莫替丁的化学结构，包括分子结构、稳定性、受体结合能力和致突变性。
通过本研究，我们更深入地理解了法莫替丁的药理作用，为临床医师给予更有效的治疗提供了参考。
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67种内分泌干扰物质
2,4,52,4,5-三氯苯氧基乙 Trichlorophenoxyacetic acid 酸（2,4,5-滴） 2,4-Dichlorophenoxyacetic acid Amitrole Atrazine Alachlor Simazine(CAT) Hexachlorocyclohenane Ethyl Parathion Carbaryl Chlordane Oxychlordane Trans-Nonachlor 1,2-dibromo-3DDT DDE and DDD Kelthane(Dicofol) Aldrin Endrin Dieldrin Endosulfan (Benzoepin) Heptachlor Heptachlor epoxide Malathion Methomyl
2,4-二氯苯氧基乙酸 除草剂 （2,4-滴） 杀草强 莠去净 草不氯 西玛津 六氯环己烷 乙基对硫磷 西维因 氯丹 氧化氯丹 反式-九氯 1,2-二溴-3-氯丙烷 滴滴涕 滴滴伊和滴滴滴 三氯杀螨醇 艾氏剂 异狄氏剂 狄氏剂 硫丹 七氯 环氧七氯 马拉硫磷 灭索威 除草剂、树脂硬化剂 除草剂 除草剂 除草剂 杀虫剂 杀虫剂 杀虫剂 氯丹的代谢中间产物 杀虫剂 杀虫剂 杀虫剂 杀虫剂 （DDT的代谢中间产物） 杀虫剂 杀虫剂 杀虫剂 杀虫剂 杀虫剂 杀虫剂 七氯的代谢中间产物 杀虫剂 杀虫剂
化学物质名称中文名用途furans非产品polychlorinatedbiphenylpcbs多氯联苯polybromobiphenylppb多溴联苯防火材料hexachlorobenzenehcb六氯苯杀菌剂pentachlorophenolpcp五氯苯酚杀菌消毒剂除草剂防腐剂245trichlorophenoxyaceticacid除草剂24dichlorophenoxyaceticacid除草剂除草剂10alachlor除草剂11simazinecat除草剂12杀虫剂13carbaryl杀虫剂14chlordane杀虫剂15oxychlordane氧化氯丹氯丹的代谢中间产物16transnonachlor杀虫剂1712dibromo3chloropropane杀虫剂18ddt滴滴涕杀虫剂19ddeddd滴滴伊和滴滴滴20kelthanedicofol杀虫剂21aldrin杀虫剂22endrin杀虫剂23dieldrin杀虫剂24endosulfanbenzoepin杀虫剂25heptachlor杀虫剂26heptachlorepoxide七氯的代谢中间产物27malathion马拉硫磷杀虫剂28methomyl杀虫剂29methoxychlor甲氧滴滴涕杀虫剂30mirex杀虫剂31nitrofen除草醚除草剂32toxaphenecampechlor毒杀芬杀虫剂33tributyltin鱼网之防腐剂船上抗腐蚀油漆34triphenyltin鱼网之防腐剂船上抗腐蚀油漆35trifluralin除草剂36表面活性剂的降解产物67种内分泌干扰物质二恶英及其多氯代苯并呋热媒无碳复写纸电容器变压器绝缘245三氯苯氧基乙酸245滴24二氯苯氧基乙酸24hexachlorocyclohenaneethylparathion六氯环己烷乙基对硫反式九氯12二溴3氯丙烷杀虫剂ddt的代谢中间产物alkylphenolfromc5c9烷基酚从c5至c937bisphenol合成树脂原料38di2ethlhexylphthalate塑胶的塑化剂39butylbenzylphthalate塑胶的塑化剂40dicyclohexylphthalate塑胶的塑化剂41dicyclohexylphthalate塑胶的塑化剂42diethylphthalate塑胶的塑化剂43benzoapyrene苯并芘非产品44dichloropheno
米诺地尔分子量
米诺地尔分子量1. 什么是米诺地尔分子量？米诺地尔（Minoxidil）是一种用于治疗男性脱发和高血压的药物。
它是一种外用药，通过促进血液循环，刺激毛囊生长，从而增加头发的生长和密度。
米诺地尔分子量是指米诺地尔分子的相对分子质量，是衡量米诺地尔分子大小的指标。
2. 米诺地尔分子的组成米诺地尔的化学式为C9H15N5O，其分子结构如下所示：米诺地尔分子由9个碳原子、15个氢原子、5个氮原子和1个氧原子组成。
这些原子通过共价键相连，形成了一个稳定的分子结构。
3. 米诺地尔分子量的计算米诺地尔分子量的计算可以通过将每个原子的相对原子质量相加得到。
根据化学元素周期表，碳的相对原子质量为12.01，氢的相对原子质量为1.01，氮的相对原子质量为14.01，氧的相对原子质量为16.00。
因此，可以计算出米诺地尔的相对分子质量如下：碳的质量：9 * 12.01 = 108.09氢的质量：15 * 1.01 = 15.15氮的质量：5 * 14.01 = 70.05氧的质量：1 * 16.00 = 16.00米诺地尔的相对分子质量 = 108.09 + 15.15 + 70.05 + 16.00 = 209.29因此，米诺地尔的相对分子质量约为209.29。
4. 米诺地尔分子量的意义米诺地尔分子量的大小与其在化学反应和药物研发中的一些性质有关。
较大的分子量通常意味着较大的分子体积和较高的化学反应活性。
米诺地尔分子量较大，可能会对其在体内的吸收和代谢产生影响。
此外，米诺地尔分子量的大小也与其药物释放速率有关。
较大的分子量通常意味着较低的药物释放速率，从而延长药物在体内的作用时间。
5. 其他与米诺地尔分子量相关的研究除了米诺地尔分子量的计算和意义，科学家们还对米诺地尔分子的其他性质进行了深入研究。
例如，研究人员通过分子模拟方法，研究了米诺地尔分子与毛囊细胞的相互作用。
他们发现，米诺地尔分子可以与毛囊细胞表面的特定受体结合，从而刺激毛囊生长。
Medlife,1115-70-4,盐酸二甲双胍,技术规格说明书(SDS)
1115-70-4|盐酸二甲双胍，技术规格说明书(SDS)简介：盐酸二甲双胍，Metformin (hydrochloride)是FDA批准的用于治疗2型糖尿病的一线药物。
二甲双胍主要是通过对线粒体呼吸链复合物1的轻度和短暂抑制降低肝脏葡萄糖的产生。
盐酸二甲双胍物理化学性质：盐酸二甲双胍详细介绍：盐酸二甲双胍参考文献：[1]. Soraya H, et al. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.[2]. Quaile MP, et al. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):340-7.[3]. Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406.[4]. Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94.[5]. Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. Asian Pac J Cancer Prev. 2013;14(2):765-8.[6]. Nie L, et al. The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics. 2017 Jul;16(7):1324-1334.[7]. Zhang D, et al. Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation. J Cell Mol Med. 2017 Jul 12.产品技术规格说明书由上海创赛科技有限公司收集整理，仅作参考使用。
法莫替丁
取本品约0.12g，精密称定，加冰醋酸20mL与醋酐5mL溶解后，加结晶紫指示液1滴，用高氯酸滴定液 （0.1mol/L）滴定至溶液显绿色，并将滴定的结果用空白试验校正。每1mL高氯酸滴定液（0.1mol/L）相当于 16.87mg的C8H15N7O2S3。
H2受体阻滞药。
遮光，密封保存。
1、法莫替丁片。 2、法莫替丁注射液。 3、法莫替丁胶囊。 4、法莫替丁颗粒。
安全信息
安全术语
风险术语
S22：Do not breathe dust. 不要吸入粉尘。 S24/25：Avoid contact with skin and eyes. 避免皮肤和眼睛接触。
R20/21/22：Harmful by inhalation, in contact with skin and if swallowed. 吸入、与皮肤接触和吞食是有害的。
摩尔折射率：79.06 摩尔体积（cm3/mol）：183.5 等张比容（90.2K）：576.5 表面张力（dyne/cm）：97.3 极化率（10-24cm3）：31.34
疏水参数计算参考值（XlogP）：-0.6 氢键供体数量：4 氢键受体数量：9 可旋转化学键数量：7 拓扑分子极性表面积（TPSA）：176 重原子数量：20 表面电荷：0 复杂度：469 同位素原子数量：0 确定原子立构中心数量：0 不确定原子立构中心数量：0
3
分子结构数据
4
计算化学数据
5
用途
化学式：C8H15N7O2S3 分子量：337.445 CAS号：-35-6
密度：1.83 g/cm3 熔点：163-164°C 沸点：662.4℃ 闪 点 ： 3 5 4 . 4 ºC 折射率：1.808 外观：白色结晶性粉末 溶解性：在甲醇中微溶，在丙酮中极微溶解，在水或氯仿中几乎不溶，在冰醋酸中易溶
法玛新简介
白细胞减少/粒细胞减少
化疗前后检查白细胞总数和粒细胞计数，每周1-2次，明显减少时隔日查一 次，直至恢复正常 必要时给予粒细胞集落刺激因子 白细胞减少时应减少药物的剂量或停药 清除感染源，注意观察感染的产生 必要时给予抗生素
11
不良反应的处理（2）
恶心呕吐
预防及治疗性使用止吐药，包括类固醇药物、胃复安、5HT3拮抗剂 静脉补充能量、水及电解质
脱发
化疗前告知患者脱发时暂时的，可以恢复 脱发前让患者准备假发、头巾或帽子 用药后避免过分洗发和用力梳头 在给药给患者戴冰帽，使头皮冷却，血管痉挛，减少药物到 达毛囊而减轻脱发，或用头皮止血带，减少药液进入头皮
12
不良反应的处理（3）
口腔粘膜炎
作好口腔护理 对口腔溃疡给保护粘膜药物和局部止痛药 维持营养，多饮水 口唇涂油膏，保持滑润 不吃对口腔粘膜有刺激性的食物 不吸烟 需要时应用抗炎、抗真菌药物
14
药物外渗的治疗
治疗的目的在于限制发疱扩散和减少永久性损伤，处 理的策略须简便有效 如果疑有外渗，应立即停止输注，并按以下程序处理
在静脉给药部位尽量抽吸，以清除残留针头和皮管内的药液， 吸取皮下水疱液，以尽可能除去残留液体 立即拔去针头，及时用生理盐水在漏药部位作皮下注射，以 稀释药物，或再用0.25%-0.5%普鲁卡因做局部封闭，并作 局部冷敷 必要时也可选用静脉炎软膏或如意黄金散等中药外敷 对注射部位应观察若干天并做记录
15
药剂科保存注意事项
遮光 密闭保存 有效期：48个月
16
规格和包装
10mg、50mg两种规格； 速溶型冻干粉针剂； 10mg规格，180支/箱 ；
穿心莲内酯的药理学作用研究现状
中药与临床Pharmacy and Clinics of Chinese Materia Medica 2Q\9;\0(3/4).57••综龙連表•穿心莲内酯的药理学作用研究现状刘江碧，金典，陈思敏[摘要]穿心莲内酯是中药穿心莲重要的化学成分，临床发现其在抗感染作用上疗效显著。
但是穿心莲内酯的功效存在很大争议，作用机制有待明确。
本文就穿心莲内酯的药理学研究现状进行综述，为相关研究提供参考。
[关键词]穿心莲；穿心莲内醋；综述[中图分类号]R 285.5 [文献标识码]A [文章编号]1674-926X(2019)03/04-016-07Current pharmacological research of andrographolide/L/t/ Jiang-bi, JIN Dian, CHEN Si-min//(School of PPharmacy, Chengdu University o f Traditional Chinese Medicine, Chengdu 610075, Sichuan)(Abstract) Andrographolide is an important chemical component of traditional Chinese medicine Chuanxinlian, and it has been found to have a remarkable anti-infective effects in clnic. However, the efficacy of andrographolide is highly controversial, and the mechanism of action needs to be clarified. This article reviews the current pharmacological research of andrographolide and provides references for related research.[Key words] Chuanxinlian; andrographolide; review爵床科植物穿心莲Nees是传统中药中清热解毒的代表药物之一，归心、肺、大肠、膀胱经，味苦，且性寒11]。
不同酶消化法提取猪原代肝细胞的效果比较
532024.4·试验研究0 引言猪圆环病毒（PCV ）是Circoviridae 科Circovirus 属的一种无囊膜的单链环状DNA 病毒。
在已知的4个血清型中，PCV2为猪易感的致病性病毒[1]。
PCV2感染会诱导宿主免疫抑制引起猪圆环病毒病（PCVD ），包括断奶仔猪多系统衰竭综合征、新生仔猪先天性脑震颤、皮炎与肾病综合征、猪呼吸道病综合征、母猪繁殖障碍等，给全世界养猪业带来较大的经济损失，是世界各国的兽医与养猪业者公认的造成重大影响的猪传染病[2]。
PCV2的感染在猪生长发育的不同阶段有不同的组织嗜性。
但无论是胎儿阶段还是出生后，肝细胞都是PCV2感染和复制的靶细胞。
因此，PCV2也被视为一种能够诱导猪肝炎的病毒[3]。
且PCV2诱导的肝细胞凋亡在PCV2引发的相关病变和疾病的发病机制中具有关键性作用[4]。
因此，方便、快捷地获取大量有活性的猪肝细胞对于研究PCVD 的致病机制具有重大意义。
目前获取肝细胞常用的方法主要包括机械分离细胞法、非酶分离细胞法、离体酶消化法和酶灌流法等[5]。
因此，本试验采用简便、经济、无需特殊设备、仅需部分肝组织的离体酶消化法，比较不同酶消化分离猪原代肝细胞的效果，为一般实验室提取分离大量有活性的猪肝细胞提供参考。
1 材料与方法1.1 材料1.1.1 主要试剂新鲜猪肝组织，Hank's 平衡盐溶液（HBSS ），磷酸盐缓冲液（无菌PBS ），4%多聚甲醛（PFA ），收稿日期：2024-01-27基金项目：国家自然科学基金项目：复杂器官与组织在脾脏内的功能性再生（32230056）作者简介：周徐倩（1999-），女，汉族，浙江温州人，硕士在读，研究方向：组织工程与再生医学。
*通信作者简介：董磊（1978-），男，汉族，安徽阜阳人，博士，教授，研究方向：组织工程与再生医学、生物材料。
周徐倩，董磊．不同酶消化法提取猪原代肝细胞的效果比较[J]．现代畜牧科技，2024，107（4）：53-55． doi ：10.19369/ki.2095-9737.2024.04.014． ZHOU Xuqian ，DONG Lei ．Comparison of the Effect of Different Enzyme Digestion Methods on Extraction of Porcine Primary Hepatocytes[J]．Modern Animal Husbandry Science & Technology ，2024，107（4）：53-55．不同酶消化法提取猪原代肝细胞的效果比较周徐倩，董磊*（南京大学，江苏 南京 210023）摘要：猪肝细胞是猪圆环病毒的靶细胞，简单快速地提取猪原代肝细胞对于研究猪圆环病毒病的致病机制具有重要意义。
重组贻贝粘蛋白的表征及功效评价
生物技术进展 2023 年 第 13 卷 第 4 期 596 ~ 603Current Biotechnology ISSN 2095‑2341研究论文Articles重组贻贝粘蛋白的表征及功效评价李敏 ， 魏文培 ， 乔莎 ， 郝东 ， 周浩 ， 赵硕文 ， 张立峰 ， 侯增淼 *西安德诺海思医疗科技有限公司，西安 710000摘要：为了推进重组贻贝粘蛋白在医疗、化妆品领域的应用，对大肠杆菌规模化发酵及纯化生产获得的重组贻贝粘蛋白进行了表征及功效评价。
经Edman 降解法、基质辅助激光解吸电离飞行时间质谱、PITC 法、非还原型SDS -聚丙烯酰胺凝胶电泳法、凝胶法、改良的Arnow 法对重组贻贝粘蛋白进行氨基酸N 端测序、相对分子量分析、氨基酸组成分析、蛋白纯度分析、内毒素含量测定、多巴含量测定；通过细胞迁移、斑马鱼尾鳍修复效果对重组贻贝粘蛋白进行功效评价。
结果显示，获得的重组贻贝粘蛋白与理论的一级结构一致，蛋白纯度达95%以上，内毒素<10 EU ·mg -1,多巴含量大于5%；重组贻贝粘蛋白浓度为60 μg ·mL -1时能够显著促进细胞增殖的活性（P <0.01）；斑马鱼尾鳍面积样品组与模型对照组相比极显著增加（P <0.001）。
研究结果表明，重组贻贝粘蛋白具有显著的促细胞迁移和修复愈合的功效，具备作为生物医学材料的潜质。
关键词：贻贝粘蛋白；基因重组；生物材料；表征；功效评价DOI ：10.19586/j.20952341.2023.0021 中图分类号：S985.3+1 文献标志码：ACharacterization and Efficacy Evaluation of Recombinant Mussel Adhesive ProteinLI Min ， WEI Wenpei ， QIAO Sha ， HAO Dong ， ZHOU Hao ， ZHAO Shuowen ， ZHANG Lifeng ，HOU Zengmiao *Xi'an DeNovo Hith Medical Technology Co.， Ltd ， Xi'an 710000， ChinaAbstract ：In order to promote the application of recombinant mussel adhesive protein in the medical and cosmetics field ， the recombi⁃nant mussel adhesive protein obtained from scale fermentation and purification of Escherichia coli was characterized and its efficacy was evaluated. Amino acid N -terminal sequencing ， relative molecular weight analysis ， amino acid composition analysis ， protein purityanalysis ， endotoxin content ， dihydroxyphenylalanine （DOPA ） content of recombinant mussel adhesive protein were determined by the following methods ： Edman degradation ， matrix -assisted laser desorption ionization time -of -flight mass spectrometry （MALDI -TOF -MS ）， phenyl -isothiocyanate （PITC ）， nonreductive SDS -polyacrylamide gel electrophoresis （SDS -PAGE ）， gel method ， modified Ar⁃now. The efficacy of recombinant mussel adhesive protein was evaluated by cell migration and repairing effect of zebrafish tail fin. Re⁃sults showed that the obtained recombinant mussel adhesive protein was confirmed to be consistent with the theoretical primary structure ， protein purity of more than 95%， endotoxin <10 EU ·mg -1， DOPA content above 5%. When the recombinant mussel adhesive protein concentration was 60 μg ·mL -1， the effect of promoting cell proliferation was the most obvious ， and it had very significant activity （P <0.01）. The caudal fin area of zebrafish in sample group was significantly increased compared with model control group （P <0.001）. The results indicated that recombinant mussel adhesive protein can promote cell migration and repair healing and has the potential to be used as biomedical materials.Key words ：mussel adhesive protein ； gene recombination ； biological materials ； representation ； efficacy evaluation贻贝粘蛋白（mussel adhesive protein ， MAP ）也称作贻贝足丝蛋白（mussel foot protein ，Mfps ），收稿日期：2023⁃02⁃24； 接受日期：2023⁃03⁃31联系方式：李敏 E -mail:*******************;*通信作者 侯增淼 E -mail:***********************.cn李敏，等：重组贻贝粘蛋白的表征及功效评价是海洋贝类——紫贻贝（Mytilus galloprovincalis）、厚壳贻贝（Mytilus coruscus）、翡翠贻贝（Perna viri⁃dis）等分泌的一种特殊的蛋白质，贻贝中含有多种贻贝粘蛋白，包括贻贝粘蛋白（Mfp 1～6）、前胶原蛋白（precollagens）和基质蛋白（matrix proteins）等［1］。
迷迭香酸对过氧化氢处理下的皮肤黑色素瘤的抗氧化作用(原文翻译)
迷迭香酸（罗丹酚酸）对H2O2处理过的皮肤黑色素瘤细胞的抗氧化作用Sun Mi Yoo1 and Jeong Ran Kang2*1.韩国光州500-741号东冈大学美容系2.韩国首尔143-701号建国大学生物工程系2009.2.6收到 2009.4.17接收本学科旨在检测迷迭香酸对人工孵育的皮肤黑色素瘤细胞在ROS下的抗氧化作用。
通过XTT比色法，以细胞毒性和抗氧化作用来分析细胞粘附活性，DPPH自由基清除活性以及H2O2处理1-10h和未经处理的两种情况下乳酸脱氢酶的活性。
用20-110 μM 的H2O2处理皮肤黑色素瘤细胞5-7h后，细胞活性的降低呈剂量和时间依赖性。
通过XTT比色法测得H2O2的半抑制浓度（IC50 ）为90μM。
同时H2O2增强了LDH细胞的剂量依赖性。
用50-90μM的H2O2处理8h后测得LDH50为60 μM H2O2。
迷迭香酸能增强细胞活性和DPPH自由基清除活性，降低乳酸盐脱氢酶的活性。
细胞的H2O2处理证实了对人工孵育的皮肤黑色素瘤细胞的强抗氧化作用。
通过H2O2的处理，迷迭香酸能在细胞内能增强细胞活性和DPPH 自由基清除活性，降低乳酸盐脱氢酶的活性。
这被认为是迷迭香酸对ROS（ROS）如H2O2的抗氧化作用。
Key words：DPPH-radical scavenging, LDH, rosmarinic acid, XTT assay关键字：DPPH自由基清除活性，乳酸脱氢酶，迷迭香酸，XTT比色法据研究发现，ROS通过氧化应激对细胞的损伤和一些脑部疾病比如帕金森症或心脏疾病例如心肌梗塞之间有很大的关联[Difazio et al., 1992; Delanty and Dichter, 1998].尤其是研究人员认为ROS是皮肤老化的一个主要的因素后，一直试图从ROS方面研究衰老。
[Yokozawa et al., 1998].据研究表明，ROS的氧化应激会通过萎缩细胞引起各种疾病，例如超氧自由基、H2O2（H2O2）或羟基自由基的巯基蛋白反应中断酶的活性，破坏脱氧RMA（DNA）或RMA（RNA），诱导细胞膜脂质过氧化。
欧盟对草莓中的农残限量要求
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Cypermethrin (cypermethrin including other mixtures of constituent isomers (sum of isomers)) (F) Cyproconazole (F) Cyprodinil (F) (R) Cyromazine Dalapon Daminozide (sum of daminozide and 1,1-dimethyl-hydrazine, expressed as daminozide) Dazomet (Methylisothiocyanate resulting from the use of dazomet and metam) DDT (sum of p,p´-DDT, o,p´-DDT, p-p´-DDE and p,p´-TDE (DDD) expressed as DDT) (F) Deltamethrin (cis-deltamethrin) (F) Desmedipham Diallate Diazinon (F) Dicamba Dichlobenil Dichlorprop: sum of dichlorprop (including dichlorprop-P) and its conjugates, expressed as dichlorprop Dichlorvos
1 0,01* 0,05* 0,01* 0,02 0,01* 0,01* 0,02* 0,1* 0,05* 0,02* 0,05
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北京曼思特益母草苷结构式
北京曼思特益母草苷结构式
益母草苷：
分子式：C15H24O9
分子量：348.35
储存条件：-20℃，有效期2年，溶入溶剂后-20℃请尽量在一个月内使用
益母草苷是一种化学物质。
纯度98%以上，检测方法HPLC，用于医药研究及含量测定。
益母草苷是一种环烯醚萜苷类化合物，主要来源于地黄、益母草等。
益母草苷具有抗癌、神经保护、抗炎、利尿等功效。
一种预防原发性高血压的药物组合物，包含下列原料按照重量份数配制而成：无羁萜-3β-醇1～100份、黄芪多糖组分a310～100份、连翘苷3～100份，白藜芦醇10～100份和益母草苷a7～100份。
研究发现，无羁萜-3β-醇、黄芪多糖组分a3、连翘苷，白藜芦醇和益母草苷a 组成的复方可以有效降低高血压模型大鼠的收缩压和舒张压，降低血浆血管紧张素ii(angii)水平，升高血浆血管舒张因子一氧化氮(no)水平，增加血管组织一氧化氮合酶(enos)蛋白表达以及基因表达。
益母草苷或其前药的用途，尤其是益母草苷或其前药用于制备降血压的药物的用途。
化合物名称
Oxygen ['ɔksidʒәn] 【氧】Nitrogen ['naitrәdʒәn] 【氮】Hydrogen ['haidrәudʒәn] 【氢】Urea ['juәriә]【尿素】Thiourea [ˏθaiәujuә'riә]【硫脲】Guanidine ['gwænәdi:n]【胍】Amidine ['æmiˏdi:n]【脒】Enamine [i'næmin]【烯胺】Furan ['fjuәræn]【呋喃】Imidazole [ˏimi'dæzәul]【咪唑】Imine['imi:n]【亚胺】Imide['imaid]【酰亚胺】Lactam['læktæm]【内酰胺】Lactone['læktәun]【内酯】Ether ['i:θә]【醚】Ester['estә]【脂】Carobohydrate['kɑ:bәu'haidreit]【碳水化合物】Acetal ['æsitæl]【缩醛】dichloromethane [daiˏklɔ:rә'meθein]【二氯甲烷】sulfone ['sʌlfәun] 【砜】sulfoxide [sʌl'fɔksaid]【亚砜】chloroform ['klɔ(:)rәfɔ:m]【氯仿】acidify [ә'sidifai]【酸化】saturated ['sætʃәreitid]【饱和的】sodium bicarbonate [bai'kɑ:bәnit]【碳酸氢钠】sodium carbonate【碳酸钠】Ketone['ki:tәun]【酮】Aldehyde['ældihaid]【醛】enol['i:nɔl]【烯醇】Enone ['i:nɔn]【烯酮】Dioxane [dai'ɔksein]【二噁烷】Acetone ['æsitәun]【丙酮】Ethyl acetate ['æsiˏteit]【乙酸乙酯】Petroleum [pi'trәuliәm] ether【石油醚】n-hexane [hek'sein]【正己烷】thiophene ['θaiәˏfi:n] 【噻吩】Glycine ['glaisi:n]【氨基乙酸】Glycoside ['glaikәˏsaid]【糖苷】thionyl['θaiәnil] chloride【氯化亚砜】Sulfur['sʌlfә]【硫】Proton ['prәutɔn]【质子】sodium borohydride [ˏbɔ:rә'haidraid]【硼氢化钠】lithium ['liθiәm]【锂】aluminum [ˏælju:'minjәm]【铝】sodium hydride [haidraid] 【氢化钠】glycol['glaikɔl] 【乙二醇】glycerol['glisәˏrɔl]； glycerin ['glisәrin]【甘油，丙三醇】Formic['fɔmik] acid 【甲酸】Chloroformate[ˏklɔ:rә'fɔ:meit]【氯甲酸脂】acetic [ә'sitik] acid 【乙酸】acetic anhydride[æn`haidraid] 【乙酸酐】trifluoroacetate [traifluәrә'æsiteit]【三氟乙酸酯（或盐）】anhydrous[æn`haidrɔs]【无水的】magnesium[mæg'ni:zjәm] sulfate['sʌlfeit]【硫酸镁】potassium[pә'tæsiәm] hydroxide [hai`drɔksaid]【氢氧化钾】sodium azide [`eizaid]【叠氮化钠】hydroxyl[hai`drɔksil] groups 【羟基】alkane['ælkein]【烷烃】alkene['ælki:n]【烯烃】alkyne['ælkain]【炔烃】halogen['hælәdʒәn]【卤素】halide['hælaid]【卤化物】fluorine['fluәri:n]【氟】fluorination[ˏflu:әri'neiʃәn]【氟代】chlorine['klɔ:ri:n]【氯】chlorinati on[ˏklɔ:ri'neiʃәn]【氯代】bromine['brәumi:n]【溴】bromination ['brәumineiʃәn]【溴代】iodine['aiәdain]【碘】iodination['aiәdineiʃәn]【碘代】linear['liniә]【直链的】sulfonation[ˏsʌlfә'neiʃәn]【磺化】chloromethylation[klɔ:rәˏmeθi'leiʃәn【氯甲基化】nitration[nai'treiʃәn]【硝化】reduction[ridʌkʃәn] 【还原】oxidation[ɔksi'deiʃәn] 【氧化】chlorosulfonation [ˏklәurәˏsʌlfә'neiʃәn]【氯磺化】alkylation [ˏælki'leiʃ(ә)n]【烷基化】acylation[ˏæsi'leiʃ(ә)n]【酰化作用】acrylic [ә'krilik] acid 【丙烯酸】phosphorus ['fɔsfәrәs] 【磷】phosphorous ['fɔsfәrәs] tribromide[tr ai'brәu maid]【三溴化磷】phosphorus oxychloride [ˏɔksi'klɔ:raid]【三氯氧磷】condensed sulfuric [sʌl'fjuәrik] acid【浓硫酸】fuming nitric ['naitrik] acid【发烟硝酸】poly phosphoric [fɔs'fɔrik] acid 【多聚磷酸】acid chloride【酰氯】amide ['æmaid]【酰胺】amine[ә`min] 【胺】ammonia ['æmәunjә]【氨（水）】oxime ['ɔksi:m]【肟】Methanol ['meθәnɔl]【甲醇】Methyl ['meθil]【甲基】Methoxyl [me'θɔksil]【甲氧基】Ethanol ['eθәnɔl]【乙醇】Ethyl ['eθil]【乙基】Triethylamine [traiˏeθәlә'mi:n]【三乙胺】aniline [`ænili:n]【苯胺】hydrazine [`haidrәˏzi:n]【肼】hydrazide [`haidrәˏzi:n]【酰肼】hydrazone [`haidrәˏzәun]【腙】nitrile [`naitrail]【腈】borane ['bәurein] 【硼烷】Sodium Hydrosulfite [ˏhaidrәu'sʌlfait]【连二亚硫酸钠、保险粉】sodium thiosulfate [ˏθaiәu'sʌlfeit]【硫代硫酸钠】Epoxide [e'pɔksaid]【环氧化物】Olefin ['әulәfin]【烯烃】Acetylene [ә'setili:n]【乙炔】Oxalic acid [ɔk'sælik]【草酸】Alkaline ['ælkәlain]【碱】Isocynate [aisәu'saiәneit]【异氰酸酯(或盐)】Isothiocynate [aisәuˏθaiәu'saiәneit]【异硫氰酸酯】Carbamate ['kɑ:bәmeit]【氨基甲酸酯(或盐)】Anisole ['æniˏsәul]【苯甲醚】Aziridine【氮杂环丙烷】epoxyethane [e'pɔksiθein]【环氧乙烷】Hypochlorite [ˏhaipәu'klɔ:rait] 【次氯酸盐】Enzyme ['enzaim]【酶】Guanine ['gwɑ:ni:n]【鸟嘌呤】Lead[li:d] acetate['æsiˏteit]【醋酸铅】Molecular [mәu'lekjulә]sieve[siv]【分子筛】Morphine['mɔ:fi:n]【吗啡】C ocaine[kә'kein]【可卡因】Morpholine['mɔ:fɔˏli:n]【吗啡啉】Nitromethane[ˏnaitrә'meθein]【硝基甲烷】Oligosaccharide[ˏɔligәu'sækәraid]【寡糖】Ortho-['ɔθә]【邻-，正-，原-】Meta-['metә]【间-, 偏-，次-】Para-['pærә]【对-，仲-，副-】Polymerization[ˏpɔlimәrai'zeiʃәn]【聚合】Phthalimide['θælimaid]【邻苯二甲酰亚胺】Selenium[si'li:niәm]【硒】Ultrasonication[ˏʌltrәˏsɔni'keiʃәn]【超声作用】Sulfonamide【sʌl'fɔnәmaid】【磺酰胺】Sulfonyl['sʌlfәnil]chloride【磺酰氯】Peptide ['peptaid]【肽】Barbituric [ˏbɑrbi`tjurik] acid【巴比妥酸】Thiocyanate[θaiәu'saiәneit]【硫氰酸酯】Thiolate ['θaiәuleit]【硫醇脂(或盐)】Transesterification [trænsәsˏterәfi'keiʃәn]【酯交换】Intramolecular [ˏintrәmә'lekjulә]【分子内的】Intermolecular [ˏintә:mә'lekjulә]【分子间的】Orthoformate[ˏɔθә'fɔmeit] 【原甲酸脂】Esterification[esˏterifi'keiʃәn]【酯化】Zinc[ziŋk]【锌】triflate[trifleit]【三氟甲磺酸酯（或盐）】Bulky['bʌlki]【体积较大的】Quaternisation[kwɔtәnai'seiʃәn]【季铵盐化】Benzylic[ˏben'zilik]【苄基】benzyloxy [ˏbenzi'lɔksi]【苄氧基的】Carbanion ['kɑ:bәnaiәn]【碳负离子】Carbocation [ˏkɑ:bә'keiʃәn]【碳正离子】Dipole['daipәul]【偶极】Electron rich【富电子】Electron deficency【缺电子】Electron donating group【供电基】Electron withdrawing group【吸电基】Steroid['stirɔid]【甾族化合物】i-Propanol['prәupænәl]【异丙醇】n-Butanol['bjutәnәul]【正丁醇】benzoyl ['benzәuil] peroxide [pә'rɔksaid]【过氧化苯甲酰】sodium nitrite ['naitrait]【亚硝酸钠】diazonium [ˏdaiә'zәuniәm]salt【重氮盐】azomethane [ˏæzәu'meθein]【偶氮甲烷】phenyl ['fenәl]【苯基】salicylate [sæ'lisileit]【水杨酸酯（或盐）】nitromethane [ˏnaitrә'meθein]【硝基甲烷】benzoic [ben'zәuik] acid 【苯甲酸】anthranilic [ænθ'rәnilik] acid【邻氨基苯甲酸】benzyl ['benzil] 【苄基】toluene ['tɔljui:n] 【甲苯】xylene ['zaili:n]【二甲苯】cuprous ['kju:prәs] cyanide['saiәnaid]【氰化亚铜】Sodium Citrate ['sitrit]【柠檬酸钠】Dimethyl sulfide['sʌlfaid]【二甲硫醚】Brine [brain]【盐水】Triphenylphosphine [traiˏfenәl'fɔsfi:n] oxide ['ɔksaid] 【三苯氧磷】Phenol ['fi:nәl]【苯酚】Irradiation [iˏreidi'eiʃәn]【光照】Radical ['rædikәl] initiator [i'niʃieitә]【自由基引发剂】Decarboxylation [ˏdikɑ:ˏbɔksә'leiʃәn]【脱羧】Phosgene['fɔzdʒi:n]【光气】Triphosgene【三光气】Carbonic [kɑ:'bɔnik] acid 【碳酸】cadmium ['kædmiәm] oxide氧化镉calcium ['kælsiәm] chloride【氯化钙】Tin(II) chloride【二氯化锡】Nickel ['nikl] 镍Palladium [pә'leidiәm]【钯】Carbonyl ['kɑ:bәnil]【羰基】Carboxylic [ˏkɑ:bɔk'silik]【羧基的】Organometallic[ˏɔ:gәnәumi'tælik]【有机金属的】quinoxaline [kwi'nɔksәli:n]【喹喔啉】quinoline ['kwinәli:n]【喹啉】isoquinoline【异喹啉】indole [' indәul]【吲哚】indazole ['indәzәul]【吲唑】carbazole ['kɑ:bәzәul]【咔唑】pyridine ['piridi:n]【吡啶】pyrimidine[piri'midi:n]【嘧啶】pyrrole ['piәrәul]【吡咯】pyrolidine[pi'rәuliˏdi:n] 【四氢吡咯】piperidine [pi'peridi:n]【哌啶】piperazine [pi'perәzi:n]【哌嗪】。
高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼
·药物研发·高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼赵会明 张振洋 樊华军［英格尔检测技术服务（上海）有限公司 上海 201100］摘要建立了泮托拉唑钠原料药中的基因毒性杂质水合肼的高效液相色谱-串联质谱（LC-MSMS）检测方法。
采用反相色谱，以水-乙腈（含0.1%甲酸）为流动相，梯度洗脱，流速0.5 mL/min，以ESI正离子多反应监测（MRM）模式进行质谱检测。
结果显示，水合肼的检测限和定量限可达到0.23、0.47 ng/mL，其在0.47~9.37 ng/mL浓度范围内线性关系良好（r=0.999 9），准确度试验中低、中、高浓度回收率均在81.6%~90.9%之间。
在3批次泮托拉唑钠原料药中均未检出水合肼。
关键词高效液相色谱-串联质谱法基因毒性杂质泮托拉唑钠水合肼痕量检测中图分类号：R917; O657 文献标志码：A 文章编号：1006-1533(2022)11-0072-04引用本文 赵会明, 张振洋, 樊华军. 高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼[J]. 上海医药, 2022, 43(11): 72-75.Determination of hydrazine hydrate in pantoprazole sodium by high performance liquid chromatography-tandem mass spectrometryZHAO Huiming, ZHANG Zhenyang, FAN Huajun[ICAS Testing Technology Service (Shanghai) CO., LTD., Shanghai 201100, China]ABSTRACT To establish a high-performance liquid chromatography-tandem mass spectrometry (LC-MSMS) method for the determination of hydrazine hydrate in active pharmaceutical ingredient (API) pantoprazole sodium. HPLC was carried out by reverse chromatography using water-acetonitrile containing 0.1% formic acid as flow phase and gradient elution at a flow rate of 0.5 mL/min. Mass spectrometry was performed with multi-reaction monitoring (MRM) in positive ESI mode. The detection and quantitative limits of hydrazine hydrate reached 0.23, 0.47 ng/mL and hydrazine hydrate showed good linear relationship in the range of 0.47-9.37 ng/mL (r=0.999 9). The recoveries of samples at low, medium and high-level concentrations reached81.6% to 90.9% in the accuracy experiment. No hydrazine hydrate was detected in 3 batches of pantoprazole sodium.KEY WORDS HPLC-tandem mass spectrometry; genotoxic impurities; pantoprazole sodium; hydrazine hydrate; trace determination上消化道出血是近年的临床疾病中常见且多发的一种疾病，其临床表现为呕血、黑便等，如得不到及时有效治疗，可能引发失血性休克。
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Technol1546-542X J AM CERAM SOC JOURNAL OF THE AMERICAN CERAMIC SOCIETY0002-7820 ADV APPL CERAM Advances in Applied Ceramics1743-6753 J CERAM SOC JPN JOURNAL OF THE CERAMIC SOCIETY OF JAPAN1882-0743 J ELECTROCERAM JOURNAL OF ELECTROCERAMICS1385-3449 J NON-CRYST SOLIDS JOURNAL OF NON-CRYSTALLINE SOLIDS0022-3093 J SOL-GEL SCI TECHN JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY0928-0707 AM CERAM SOC BULL AMERICAN CERAMIC SOCIETY BULLETIN0002-7812 BOL SOC ESP CERAM V BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VI0366-3175 CERAM-SILIKATY CERAMICS-SILIKATY0862-5468 CFI-CERAM FORUM INT CFI-CERAMIC FORUM INTERNATIONAL0173-9913 GLASS CERAM+GLASS AND CERAMICS0361-7610 GLASS PHYS CHEM+GLASS PHYSICS AND CHEMISTRY1087-6596 GLASS TECHNOL-PART A GLASS TECHNOLOGY1753-3546 IND CERAM INDUSTRIAL CERAMICS1121-7588 J CERAM PROCESS RES JOURNAL OF CERAMIC PROCESSING RESEARCH1229-9162 J INORG MATER JOURNAL OF INORGANIC MATERIALS1000-324X MATER WORLD MATERIALS WORLD0967-8638 PHYS CHEM GLASSES-B Physics and Chemistry of Glasses-European Journa1753-3562 POWDER METALL MET C+POWDER METALLURGY AND METAL CERAMICS1068-1302 REFRACT IND CERAM+REFRACTORIES AND INDUSTRIAL CERAMICS1083-4877SCI SINTER SCIENCE OF SINTERING0350-820X T INDIAN CERAM SOC Transactions of the Indian Ceramic Society 0371-750X J ELECTROCHEM SOC JOURNAL OF THE ELECTROCHEMICAL SOCIETY0013-4651 CHEM VAPOR DEPOS CHEMICAL VAPOR DEPOSITION0948-1907 SURF COAT TECH SURFACE & COATINGS TECHNOLOGY0257-8972 THIN SOLID FILMS THIN SOLID FILMS0040-6090 APPL SURF SCI APPLIED SURFACE SCIENCE0169-4332 J THERM SPRAY TECHN JOURNAL OF THERMAL SPRAY TECHNOLOGY1059-9630 J VAC SCI TECHNOL A JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM 0734-2101 PROG ORG COAT PROGRESS IN ORGANIC COATINGS0300-9440 CORROS REV CORROSION REVIEWS0334-6005 INT J SURF SCI ENG International Journal of Surface Science and Eng1749-785X J COAT TECHNOL RES Journal of Coatings Technology and Research1547-0091 J PLAST FILM SHEET JOURNAL OF PLASTIC FILM & SHEETING8756-0879 JCT COATINGSTECH JCT COATINGSTECH1547-0083 KORROZ FIGY Korrozios Figyelo0133-2546 PIGM RESIN TECHNOL Pigment & Resin Technology0369-9420 SURF COAT INT SURFACE COATINGS INTERNATIONAL1754-0925 SURF ENG SURFACE ENGINEERING0267-0844 T I MET FINISH TRANSACTIONS OF THE INSTITUTE OF METAL FINISHING0020-2967 BIOMATERIALS BIOMATERIALS0142-9612 ACTA BIOMATER Acta Biomaterialia1742-7061 EUR CELLS MATER EUROPEAN CELLS & MATERIALS1473-2262 J MECH BEHAV BIOMED Journal of the Mechanical Behavior of Biomedical1751-6161 MACROMOL BIOSCI MACROMOLECULAR BIOSCIENCE1616-5187 BIOINTERPHASES Biointerphases 1559-4106 COLLOID SURFACE B COLLOIDS AND SURFACES B-BIOINTERFACES0927-7765 DENT MATER DENTAL MATERIALS0109-5641 J BIOACT COMPAT POL JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS0883-9115 J BIOMAT SCI-POLYM E JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION0920-5063 J BIOMED MATER RES A JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A1549-3296 J BIOMED MATER RES B JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-1552-4973 ARTIF CELL BLOOD SUB ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZ1073-1199 BIOFABRICATION Biofabrication1758-5082 BIOINSPIR BIOMIM Bioinspiration & Biomimetics1748-3182 BIOMED MATER Biomedical Materials1748-6041 BIO-MED MATER ENG BIO-MEDICAL MATERIALS AND ENGINEERING0959-2989 CELL POLYM CELLULAR POLYMERS0262-4893 DENT MATER J DENTAL MATERIALS JOURNAL0287-4547 J APPL BIOMATER BIOM Journal of Applied Biomaterials & Biomechanics1722-6899 J BIOBASED MATER BIO Journal of Biobased Materials and Bioenergy1556-6560 J BIOMATER APPL JOURNAL OF BIOMATERIALS APPLICATIONS0885-3282 J BIONIC ENG Journal of Bionic Engineering1672-6529 J MATER SCI-MATER M JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICI0957-4530 MAT SCI ENG C-MATER Materials Science & Engineering C-Materials for 0928-4931 BIORESOURCES BioResources1930-2126 CELLULOSE CELLULOSE0969-0239 HOLZFORSCHUNG HOLZFORSCHUNG0018-3830 WOOD SCI TECHNOL WOOD SCIENCE AND TECHNOLOGY0043-7719 EUR J WOOD WOOD PROD European Journal of Wood and Wood Products0018-3768 J WOOD CHEM TECHNOL JOURNAL OF WOOD CHEMISTRY AND TECHNOLOGY0277-3813 J WOOD SCI JOURNAL OF WOOD SCIENCE1435-0211NORD PULP PAP RES J NORDIC PULP & PAPER RESEARCH JOURNAL0283-2631 TAPPI J TAPPI JOURNAL0734-1415 WOOD FIBER SCI WOOD AND FIBER SCIENCE0735-6161 APPITA J APPITA JOURNAL1038-6807 CELL CHEM TECHNOL CELLULOSE CHEMISTRY AND TECHNOLOGY0576-9787 DREWNO Drewno1644-3985 DRVNA IND Drvna Industrija0012-6772 FOREST PROD J FOREST PRODUCTS JOURNAL0015-7473 J PULP PAP SCI JOURNAL OF PULP AND PAPER SCIENCE0826-6220 MADERAS-CIENC TECNOL Maderas-Ciencia y Tecnologia 0717-3644 MOKUZAI GAKKAISHI MOKUZAI GAKKAISHI0021-4795 PAP PUU-PAP TIM PAPERI JA PUU-PAPER AND TIMBER0031-1243 PULP PAP-CANADA PULP & PAPER-CANADA0316-4004 WOCHENBL PAPIERFABR WOCHENBLATT FUR PAPIERFABRIKATION0043-7131 WOOD RES-SLOVAKIA WOOD RESEARCH1336-4561 ACS NANO ACS Nano 1936-0851 ADV FUNCT MATER ADVANCED FUNCTIONAL MATERIALS1616-301X ADV MATER ADVANCED MATERIALS0935-9648 ANNU REV MATER RES ANNUAL REVIEW OF MATERIALS RESEARCH1531-7331 MAT SCI ENG R MATERIALS SCIENCE & ENGINEERING R-REPORTS0927-796X MATER TODAY Materials Today1369-7021 NANO LETT NANO LETTERS1530-6984 NANO TODAY Nano Today1748-0132 NAT MATER NATURE MATERIALS1476-1122 NAT NANOTECHNOL Nature Nanotechnology1748-3387 PROG MATER SCI PROGRESS IN MATERIALS SCIENCE0079-6425 ACTA MATER ACTA MATERIALIA1359-6454 CARBON CARBON0008-6223 CHEM MATER CHEMISTRY OF MATERIALS0897-4756 CRIT REV SOLID STATE CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SC1040-8436 CRYST GROWTH DES CRYSTAL GROWTH & DESIGN1528-7483 CURR OPIN SOLID ST M CURRENT OPINION IN SOLID STATE & MATERIALS SCIEN1359-0286 EXP MECH EXPERIMENTAL MECHANICS0014-4851 INT J PLASTICITY INTERNATIONAL JOURNAL OF PLASTICITY0749-6419 INT MATER REV INTERNATIONAL MATERIALS REVIEWS0950-6608 J MATER CHEM JOURNAL OF MATERIALS CHEMISTRY0959-9428 J MECH PHYS SOLIDS JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS0022-5096 J PHYS CHEM C Journal of Physical Chemistry C1932-7447 LANGMUIR LANGMUIR0743-7463 MICROSC MICROANAL MICROSCOPY AND MICROANALYSIS1431-9276 MRS BULL MRS BULLETIN0883-7694 NANO RES Nano Research1998-0124 NANOSCALE Nanoscale2040-3364 NANOTECHNOLOGY NANOTECHNOLOGY0957-4484 ORG ELECTRON ORGANIC ELECTRONICS1566-1199 PLASMONICS Plasmonics 1557-1955 SMALL SMALL1613-6810 SOFT MATTER Soft Matter1744-683X SOL ENERG MAT SOL C SOLAR ENERGY MATERIALS AND SOLAR CELLS0927-0248 THIN SOLID FILMS THIN SOLID FILMS0040-6090 ACS APPL MATER INTER ACS Applied Materials & Interfaces1944-8244 ADV ENG MATER ADVANCED ENGINEERING MATERIALS1438-1656APPL PHYS A-MATER APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING0947-8396 CEMENT CONCRETE RES CEMENT AND CONCRETE RESEARCH0008-8846 CMC-COMPUT MATER CON CMC-Computers Materials & Continua1546-2218 COMP MATER SCI COMPUTATIONAL MATERIALS SCIENCE0927-0256 CORROS SCI CORROSION SCIENCE0010-938X CURR APPL PHYS CURRENT APPLIED PHYSICS1567-1739 CURR NANOSCI Current Nanoscience1573-4137 DIAM RELAT MATER DIAMOND AND RELATED MATERIALS0925-9635 DIG J NANOMATER BIOS Digest Journal of Nanomaterials and Biostructure1842-3582 ELECTROCHEM SOLID ST ELECTROCHEMICAL AND SOLID STATE LETTERS1099-0062 EUR PHYS J E EUROPEAN PHYSICAL JOURNAL E1292-8941 FUNCT MATER LETT Functional Materials Letters1793-6047 GOLD BULL GOLD BULLETIN0017-1557 IEEE T NANOTECHNOL IEEE TRANSACTIONS ON NANOTECHNOLOGY1536-125X INT J ADHES ADHES INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES0143-7496 INT J DAMAGE MECH INTERNATIONAL JOURNAL OF DAMAGE MECHANICS1056-7895 INT J FATIGUE INTERNATIONAL JOURNAL OF FATIGUE0142-1123 INTERMETALLICS INTERMETALLICS0966-9795 J ALLOY COMPD JOURNAL OF ALLOYS AND COMPOUNDS0925-8388 J MATER RES JOURNAL OF MATERIALS RESEARCH0884-2914 J MATER SCI JOURNAL OF MATERIALS SCIENCE0022-2461 J MICROMECH MICROENG JOURNAL OF MICROMECHANICS AND MICROENGINEERING0960-1317 J NANOPART RES JOURNAL OF NANOPARTICLE RESEARCH1388-0764 J NANOSCI NANOTECHNO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY1533-4880 J NON-CRYST SOLIDS JOURNAL OF NON-CRYSTALLINE SOLIDS0022-3093 J NUCL MATER JOURNAL OF NUCLEAR MATERIALS0022-3115 MACROMOL MATER ENG MACROMOLECULAR MATERIALS AND ENGINEERING1438-7492 MAT SCI ENG A-STRUCT MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL M0921-5093 MATER CHEM PHYS MATERIALS CHEMISTRY AND PHYSICS0254-0584 MATER LETT MATERIALS LETTERS0167-577X MATER RES BULL MATERIALS RESEARCH BULLETIN0025-5408 MATER SCI ENG B-ADV Materials Science and Engineering B-Advanced Fun0921-5107 MECH ADV MATER STRUC MECHANICS OF ADVANCED MATERIALS AND STRUCTURES1537-6494 MECH MATER MECHANICS OF MATERIALS0167-6636 METALL MATER TRANS A METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSI1073-5623 MICROPOR MESOPOR MAT MICROPOROUS AND MESOPOROUS MATERIALS1387-1811 NANOSCALE RES LETT Nanoscale Research Letters1931-7573 OPT MATER OPTICAL MATERIALS0925-3467 PHOTONIC NANOSTRUCT Photonics and Nanostructures-Fundamentals and Ap1569-4410 PHYS CHEM MINER PHYSICS AND CHEMISTRY OF MINERALS0342-1791 PHYS STATUS SOLIDI-R Physica Status Solidi-Rapid Research Letters1862-6254 SCI ADV MATER Science of Advanced Materials1947-2935 SCI TECHNOL ADV MAT SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS1468-6996 SCRIPTA MATER SCRIPTA MATERIALIA1359-6462 SMART MATER STRUCT SMART MATERIALS & STRUCTURES0964-1726 SOFT MATER SOFT MATERIALS1539-445X SYNTHETIC MET SYNTHETIC METALS0379-6779 WEAR WEAR0043-1648 ACI MATER J ACI MATERIALS JOURNAL0889-325X ACI STRUCT J ACI STRUCTURAL JOURNAL0889-3241 ACTA MECH SOLIDA SIN ACTA MECHANICA SOLIDA SINICA0894-9166 ADV CEM RES ADVANCES IN CEMENT RESEARCH0951-7197ADV MATER PROCESS ADVANCED MATERIALS & PROCESSES0882-7958 ANN CHIM-SCI MAT ANNALES DE CHIMIE-SCIENCE DES MATERIAUX0151-9107 ARCH CIV MECH ENG Archives of Civil and Mechanical Engineering1644-9665 ATOMIZATION SPRAY ATOMIZATION AND SPRAYS1044-5110 B MATER SCI BULLETIN OF MATERIALS SCIENCE0250-4707 CHALCOGENIDE LETT Chalcogenide Letters1584-8663 CIRCUIT WORLD CIRCUIT WORLD0305-6120 COMBUST EXPLO SHOCK+COMBUSTION EXPLOSION AND SHOCK WAVES0010-5082 CONSTR BUILD MATER CONSTRUCTION AND BUILDING MATERIALS0950-0618 CORROS ENG SCI TECHN CORROSION ENGINEERING SCIENCE AND TECHNOLOGY1478-422X CORROSION CORROSION0010-9312 ELECTRON MATER LETT Electronic Materials Letters1738-8090 FATIGUE FRACT ENG M FATIGUE & FRACTURE OF ENGINEERING MATERIALS & ST8756-758X FERROELECTRICS FERROELECTRICS0015-0193 FIBRE CHEM+FIBRE CHEMISTRY0015-0541 FIRE MATER FIRE AND MATERIALS0308-0501 FIRE SAFETY J FIRE SAFETY JOURNAL0379-7112 FIRE TECHNOL FIRE TECHNOLOGY0015-2684 FULLER NANOTUB CAR N FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES1536-383X GEOSYNTH INT GEOSYNTHETICS INTERNATIONAL1072-6349 GRANUL MATTER GRANULAR MATTER1434-5021 HIGH TEMP MAT PR-ISR HIGH TEMPERATURE MATERIALS AND PROCESSES0334-6455 HIGH TEMP MATER P-US HIGH TEMPERATURE MATERIAL PROCESSES1093-3611 IEEE T ADV PACKAGING IEEE TRANSACTIONS ON ADVANCED PACKAGING1521-3323 IEEE T COMPON PACK T IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TE1521-3331 INDIAN J ENG MATER S INDIAN JOURNAL OF ENGINEERING AND MATERIALS SCIE0971-4588 INFORM MIDEM INFORMACIJE MIDEM-JOURNAL OF MICROELECTRONICS EL0352-9045 INORG MATER+INORGANIC MATERIALS0020-1685 INT J FRACTURE INTERNATIONAL JOURNAL OF FRACTURE0376-9429 INT J MATER PROD TEC INTERNATIONAL JOURNAL OF MATERIALS & PRODUCT TEC0268-1900 INT J MIN MET MATER International Journal of Minerals Metallurgy and1674-4799 INT J NANOTECHNOL International Journal of Nanotechnology1475-7435 INT J NUMER ANAL MET INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTIC0363-9061 INT J REFRACT MET H INTERNATIONAL JOURNAL OF REFRACTORY METALS & HAR0263-4368 INT J SURF SCI ENG International Journal of Surface Science and Eng1749-785X J ADHES SCI TECHNOL JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY0169-4243 J ADHESION JOURNAL OF ADHESION0021-8464 J ADV CONCR TECHNOL Journal of Advanced Concrete Technology 1346-8014 J ADV MATER-COVINA JOURNAL OF ADVANCED MATERIALS1070-9789 J COMPUT THEOR NANOS Journal of Computational and Theoretical Nanosci1546-1955 J CULT HERIT JOURNAL OF CULTURAL HERITAGE1296-2074 J ELASTICITY JOURNAL OF ELASTICITY0374-3535 J ELASTOM PLAST JOURNAL OF ELASTOMERS AND PLASTICS0095-2443 J ELECTRON MATER JOURNAL OF ELECTRONIC MATERIALS0361-5235 J ENERG MATER Journal of Energetic Materials 0737-0652 J ENG MATER-T ASME JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-0094-4289 J EXP NANOSCI Journal of Experimental Nanoscience1745-8080 J FIRE PROT ENG Journal of Fire Protection Engineering1042-3915 J FIRE SCI JOURNAL OF FIRE SCIENCES0734-9041 J FRICT WEAR+Journal of Friction and Wear1068-3666 J INTEL MAT SYST STR JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRU1045-389X J LASER MICRO NANOEN Journal of Laser Micro Nanoengineering1880-0688J MAGN MAGN MATER JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS0304-8853 J MATER CIVIL ENG JOURNAL OF MATERIALS IN CIVIL ENGINEERING0899-1561 J MATER ENG PERFORM JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE1059-9495 J MATER PROCESS TECH JOURNAL OF MATERIALS PROCESSING TECHNOLOGY0924-0136 J MATER SCI TECHNOL JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY1005-0302 J MATER SCI-MATER EL JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTR0957-4522 J MECH MATER STRUCT Journal of Mechanics of Materials and Structures1559-3959 J MICRO-NANOLITH MEM Journal of Micro-Nanolithography MEMS and MOEMS1932-5150 J NANO RES-SW Journal of Nano Research1662-5250 J NANOMATER Journal of Nanomaterials1687-4110 J NEW MAT ELECTR SYS JOURNAL OF NEW MATERIALS FOR ELECTROCHEMICAL SYS1480-2422 J OPTOELECTRON ADV M JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIAL1454-4164 J OVONIC RES Journal of Ovonic Research1584-9953 J PHASE EQUILIB DIFF JOURNAL OF PHASE EQUILIBRIA AND DIFFUSION1547-7037 J PHYS CHEM LETT Journal of Physical Chemistry Letters1948-7185 J POROUS MAT JOURNAL OF POROUS MATERIALS1380-2224 J SOC INF DISPLAY Journal of the Society for Information Display1071-0922 J SUPERHARD MATER+Journal of Superhard Materials 1063-4576 J WUHAN UNIV TECHNOL JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERI1000-2413 JOM-US JOM-JOURNAL OF THE MINERALS METALS & MATERIALS S1047-4838 KONA POWDER PART J KONA Powder and Particle Journal0288-4534 KOREAN J MET MATER Korean Journal of Metals and Materials1738-8228 KOVOVE MATER KOVOVE MATERIALY-METALLIC MATERIALS0023-432X LASER ENG LASERS IN ENGINEERING0898-1507 MACH SCI TECHNOL MACHINING SCIENCE AND TECHNOLOGY1091-0344 MAG CONCRETE RES MAGAZINE OF CONCRETE RESEARCH0024-9831 MAT SCI SEMICON PROC MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING1369-8001 MATER CONSTRUCC MATERIALES DE CONSTRUCCION0465-2746 MATER CORROS MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION0947-5117 MATER DESIGN MATERIALS & DESIGN0261-3069 MATER HIGH TEMP MATERIALS AT HIGH TEMPERATURES0960-3409 MATER MANUF PROCESS MATERIALS AND MANUFACTURING PROCESSES1042-6914 MATER RES INNOV MATERIALS RESEARCH INNOVATIONS1432-8917 MATER RES-IBERO-AM J Materials Research-Ibero-american Journal of Mat1516-1439 MATER SCI TECH-LOND MATERIALS SCIENCE AND TECHNOLOGY0267-0836 MATER SCI+MATERIALS SCIENCE1068-820X MATER SCI-MEDZG Materials Science-Medziagotyra 1392-1320 MATER SCI-POLAND MATERIALS SCIENCE-POLAND0137-1339 MATER STRUCT MATERIALS AND STRUCTURES1359-5997 MATER TECHNOL MATERIALS TECHNOLOGY1066-7857 MATER TEHNOL Materiali in Tehnologije 1580-2949 MATER TRANS MATERIALS TRANSACTIONS1345-9678 MATER WORLD MATERIALS WORLD0967-8638 MATERIA-BRAZIL Materia-Rio de Janeiro1517-7076 MATERIALWISS WERKST MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK0933-5137 MATH MECH SOLIDS MATHEMATICS AND MECHANICS OF SOLIDS1081-2865 MET MATER INT METALS AND MATERIALS INTERNATIONAL1598-9623 METALL MATER TRANS B METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCE1073-5615 METALLOFIZ NOV TEKH+METALLOFIZIKA I NOVEISHIE TEKHNOLOGII1024-1809 MICRO NANO LETT Micro & Nano Letters1750-0443 MICROELECTRON INT MICROELECTRONICS INTERNATIONAL1356-5362 MICROSYST TECHNOL MICROSYSTEM TECHNOLOGIES0946-7076MODEL SIMUL MATER SC MODELLING AND SIMULATION IN MATERIALS SCIENCE AN0965-0393 NANO NANO1793-2920 NEW CARBON MATER NEW CARBON MATERIALS1007-8827 OPTOELECTRON ADV MAT Optoelectronics and Advanced Materials-Rapid Com1842-6573 P I MECH ENG L-J MAT PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENG1464-4207 PARTICUOLOGY Particuology1674-2001 PHILOS MAG PHILOSOPHICAL MAGAZINE1478-6435 PHYS STATUS SOLIDI A PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIA1862-6300 PLAST ENG PLASTICS ENGINEERING0091-9578 PROG NAT SCI PROGRESS IN NATURAL SCIENCE1002-0071 RAPID PROTOTYPING J RAPID PROTOTYPING JOURNAL1355-2546 RARE METAL MAT ENG RARE METAL MATERIALS AND ENGINEERING1002-185X RARE METALS RARE METALS1001-0521 RECENT PAT NANOTECH Recent Patents on Nanotechnology1872-2105 REV ADV MATER SCI REVIEWS ON ADVANCED MATERIALS SCIENCE1606-5131 REV ROM MATER Revista Romana de Materiale-Romanian Journal of 1583-3186 ROAD MATER PAVEMENT Road Materials and Pavement Design1468-0629 SAMPE J SAMPE JOURNAL0091-1062 SCI CHINA TECHNOL SC Science China-Technological Sciences1674-7321 SCI MODEL SIMUL Scientific Modeling and Simulations1874-8554 SCI TECHNOL ENERG MA Science and Technology of Energetic Materials 1347-9466 SCI TECHNOL WELD JOI SCIENCE AND TECHNOLOGY OF WELDING AND JOINING1362-1718 SEMICOND SCI TECH SEMICONDUCTOR SCIENCE AND TECHNOLOGY0268-1242 SENSOR MATER SENSORS AND MATERIALS0914-4935 SOLDER SURF MT TECH SOLDERING & SURFACE MOUNT TECHNOLOGY0954-0911 T FAMENA Transactions of FAMENA 1333-1124 VACUUM VACUUM0042-207X ZKG INT ZKG INTERNATIONAL0949-0205 SIAM J IMAGING SCI SIAM Journal on Imaging Sciences1936-4954 IEEE T MED IMAGING IEEE TRANSACTIONS ON MEDICAL IMAGING0278-0062 REMOTE SENS ENVIRON REMOTE SENSING OF ENVIRONMENT0034-4257 INT J REMOTE SENS INTERNATIONAL JOURNAL OF REMOTE SENSING0143-1161 ISPRS J PHOTOGRAMM ISPRS JOURNAL OF PHOTOGRAMMETRY AND REMOTE SENSI0924-2716 PHOTOGRAMM ENG REM S PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING0099-1112 PHOTOGRAMM REC PHOTOGRAMMETRIC RECORD0031-868X EURASIP J IMAGE VIDE EURASIP Journal on Image and Video Processing1687-5176 IEEE J-STARS IEEE Journal of Selected Topics in Applied Earth1939-1404 IMAGING SCI J IMAGING SCIENCE JOURNAL1368-2199 INT J IMAG SYST TECH INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TEC0899-9457 J APPL REMOTE SENS Journal of Applied Remote Sensing1931-3195 J ELECTRON IMAGING JOURNAL OF ELECTRONIC IMAGING1017-9909 J IMAGING SCI TECHN JOURNAL OF IMAGING SCIENCE AND TECHNOLOGY1062-3701 J REAL-TIME IMAGE PR Journal of Real-Time Image Processing1861-8200 PHOTOGRAMM FERNERKUN Photogrammetrie Fernerkundung Geoinformation1432-8364 RIV ITAL TELERILEVAM Rivista Italiana di Telerilevamento1129-8596 SIGNAL IMAGE VIDEO P Signal Image and Video Processing1863-1703 SMPTE MOTION IMAG J SMPTE MOTION IMAGING JOURNAL0036-1682 ANN FAM MED ANNALS OF FAMILY MEDICINE1544-1709 BRIT J GEN PRACT BRITISH JOURNAL OF GENERAL PRACTICE0960-1643 J AM BOARD FAM MED Journal of the American Board of Family Medicine1557-2625 SCAND J PRIM HEALTH SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE0281-3432 AM FAM PHYSICIAN AMERICAN FAMILY PHYSICIAN0002-838X。
替吡法尼——精选推荐
替吡法尼详细信息
本文详细介绍了替吡法尼的产品信息，包括中英文名称、别名、cas号、分子结构等基本信息，以及产品的物化性质、产品用途、产品上下游产品等综合信息，为广大化学品研究、化工产品生产制造从业者提供专业的产品信息。
本文所有信息来源化工字典。
替吡法尼
/detail-替吡法尼.html
产品介绍：
中文名称:替吡法尼
中文别名: (R)-6-(氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基)-4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮
英文名称:Tipifarnib
英文别名:
CAS:192185-72-1
分子结构式：
EINECS:
分子式:C27H22Cl2N4O
分子量:489.3958
风险术语:
安全术语:
物化性质:
熔点:
相对密度:1.33g/cm3 溶解性:
用途:
上游原料:
下游产品:。
乙位萘乙醚93-18-5
9.1 基本的理化特性的信息
a) 外观与性状
形状 : 无数据资料
颜色 : 无数据资料
b) 气味
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c) 气味临界值
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d) pH值
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e) 熔点/凝固点
37.5℃
f) 起始沸点和沸程
282℃
g) 闪点
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https:// 2/4
化学品安全技术说明书
国际海运危规 海运污染物 :否 国际空运危规 : 否
14.6 对使用者的特别预防
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15 法规信息
15.1 专门对此物质或混合物的安全，健康和环境的规章 / 法规
法规信息 无数据资料
Powered by TCPDF ()
https:// 4/4
h) 蒸发速率
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i) 可燃性(固体,气体) 无数据资料
j) 高的/低的燃烧性或爆炸性限度 无数据资料
k) 蒸气压
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l) 相对蒸气密度
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m) 相对密度
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n) 溶解性 / 水溶性 无数据资料
o) 辛醇/水分配系数的对数值 无数据资料
p) 自燃温度（°C / °F） 无数据资料
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12.4 土壤中的迁移
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12.5 PBT 和 vPvB的结果评价
无数据资料
12.6 其它不利的影响
无数据资料
13 废弃处置
13.1 废物处理方法
产品 无数据资料 污染了的包装物 无数据资料 进一步的说明: 无数据资料
14 运输信息
14.1 UN编号
欧洲陆运危规 : 无数据资料 国际海运危规 : 无数据资料 国际空运危规 : 无数据资料