Observation of X-ray variability in the BL Lac object 1ES1959+65
全功能荧光显微镜简介英文AS_69066_TG_611900_GB_1124-1
CAPTURING HIGH-RESOLUTION IMAGES
Using the BZ-X700
For large areas that cannot be seen within a single field-of-view, a motorized XY stage can capture and stitch together the entire region of interest in high resolution. Even for tilted specimens or specimens that have height differences, it is possible to create an image in which the entire specimen is in focus. This is accomplished by capturing multiple images in the Z-direction and stacking together only the parts that are in focus. Only the desired cells can be extracted from the whole slice and the proportion can be automatically calculated using Hybrid Cell Count.
Uneven light intensity leads to shading at the seams. Stitch lines are eliminated with shade correction.
n Comparison with conventional software
学者简介生理学科学家实验的故事
学者简介:生理学科学家实验的故事Claude Bernard: 内环境稳态概念的提出者19世纪法国著名的实验生理学家克劳·伯尔纳(Claude Bernard ,1813—1878),晚年提出“内环境稳态”(internal environment homeostasis )的概念,是其许多重大贡献中最伟大的。
Bernard 提出机体生存在两个环境中,一个是不断变化着的外环境,另一个是比较稳定的内环境。
内环境是围绕在生命有机体细胞周围的体液,深居于机体的内部,为活细胞提供一个适宜的生活环境。
内环境本身很大的一个特点在于它的理化性质变动非常小,例如它的组分数量与功能都是相对恒定的。
他总结出一句话:“内环境恒定是机体自由和独立生存的首要条件。
”这被有识之士认为是Bernard 对生命现象高度概括的具有丰富内容的一句名言。
Claude Bernard and internal environment homeostasisIn 19th century, Claude Bernard, a France famous experimental physiologist, demonstrated the concept of “internal environment homeostasis ”. It is the most important one in his many contributions for physiology. Bernard illustrated the body lived in two environments. One was the variability external environment, another was stable internal environment. Internal environment is present within and around the cells of the body and is called extracellular fluid. Internal environment provides a adequate living environment for the cells of the body. One prominent characteristic of internal environment is variation in narrow range of its physical and chemical characteristic. He conclude internal environment is the primary condition that the body can free and independent survival. Thisconclusion was posited a highly summarily and abundance content saying for the life phenomena by many scientists.External environmentExtracellular fluid: The internal environmentIntracellular fluid of most cells Material enters and leaves the bodyKarl Landsteiner和ABO血型的故事在1900年,维也纳大学病理解剖系的年轻助教卡尔·兰德斯坦纳(Karl Landsteiner, 1868—1943)在他的22位同事的正常血液中,发现红细胞和血浆之间有反应,也就是说,某些血浆能使另一些人的红细胞凝集。
(完整版)医学影像专业英语
(1)To prospectively evaluate the effect of heart rate, heart rate variability, and calcification dual-source computed tomography (CT) image quality and to prospectively assess diagnostic accuracy of dual-source CT for coronary artery stenosis. by using invasive coronary angiography as the reference standard.前瞻性评价心率、心率变异性及钙化双源计算机断层扫描成像质量的影响及对冠状动脉狭窄的双源性冠状动脉狭窄诊断的准确性评价。
以侵入性冠状动脉造影为参照标准。
(2)Chest radiography plays an essential role in the diagnosis of thoracic disease and is the most frequently performed radiologic examination in the United States. Since the discovery of X rays more than a century ago, advances in technology have yieled numerous improvements in thoracic imaging. Evolutionary progress in film-based imaging has led to the development of excellent screen-film systems specifically designed for chest radiography.胸部X线摄影中起着至关重要的作用在胸部疾病的诊断,是最常用的影像学检查在美国。
The proposed thesis title is Observations of X-ray Counterparts to Gamma-ray Bursts in
Donald A. Smith MIT Room 37-432 September 14, 1997
The ASM has proven to be more e cient for GRB detection than was previously expected. At present, six GRBs have been positively identi ed in the ASM data by comparison with BATSE and/or Ulysses triggers. A further four events have possible Konus and/or Ulysses counterparts, but they have not yet been unambiguously indenti ed. There remain two further ashes of X-rays that may be GRBs unobserved by other instruments. The criteria used to isolate these events are (1) variability in the time series data (1=8-s resolution) in a 90-s dwell, and (2) the detection of a new source with high signi cance (and goodness of t) in the positional data. Crossed lines of position are available for ve of these fourபைடு நூலகம்een sources because (1) the burst occurred in the region of overlap of the two FOVs or (2) the burst duration was su ciently long in the ASM band for the normal stepping to yield detections in two SSCs during di erent dwells. The latter category includes GRB 970815 and GRB 970828, which were rapidly located by the ASM with error regions of order 20 70 in size (Smith et al. 1997, Remillard et al. 1997). The recent ASM detection and localization of GRB 970828 (Remillard at al. 1997) demonstrated both the potential of the ASM trigger capability and the response time of the ASM/PCA system. Members of the MIT team identi ed an ASM transient TOO alarm as a likely GRB and obtained a 60 position within 2 hr of the burst. The PCA, 4-m Herschel telescope, and the VLA were all on target 4 h after the burst. This was all accomplished with much human intervention. We are developing a comprehensive set of interacting software to identify, localize and report on bright, isolated GRBs within tens of minutes of the initial trigger. Although the ASM is proving e cient at agging bright transient X-ray events, the identi cation of a transient source as a GRB is clari ed when a real-time GCN (formerly BACODINE) burst notice is received and the (large) gamma-ray error box includes the region being viewed by the ASM. The BATSE catalog can also be used in conjunction with the ASM to put upper limits on the rate of GRB intensity decay. The ASM typically scans over any given spot on the sky within 2 ? 12 hours of a given trigger time. BeppoSAX has detected X-ray afterglow 6 ? 8 hours after a few gamma-ray bursts at an intensity of > 10 Crab. The ASM can achieve at best a sensitivity of 5 mCrab, so we would not be able to repeat their detections, but it is important to perform a comprehensive search, to verify that there are no exceptionally bright afterglows, that no bursts repeat within the mission duration, and that the BeppoSAX bursts were typical. I therefore propose to use the full capabilities of the ASM to determine location, variability, and spectral characteristics of the X-ray counterparts to gamma-ray bursts. I believe these e orts will represent a useful contribution to the eld of Physics.
X-ray 辐射X射线英文PPT
X - ray irradiation 射线的照射
Penetrating Action 穿透作用
Ionization Effect 电离作用
Biological response 生物反应
Application method Application examples 应 用 例
Measure 测量
Non-destructive Inspection 非破坏检查
・Concentration measurement 浓度计测 ・Density measurement 密度计测
・ X light perspective X光透视
・ CT detection CT检查
Diagnosis 诊断
・X - ray radiography X射线造影
Radiation
Ezreal & Allen
Vocabulary
X-ray:X射线 X-ray spectrum:射线谱 Coherent scattering:相干散射 Incoherent scattering:非相干散射 attenuation of X-ray: X射线的衰减 Absorb of X-ray: X射线的真吸收 Optic-electric effect:光电效应 fluorescent radiation:荧光辐射
h = Planck's constant = 1.38 10-16 erg sec
X-Ray Tubes
X-Ray Tubes
1-高压变压器;2-钨丝变压器; 3-X射线管;4-阳极; 5-阴极;6-电子;7-X射线
7 3
5
6
4 2
1
Application of X-ray
BasicConceptsofMedicalInstrumentation医疗器械的基本概念-46
Measurand: Physical quantity
• Biopotential • Pressure • Flow • Dimensions (imaging) • Displacement (velocity, acceleration, force) • Impedance • Temperature • Chemical Concentration
Medical Research Studies
- Observational: Characteristics of patients are observed
and recorded -Case-series: describe characteristic of group -Case-control: observe group that have some disease -Cross-sectional: Analyze characteristics of patients -Cohort: determine if a particular characteristic is a precursor for a disease.
be less sensitive to interference. (preferred) 1. Adding new components designed to offset the
undesired inputs.
1.7 Compensation Techniques
• Inherent Insensitive
1.3 Sampling and Continuous Modes
• Sampling and collecting data will depend on the following:
(完整版)医学影像专业英语
(1)To prospectively evaluate the effect of heart rate, heart rate variability, and calcification dual-source computed tomography (CT) image quality and to prospectively assess diagnostic accuracy of dual-source CT for coronary artery stenosis. by using invasive coronary angiography as the reference standard.前瞻性评价心率、心率变异性及钙化双源计算机断层扫描成像质量的影响及对冠状动脉狭窄的双源性冠状动脉狭窄诊断的准确性评价。
以侵入性冠状动脉造影为参照标准。
(2)Chest radiography plays an essential role in the diagnosis of thoracic disease and is the most frequently performed radiologic examination in the United States. Since the discovery of X rays more than a century ago, advances in technology have yieled numerous improvements in thoracic imaging. Evolutionary progress in film-based imaging has led to the development of excellent screen-film systems specifically designed for chest radiography.胸部X线摄影中起着至关重要的作用在胸部疾病的诊断,是最常用的影像学检查在美国。
数字X线摄影系统
“骨肉分离”,分别观察骨组织和软组织
FDA Approved
第二代功能DR
能量减影 – 病例 1
第二代功能DR
能量减影 – 病例 2
第二代功能DR
平板读出时间0.13S,其他数字平板探测器的读出时间至少1.25S,甚至达15秒以上 DR能量减影、断面三维合 成及图像拼接技术的基础 血管机连续采集成像的基础
二、直接X线数字摄影装置(DDR)
DDR指采用一维或二维X线探测器直接把X线转换为模拟电信号进行数字化的方法,不同于先获得模拟图像,再对模拟图像进行数字化的方法。 平板型探侧器 (flat panel detector,FPD)DDR。
二、直接X线数字摄影装置(DDR)
二、直接X线数字摄影装置(DDR)
三、DDR使用的探测器
2.非晶态硒型平板探测器:主要由集电矩阵、硒层、电介层、顶层电极和保护层等构成.集电矩阵由按阵元方式排列的薄膜晶体管(thin-film transistor, TFT)组成,非晶态硒层涂覆在集电矩阵上,它对X线敏感,并有很高的解像能力。
非晶态硒型平板探测器
偏压
第二代功能DR
Tissue Equalization(组织均衡) Dual Energy Subtraction (能量减影) CAD---Computer Aided Detection (计算机辅助诊断)
DR的高级临床应用功能
英语
1.VOCABULARY AND STRUCTURES(5/5 分数)a) The possibility of moving toward _____ patients and the responsibilities that it implies undoubtedly with change psychologist’s future role.A. meditatingB. medicating B. medicating - 正确C. mediatingD. mediatizing b) The main compositions of the respiratory ______ are the airways and lungs.A. synthesisB. syngeneicC. system C. system - 正确D. systolec) Heart failure occurs when the heart is unable to maintain ______ cardiac output for the body’s need.A. sufficient A. sufficient - 正确B. subsequentC. suffocationD. successived) The physician must have the exact dosage and time _____ for administration written on the chart.A. durationB. spanC. frequencyD. interval D. interval - 正确e) Recent studies suggest angiotensin has a long-term pressor_____ .A. efficacyB. effectorC. effect C. effect - 正确D. effusion您已经使用了2次中的2次提交2. READING COMPREHENSION(5/5 分数)What is type 2 diabetes?The cells in your body need insulin to change glucose, the sugar that comes from the food you eat, into energy you need to live. Without insulin, this sugar cannot get into your cells to do its work. It stays in your blood instead. Your blood sugar level then gets too high.Type 2 diabetes usually begins with insulin resistance. This means that your pancreas is making enough insulin, but your cells are not able to use it. When your cells don’t get the sugar they need, your pancreas works harder at first to make more insulin. But after a while, your pancreas stops being able to make enough insulin.High blood sugar can harm many parts of the body. It can damage blood vessels and nerves throughout your body. You will have a bigger chance of getting eye, heart, blood vessel, nerve, and kidney disease.Your weight, level of physical activity, and family history affect how your body responds to insulin. People who are overweight, get little or no exercise, or have diabetes in the family are more likely to get type 2 diabetes.Type 2 diabetes is usually found in adults, which is why it used to be called adult-onset diabetes. But now more and more children and teens are getting it too. Type 2 diabetes is a disease that you will always have, but you can live a long and healthy life by learning how to manage it.How is type 2 diabetes diagnosed?Most likely you found out that you have diabetes when you saw your doctor for a regular checkup or for some other problem. Your doctor probably diagnosed type 2 diabetes by examining you, asking about your health history, and looking at the results of blood sugar tests.How is it treated?A healthy diet helps keep your blood sugar under control and helps prevent heart disease. Eating the right amount of carbohydrate at each meal is very important. Carbohydrate is found in sugar and sweets, grains, fruit, starchyvegetables and milk and yogurt. A dietitian or a certified diabetes educator can help you plan your meals.Eating right and getting more exercise are enough for some people to control their blood sugar levels. Others also need to take one or more medicines, including insulin.You may need to take other steps to prevent other problems from diabetes. These problems are called complications. People with diabetes are more likely to die from heart and blood vessel problems like heart attack and stroke. If you are 30 or older, talk to your doctor about taking a low-dose aspirin each day to help prevent these or other large blood vessel diseases. You may also need medicine for high blood pressure or high cholesterol. If you smoke, quitting may help you avoid problems with your heart and large blood vessels. (478)Adopted from NorthShore University HealthSystem (NorthShore) at:https://www. /globalassets/diabetes/patienteducation/educationpackettypeiidiabetes.pdff) From the first paragraph we may get to know that the sugar we take-in via food should be digested to the cells otherwise it will_________.A. hurt our insulinB. accumulated at the blood stream B. accumulated at the blood stream - 正确C. erode our pancreasD. poison our blood vesselsg) Insulin resistance as the author mentioned in the passage is that your body can not make full use of______, and then the pancreas stops to produce it in a normal way.A. insulin that pancreas produced A. insulin that pancreas produced - 正确B. insulin that the cells producedC. insulin that produced for bloodD. insulin that produced for pancreash) According to the passage, which of the following item is NOT mentioned to the sufferers of type 2 diabetes?A. The age of the sufferers.B. The gender of the sufferers. B. The gender of the sufferers. - 正确C. The life-long duration of the disease.D. The disease can be controlledi) When diagnosing type 2 diabetes, which of the following test index is not the major reference factor?A. Physical check-up results.B. Results of bloods sugar.C. Interview of your health history.D. X-ray reports for your chest. D. X-ray reports for your chest. - 正确j) As for the treatment method, if a patient over 30 years old the doctor would suggest the patient to take __________ as a special means to prevent the lesions to blood vessels.A. a low-dose aspirin each day A. a low-dose aspirin each day - 正确B. medicines for complicationsC. a special dietD. a special insulin injection您已经使用了2次中的2次提交CLOZE TEST(4/5 分数)Anesthesiology is the practice of medicine which involves the perioperative care of patients and the treatment of pain. The field is predominately a (k)_________specialty, which cares for patients (l)_____ pre-operatively,post-operatively and in critical care units. It also involves the treatment of acute and chronic pain as one of its major (m)_____. The practice of anesthesiology includes a wide (n)______ of patients: all ages, all degrees of illnesses and both sexes. The subspecialties include: pediatric, cardiac, neuro, obstetrical, ambulatory anesthesia as well as critical care medicine and pain management. Individuals interested in anesthesiology are those who enjoy physiology and applied (o)_______ in the clinical setting. They must be comfortable with managing acute life threatening problems and enjoy working in the operating room.k)A. clinic-focusedB. hospital-based B. hospital-based - 正确C. bed-sidedD. problem-basedl)A. acutelyB. severely B. severely - 不正确C. advancedD. sharplym)A. kindsB. ranksC. fieldsD. subspecialties D. subspecialties - 正确n)A. rangesB. raysC. spectrum C. spectrum - 正确D. categorieso)A. medicineB. pharmacology B. pharmacology - 正确C. pathologyD. anatomy 您已经使用了2次中的2次提交2.单选题(5/5 分数)1)Select the best answer and write the letter of your choice of each number.a)The word “ carcinogenic “ is formed with prefix ofcardio-carbo-carcin- carcin- - 正确carbam-b) The word “earwax” is a ______ word with ear and wax.compounding compounding - 正确prefixingcombatingcomplexingc) The suffixes “-ate” “-fy” and “-ize” in word usually form_____.adverbsadjectivesconjunctionsverbs verbs - 正确d) In the words “ dysphagia”, ”dysrhythmia”, dystonia” “dys-“ functions as prefix and has a meaning as________.firmdifficult difficult - 正确acutepaine) The suffixed “-ic” “-ous”, “-al” are found in _________.verbsnounspronounsadjectives adjectives - 正确单选题(5/5 分数)2)Complete the following sentences with the right medical terms given belowf) . The chain of events between ________ of a drug and production of these effects in the body can be divided into two important components, both of which contribute to variability in drug actions.administration administration - 正确preparationproscriptioninjectiong) Preoperative cardiac________ is routinely performed to provide definitive assessment of aortic valve area and the pressure gradient, as well as to assess the coronary arteries for significant stenosis.involvementtransformationalterationcatheterization catheterization - 正确h) The nervous system controls the secretion of many ______ glands, and some hormones in turn affect the function of the nervous system.exocrineendocrine endocrine - 正确endocardialentodermi) The secretion of insulin—which acts to lower the plasma glucose _____—is stimulated by a rise in glucose concentration, for example, and is inhibited by a fall in blood glucose.concentration concentration - 正确accumulationheap-upsummaryj) Bleeding may also occur spontaneously in patients who have received ______ or thrombolytic drugs, or who have coagulation disorders such as hemophilia.anticoagulants anticoagulants - 正确coenzymecoplanarcircumoral4.1单选题(3/5 分数)1. Read the following passage and then do the exercises (multiple choice) given below.Classification of Muscle ActionsIt is useful to be able to describe the effect of muscle contraction on a joint in terms which may be applied throughout the body and which are related to the anatomical position. The descriptive terms express very poorly, however, the complexities of movement, since they resolve movement to arbitrary planes of action. Flexion is the term used to describe the bending of a pan or the making of an angle, most easily visualized in the bending of the elbow or the knee. The opposite term extension fundamentally means a straightening. In the anatomical position most of the members of the body are in the extended position; the arms and legs are straight, as is also the back. In the case of the foot, these terms lead to some confusion since, in the erect position, the ankle is almost continuously semiflexed. From this position, further flexion is more readily understood under the term dorsiflexion and extension under the term plantar flexion. Plantar flexion is obviously bending in the direction of the sole; dorsiflexion, bending in the direction of the dorsum. For movement away from or toward the central axis of the body the terms abduction and adduction are applied. These terms lead to no confusion except in the hands and feel where there is movement of the digits away from and toward a plane wholly within these parts. Rotational movement is also recognized. Rotation of the anterior surface of a member toward the midplane of the body is medial rotation; rotation away from the midplane is lateral rotation. The rotary action of the forearm and hand, which can he readily observed as the hand is turned palm up or palm down, has a special designation. Pronation is rotation so as to turn the palm downward or backward; supination carries the palm upward or forward. There is a similar though less extensive movement of the foot in which rotation takes place in tile tarsal joints. The rotation of the foot so that the sole turns outward is eversion; the opposite movement so that the sole turns inward is inversion. A special case of rotation is that which is seen in the very important opposing action of the thumb. This movement of rolling the thumb over onto the hand so that the pads of the digits converge into a firm grasp is termed opposition; it is exhibited to a lesser degree in the little finger and in the great and small toes. Circumduction is circular movement; to produce this type of motion, flexion and extension, abduction and adduction are combined in a proper sequence. Special terms, such as protrusion and retraction, elevation and depression, will be referred to in their proper context but are relatively self-evident.a)Muscle actions in various patterns, have been mentioned this passage except________.contractionflotation flotation - 正确flexionextensionb) The term “flexion” refers bending of a joint muscle, “semiflexion” means half of the bending, while “dorsiflexion” may mean_________.aA. the muscle bending in backward directionB. the muscle bending in forward directionC. the muscle bending in outward direction C. the muscle bending in outward direction - 不正确D. none of abovec) “Plantar flexion” in the passage may means__________b.A. the bending of one’s angles in various directions A. the bending of one’s angles in various directions - 不正确B. the bending of one’s thenar in various dir ections.C. the bending of one’s figures in rotative waysD. the bending of one’s head both forward and backwardd) In this passage we can see the motions of various muscles that are connected_________.A. with our motional organs such as foot and handB. with our neural connective organs B. with our neural connective organs - 正确C. with our craniums and upper part of our bodyD. with the artery and veins in our bodye) The language used in this passage may be described as________.A. instructive with concepts interpretationsB. plain with figurative illustrationsC. complexity with logical analysis of theoretical ideasD. narrative with definitions to specific term in anatomy D. narrative with definitions to specific term in anatomy - 正确您已经使用了2次中的2次提交4.2单选题(5/5 分数)1. Read the following passage and then do the exercises (multiple choice) given below.PRINCIPLES OF PHARMACODYNAMICSOnce a drug accesses a molecular site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive. For drugs used in the urgent treatment of acutesymptoms, little or no delay is anticipated (or desired) between the drug-target interaction and the development of a clinical effect. Examples include vascular thrombosis, shock, malignant hypertension, status epilepticus, or arrhythmias. For many conditions, however, the indication for therapy is less urgent, and in fact a delay between the interaction of a drug with its pharmacologic target(s) and a clinical effect is common. Pharmacokinetic mechanisms that can contribute to such a delay include uptake into peripheral compartments or generation and accumulation of active metabolites. A common pharmacodynamic mechanism is that the clinical effect develops as a downstream consequence of the initial molecular effect the drug produces. Thus, administration of a proton-pump inhibitor or an H2-receptor blocker produces an immediate increase in gastric pH but ulcer healing that is delayed. Cancer chemotherapy inevitably produces delayed therapeutic effects, often long after drug is undetectable in plasma and tissue. Translation of a molecular drug action to a clinical effect can thus be highly complex and dependent on the details of the pathologic state being treated. These complexities have made pharmacodynamics and its variability less amenable than pharmacokinetics to rigorous mathematical analysis. Nevertheless, some clinically important principles can be elucidated.A therapeutic drug effect assumes the presence of under lying pathophysiology. Thus, a drug may produce no action, or a different spectrum of actions, in unaffected individuals compared to patients. Further, concomitant disease can complicate interpretation of response to drug therapy, especially adverse effects. For example, increasing dyspnea in a patient with chronic lung disease receiving amiodarone therapy could be due to drug, underlying disease, or an intercurrent cardiopulmonary problem. Thus the presence of chronic lung disease, and interpretation of the symptom of increasing dyspnea, is one factor that should be considered ins election of antiarrhythmic therapies. Similarly, high doses of anticonvulsants such as phenytoin may cause neurologic symptoms, which may be confused with the underlying neurologic disease.The concept that a drug interacts with a specific molecular receptor does not imply that the drug effect will be constant over time, even if stable drug and metabolite concentrations are maintained. The drug receptor interaction occurs in a complex biologic milieu that itself can vary to modulate the drug effect. For example, ion channel blockade by drugs, an important anticonvulsant and antiarrhythmic effect, is often modulated by membrane potential, itself a function of factors such as extracellular potassium or ischemia. Thus, the effects of these drugs may vary depending on the external milieu. Receptors may be up- or downregulated by disease or by the drug itself. For example, adrenergicblockers upregulate ß-receptor density during chronic therapy. While this effect does not usually result in resistance to the therapeutic effect of the drugs, it may produce severe agonist–mediated effects (such as hypertension or tachycardia) if the blocking drug is abruptly withdrawn.(From: Kasper, et al. Ed ; Harrison's Principles of Internal Medicine 16th . © 2005, by The McGraw-Hill Companies, Inc p18.)a)According to the passage the drug in clinic application may achieve its efficacy in the following procedures except________.A.the drug molecule accesses the site of actionB.the drug molecules are accumulated in the blood stream rapidly B.the drug molecules are accumulated in the blood stream rapidly - 正确C.the drug molecule alters the function of the molecule targetD.the drug molecule and drug-target interaction to form its effect (B)b)The delay in action is known as common in the chemotherapy of the symptom ________ in clinic practice.vascular thrombosisstatusepilepticustachyarrhythmiahydronephrosis hydronephrosis - 正确c) When administration of a proton-pump inhibitor or an H2-receptor blocker produces an immediate increase in gastric pH but ulcer healing that is delayed, because _______.A. the drug produces a downstream consequence of the initial molecular effect A. the drug produces a downstream consequence of the initial molecular effect - 正确B. the drug produces an afterwards result of delayed effectC. the drug combines the target receptor and makes a prolonged effectD. the drug impact its effect on the receptor cell in an indirect wayd) Which of the following may be the reason for the no clinic action when administrated a certain drug for a specific disease or symptom?A. As the under lying pathophysiology, as the disease and symptom may commit different actions to astray or reject the drug of its functions.B. As the under lying pathophysiology, the drug may take no effect or other spectrum of action in affected individuals but its effector molecule acts with other functions than we desired.C. As the under lying pathophysiology, the drug may reach to a wrong site and combined with different receptor cell thus made no clinic effectD. As the under lying pathophysiology, the drug may take no effect or otherspectrum of action in unaffected individuals and the concomitant disease can complicate interpretation of response to drug therapy, especially adverse effects. D. As the under lying pathophysiology, the drug may take no effect or other spectrum of action in unaffected individuals and the concomitant disease can complicate interpretation of response to drug therapy, especially adverse effects. - 正确e) In this passage we can learn principles that a medicine in clinic administration may have __________.clinic efficacyno actionadviser effectall the three all the three - 正确您已经使用了2次中的2次提交单选题(5/5 分数)1. Read the following passage and then do the exercises (multiple choice) given below.Objectives relating to knowledgeGraduates completing basic medical education should have knowledge of the following areas:1. Scientific method relevant to biological, behavioural and social sciences at a level sufficient to understand the basis for present medical practice, and to assimilate the advances in knowledge that will occur over their working life.2. The normal structure, function and development of the human body and mind at all stages of life, the interactions between body and mind, and the factors that may disturb these.3. The etiology, pathology, symptoms and signs, natural history, and prognosis of common mental and physical ailments in children, adolescents, adults and the aged. (Graduates should have a detailed knowledge of the conditions that require urgent treatment and those that are of particular local significance.)4. Common diagnostic procedures, their uses and limitations.5. Management of common conditions including pharmacological, physical, nutritional and psychological therapies.6. Normal pregnancy and childbirth, the more common obstetrical emergencies, the principles of antenatal and postnatal care, and medical aspects of family planning.7. The principles of health education, disease prevention, amelioration of suffering and disability, rehabilitation, and the care of the dying.8. Cultural and social factors affecting human relationships, the psychological well-being of patients and their families, and the interactions between humans and their social and physical environment.9. Systems of provision of health care including their advantages and limitations, the costs associated with health care, the principles of efficient and equitable allocation of finite resources, and methods of meeting the health care needs of disadvantaged groups within the community.10. The principles of ethics that relate to health care and the legal responsibilities of the medical profession.Objectives relating to skillsGraduates completing basic medical education should have developed the following skills to an appropriate level for their stage of training:1. The ability to take a tactful, accurate, organized and problem-focused medical history.2. The ability to perform an accurate physical and mental state examination.3. The ability to choose the appropriate and practical clinical skills to apply in a given situation.4. The ability to interpret and integrate the history and physical examination findings to arrive at an appropriate diagnosis or differential diagnosis.5. The ability to select the most appropriate and cost-effective diagnostic procedures.6. The ability to formulate a management plan, and to plan management in concert with the patient.7. The ability to communicate clearly, considerately and sensitively with patients, relatives, doctors, nurses, other health professionals and the community.8. The ability to counsel sensitively and effectively, and to provide information in a manner that ensures patients and families can be truly informed when consenting to any procedure.9. The ability to recognize serious illness and to perform common emergency and life-saving procedures such as caring for the unconscious patient and cardiopulmonary resuscitation.10. The ability to interpret medical evidence in a critical and scientific manner, and to use libraries and other information resources to pursue independent inquiry relating to medical problems.Objectives relating to attitudes as they affect professional behaviourDuring basic medical education, students should acquire the following professional attitudes, which are regarded as fundamental to medical practice:1. Respect for every human being, with an appreciation of the diversity of human background and cultural values.2. An appreciation of the complexity of ethical issues related to human life and death including the allocation of scarce resources.3. A desire to ease pain and suffering.4. An awareness of the need to communicate with patients and their families, and to involve them fully in planning management of their condition.5. A desire to achieve the optimal patient care for the least cost to allow maximum benefit from the available resources.6. Recognition that the health interests of the patient and the community are paramount.7. A willingness to work effectively in a team with other health care professionals.8. An appreciation of the responsibility to maintain standards of medical practice at the highest possible level throughout a professional career.9. An appreciation of the need to recognize when a clinical problem exceeds their capacity to deal with it safely and efficiently and of the need to refer the patient for help from others when this occurs.10. A realization that it is not always in the interests of patients or their families to do everything which is technically possible to make a precise diagnosis or to attempt to modify the course of an illness.From World Health Organization Western Pacific Region(2001), WHO Guidelines for Quality Assurance of Basic Medical Education in the Western Pacific Regiona)According to the passage medical education quality system may including all of the following aspects of competences but __________.A.mastering the knowledges that related to medical practice in all aspects of biologic sciences and medicines, humanities and social scienceB.mastering the skills that related to clinic practice, communication and making use of respective informationC.understanding the concepts about medicine that may focus on interpretation of human himself and the relations with the world around C.understanding the concepts about medicine that may focus on interpretation of human himself and the relations with the world around - 正确D.develop the attitude toward their future profession and which may affect their behaviours laterb)In the first section, we can learn that the required knowledges a medical student should master may consist ________________.A.the natural processes of human individual and the diseases as well as how to deal with them A.the natural processes of human individual and the diseases as well as how to deal with them - 正确B.the sources that cause our diseases or alimentsC.the relations between individual and social community that maydecide your social statusD. the principles of nature and the earth that may affect our life and the environmentc) Systems of provision of health care may have the contents of________.A. how much our health may costB. how to make full use of the medical resources for the people at largeC. methods for make use of the health facilitatesD. all above D. all above - 正确d) The ability to counsel sensitively and effectively, and to provide information should be _____________.A. contented to the needs and demands of the patient and the familyB. frankly and objectively to ensure the colleagues for their caseC. truly and objectively and tactically for the patient and his family C. truly and objectively and tactically for the patient and his family - 正确D. decisively and absolutely for the case of treatment procedurese) In the career of medicine, a person should _________ all human being, as the foundation of his/her moral, regardless of their nationality, gender and social status.appreciateunderstandconsideraterespect respect - 正确您已经使用了2次中的2次提交单选题(5/5 分数)2、Read the following passage and then do the exercises (multiple choice) given below.Diabetes self-management education and support (DSME/S) provides the foundation to help people with diabetes to navigate these decisions and activities and has been shown to improve health outcomes.1-7 Diabetes self- management education (DSME) is the process of facilitating the knowledge, skill, and ability necessary for diabetes self-care. Diabetes self-management support (DSMS) refers to the support that is required for implementing and sustaining coping skills and behaviors needed to self- manage on an ongoing basis. Although different members of the health care team and community can contribute to this process, it is important for health care providers and theirpractice set- tings to have the resources and a systematic referral process to ensure that patients with type 2 diabetes receive both DSME and DSMS in a consistent manner. The initial DSME is typically provided by a health professional, whereas ongoing support can be provided by personnel within a practice and a variety of community-based resources. DSME/S programs are designed to address the patient’s health beliefs, cultural needs, current knowledge, physical limitations, emotional concerns, family support, financial status, medical history, health literacy, numeracy, and other factors that influence each person’s ability to meet the challenges of self-management.The number of people with type 2 diabetes who receive DSME/S(Diabetes Self-management Education and Support), despite its proven benefits, is low. For example, only 6.8% of individuals with newly diagnosed type 2 diabetes with private health insurance participated in DSME/S within 12 months of diagnosis.66 Furthermore, only 4% of Medicare participants received DSME/S and/ or MNT.4 To increase the number of individuals with diabetes who receive DSME/S services described in this position statement, it is necessary to consider the barriers that currently limit provision. Barriers are associated with a number of factors, including the health system, the individual health care professional, community resources, and the individual with diabetes. Barriers can include a misunderstanding of the necessity and effectiveness of DSME/S, confusion regarding when and how to make referrals, lack of access to DSME/S services, and patient psychosocial and behavioral factors.67 Provider misconceptions that can limit access to DSME/S include a misunderstanding of reimbursement issues and the misconception that one or a few initial education visits are adequate to provide patients with the skills needed for lifelongself-management. Lack of or poor reimbursement for DSME/S also can hamper patients’ participation. Even when DSME/S programs are operating at peak service, they often struggle to cover costs—making it easy to eliminate programs despite their wider influence on reducing costs and improving health outcomes.13Although people with diabetes report wanting to be actively engaged in their health care, most indicate that they are not actively engaged by their providers and that education and psychological services are not readily available.68 In order to enhance patient and family engagement in DSME/S, provider communication about the necessity of self-management to achieve treatment and quality-of-life goals and the essential nature of both DSME and ongoing support throughout a lifetime of diabetes is essential.Removing barriers to access and increasing quality care can be achieved by。
and
G. V. Jung
Accepted for publication in the Astrophysical Journal
ABSTRACT
The Oriented Scintillation Spectrometer Experiment on the Compton Gamma Ray Observatory observed the Galactic black hole candidate GX 339?4 as a target of opportunity in 1991 September, in response to the outburst reported by BATSE. We report here on energy spectra in the 50 keV to 10 MeV range obtained by OSSE. The source was detected from 50 to 400 keV at a level relative to the Crab nebula of 30%. The observed spectrum was described reasonably well by a power law with an exponential cuto ; a least-squares t yielded a photon index of :88 :05 and a cuto energy of (68 2) keV. The addition of a Compton re ection component did not signi cantly improve the overall t. An optically-thin thermal bremsstrahlung spectrum also provides a good t, and the thermal Comptonization model of Sunyaev and Titarchuk, while de cient in describing the data above about 200 keV, cannot formally be ruled out. A pure power law with re ection does not t the observed spectrum. During a follow-up observation made in 1991 November, the intensity of the source below 100 keV
遗传学名词解释(英文)
细菌遗传合成代谢功能的突变型(anabotic function mutants)合成代谢功能(anabolic functions):野生型(wild type)在基本培养基上具有合成和生长所必需的有机物的功能营养缺陷型(auxotroph):野生型品系的任何一个基因突变,都不能进行一个特定的生化反应,从而阻碍整个合成代谢功能的实现分解代谢功能的突变型(catabolic functional mutation分解代谢功能(catabolic function):指野生型E coli能利用比葡萄糖复杂的不同碳源,转化成葡萄糖或其他简单的糖类,也能把复杂的氨基酸或脂肪分子降解成乙酸或三羧酸循环的中间产物的功能抗性突变型细菌由于某基因的突变而对某些噬菌体或抗菌素产生抗性(resistant),从而使其不能吸附或吸附在这种突变细菌上的能力降低conjugation (接合生殖)F因子又称性因子或致育因子(sex or fertility factor),它是能独立增殖的环状DNA分子F+细菌丢失F因子,成为F-细菌(acriflavine处理)F-受体细胞只接受部分的供体染色体,这样的细胞称为部分二倍体(partial diploid)或半合子(merozygote)内基因子(endogenote)和外基因子(exogenote)重组作图(recombination mapping)是根据基因间重组率进行基因定位末端(outside marker),受体部位(recept site):外源DNA片段进入受体细菌形成临时性通道的特定区域感受态细胞(receptor site):能接受外源DNA分子并被转化的细菌细胞感受态因子(competence factor):促进转化作用的酶或蛋白质分子噬菌体所携带供体(细菌)染色体片段是完全随机的,即供体基因组中所有基因具有同等机会被转导形成部分二倍体,经交换和重组后,形成转导频率大致相等的不同转导子,这种转导称为普遍性转导(general transduction)共转导或并发转导(cotransduction):指两个基因同时转导的现象,如果两个基因共转导的频率愈高,表明两个基因连锁愈紧密,相反共转导频率愈低,则表明两个基因距离愈远双因子转导(two-factor transduction)实验:就是每次观察两个基因的转导,通过每两个基因的共转导频率确定这些基因在染色体上的顺序溶菌酶(lysozyme)原噬菌体(prophage)或原病毒(provirus):是指整合到宿主染色体中的噬菌体基因组溶源性(lysogeny):有些细菌带有某种噬菌体,但并不立即导致溶菌,这种现象称为溶源性;这种细菌称为溶源性细菌或溶源菌(lysogenic bacterium),此过程称为溶源周期裂解途径:裂解周期(lytic cycle)溶源途径:溶源周期(lysogenic cycle)条件致死突变型。
活动星系核X射线本征谱指数与爱丁顿比关系的研究进展
活动星系核X射线本征谱指数与爱丁顿比关系的研究进展倪嘉阳;薛永泉【摘要】活动星系核是中央核区有剧烈活动的(河外)星系总称.随着观测技术不断进步,人们对活动星系核的研究越来越多,对其理解也越来越深刻.总结整理了近年来对活动星系核X射线本征谱指数与爱丁顿比关系的观测结果,揭示出如下V形关系图像:随着爱丁顿比由大变小,X射线本征谱指数与爱丁顿比由存在正相关关系,转变为存在负相关关系.一般认为,这一观测现象反映了随着吸积率的降低,黑洞吸积模式发生了变化,由高吸积率时的标准薄盘吸积变为低吸积率时的辐射无效吸积流.这表明,基于标准薄盘的最基本的活动星系核统一模型虽然能够成功地解释较高光度活动星系核的很多观测现象,但却需要做一定的修正,以解释低光度活动星系核的一些观测性质.同时,将来有希望利用这一相关关系估算活动星系核一些重要参数,如中央超大黑洞质量、吸积率等,从而帮助人们更好地理解活动星系核的辐射机制和演化过程.最后对这一领域的研究进行了总结与展望.%Active galactic nuclei (AGN) are galaxies that have strong activities at their centers. Due to continual progress in observational technologies, a wide variety ofresearches on AGN have been carried out, leading to profound understanding of the nature of AGN. This paper collects and summarizes recent observational results about the correlation between X-ray intrinsic photon index and Eddington ratio in AGN, which present a V-shape correlation:as the Eddington ratio decreases continuously, such a correlation changes from being positive into being negative. It is generally believed that these observational results reflect that, as the accretion rate decreases, the black hole accretion mode changes as well, from theoriginal standard thin disk into radiatively ine?cient accretion flow. This indicates that the very basic AGN unification models based on the standard thin accretion disk have to be modified in order to well explain some observed properties of the low-luminosity AGN, although those models enjoy great success in explaining many observations of the AGN with higher luminosities. In the future, it is possible to use this correlation (if refined further) to estimate some important AGN parameters such as the black hole mass and accretion rate, which will facilitate our better understanding of the radiation mechanisms and evolution of AGN. Finally, this paper is concluded with some future prospects in this research field.【期刊名称】《天文学进展》【年(卷),期】2017(035)004【总页数】19页(P398-416)【关键词】活动星系核;X射线天文学;吸积物理【作者】倪嘉阳;薛永泉【作者单位】中国科学技术大学天文学系,合肥 230026;中国科学院星系与宇宙学重点实验室,合肥 230026;中国科学技术大学天文学系,合肥 230026;中国科学院星系与宇宙学重点实验室,合肥 230026【正文语种】中文【中图分类】P157.6活动星系核(active galactic nucleus,简称AGN)是宇宙中光度最大的一类天体,其在整个电磁波段都有很强的辐射。
三株肿瘤细胞对X射线辐射敏感性的比较
杨宇琴 王丽丽 柯尊 晖 玉业英 黎 晨 尤培蒙 韩 冰 杨 田 郭 忠 赵 晋
(西 北 民族 大 学 医 学 院 兰 州 730030)
摘要 比较 研 究 x 射 线对 人 子 宫 颈 癌 细 胞 (HeLa)、人 肝 癌 细胞 (HepG2) ̄]Jk.粘 液 表 皮 样 癌 细  ̄ (MEC一11的辐 射 敏 感 性 。 x射 线 照 射 三 株 细 胞 至 吸 收 剂 量 2、4、 6、8 Gy后 0.5、4和 24 h,用 克 隆 形 成 实 验 测 定 细 胞 增 殖 , 中 性 彗 星 电泳 法 检 测 DNA 双 链 损 伤 (DNA double strand breaks,DSB),免 疫 荧 光 染 色 法 检 测 磷 酸 化 组 蛋 白 H2AX (yH2AX)焦 点的形成 。结 果显示:2、4、6、8 Gy剂量组及照射后不 同时间点均 以 Hela细胞 的存活分数 (Survival fraction,SF)最 高 ;CASP软 件 分 析 显 示 ,DSB 增 加 呈 现 时 间和 剂 量 依 赖 关 系 , 照 射 后 4 h尾 矩 fTail moment,TM)增 加 最 为 明 显 ,其 中 以 MEC.1细 胞 增 加 最 为 显 著 ; 照 射 后 0.5和 4 h,yH2AX 阳 性 细 胞 率 达 到 100%,照射后 24 h逐渐下 降,其中 Hela细胞下 降最为 明显。结果提示 ,克 隆形成 实验、 中性彗星 电泳和 7H2AX 焦 点 检 测 法 的联 合 使 用 能 有 效 预测 肿 瘤 细 胞 辐 射 敏 感 性 。 关键 词 x 射 线 ,肿 瘤 细 胞 , 辐 射 敏 感 性 中图 分 类 号 R739.4 DOI:10.11889,j.1000—3436.2018.rrj.36.030203
自动化质量控制解决方案商品说明书
NewsConsumer behavior is changing. The trend for greater product diversity, proliferation of package sizes and the desire for healthier beverages are putting additional pressure on manufacturers. Automated quality control solutions offer the flexibility to handle product variability without reducing efficiency or safety.Increased Beverage ProductivityConsumers Demand Variety and Clear Labellingrectly labeled products could lead to con-sumer dissatisfaction, the loss of goodwill and the possibility of an expensive prod-uct recall to rectify problems. The use of vision inspection technology ensures that every label on every product is checked for correctness, quality, position and that the correct barcodes, lot numbers and expiry dates are included.Smaller sizesDrink containers are shrinking as con-sumers reach for more convenient and ef-ficient packaging suited to a more active lifestyle. P ackages sized to serve one or two people have become a big trend and present an opportunity for increased prof-itability for manufacturers. Smaller pack-ages can frequently be handled at higherStanding out from the competition in an increasingly saturated industry is a chal-lenge for beverage manufacturers of all sizes. The need to keep up with rapidly changing consumer demands intensi-fies that challenge. Recent research from PMMI, the Association for Packaging and P rocessing Technologies, predicts some interesting and demanding trends for the current year.Health and transparencyConsumers are moving towards health-ier beverages. Clear and accurate label-ing is essential to communicate product benefits to the consumer. But frequent product change-overs in bottling plants to meet market demands can increase the risk of mislabeling or label mix-up. Incor-Industrial Weighing & Product InspectionBeverages212METTLER TOLEDO Beverages News 21A u t o m a t e d Q u a l i t y C o n t r o lP rotecting the welfare of consumers is paramount for manufacturers and the use of x-ray inspection to detect physi-cal contaminants is seen as essential by many manufacturers. X-ray can also be used to check closures and fill levels, even in opaque containers.Vision and x-ray inspection systems are able to perform a wide variety of qual-ity and integrity checks to support the beverage industry in meeting market de-mands of the future. METTLER TOLEDO is able to provide advice in choosing the optimum technology for each application.❝ /pi-bespeeds providing opportunities for in-creased throughput and enhanced processefficiency. The advent of higher-speed processing has meant that traditional hu-man-eye inspection is impossible. Vision technology has evolved and can handle inspection at very high speeds.Increase in PET bottles P ET bottles still rank among the most successful consumer packaging formats, and they continue to be a primary solu-tion for fast-growing beverage products. Demands for improved sustainability, re-duced product weight and attractive ap-pearance are helping to drive usage. As-suring the quality of bottles is important. The bottle neck and screw thread need to be correctly formed and caps must be checked to ensure seal integrity. These are further functions that vision inspec-tion can perform.Continued use of glassGlass continues to be widely used. The previously mentioned issue of increased speed can also lead to an increased risk of contamination, particularly from glass fragments which may occur during han-dling and filling.Publisher / Production Mettler-Toledo GmbH Industrial Division Heuwinkelstrasse CH-8606 Nänikon SwitzerlandSubject to technical changes © 09/2017 Mettler-Toledo GmbHHigh-speed inspection with x-ray technology identifies all manner of physical contaminants.❝ /safeline-xray-beX-ray Detects ContaminantsNew Industrial Weighing CatalogFind Your Required Solutionwith Our Full Product Portfolio ❝ /ind-catalog-be3METTLER TOLEDO Beverages News 21Batching that Growes with Your Business Better Manual and Automated ControlDeciding whether to switch from manual to automated batching can be complex. Make your decision easier by choosing a batch controller that gives you the flexibility to transition easily as your business matures and grows.The terminal can handle up to 28 mate-rials with recipe-specific control includ-ing conditional control tasks, recipe res-caling, timing functions, and control of discrete inputs and outputs.Whether you batch manually or use auto-mation, METTLER TOLEDO’s IND780 willimprove your process and make it easy to switch when the time is right./780batch-be P reparing a batch by hand is labor-in-tensive. But switching to a completely automated solution depends on numer-ous factors such as costs or project com-plexity. IND780batch is a batch control-ler that provides all the flexibility, power, and reliability in a single terminal to help you with whatever type of batch process-ing you use.Error-free manual batching IND780batch can manage your manual material formulation process by prompt-ing your operator through the recipe and eliminating variables that cause mis-takes and re-work. The ability to connect a bar code reader along with track-and-trace features allows the operator to col-lect batch history information for com-plete batch documentation.An automatic batch controller IND780batch works also as a stand-alone solution that does not require interface to a PLC or DCS while delivering the benefits of a full-featured batch control solution.IND780batchHand AddBench ScaleMaterial 1Hand AddScaleDischarge MaterialTo storage tankFast Feed Fine FeedFast Feed Fine Feed Fast Feed Fine FeedMaterial 24A single shard of glass in a bottle could have devastating effects – both on the consumer and the reputation of the manufacturer. X-ray inspection systems are vital on production lines using glass to ensure only high-quality, contaminant-free beverages reach the retail supply chain.Seeing the Problem ClearlyInspection Solutions for Glass BottlesG l a s s C o n t a m i n a n t D e t e c t i o ning inspection performance and production uptime for manufacturers.High speedsDepending on the application, the X3750 can accurately inspect up to 1,200 bot-tles per minute, optimizing process effi-ciency. A high-speed automated reject-de-vice ensures contaminated products are removed without slowing production. The machine’s data logging and x-ray image library include automatic time and date stamps for rejected products, enabling manufacturers to demonstrate due dil-igence.Flexibility and consumer safety The X3750 x-ray inspection system can be adjusted to suit a wide range of bot-tle sizes using full-length guide-rail sys-tems. This ensures smooth product han-dling and repeatable product changeovers which are vital to ensure productivity lev-els are maximized.The challengeGlass bottles are among the most challeng-ing packaging formats to inspect. This is primarily because the contaminants are most likely to be glass of the same mate-rial and density as the packaging itself. The size and shape of bottles can add to the complexity of inspection, as the base, side-walls and neck can mask a contaminant, causing inspection blind spots.A further challenge is unusually shaped bottles that present themselves to the x-ray system in different orientations and have no fixed reference points. This can lead to false rejects as the x-ray images captured are constantly changing.The only solutionTo overcome these challenges, METTLER TOLEDO has developed the X3750 x-ray inspection system to specifically address these issues. X-ray inspection is the only technology capable of detecting glass con-taminants within glass bottles.Overcoming the problemThe X3750 is the most advanced x-ray system on the market for glass-in-glass inspection. It features an angled x-ray beam and innovative detector technology allowing inspection throughout all areas of a bottle by sending x-rays through the base area while simultaneously inspect-ing through the sides of the bottle.This provides all-round inspection, as the “crown” or domed base of the bot-tle appears flat, effectively removing blind spots. The beam passes level with the shoulder of the container (below the threads and cap) and produces a far less complex image, enhancing detection ca-pability. 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A rapid response dissolved oxygen sensor with a low detection limit reduces beer loss at the filling line and ensures beer shelf life is maximized.Optical technology delivers fast responseOptical sensors have no electrolyte, so po-larization is not required. And the ab-sence of electrolyte and internal mem-brane is why optical sensors have very low maintenance. Compared with am-perometric probes, optical sensors have far higher signal stability. They also have an extremely fast response rate: typically98 % of final value in less than 20 sec-onds. That can result in a significant sav-ing of product at the filling line.METTLER TOLEDOʼs InP ro 6970 i opti-cal dissolved oxygen sensor has been de-signed specifically for the needs of the brewery industry. It is fully CIP and SIP resistant and highly tolerant of pressure shocks, rapid temperature changes, andEliminate polarization of DO sensorsAmperometric DO sensors have served the brewery industry well for many years. 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医学影像学总论
Principle 原理
Analog/digital converter Voxel, digital matrix
Digital/analog converter Pixel, CT image
CT Equipment CT装置
Regular CT Scanner, computer, imaging scan time, resolution, function
● Simple X-ray examination Fluoroscopy Radiography
Methods of Examination 检查方法
● Special X-ray examination Tomography Mammography Others
Methods of Examination 检查方法
Introduction Digital fluorography ADC Subtraction
Techniques Intra-arterial DSA Intravenous DSA
Clinical Application临床应用
Substitute regular angiography Interventional procedures
VI. Application of Various imaging
VII. Digital Radiography, PACS, Information Radiology
Hounsfield unit (HU) Serial tomographic images 系列断层
CT Techniques CT技术
Plain CT scan Contrast enhancement CT High resolution CT New techniques
环磷腺苷葡胺结合胺碘酮对室性心律失常患者心率变异性及炎症指标的影响
室性心律失常是指由心室的异位起搏点提前发放冲动 引起[1]。轻者临床表现为心悸 ,若室速时间过长会引发或加 重心力衰竭 ,出现休克 、晕厥 、低血压 ,严重者可能猝死。因 此 ,积极有效的降低心率对提高疗效 、改善患者生活质量尤 为重要。目前,临床治疗多采用抗心律失常药物治疗室性心 律失常,其中胺碘酮最常见,能减少室性早搏的级别和数目, 降低发生猝死的风险 ,但治疗效果不够理想[2]。环磷腺苷葡 胺具有扩张血管的作用 ,能增强心肌的收缩力 ,可减少心肌
CUI Tanchun
(Department of Cardiovascular Medicine, Shenyang Emergency Center, Liaoning, Shenyang, 110006, China)
Abstract: Objective To investigate the effect of adenosine monophosphate combined with amiodarone on heart rate variability and inflammation in patients with ventricular arrhythmia. Methods 111 patients with ventricular arrhythmias admitted to our hospital from April 2017 to April 2019 were selected as the reseach subjects, and they were divided into the control group (n=56) and observation group (n=55) according to the random number table method. The control group was treated with amiodarone, the observation group was treated with adenosine monophosphate on the basis of control group. Both groups were treated continuously for 15 d, the efficacy, heart rate allergy, inflammatory indexes and BNP were compared between the two groups. Results The total effective rate and SDANN, RMSSD, SDNN in the observation group were higher than those in the control group, hs-CRP, TFN-α, IL-6, BNP and other indicators were lower than the control group, the difference was statistically significant (P< 0.05). Conclusion The combination of adenosine monophosphate and amiodarone in the treatment of ventricular arrhythmias, can improve heart rate variability, reducing inflammation, and then improve the therapeutic effect.
17_-_X-Rays_I
Initiating Event (cont.)
• An electron of kinetic energy T > 69.5 keV can do likewise by ejecting a K-shell electron in a hard collision • Notice that the electron is not required to have an incident energy exceeding twice the binding energy to accomplish this, even though an electron is conventionally supposed to be able to give no more than half its energy to another electron
X-Ray Production and Quality I
Production Unfiltered Energy Spectrum
Introduction
• The word “quality” as applied to an x-ray beam ordinarily may be taken as synonymous with “hardness”, i.e., penetrating ability • In the earlier days of radiotherapy, before megavolt x- or γray beams became generally available, the effectiveness of x-ray treatment of deep-seated tumors depended upon the ability of the orthovoltage (<300-kV) x-rays to penetrate to the tumor while limiting the dose to overlying tissues. • For that application, the more strongly penetrating the beam, the higher its quality
海洋生物样品基质Χ射线质量衰减系数-Core
第19卷第5期(总第113期)辐射防护通讯1999年10月・经验交流・海洋生物样品基质Χ射线质量衰减系数Χ2R ay M ass A ttenuati on Coefficients of M arine O rganis m M atrix刘广山 黄奕普(厦门大学亚热带海洋研究所,361005) L iu Guangshan H uang Y i pu(D epart m en t of O ceanography,X ia m en U n iversity,361005)摘 要 计算了各种海洋生物样品基质的Χ射线质量衰减系数。
结果表明,不同生物样品基质的Χ射线质量衰减系数存在差异,在10~100ke V能区差异较大。
关键词: 海洋生物 样品基质 Χ射线质量衰减系数Abstract T heΧ2ray m ass attenuati on coefficien ts of sa mp le m atrixes of m arine o rgan is m sw ere calcu2 lated.T he results have show n that there are difference a mong vari ous sa mp le m atrixes of m arine o r2 gan is m s,es pecially in the energy range of10~100ke V.Key W ords: Sam ple ma tr i x M ar i n e organ is m Χ-ray ma ss a ttenua ti on coeff i c i en t1 引言海洋环境中存在的天然放射性核素和人类活动输入到海洋的各种人工放射性核素,通过饮食进入生物体并在其中累积。
辐射防护研究中,通过测定食用生物放射性核素含量估算由于食用海洋生物对公众产生的附加剂量[1]。
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a rXiv:as tr o-ph/23335v12Mar22Observation of X–ray variability in the BL Lac object 1ES1959+65Berrie Giebels 1,Elliott D.Bloom,Warren Focke,Gary Godfrey,Greg Madejski,Kaice T.Reilly,Pablo M.Saz Parkinson,Ganya Shabad Stanford Linear Accelerator Center,Stanford University,Stanford,CA 94309Reba M.Bandyopadhyay 2,Gilbert G.Fritz,Paul Hertz 3,Michael P.Kowalski,Michael N.Lovellette,Paul S.Ray,Michael T.Wolff,Kent S.Wood,Daryl J.Yentis E.O.Hulburt Center for Space Research,Naval Research Laboratory,Washington,DC 20375and Jeffrey D.Scargle Space Science Division,NASA/Ames Research Center,Moffett Field,CA 94305-1000ABSTRACT This paper reports X–ray spectral observations of a relatively nearby (z =0.048)BL Lacertae (BL Lac)object 1ES1959+65,which is a potential TeV emit-ter.The observations include 31short pointings made by the Unconventional Stellar Aspect (USA)Experiment on board the Advanced Research and Global Observation Satellite (ARGOS),and 17pointings by the PCA on board the Rossi X–ray Timing Explorer (RXTE).Most of these observations were spaced by lessthan 1day.1ES1959+65was detected by the ARGOS USA detector in the range 1-16keV,and by the PCA in the 2-16keV range but at different times.During the closely spaced RXTE observations beginning on 2000July 28,an ending of one flare and a start of another are visible,associated with spectral changes,where the photon index Γranges between ∼1.4and 1.7,and the spec-trum is harder when the source is brighter.This implies that 1ES1959+65is anXBL-type blazar,with the X–ray emission likely to originate via the synchrotronprocess.The USA observations reveal anotherflare that peaked on2000Novem-ber14and doubled theflux within a few days,again associated with spectralchanges of the same form.The spectral variability correlated with theflux andtiming characteristics of this object that are similar to those of other nearby BLLacs,and suggest relativistic beaming with a Doppler factorδ≥1.6and mag-neticfields of the order of a few mG.We also suggest that the steady componentof the X–ray emission–present in this object as well as in other XBLs–maybe due to the large-scale relativistic jet(such as measured by Chandra in manyradio-loud AGN),but pointing very closely to our line of sight.Subject headings:1.IntroductionOver a dozen BL Lacs have been detected at GeV energies(Mukherjee et al.1997), but only a few nearby BL Lacs have been identified at TeV energies so far.Mkn421 (z=0.031)(Punch et al.1992)and Mkn501(z=0.034)(Quinn et al.1996)are now strongly confirmed sources,seen by more than one ground-based atmosphericˇCerenkov telescope(ACT)at or above the5σlevel.Two more,1ES2344+514(z=0.044)(Catanese et al.1998)and PKS2155-304(z=0.116)(Chadwick et al.1999),have been detected only once and are less conclusive.This strongly suggests that low-redshift X–ray selected BL Lac objects(XBLs)such as these may be the only extragalacticγ-ray sources observable at TeV energies.This is because on the one hand more distant objects would have their TeV emission strongly absorbed by the extragalactic background light(EBL),and on the other bright X–ray emission,presumably originating from synchrotron radiation and thus revealing the distribution of radiating particles,implies even higher intrinsic GeV-TeV emission(see, e.g.Tavecchio,Maraschi&Ghisellini(1998)).The BL Lac object1ES1959+65(z=0.048),is an XBL also present in the third EGRET catalog with an average measuredflux of1.8×10−7photons cm−2s−1for E>100 MeV(Hartman et al.1999).It is thus a natural source for TeV emission,and Stecker,De Jager&Salamon(1996),using simple scaling arguments,have predicted for it the third highestflux above0.3and1TeV,after Mkn421and Mkn501.More recently,Costa-mante&Ghisellini(2001)have also pointed it out as a candidate TeV emitter.Quoting Weekes(1999),the Utah Seven Telescope Array has reported the detection of1ES1959+65 based on57hours of observation in1998(Kajino et al.1999),with an energy threshold of 600GeV.Theflux level was not reported but the total signal was at the3.9σlevel.Thisis not normally considered sufficient to claim the detection of a new source;however,within this database there were two epochs which were selected a posteriori which gave signals above the canonical5σlevel.This source has not yet been confirmed by any other group; it was observed by the Whipple group but noflux was detected(Catanese et al.1997).Of particular interest in this source is also the fact that its distance is of the same order as the two other confirmed TeV sources,making it a good candidate to probe the EBL that can in turn probe cosmological problems such as the formation of galaxies(see e.g.Primack et al.(1999);Guy et al.(2000)).1ES1959+65is also part of a200mJy radio-selected sample at5GHz(Marcha et al.1996;Bondi et al.2001)and it was seen in the Einstein Slew Survey(Perlman et al.1996).Multiple photometric optical values were found in the literature,showing a great variation of the source brightness in the optical band from V=16 to V=12.8.A complete study of the optical band can be found in Villata et al.(2000) where variability on short timescales(a few days)was reported.The capabilities of the USA and the PCA instruments to monitor the X–ray emis-sion are particularly well suited for the detailed study of the X–ray energy spectrum of 1ES1959+65,and its temporal evolution.Here,we present31USA and17PCA observa-tions of1ES1959+65.The PCA data are two sets of intraday observations,obtained from unpublished RXTE archival data,that span a few days in which the end of aflare and beginning of anotherflare are detected.The USA observations are short daily monitoring observations that span7weeks,ending with a strongflare,where the X–rayflux tripled in 7days(the USA data were taken in the context of a multi-wavelength campaign that was not successful in the TeV range due to bad weather at the ACT site).In Section2,we report the details of the observations;in Section3,we report the main features of the data; in Section4,we discuss the implications of the X–ray spectral variability and the quiescent X–ray emission detected in1ES1959+65;we present our conclusions in Section5.2.Observations and Data AnalysisA DataThe USA Experiment observed1ES1959+65about once per day between2000Septem-ber21(MJD51808)and November11(MJD51859).(For a detailed description of the USA experiment see Ray et al.(1999),Wood et al.(2000)and Shabad(2000).)The USA detector was used in the“ping”mode where within one observation the source is pointed at2or3times for T ON seconds and then a background is taken for T OF F seconds,where typically,T ON=T OF F=60seconds and an observation lasted for∼300s(for more details on the“ping”observation mode see Giebels et al.(2000)).This type of observation hasthe advantage of not relying on a background model but rather on a direct measurement of the background,but results in some loss of signal within an observation A data were extracted from FITS formattedfiles using CFITSIO.Care was taken to use an OF F position as devoid as possible of bright X–ray sources,and at least2◦away from the source. Observations were made in low background regions of the orbit,where the counting rate was approximately30cts/s or1%of the Crab level in the same conditions.The segments of the observation where the background is too high,especially at the beginning and the ending of each observation,are rejected.For the present investigation,we use only observations where at least2pairs of ON-OFF pointings are available for each observation.Within those restrictions,31observations were used from which∼16ks of data were selected.We present the X–ray lightcurve for1ES1959+65in Figure1;in that Figure,the stan-dard deviation of the average in the background was added in quadrature to the error on the count rate for each observation.The data were then corrected for obscuration by the instrument support structure when necessary,and also for the collimator response.Every point in the lightcurve is a single observation.The lightcurve(normalized to the USA Crab rate in the energy range defined below,or3500cts/s)for the total range is shown in the top panel of Figure1.The data were taken in the spectral mode,where the instrument integrates a spectrum covering an energy range of approximately1–17keV in48pulse height analyzer(PHA) channels every10ms.In this work,we make no use of the lowest(0)and the highest(47) PHA channels;the PHA channels1–46(∼1−16keV)are referred to as the total USA range. The spectral characteristics of the time series were studied by dividing the USA data into two energy bands,the PHA channels1–10(soft band)and11–46(hard band),corresponding to approximately1–3keV and3–16keV,respectively.A hardness ratio,shown in the second from top panel in Figure1,is the ratio of the counting rate in the hard band over the soft band.The dates are given in Modified Julian Date(MJD)−51000.2.2.RXTE/PCA DataUnpublished PCA data of1ES1959+65were obtained from the RXTE data archive. The RXTE/PCA observed1ES1959+6512times from2000July28through August2, and5times between2000September1–6,with exposures of∼900s in the July-August observations and a few ksec each in September.The STANDARD2data were extracted using the HEASARC ftools andfiltered using the RXTE GOF-recommended criteria(layer1only, for better signal to noise,PHA channels0to27(lightcurves only)or approximately1-10keV, Earth elevation angle greater than10degrees,pointing offset less than0.02degrees,timesince the peak of the last SAA passage greater than30minutes and electron contamination less than0.1).The lightcurve and spectral data are from unit2(PCU2)only since a faint background model is not yet available for unit0during gain epoch5.The background models of Epoch4were used.Lightcurves were extracted using the ftools saextrct(through the rex script)and lcurve.The variable PCA background was modeled with pcabackest, which uses observations of X–ray blank,high latitude areas of the sky(Jahoda et al.1996). Spectralfits were done using XSPEC v.11.0.1and response matrices generated by the ftool pcarmf.The source was not detected with a better significance than∼2σwith the RXTE/HEXTE instruments.A likely explanation is the steep spectrum,derived from the PCA data,that falls below the HEXTE sensitivity.2.3.Archival DataAn observation with the BeppoSAX instrument in1997(Beckmann2000;Beckmann& Wolter2001)resulted in a measuredflux of1.3×10−11erg cm−2s−1in the2–10keV band and a spectral index ofα=1.64.Thisflux is an order of magnitude fainter than the brightest flux measured here by the PCA.However,the results published by(Beckmann2000)should be treated with caution,as there is an apparent error in the value of the Galactic column adopted by them(they adopt1020rather than1.027×1021atoms cm−2adopted by us on the basis of the COLDEN program available as a part of the Chandra Proposal Planning Toolkit,based on relatively reliable21cm data).The analysis of the PSPC All-Sky Survey data by those authors implies that assuming a simple power law,thefitted absorption is 1.6×1021atoms cm−2,somewhat larger than the Galactic value.However,this might be because the intrinsic X-ray spectrum steepens somewhat towards higher energies,as is often the case for other XBL-type blazars,and an assumption that the observed spectrum is a simple absorbed power law overestimates thefitted absorption.Note that the higher column density makes no difference in the results from the USA or RXTE data.The Einstein Slew Survey Sample of BL Lac Objects(Perlman et al.1996)quotes aflux of3.65µJy at2keV, which is∼40%brighter than the BeppoSAX measurement.We also extracted the ROSAT HRI archival data for this source,and used the ROSAT all-sky data.ROSAT HRI observed it on1996April1;the observation lasted for a total of half a day,yielding about2800sec of good data.The data were reduced in a standard manner,revealing that the net source counting rate was∼1.57ct s−1,with no indication of variability,but this is not too surprising given the short observation length.The conversion of the HRI count rate toflux is dependent on the source spectrum,which has to be assumedas there is essentially no spectral information in the HRI data.Since we do not know the soft X-ray spectrum at the epoch of the HRI observation,we assume the energy indexα=1.5, but two different values of N H,the Galactic value of1021cm−2and thefitted ROSAT value of1.6×1021cm−2.To obtain the conversion from the HRI counting rate to the observedflux, we used the PIMMS tool provided by HEASARC(and checked the results using XSPEC with the HRI effective area curve).Assuming the Galactic column of1021cm−2,we obtain the0.1-2.4keVflux of5.5×10−11erg cm−2s−1and1-2keVflux of2.2×10−11erg cm−2 s−1.Assuming thefitted ROSAT value of1.6×1021cm−2,we infer the0.1-2.4keVflux of5.4×10−11erg cm−2s−1and1-2keVflux of2.5×10−11erg cm−2s−1.In any case, this corresponds to(roughly)2mCrab,which is lower than the13mCrab level from the Rosat all-sky Survey Bright Source Catalog(1RXS-B).This simply implies that during the ROSAT survey,1ES1959+65was significantly brighter than during the Einstein,ROSAT HRI or BeppoSAX observations,and the episodes of highflux as seen by the USA or RXTE observations described hereafter are not unique.3.Observational Results3.1.Flares in the USA and RXTE DataThe USA and RXTE observations of1ES1959+65conducted from July through Novem-ber2000show that the source was bright and variable in the X–ray band,with the X–ray spectrum significantly harder than observed during the periods of lower brightness.Specifi-cally,these data show that during the last quarter of2000,1ES1959+65underwent an X–ray flare reaching the12mCrab level in the1-16keV band on November14(MJD51863).Vari-ability of a factor∼6was detected within20days,and a factor∼3within7days(Figure1). By comparison,the peakflux detected by USA on Mkn421in2000reached approximately 40mCrab at maximum.Visual inspection of the USA(as well as the RXTE)lightcurves, and in particular of the largestflare,indicates that the source does not appear to vary sig-nificantly on timescales shorter than a day;thus the variability is not undersampled.These observations show that1ES1959+65was in a variable state for at least4months.To com-plete the coverage of thisflare,3data points from the RXTE/ASM were normalized to the Crab and added to the lightcurve in Figure1;this shows theflare continuing to decrease. The varying spectral index and differences in the energy response of both instruments com-plicate the comparison.Nonetheless,the full-width at half-maximum region of theflare with these additional points spans5±1day,and the doubling time is2.5days.The PCA archival data obtained2months prior to the USA observations show65%flux changes in3.5days;the highest observed value was F(2-10keV)=1.4×10−10ergcm−2s−1,but the peak value is unknown,since the observed maxima are at the endpoints of the observed period,when the source was falling or rising as shown in Figure2.The USA lightcurve shows that the PCA did not cover the typical variation period which appears to be>4days.The samefigure shows a decreasingflux extending over3.5days,and after30 days observations resume for4days where a steady increase offlux is seen.Theflux did not change more than a few percent on timescales shorter than a day in the PCA data.In the three panels in Figure3it is apparent that variations are larger in the harder bands in the decreasing part of the PCA observations.3.2.Flux-Spectrum CorrelationsThe PCA data were used to perform spectralfits as a function of theflux in the2-10 keV energy range.The data werefit to a single power-law function with indexα,such that the photonflux N(E)=N0E−(α+1)and the absorbing column N H=10.27×1020cm−2.The absorbed power law model provides an adequatefit for all RXTE PCA pointings. Spectral indices were obtained for every observation,and in some cases,intraday observations where the estimated indices andfluxes were similar were added together to improve the significance on a daily timescale.The spectralfits are shown in Table2along with the month,day and fraction of the day of the beginning of each observation.The X–ray spectrum follows a“loop”in the spectral index-flux plane,as seen in Figure 4,and it is not surprising that the X–ray spectrum shows significant evolution during the flare given that there is a more rapid rise and drop in the hard X–ray band(see§4for discussion).The steepest spectrum in the PCA data was observed at thefirst observations in the declining phase July28(α=1.68),and the hardest spectrum was seen on2dates separated by a month and at a similarflux(α=1.37)which is a hint that the same physical mechanism is generating theseflux variations.In the case of the USA observation, poorer photon statistics and an incomplete energy calibration limited the spectral study to a hardness ratio(HR)estimation plotted on the same Figure1.The USAfluxes and HR are shown in table1.During the strongestflare,that started around(MJD-51000)=857,a20% variation in the HR is observed.4.Discussion4.1.Doppler Boosting of the Flux of1ES1959+65The electromagnetic emission in blazars is very likely to be Doppler-boosted(or beamed) towards the observer.In the radio regime,the evidence comes from superluminal expansions observed with VLBI.Similar superluminal expansions have now been seen in the optical band with the HST in nearby galaxies such as M87.Relativistic beaming is also required in order to avoid absorption of GeV photons by X–ray photons via the e+/e−pair-production process. It is thus possible to use the X–ray variability data as well as the fact that1ES1959+65is an EGRET-detected BL Lac object,to establish a limit for the Doppler factorδ,withδdefined in the standard way as[Γ(1−βcosθ)]−1,whereΓis the bulk Lorentz factor of the plasma in the jet,β=v/c andθis the angle to the line of sight.Assuming that theγ-rays and X–rays from1ES1959+65are produced in the same region,it is possible to calculate the opacity for pair productionτγγfrom the source sizes inferred from the USA and RXTE/PCA data.The formula given by equation(3)in Mattox et al.(1993)for the optical depth for an outflow which is nonrelativistic in its comoving frame,as corrected by Madejski et al.(1996),isτ=2×103(1+z)2α(1+z−√µJy(EγThe X–ray data presented above imply that the X–ray spectrum of1ES1959+65hardens as the source brightens.This is often measured in BL Lac objects;a hardening of the spectrum whenflares occur,and a blueward shift of the peak of the synchrotron emission (and presumably higher energy inverse-Compton emission)by factors that can be as large as100was measured in the cases of Mkn501(Pian et al.1998),1ES1426+428and PKS 0548−322(Costamante et al.2001).In the case of PKS2005-489(Perlman et al.1999),a more moderate shift of a factor of3or less of the synchrotron emission was found.4.2.Synchrotron Models and Inferred ParametersThe spectral change is best illustrated as a correlation betweenflux and the photon ing PCA data this correlation is illustrated in Figure4.Even though the two observations were separated by a month and are certainly related to two differentflares,it is still interesting to compare this spectral evolution since the time series have similar rise and fall timescales,which are also comparable to what is seen in the USA detector.It is thus likely that the twoflares originate from a similar mechanism and that the correlation plot has some validity.The“clockwise motion”(shown with arrows)observed in the data for1ES1959+65 has also been seen inflares in Mkn421(Takahashi et al.2000,1996),in PKS2155−304 (Sembay et al.1993)and in H0323+022(Kohmura et al.1994),although in some cases counterclockwise patterns have also been seen(Mkn501,Catanese&Sambruna(2000)). The spectrum steepens more rapidly than theflux in the declining phase and hardens rapidly in the brightening phase,indicating that the variations of the hard X–rays occur faster than those in the soft X–rays both during the increase and the decrease of the brightness of the source.The spectral index change of14%seen here is comparable to the10%seen in Mkn421.The variation observed in theflux-index plane can provide information about the acceleration process(Kirk&Mastichiadis1999).Counter-clockwise patterns are expected when acceleration,variability and cooling timescales are similar in aflare.In this case the acceleration process proceeds from low energy to high energy changing the number of particles and making the softer energies varyfirst.Clockwise patterns,where the harder energies varyfirst,can be explained inflares where the variability and acceleration timescales are much less than the cooling timescale.For a homogeneous emitting region,the radiative lifetime of a relativistic electron emitting synchrotron photons with energy E keV is(in the observer’s frame)τsync=1.2×δ−1/2s(Rybicki&Lightman1979).This should give some estimate of the 103B−3/2E−1/2keVmagneticfield B,even though the extent to which the timescale of theflux decrease was due to the propagation of the signal throughout the source and to what extent it was causedby the synchrotron cooling is not known.However,it is possible to measure the relative decrease of theflux∆F/F in three energy bands in a time∆T using the PCA data as seen in Figure3.To estimate the timescale for a drop by a factor of two in each energy band, the measured timescale is divided by a factor2∆F/F.The factor∆F/F is smallest for the lowest energy band(24%)as expected.It is now possible tofindτ1/2(E)=7.7,4.9and 1.9×105s,respectively,for3,7and12keV photons.According to Takahashi et al.(1996) we writeτsync(E)−τsync(12keV)=1.2×103B−3/2δ−1/2(E−1/2keV−12−1/2).Comparing the decline of theflux of3keV and12keV photons yield B=0.007δ−1/3G,while the decay of the7keV and12keV photons yield a similar result of B=0.005δ−1/ingδ=1.6we infer B=4×10−3G.It is interesting to note here that this is a similar value to that found by Perlman et al.(1999)(P99hereafter)in an outburst of PKS2005−489where variability on timescales of days was observed.The peak observed frequency of the synchrotron emissionνs of an electron withγel is given byνs≃1.2×106Bγ2elδ−ing the magneticfield inferred above,the Lorentz factors of the electronsγel radiating at energy E can be estimated from E=2×10−14γ2elδkeV.This implies thatγel of electrons4radiating in the X–ray band is∼107.The value of B calculated as above is significantly lower than0.2G,andγel higher than5×105inferred for Mkn421by Takahashi et al.(1996),but the values inferred by us are similar to those quoted for PKS2005−489by P99where a possible undersampling was invoked to explain the possibility of faster(shorter than∼1day)variability,which in turn would make the inferred value for B a lower limit andγel an upper limit.We believe that in1ES1959+65theflux is sampled relatively densely,and thus the variability is unlikely to be undersampled.This means that the difference in the inferred values of B andγel in1ES1959+65as compared to Mkn421is unlikely to be a result of the source being more compact,while this could be the case for the potentially undersampled data for PKS 2005−489(P99).With our inferred source parameters being so close to the values found for PKS2005−489,it is now quite possible that real differences between these two sources and Mkn421exist.A conclusive test of the physical parameters in this source would be a clear detection of the TeVγ-ray emission,and any correlation with the X–rayflux.Also, longer,more sensitive and well-sampled observations in the X–ray band are needed to either confirm or disprove that the variability pattern of1ES1959+65and its spectral properties are as described here.A noticeable difference between PKS2005−489and1ES1959+65is that whereas in the latter a variation in the spectral index∆α=0.6was associated with aflux change of a factor of30,in the former a∆α=0.35produced only a65%change intheflux.Also note in the USA data,a doubling of the hardness ratio is accompanied by a factor of6increase influx.4.3.Continuous Emission:Knot Radiation?The USA lightcurve exhibits a non-zero X–rayflux outside of theflaring events of a few10−11erg cm−2s−1(or a few mCrab,taking1Crab≈1.7×10−8erg cm−2s−1in the 2–10keV band).The existence of a steady underlying emission in at least one other BL Lac object,Mkn421,has been invoked in order to obtain meaningfulfits with an exponential decay to X–rayflares(Fossati et al.2000).It is intriguing to investigate if such steadyflux could originate in more extended jets such as those recently resolved by the Chandra and XMM telescopes,but aligned more closely to our line of sight and thus brighter.Such knots (or hotspots)in large-scale(hundreds of parsecs or more)jets have indeed been seen from radio to X–ray energies in many non-aligned sources i.e.sources where the jet is sufficiently misaligned to allow us to resolve the structure of the jet;of course such structures must also originate on a relatively large spatial scale as compared to the sub-parsec jets responsible for the rapid,day-scale variability.These knots are persistent structures visible on timescales of years,and individual spectral energy distributions(SEDs)have been established for knots in multiple sources such as M87(Marshall,Miller et al.2001)or PKS0637−752(Chartas et al.2000).Theirfluxes are usually a fraction of theflux arising from the unresolved core,but a closer alignment to our line of sight than for those sources resolved by Chandra and XMM would result in greater Doppler boost and could provide a continuous background seen in BL Lac-type objects,presumably the objects most closely aligned to our line of sight.To verify if aflux of a few10−11erg cm−2s−1could originate from aligned X–ray knots, somefluxes are taken from the literature for the cases where the angles to the line of sight(θhereafter)and Lorentz factors are available from radio observations.With this,it is possible to estimate theflux enhancement forθ∼0◦and the luminosity at a distance similar to that of1ES1959+65.The observedflux would depend on three factors:•A change in Doppler boost that multiplies theflux F by(˜δ/δ)4(see Urry&Shafer(1984) for luminosity conversions)where˜δis the Doppler factor for the same source but with an angleθ=0◦.Thus the amplification would be[1−βcosθΓ2•The distance difference changes theflux by a factor of(z/0.048)2•a K-correction has to be applied since the bandwidth is narrowed,changing theflux bya factor of(1+zparison with3C66B3C66B is a low-luminosity FRI radio galaxy(z=0.0215).Its jet has knots resolved inthe radio,optical and X–ray band(Hardcastle et al.(2001)and references therein).FromGiovannini et al.(2001)wefind thatθseems well constrained(about45◦)but thatΓis not(between1and7).The set(θ,Γ)∼(45◦,7)is a possible configuration of the jet that would come withinthe right order of magnitude to explain the origin of the X–ray radiation by IC scattering ofseed photons from a hidden BL Lac in the nucleus of3C66B.From Hardcastle et al.(2001)theflux density at1keV,for the2brightest knots out of5(A and B),is approximately10nJy.A value ofα=1.31is used,the one found for the jet,though the exact value doesnot matter much given the comparable redshift of3C66B to the one of1ES1959+65.Theinferred value of A∼1.6×105yields∼4×10−9erg cm−2s−1(or230mCrab)offlux comingfrom the knots in the case of an angle at0◦.Using an angle of∼4◦would reduce thefluxratio by a factor of2only and make it still a bright steady source.The level of expectedradiation in this case is actually so high that a similar object pointing closer to the line ofsight would not be unnoticed in radio emission,thus the(θ,Γ)∼(45◦,7)set seems quiteextreme.Taking a slower jet(β∼0.75)also mentioned in Hardcastle et al.(2001)thefluxcoming from the knots of3C66B would be a factor of6×104lower than in the previouscase,significantly below the level of a few10−11erg cm−2s−1.The results from M87and3C66B show that it is possible that radiation from knotsmoving close to the line of sight can generate a significant fraction of the baseline level of X–rayflux invoked in at least two cases,Mkn421and1ES1959+65here,assuming they containknots similar to those observed in M87or3C66B.Recent VLBI observations show that theline of sight angle with Mkn421is constrained to be in the0◦−30◦range(Giovannini et al.2001),thus a small angle to the line of sight is a possibility for this source.In a moregeneral way,UPS91predict that FR I radio galaxies should have jets with bulkflow speedsin the range fromΓ∼5to∼35,with most nearΓ∼7,and they derive a critical angleθcrit∼10◦for the FR I/BL Lac division.If bright knots are common in BL Lac objects then the amplification factors associated with the large Lorentz factors invoked here could generate a continuous background at the level mentioned above(assumingθis of the order of a few degrees only).A more thorough search for evidence of continuous emission in blazars and other signatures of boosted knot radiation is currently under way.。