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紧张素Ⅱ表达,增加胰岛素抵抗、抑制凝血因子活性
和血管平滑肌细胞的增殖及B 型钠尿肽的表达等
[17-21]
。
综上所述,维生素D 水平与CIMT 密切相关,维生素D 缺乏可能是颈动脉斑块发生的危险因素之一。本研究属于回顾性分析,
存在一定的选择偏倚。未来还应开展更多前瞻性研究,进一步明确维生素D 缺乏与颈动脉病变发生的关系,并针对维生素D 缺乏的患者,观察给予补充维生素D 治疗后CIMT 和颈动脉斑块发生的变化。
[参考文献]
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[收稿日期]2018-10-22[责任编辑]李洁
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·025·宁夏医学杂志2019年6月第41卷第6期Ningxia Med J ,Jun.2019,Vol 41,No.6