最新人工合成基因组
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VENTERINSTITVTE CRAIGVENTER HAMSMITH CINDIANDCLYDE GLASSANDCLYDE 代表5个作者: Craig Venter, Hamilton Smith, John Glass, Clyde Hutchison
人工合成基因组
Genome transplantation in bacteria: changing one
species to another
天然完整基因组种间转移:
As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA
carried by the M. mycoides LC
chromosome, contain the complete donor genome and are free of detectable recipient genomic sequences. These cells that result from genome transplantation are phenLeabharlann Baidutypically identical to the M. mycoides LC donor strain as judged by several criteria.
NCBI checked into the genetic sequence submitted by Venter’s Institute and found the watermarks hidden in plain sight.
The five coded messages that will go down in history as embedded in the first synthetic genome
--- Science. 2007 Aug 3; 317:632-8
合 成 基 因 组 结 构 图
人工合成基因组中的水印
The secret amino acid messages contained in "watermarks" that were embedded in the world’s first manmade bacterial genome.
from Mycoplasma mycoides（蕈状支
原体 ） large colony (LC), virtually
free of protein, was transplanted into
Mycoplasma capricolum（山羊支原体）
cells by polyethylene glycol(PEG)mediated transformation. Cells selected for tetracycline resistance,
人工合成基因组
Genome transplantation in bacteria: changing one
species to another
天然完整基因组种间转移:
As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA
carried by the M. mycoides LC
chromosome, contain the complete donor genome and are free of detectable recipient genomic sequences. These cells that result from genome transplantation are phenLeabharlann Baidutypically identical to the M. mycoides LC donor strain as judged by several criteria.
NCBI checked into the genetic sequence submitted by Venter’s Institute and found the watermarks hidden in plain sight.
The five coded messages that will go down in history as embedded in the first synthetic genome
--- Science. 2007 Aug 3; 317:632-8
合 成 基 因 组 结 构 图
人工合成基因组中的水印
The secret amino acid messages contained in "watermarks" that were embedded in the world’s first manmade bacterial genome.
from Mycoplasma mycoides（蕈状支
原体 ） large colony (LC), virtually
free of protein, was transplanted into
Mycoplasma capricolum（山羊支原体）
cells by polyethylene glycol(PEG)mediated transformation. Cells selected for tetracycline resistance,