CFM 1571 hydrochloride_sGC激活剂_1215548-30-3_Apexbio
MK2-IN-1_hydrochloride_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jul.-24-2017Print Date:Jul.-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MK2-IN-1 (hydrochloride)Catalog No. :HY-12834ACAS No. :1314118-94-91.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MK2 InhibitorFormula:C27H26Cl2N4O2Molecular Weight:509.43CAS No. :1314118-94-94. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Pink to red (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Roche MagNA Lyser 产品说明书
Ordering Information Cat. No. Product ***********MagNA Lyser Instrument (230 Volt)***********MagNA Lyser Instrument (110 Volt)(Instruments supplied with rotor and rotor cooling block)***********MagNA Lyser Green Beads (100 tubes)Related Products Cat. No. Product***********MagNA Pure LC DNA Isolation Kit II (Tissue)***********MagNA Pure LC mRNA Isolation Kit II (Tissue)03 330 591 001MagNA Pure LC RNA Isolation Kit III (Tissue)***********MagNA Pure LC DNA Isolation Kit III (Bacteria, Fungi)***********MagNA Pure LC RNA Isolation Tissue Lysis Buffer – Refill (70 ml)System DescriptionHomogenize up to 16 samples in just a few seconds.Save valuable lab space with a small benchtop instrument.Reduce hands-on time by replacing the mortar and pestle and other manual methods.Integrate your workflow with the automated nucleic acid isolation of the MagNA Pure LC Instrument.Perform consistent and reproducible sample disruption.Process many different sample types.Prevent nucleic acid degradation with the benchtop cooling unit.Ease your setup with a removable rotor and prefilled disposable vials.Automate with an easy-to-use instrumentVersatile, efficient, and rapid pre-preparationFigure 71. Add your sample and lysis buffer to the MagNA Lyser Green Beads.2. Homogenize with the MagNA Lyser Instrument.3. Centrifuge to pellet the debris.4. Proceeed with the supernatant to prepare nucleic acids or proteins.For detailed information,visit or contact your local representative.Trademarks:MagNA Pure, MagNA Lyser, LightCycler, and the MagNA Pure Logo are trademarks of a member of the Roche Group.The technology used for the LightCycler System is licensed from Idaho Technology Inc., Salt Lake City, UT, USA.Fully automated sample preparationon the PCR Workflow SystemRoche Diagnostics GmbH Roche Applied Science Nonnenwald 282372 Penzberg Germany0000Roche Applied Science Part of Roche DiagnosticsMagNA Lyser InstrumentStart the Ball Rollingwith Automated Tissue HomogenizationᕤᕣᕢᕡFigure 6Components of the system.The MagNA Lyser InstrumentAutomated tissue homogenizationProcessing conditionsRefer to the following tables for guidelines on setting up your homogenizationSample material(10 mg)*Time settings(seconds)Cooling(between the runs)Speed Average yield(µg)***Average purity(OD 280/260 nm)***Spleen 2 x 25 906,00030–40 1.9Liver 25-6,00016–18 1.8Lung 2 x 25906,00025 1.8Kidney25-6,000201.8Maize leaves **20-5,00010n.d.Maize polenta **20-5,0008n.d.Tortilla chips **20-5,0001n.d.*Aliqout containing 10 mg sample material (here mouse and food samples) was taken for the DNA purificationusing the MagNA Pure LC DNA Isolation Kit II (Tissue), (see pack insert)**Centrifugation after the homogenization for 5 minutes at 2,200 x g*** Yield and purity strongly depend on the condition of the sample material n.d.not determinedData kindly provided by Dr. Peterhänsel, RWTH Aachen, GermanyFigure 1Gel electrophoresis from genomic DNA isolated from tissue homogenized with the MagNA LyserInstrument, using the MagNA Pure LC DNA Kit II (Tissue).Marker: DNA Marker III*Aliquot containing 10 mg sample material (here mouse and human research samples) was taken to purify RNAeither with the MagNA Pure LC RNA Isolation Kit III (Tissue) or the MagNA Pure LC mRNA Isolation Kit II (Tissue) homogenized with the MagNA Lyser Instrument.** Yield and purity strongly depend on the condition of the sample material. The yield for mRNA was not determined.Sample material(10 mg)*Time settings(cycles/seconds)Cooling(between/afterthe runs in seconds)SpeedAverage yield (mg)(total RNA)**Average purity(OD 280/260 nm)**RNA/mRNARarely expressed targets in small numbers of target cells,as seen in experiments about minimalresidual diseases,are difficult to detect.Increasing the cell number can improve sensitivity and lead to accurate results.Without the MagNA Lyser pre-processing,the MagNA Pure mRNA HS Kit can efficiently obtain mRNA from a maximum of 1 x 107white blood cells (WBCs),as shown in research studies with human samples.However,using greater cell numbers results in a saturation effect with quantitative assays (Figure 3).Homogenization of the lysate with the MagNA Lyser Instrument prior to the purification eliminatesthe amplification saturation at 1 x 107cells and allows the use of up to 2.5 x 107WBCs (Figure 4 and 5),enhancing the analytical sensitivity of the assay.Eliminate sensitivity barriers with increased sample inputFigure 3mRNA was purified from different amounts of human white blood cells with the MagNA Pure mRNA HS Kit. G6PDH was amplified using the LightCycler t(9;22) Quantification Kit (see text beside).Figure 4mRNA was purified from different amounts of human white blood cells with the MagNA Pure mRNA HS Kit. The lysates from 2.5 x 107cells and 5 x 107cells were homogenized with the MagNA Lyser Instrument (2x50 seconds with 90 seconds cooling in between) prior to the mRNA purification. G6PDH was amplified using the LightCycler t(9;22) Quantification Kit (see text beside).Figure 5Scalability from 1 x 106cells to 2.5 x 107cells is represented in the graph and the table of the relationship between crossing points and cell numbers. The limitation of cell input is indicated by no change in crossing point with increased cell number (see text beside).Cell number 5 x 1072.5 x 1071 x 1075 x 1061 x 106Log (cell number)7.77.47.06.76.0Crossing point 20.320.321.822.424.4crossingpointLog(cell number)252423222120195.86.36.87.37.8Figure 2Gel electrophoresis from total RNA isolated from tissue homogenized with the MagNA Lyser Instrument, using the MagNA Pure LC RNA Kit III (Tissue).Ma r k e rS p l e e nL i v e rL u n gK i d n e yM a r k e rMa i z e l e a v e sMa i z e l e a v e sS p l e e nL i v e r11 kb5 kb5 kb28 S rRNA 18 S rRNASpleen 2 x 50 90 6,500–7,000 30–40 1.9Liver 50 - 6,500–7,000 13–17 2.0Thymoid tissue60906,500n.d.n.d.Heart 60 90 6,500 n.d. n.d.Abdominal fat 60 90 6,500 n.d. n.d.Aorta 60 90 6,500 n.d. n.d. Other samples1+n x 50 90 6,500–7,000- -1 x 105 x 101 x 10- 5 x 101 x 105 x 105 x 10- 5 x 102.5 x 10 5 x 10。
3-氯-2-肼基吡啶 分子量
3-氯-2-肼基吡啶分子量
3-氯-2-肼基吡啶（3-chloro-2-hydrazinylpyridine）是一种有机化合物，化学式为C5H5ClN4，分子量为158.57 g/mol。
它是一种重要的中间体化合物，在医药和农药等领域具有广泛的应用。
3-氯-2-肼基吡啶是一种白色到浅黄色的固体，具有较高的稳定性和溶解性。
它可以通过吡啶-3-羧酸和盐酸肼反应得到，也可以通过其他合成路线进行制备。
在生产过程中，需要严格控制反应条件，以保证产物的纯度和产率。
在医药领域，3-氯-2-肼基吡啶被广泛用于合成药物。
它可以作为一种重要的合成中间体，参与到许多药物的合成过程中。
比如，它可以用于合成抗癌药物、抗菌药物等。
同时，3-氯-2-肼基吡啶本身也具有一定的生物活性，可以作为一种药物原料直接用于制备药物。
在农药领域，3-氯-2-肼基吡啶也是一种重要的中间体。
它可以用于合成各种类型的农药，如杀菌剂、杀虫剂等。
这些农药在农业生产中起到了重要的作用，可以有效地控制农作物病虫害，提高农作物产量。
除了医药和农药领域，3-氯-2-肼基吡啶还可以用于其他领域。
比如，它可以用于有机合成反应中的催化剂，可以参与到材料合成中，还可以用于有机电子材料的制备等。
总的来说，3-氯-2-肼基吡啶作为一种重要的中间体化合物，具有广泛的应用前景。
随着化学合成技术的不断发展和改进，相信它将会在更多的领域展现其价值，为人们的生活和生产带来更多的便利。
1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚
相对密度（水=1）：1.59-1.63
相对密度（空气=1）：无资料
饱和蒸气压／kPa：0.27（175℃）
燃烧热（kJ/mol）：-3810.95
临界温度／℃：无资料
临界压力／MPa：无资料
闪点／℃：56
自燃温度／℃：无意义
爆炸下限（%）：2.8
爆炸上限（%）：30.5
分子式：C10H6Cl8
相对分子质量：409.779
危险化学品序号：43
CAS号：57-74-9
UN编号：2996
危险性类别：急性毒性-经皮,类别3；致癌性,类别2；危害水生环境-急性危害,类别1；危害水生环境-长期危害,类别1
理化特性
外观与性状：无色或淡黄色液态，工业品为有杉木气味的琥珀色液体
熔点／℃：无资料
1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚
标识
中文名：1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚；氯丹；八氯化茚
英文名：chlordane;1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindan;M-410
分解温度／℃：沸点分解
溶解性：不溶于水，溶于多数有机溶剂
危险性概述
物理和化学危险：不燃，无特殊爆燃特性。
健康危害：急性中毒：中毒症状发生较快，几小时即可死亡。主要症状为中枢神经系统兴奋症状，如激动、震颤、全身抽搐；摄入中毒症状出现更快，有恶心、呕吐、全身抽搐。严重中毒紫抽搐剧烈和反复发作后陷于木僵、昏迷和呼吸衰竭。慢性中毒：主要症状为神经系统功能紊乱，肝、肾退行性改变。有头痛、眼球痛、全身乏力、失眠、噩梦、头晕、心前区不适、四肢麻木和酸痛。
细胞内氧化应激活性氧ROS初级荧光测定试剂盒产品说明书中文版主要用途
细胞内氧化应激活性氧（RoS）初级荧光测定试剂盒产品说明书（中文版）主要用途细胞内氧化应激活性氧（ROS）初级荧光测定试剂是一种旨在通过透膜荧光染色剂二氯荧光乙酰乙酸盐，在细胞氧化条件下，产生荧光，来定量检测细胞内活性氧族的生成和增加的权威而经典的技术方法。
该技术由大师级科学家精心研制、成功实验证明的。
可以被用于细胞凋亡、信号传递、衰老、代谢和营养学等的研究。
产品严格无菌，即到即用，操作简易，活体检测，性能稳定。
技术背景超氧自由基阴离子（superoxideradica1：O2）＞过氧化氢（hydrogenperoxide；H2O2）、羟自由基或氢氧基（hydroxy1radica1：0H）、过氧化基（peroxy1radica1；R00'氢过氧自由基Chydroperoxy1;H00烷氧自由基（a1coxy!radica1）.氮氧基（niiricOxide；NO）、过氧亚硝基阴离子（PeroXyniIri1eanion；ONOO）次氯酸（hyρoch1orousacid；HoC1）、半酸自由基（semiquinoneradica1单线态氧气（Sing1etoxygen）等细胞内活性氧族（ReaciiveOxygenSpecies;ROS）的产生和增多，将导致细胞哀老或凋亡。
2,,7-二氯荧光乙酰乙酸盐（2'.7idich1orof1uOreSCeindiaCe1ate,DCFH-DA）一种完全自由通过细胞膜的染色剂。
一旦被过氧化氢、过氧化基、过氧亚硝基阴离子等氧化，便产生荧光。
据此测定细胞内活性氧族的浓度。
产品内容清理液（Reagen1A）亳升染色液（Reagen1B）微升稀释液（Reagen1e）亳升保存液（Reagen1D）受升产品说明书1份保存方式保存染色液（Reagen1B）在一20七冰箱里，严格避免光照；其余的保存在4C冰箱里，有效保证12月用户自备胰蛋白酶乙二胺四乙酸混合液（GMS12024）：用于细胞脱离完全细胞培养液（GMSI2052）：用于细胞操作所需的培养基15亳升锥形离心管：用于细胞操作的容器15亮升离心管：用于细胞染色的容器血细胞计数仪：用于细胞计数台式离心机：用于沉淀细胞细胞流式仪：用于细胞荧光分析（共聚焦）荧光显微镜：用于观察荧光细胞荧光分光光度仪或衡标仪：用于定量检测荧光细胞实验步骤一、间接法实验开始前，将一20℃冰箱里的试剂盒中的染色液（ReagentB）置入冰槽里融化，稀释液（ReagentC）放进37°C恒温水槽里预热。
盐酸羟胺结构式
盐酸羟胺结构式
分子结构HONH2HCl
分子式HONH3Cl；NH3OHCl
CAS号5470-11-1
中文名称：盐酸羟胺
英文名称：Hydroxylamine hydrochloride
中文别名：盐酸羟胺; 氯化羟胺; 羟基氯化胺; 氢氯羟胺; 羟胺盐酸; 羟胺盐酸盐; 盐酸胲英文别名：Hydroxylamine hydrochloride; hydroxylamine,hydrochloride
贝尔斯坦号/MDL：MFCD00051089
EINECS：226-798-2
外观与性状：无色或灰白色结晶固体
密度：1.67 g/mL at 25 °C(lit.)
熔点：155-157 °C (dec.)(lit.)
沸点：56.5oC at 760mmHg
水溶解性：560 g/L (20 oC)
存储条件/存储方法：
1.应贮存在阴凉、通风、干燥的库房内。
2.本品采用内层衬塑料袋，中层衬纸袋，外层用聚乙烯的编织袋，再用木桶或纸桶包装，每袋25kg。
本品易吸潮，加热时可深度分解，故需密封存放于干燥处，防潮、防热。
按有毒物品规定贮运。
稳定性相关：
1.吸湿性强，受潮高于151℃则分解。
在17℃时，100g水中可溶解83.8g。
2.本品剧毒，对皮肤有刺激性。
生产设备应密闭，防止跑、冒、滴、漏，操作人员应穿戴防护用具。
溅及皮肤时，可用大量水冲洗。
法舒地尔杂质谱
37
8-异喹啉磺酸乙酯
现货
38
4392-52-3
现货
39
1,3-二溴丙烷
现货
40
8-异喹啉二聚体
现货
41
5-异喹啉磺酸氮氧化物
现货
42
1，3-丙二胺
现货
43
现货
44
现货
45
现货
46
现货
47
现货
48
现货
49
现货
50
现货
51
52
湖南增达生物科技有限公司是国内研究法舒地尔药物杂质最全，杂质谱最多的企业，具有大量库存。同时具有1000多个现货药物杂质库存。
分子式：C4H17N3O2·HCl
分子量：327.83
结构式：
编号
名称
结构分子式、量
货期
FSDR-1
FasudilDimer
CAS:1337967-93-7
C25H22N4O4S2 482.58
现货
FSDR-2
Fasudil Impurity 1
C15H19ClN2O2S 326.84
现货
FSDR-3
CAS:1350827-92-7
C37H39N7O7S3 789.94
现货
FSDR-6
Fasudil Pyridine N-Oxide TFA Salt
CAS:186544-56-9(Free Amine
C37H39N7O7S3 789.94
现货
FSDR-7
现货
FSDR-9
1,4-bis(phenylsulfonyl)-1,4-diazepane
现货
22
7-位异喹啉磺酸
科迪华氯氟吡啶酯原药获巴西批准
14/875环球农化近期，科迪华向AgroPages证实，公司旗下Rinskor（氯氟吡啶酯）原药已获巴西Anvisa批准，可在巴西销售。
氯氟吡啶酯是一种新的活性成分，作用模式与现有成分不同，新型除草剂Loyant将采用此种活性成分。
科迪华表示，Rinskor将是“防除水稻主要抗性杂草和难除杂草的重要工具”，可高效防除稻田莎草、水生植物和阔叶杂草，推荐苗后施用。
此外，该产品还获得了国际认可，例如曾获得“绿色化学挑战奖”。
新产品供给与Coopersulca （Santa Catarina州）有合作关系的水稻种植者。
据科迪华技术人员称，该产品是美国抗性杂草国际研究中心广泛研究的成果。
Coopersulca负责营销的Luiz FernandoBendo说：“抗性杂草是稻农面临的最大挑战。
与杂草抗性管理相关的挑战催生了对创新技术的需求，而Loyant可以解决稻田杂草日益增长的抗性问题。
”Bendo说：“杂草对ALS产生抗性正在成为一个严峻的问题。
采用Rinskor作为活性成分的除草剂Loyant可防除水稻中对ALS、草甘膦、ACCase、PPO和三嗪类除草剂产生抗性的杂草以及其他抗性杂草。
”科迪华指出，氯氟吡啶酯制剂产品仍需经过监管机构的批准，目前在巴西MAPA（农业、畜牧业和供应部）的登记工作已进展到最后阶段，这款新型除草剂预计将在未来几年投放市场。
科迪华氯氟吡啶酯原药获巴西批准北美地区Nufarm登记的原药，含量99%Albaugh登记的原药，含量99.2%Fludioxonil 40.3% SC DYNA-SHIELDFludioxonil 11.8% SC Fludioxonil TURF拉美地区Fludioxonil 25g/L+metalaxyl-M 10g/L SCMAXIM XLFludioxonil 25g/L+metalaxyl-M 10g/L+Azoxystrobin g/L SC DynastyFludioxonil 25g/L+Definoconazole 20g/L SC Celest XL中国企业除了关注上述剂型之外，还需要特别关注咯菌腈与传统杀菌剂的混配剂型，通过组合效应降低用药成本，并在作物上形成较好的杀菌谱组合。
迈瑞三羟甲基氨基甲烷用途
迈瑞三羟甲基氨基甲烷用途迈瑞三羟甲基氨基甲烷，也简称为MCHA，是一种有机化合物，常用作添加剂和基础材料。
以下是迈瑞三羟甲基氨基甲烷的一些主要用途：1. 医药领域：迈瑞三羟甲基氨基甲烷是合成多种药物的重要原料之一。
它可以通过化学反应与其他药物分子结合，形成稳定的化合物。
这些药物可以用于治疗多种疾病，如高血压、心脏病、癌症等。
同时，迈瑞三羟甲基氨基甲烷还可以作为药物的缓释剂，帮助增加药物的持续释放时间，提高其疗效。
2. 化妆品和护肤品：迈瑞三羟甲基氨基甲烷可以用作化妆品和护肤品的抗菌剂。
护肤品中常常需要抑制细菌和真菌的生长，迈瑞三羟甲基氨基甲烷可以起到这样的作用。
它能有效抑制细菌的繁殖，保持产品的新鲜和卫生。
3. 食品和饮料加工：在食品和饮料加工过程中，迈瑞三羟甲基氨基甲烷可以被用作酸度调节剂和稳定剂。
它能够调整食品和饮料的酸碱度，增加产品的稳定性，延长其保质期。
除此之外，迈瑞三羟甲基氨基甲烷还可以用于凝固剂的制备，如果冻、布丁等。
4. 工业领域：迈瑞三羟甲基氨基甲烷在工业上还有一些重要的应用。
例如，它可以用作生物染料和感光剂的原料，用于印刷和光敏材料的制备。
此外，迈瑞三羟甲基氨基甲烷还可以用作合成树脂和聚合物的交联剂，提高材料的强度和耐磨性。
5. 化学实验室：迈瑞三羟甲基氨基甲烷常常被用于化学实验室。
它可以用作中和剂和缓冲液的配制。
在实验过程中，加入适量的迈瑞三羟甲基氨基甲烷可以调整试剂溶液的酸碱度，保持反应的稳定性。
此外，迈瑞三羟甲基氨基甲烷还可以用作染色剂的定性和定量分析。
总结起来，迈瑞三羟甲基氨基甲烷是一种多功能的有机化合物，在医药、化妆品、食品、饮料、工业和化学实验室等领域都有重要的应用。
它可以用来合成药物、抗菌剂、酸度调节剂和稳定剂，同时还可以用于制备染料、感光剂、交联剂等。
通过这些应用，迈瑞三羟甲基氨基甲烷为各行各业提供了一种重要的化学材料。
Anhydrochlortetracycline (hydrochloride)_金霉素杂质,蛋白合成的弱抑制剂_65490-24-6_Apexbio
化学名:
SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
(4S,4aS,12aS)-7-chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydr o-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecar boxamide, monohydrochloride
特别声明
产品仅用于研究， 不针对患者销售，望谅解。 每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
产品说明书
化学性质
产品名: Anhydrochlortetracycline (hydrochloride) 修订日期: 6/30/2016
产品名:
Cas No.: 分子量: 分子式:
Anhydrochlortetracycline (hydrochloride) 65490-24-6 497.3
C22H21ClN2O7 • HCl
ApexBio Technology
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
Protein synthesis
产品描述:
Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.
百灵威核磁耗材产品
NMR Consumables and Accessories
客服热线：400-666-7788
全球 NMR 耗材 引领 60 年
百灵威
百灵威科技有限公司成立于 1992 年，始终以“为科研和生产提供世界一流的产品和服务”为宗旨，致力于超精细化学品的研发与 制造。经过近二十年的发展，百灵威已具备为化学、分析、生物、材料、物理及药物研发等领域提供近五十万种产品和专业服务 的能力。 百灵威拥有一支强大的具有丰富经验和创新能力的研发团队，在江苏、河北设立的两个研发中心可迅速研发出毫克至数百公斤级 的医药、生化、材料等中间体及特殊高端化学品，并可为客户定制合成各类产品，尤其擅长小分子药物中间体以及催化剂配体的 合成。 百灵威人坚信“发展民族科技”的理念，坚持依靠中国人自己的智慧和力量， 不断建设和发展位于潮白河畔的现代化工业生产基地，发挥百灵威在尖端技术研究、敏捷制造和系统性物流管理等方面的突出优 势，积极地将中国的各种高端化合物推荐给国际同行，为促进中国化学事业发展，推动世界文明与和谐进步而奋斗不息。 百灵威的使命 促进科技和工业发展，造福人类……
管壁厚度(mm) 平均凸度(µm)
包装
0.27
<60>
50只/塑料筒装
0.27
<60>
50只/塑料筒装
0.43
<60>
50只/塑料筒装
0.43
<60>
100只/纸盒装
0.43
<60>
50只/塑料筒装
0.43
<60>
100只/纸盒装
0.60
<60>
50只/塑料筒装
SampleJet®核磁管
成都普瑞法科技开发有限公司 水飞蓟宾(Silybin) 说明书
成都普瑞法科技开发有限公司Chengdu Biopurify Phytochemicals Ltd.Material Safety Data Sheet Version 2.7Revision Date 11/01/20171. Chemical Product and company IdentificationProduct Name:水飞蓟宾English Name: Silybin(Mixture A&B)Catalogue No:22888-70-6Supplier: Chengdu Biopurify Phytochemicals Ltd.Address: No.11 Building,No.388 Rongtaidadao CNSTP,Wenjiang Zone,Chengdu Sichuan 611130 ChinaTel：+86-28-82633987 Fax：+86-28-82633165Website: Email: **********************2、Composition, Information on IngredientsAlias: Silybin(Mixture A&B)CAS Number:22888-70-6Mol. Formula: C25H22O10Mol. Weight :482.441Identified uses: Laboratory chemicals, for R&DStorage: Room temperature for transportation, 2~8℃ for long term storage, protected from strong light, keep package airproofed when not in use.3、Hazards identificationClassification of the substance or mixtureNot a hazardous substance or mixture according to Regulation (EC) No 1272/2008This substance is not classified as dangerous according to Directive 67/548/EEC.Label elementsNot a hazardous substance or mixture according to EC-directives 67/548/EEC or 1999/45/EC. Other hazards -The chemical, Physical and toxicological properties of this product have not been thoroughlyinvestigated. Use appropriate procedures to prevent opportunities for direct contact with the skin or eyes and to prevent inhalation.4、First-aid measuresIf inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration.Consult a doctor.In case of skin contactWash off with soap and plenty of water. Consult a doctor.In case of eye contactFlush eyes with water as a precaution. Consult a doctor.If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a doctor.Indication of any immediate medical attention and special treatment neededNo data availableShow this safety data sheet to the doctor in attendance.Immediate medical attention is required.5、Fire-fighting measuresConditions of flammabilityNot flammable or combustible.Suitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special protective equipment for firefightersWear self contained breathing apparatus for fire fighting if necessary.Hazardous combustion productsHazardous decomposition products formed under fire conditions. - Carbon oxides6、Accidental release measuresPersonal precautionsUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.Environmental precautionsDo not let product enter drains.Methods and materials for containment and cleaning upPick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.7、Handing and storageHandling:Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Keep away from sources of ignition. Avoid prolonged or repeated exposure.Storage:Store in a well closed container. Protected from air and light, put into refrigerate or freeze forlong term storage.Specific end usesUse in a laboratory fume hood where possible. Refer to employer is COSHH risk assessment.8、Exposure controls, personal protectionContains no substances with occupational exposure limit values.Personal protective equipmentRespiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Hand protectionHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye protectionFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin and body protectionComplete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measuresHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.9、Physical and chemical propertiesPhysical Description : Off-white powderProperty ValuespH No information availableMelting point/freezing point164-174ºCBoiling point793ºC at 760mmHgFlash point274.5ºCDensity 1.527g/cm3Evaporation rate No information availableUpper flammability limits No information availableLower flammability limit No information availableVapor pressure 1.63E-26mmHg at 25°CVapor density No information availableSpecific gravity No information availableWater solubility No information availableSolubility in other solvents No information availablePartition coefficient No information availableAutoignition temperature No information availableKinematic viscosity No information availableDecomposition temperature No information availableExplosive properties No information availableOxidizing properties No information available10、Stability and reactivityChemical stabilityStable under recommended storage conditions.Possibility of hazardous reactionsno data availableConditions to avoidno data availableMaterials to avoidStrong oxidizing agentsHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxidesOther decomposition products - no data available11、Toxicological informationAcute toxicityOral LD50: no data availableInhalation LC50: no data availableDermal LD50: no data availableOther information on acute toxicity: no data availableno data availableSerious eye damage/eye irritationno data availableRespiratory or skin sensitisationno data availableGerm cell mutagenicityno data availableCarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.Reproductive toxicityno data availableTeratogenicityno data availableSpecific target organ toxicity - single exposure (Globally Harmonized System)no data availableSpecific target organ toxicity - repeated exposure (Globally Harmonized System)no data availableAspiration hazardno data availablePotential health effectsInhalation May be harmful if inhaled. Causes respiratory tract irritation.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes May be caused eye irritation.Synergistic effectsno data availableAdditional InformationRTECS: Not available12、Ecological informationToxicityno data availablePersistence and degradabilityno data availableBioaccumulative potentialno data availableMobility in soilno data availablePBT and vPvB assessmentno data availableOther adverse effectsno data available13、Disposal considerationsProductOffer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.Contaminated packagingDispose of as unused product.14、Transport informationClassified according to the criteria of the UN Model Regulations as reflected in the IMDG Code, ADR, RID and IATA.UN numberDoes not meet the criteria for classification as hazardous for transport.UN proper shipping nameADR/RID: Not dangerous goodsIMDG: Not dangerous goodsIATA: Not dangerous goodsTransport hazard class(es)Does not meet the criteria for classification as hazardous for transport.Packaging groupDoes not meet the criteria for classification as hazardous for transport.Environmental hazardsThis product is not classified as environmentally hazardous according to the UN Model Regulations, nor a marine pollutant according to the IMDG Code.Special precautions for userno data available15、Regulatory informationThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.Safety, health and environmental regulations/legislation specific for the substance or mixtureno data availableChemical Safety AssessmentFor this product a chemical safety assessment was not carried out16、Other informationDISCLAIMERFor R&D use only. Not for drug, household or other uses.WARRANTYThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Biopurify and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.。
新颖抗病激活剂类杀菌剂flutianil
作 者 简介 ：张一 宾（ １ ９ ４ ４ ＿ ＿ ） ， 男 ，高 级 工程师 ，长期 从事 农药 信 息研 究工作 ，Ｅ － ｍａ ｉ ｌ ： ｓ ｊ ｎ ｙ ｗｐ ＠１ ６ ３ ． ｃ ｏ ｎ。 ｒ 收 稿 日期 ：２ ０ １ ７ — ０ ５ — ３ ０ 。
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图 ４ 杀菌剂 ｆ ｌ ｕ ｔ ｉ ａ ｎ ｉ ｌ 的合成路线
图 ３ 先导化合物各部分取代及 活性（ 防治 自粉病）
Ｆ ｌ ｕ ｔ ｉ ａ ｎ ｉ ｌ 的合成路 线见 图 ４ 。 目前 ｆ ｌ ｕ ｔ ｉ ａ ｎ ｉ ｌ 的生产
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世 界 农 药
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新 颖抗病激 活剂 类杀 菌剂ｆ ｌ ｕ ｔ ｉ ａ ｎ ｉ ｌ
张一 宾
（ 上 海市 农 药研 究所 ，上 海 ２ ０ ０ ０ ３ ２ ）
ＤＯＩ ：１ ０ ． １ ６ ２ ０ １ ／ ｊ ． ｃ ｎ ｋ ｉ ． ｃ ｎ ３ １ — １ ８ ２ ７ ／ ｔ ｑ ． ２ ０ １ ７ ． ０ ３ ． １ ２
国家药品监督管理局关于暂停使用亲水性聚丙烯酰胺凝胶的通知
国家药品监督管理局关于暂停使用亲水性聚丙烯酰胺
凝胶的通知
文章属性
•【制定机关】国家药品监督管理局
•【公布日期】1999.01.05
•【文号】药管械[1999]01号
•【施行日期】1999.01.05
•【效力等级】部门规范性文件
•【时效性】现行有效
•【主题分类】药政管理
正文
国家药品监督管理局关于暂停使用亲水性聚丙烯酰胺凝胶的
通知
（药管械[1999]01号）
各省、直辖市、自治区医药管理局：
由乌克兰英捷尔法勒公司生产的亲水性聚丙烯酰胺凝胶已于1997年12月在我国办理了进口医疗器械产品注册，注册号为国药器监(进)字97第1252号。
该产品系外科整形用品，用于体内软组织填充，对产品质量及医生的操作方法均有严格的要求，否则将会影响到使用者的健康与安全。
虽然在注册审查中已对该产品的质量及安全性指标进行过严格的检测，在注册证上也已注明只能由经过培训的医生在合法的医疗机构使用，但该产品在我国上市以后，我司陆续接到一些用户的反映，诉说使用该产品后对身体造成了不良影响。
据了解，社会上一些美容单位，为了盈利，从不同渠道进口了“水凝胶”产品，给患者使用，许多产品的来源及医生的资格都未经认定。
在这种情况下，为了维护人民群众的利益，我司决定于近期组织有关专家对该产品及其临床应用和监督管理问
题再次进行论证。
论证之前，国内各经销单位及医疗单位暂停销售和使用该产品，待论证后我司再通知是否允许该产品继续在我国销售使用。
请你们在接到本通知后，立即通知本辖区内的有关经营和医疗单位，并监督执行。
国家药品监督管理局医疗器械司
一九九九年一月五日。
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IC50:血小板的 IC50 为 2.84 μM. 可溶性鸟苷酸环化酶(sGC)是一氧化氮(NO)激活的关键信号传导酶.受损的生物利用度和对内 源性 NO 的响应参与心脑血管等疾病的发病机制.CFM 1571 是一氧化氮受体的活化剂,一氧化 氮受体是一种可溶性鸟苷酸环化酶.
体外实验:CFM 1571 可以活化可溶性鸟苷酸环化酶,强效抑制血小板凝集.CFM 1571 也表现出 类似于苄达明(benzydamine)的酶活性.CFM 1571 对 NOS 异构体的作用也进行了研究,对 iNOS 和 nNOS 具有最小的抑制作用,分别为 25％和 17％.此外,CFM 1571 对研究的其它酶无显著活 性[1]. 在体实验:大鼠的药代动力学研究表明,化合物 CFM 1571 具有温和的口服生物利用度(12％). 另外 CFM 1571 具有优异的选择性,对磷酸二酯酶或一氧化氮合酶无显著抑制作用[1]. 临床试验:截至目前,CFM 1571 尚处于临床前开发阶段.
参考文献: [1] Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK. Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem. 2001 Jan 4;44(1):78-93.
运输条件:
1-benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-py razole-5-carboxamide hydrochloride
CN(CCCOC(C=C1C(NC2=CC=C(OC)C=C2)=O)=NN1CC3=CC=CC=C3)C.Cl
Soluble in DMSO > 10 obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式:
CFM 1571 hydrochloride 1215548-30-3 444.95 C23H28N4O3.HCl
产品名: CFM 1571 hydrochloride 修订日期: 6/30/2016
化学名:
SMILES: 溶解性: 储存条件: 一般建议:
特别声明
产品仅用于研究，
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Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Others
信号通路:
Guanylyl Cyclase
产品描述: