TRGT-HL-PTCL-03055-US-STOOL OR BAR STOOL-V10
环状RNA_0015278与甲状腺乳头状癌及预后的相关性
第 44 卷第 4 期 2023 年 4 月安徽医学Anhui Medical Journal环状RNA_0015278与甲状腺乳头状癌及预后的相关性丁华杰 那磊 杨绍石 李莎 史华宁 龚雪[摘 要] 目的 探讨甲状腺乳头状癌(PTC )患者环状RNA_0015278(circ _0015278)表达与甲状腺癌及预后的相关性。
方法 回顾性分析2016年6月至2021年12月承德医学院附属医院收治的甲状腺切除术后PTC 患者206例,通过逆转录定量聚合酶链反应(RT-qPCR )检测PTC 及癌旁组织中circ _0015278的表达,以病理结果为金标准,使用受试者工作特征(ROC )曲线评价circ _0015278在PTC 及癌旁组织中的诊断价值;circ _0015278表达按照分位数划分四等级,使用Spearman 相关分析,分析不同等级分位数circ _0015278表达与PTC 5年复发率、死亡率的相关性。
使用KM 曲线对数秩检验对不同等级分位数circ _0015278表达患者随访5年的无病生存率(DFS )和总生存率(OS )进行比较。
通过单变量和多变量Cox 比例风险回归模型分析影响PTC 患者预后的因素。
结果 PTC 组织中c irc _0015278表达与癌旁组织相比明显降低,差异有统计学意义(Z =-14.146,P <0.001);以病理结果为金标准建立PTC 及癌旁组织c irc _001527表达的ROC 曲线,以表达量0.740为截断值时对鉴别PTC 及癌旁组织有较好价值(AUC :0.903,95%CI :0.847~0.932),灵敏度为76.7%,特异度为89.2%;较高的circ_0015278表达与肿瘤复发率降低相关(r =-0.162,P =0.011),与死亡率无关(r =-0.102,P =0.110);不同等级分位数circ_0015278表达的DFS 之间差异有统计学意义(χ2=3.268,P =0.017),利于DFS 延长。
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生物信息学网站分子生物学数据库综合目录1. SRS序列查询系统(分子生物学数据库网络浏览器) http://www.embl-heidelberg.ed/srs5/2. 分子生物学数据库及服务器概览/people/pkarp/mimbd/rsmith.html3. BioMedNet图书馆4. DBGET数据库链接http://www.genome.ad.jp/dbget/dbget.links.html5. 哈佛基因组研究数据库与精选服务器6. 约翰. 霍普金斯大学(Johns Hopkins University) OWL网络服器/Dan/proteins/owl.html7. 生物网络服务器索引,USCS /network/science/biology/index.html8. 分子生物学数据库列表(LiMB) gopher:///11/molbio/other9. 病毒学的WWW服务器,UW-Madison /Welcome.html10. UK MRC 人类基组图谱计划研究中心/11. 生物学家和生物化学家的WWW资源http://www.yk.rim.pr.jp/~aisoai/index.html12. 其他生物网络服务器的链接/biolinks.html13. 分子模型服务器与数据库/lap/rsccom/dab/ind006links.html14. EMBO实际结构数据库http://xray.bmc.uu.se/embo/structdb/links.html15. 蛋白质科学家的网络资源/protein/ProSciDocs/WWWResources.html16. ExPASy分子生物学服务器http://expasy.hcuge.ch/cgi-bin/listdoc17. 抗体研究网页18. 生物信息网址http://biochem.kaist.ac.kr/bioinformatics.html19. 乔治.梅森大学(George Mason University)的生物信息学与计算分子生物学专业/~michaels/Bioinformatics/20. INFOBIOGEN数据库目录biogen.fr/services/dbcat/21. 国家生物技术信息研究室/data/data.html22. 人类基因组计划情报/TechResources/Human_Genome23. 生物学软件及数据库档案/Dan/software/biol-links.html24. 蛋白质组研究:功能基因组学的新前沿(著作目录) http://expasy.hcuge.ch/ch2d/LivreTOC.html序列与结构数据库一.主要的公共序列数据库1. EMBL WWW服务器http://www.EMBL-heidelberg.ed/Services/index.html2. Genbank 数据库查询形式(得到Genbank的一个记录) /genbank/query_form.html3. 蛋白质结构数据库WWW服务器(得到一PDB结构) 4. 欧洲生物信息学研究中心(EBI) /5. EBI产业支持/6. SWISS-PROT(蛋白质序列库) http://www.expasy.ch/sprot/sprot-top.html7. 大分子结构数据库/cgi-bin/membersl/shwtoc.pl?J:mms8. Molecules R Us(搜索及观察一蛋白质分子) /modeling/net_services.html9. PIR国际蛋白质序列数据库/Dan/proteins/pir.html10. SCOP(蛋白质的结构分类),MRC /scop/data/scop.l.html11. 洛斯阿拉莫斯的HIV分子免疫数据库/immuno/index.html12. TIGR数据库/tdb/tdb.html13. NCBI WWW Entrez浏览器/Entrez/index.html14. 剑桥结构数据库(小分子有机的及有机金属的结晶结构) 15. 基因本体论坛/GO/二. 专业数据库1. ANU生物信息学超媒体服务(病毒数据库、分类及病毒的命名法) .au/2. O-GL YCBASE(O联糖基化蛋白质的修订数据库) http://www.cbs.dtu.dk/OGLYCBASE/cbsoglycbase.html3. 基因组序列数据序(GSDB)(已注释的DNA序列的关系数据序) 4. EBI蛋白质拓扑图/tops/Serverintermed.html5. 酶及新陈代谢途径数据库(EMP) /6. 大肠杆菌数据库收集(ECDC)(大肠杆菌K12的DNA序列汇编) http://susi.bio.uni-giessen.de/ecdc.html7. EcoCyc(大肠杆菌基因及其新陈代谢的百科全书) /ecocyc/ecocyc.html8. Eddy实验室的snoRNA数据库/snoRNAdb/9. GenproEc(大肠杆菌基因及蛋白质) /html/ecoli.html10. NRSub(枯草芽胞杆菌的非冗余数据库) http://pbil.univ-lyonl.fr/nrsub/nrsub.html11. YPD(酿酒酵母蛋白质) /YPDhome.html12. 酵母基因组数据库/Saccharomyces/13. LISTA、LISTA-HOP及LISTA-HON(酵母同源数据库汇编) /14. MPDB(分子探针数据库) http://www.biotech.est.unige.it/interlab/mpdb.html15. tRNA序列及tRNA基因序列汇编http://www.uni-bayreuth.de/departments/biochemie/trna/index/html16. 贝勒医学院(Baylor College of Medicine)的小RNA数据库/dbs/SRPDB/SRPDB.html17. SRPDB(信号识别粒子数据库) /dbs/SRPDB/SRPDB.html18. RDP(核糖体数据库计划) /19. 小核糖体亚蛋白RNA结构http://rrna.uia.ac.be/ssu/index.html20. 大核糖体亚蛋白RNA结构http://rrna.uia.ac.be/lsu/index.html21. RNA修饰数据库/RNAmods/22. 16SMDB及23SMDB(16S和23S核糖体RNA突变数据库)/Departments/Biology/Databases/RNA.html23. SWISS-2DPAGE(二维凝胶电泳数据库) http://expasy.hcuge.ch/ch2d/ch2d-top.html24. PRINTS /bsm/dbbrowser/PRINTS/PRINTS.html25. KabatMan(抗体结构及序列信息数据库) /abs26. ALIGN(蛋白质序列比对一览) /bsm/dbbrowser/ALIGN/ALIGN.html27. CATH(蛋白质结构分类系统) /bsm/cath28. ProDom(蛋白质域数据库) http://protein.toulouse.inra.fr/29. Blocks数据库(蛋白质分类系统) /30. HSSP(按同源性导出的蛋白质二级结构数据库) http://www.sander.embl-heidelberg.de/hssp/31. FSSP(基于结构比对的蛋白质折叠分类) /dali/fssp/fssp.html32. SBASE蛋白质域(已注释的蛋白质序列片断) http://www.icgeb.trieste.it/~sbasessrv/33. TransTerm(翻译控制信号数据库) /Transterm.html34. GRBase(参与基因调控的蛋白质的相关信息数据库) /~regulate/trevgrb.html35. REBASE(限制性内切酶和甲基化酶数据库) /rebase/36. RNaseP数据库/RNaseP/home.html37. REGULONDB(大肠杆菌转录调控数据库) http://www.cifn.unam.mx/Computational_Biology/regulondb/38. TRANSFAC(转录因子及其DNA结合位点数据库) http://transfac.gbf.de/39. MHCPEP(MHC结合肽数据库) .au/mhcpep/40. ATCC(美国菌种保藏中心) /41. 高度保守的核蛋白序列的组蛋白序列数据库/Baxevani/HISTONES42. 3Dee(蛋白质结构域定义数据库) /servers/3Dee.html43. InterPro(蛋白质域以及功能位点的完整资源) /interpro/序列相似性搜索1. EBI序列相似性研究网页/searches/searches.html2. NCBI: BLAST注释/BLAST3. EMBL的BLITZ ULTRA快速搜索/searches/blitz_input.html4. EMBL WWW服务器http://www.embl-heidelberg.de/Services/index.html#55. 蛋白质或核苷酸的模式浏览/compbio/PatScan/HTML/patscan.html6. MEME(蛋白质超二级结构模体发现与研究) /meme/website7. CoreSearch(DNA序列保守元件的识别) http://www.gsf.de/biodv/coresearch.html8. PRINTS/PROSIT浏览(搜索motif数据库) /cgi-bin/attwood/SearchprintsForm.pl9. 苏黎世ETH服务器的DARWIN系统http://cbrg.inf.ethz.ch/10. 利用动态规划找出序列相似性的Pima IIhttp://bmerc-www.bu.ede/protein-seq/pimaII-new.html11. 利用与模式库进行哈希码(hashcode)比较找到序列相似性的DashPat /protein-seq/dashPat-new.html12. PROPSEARCH(基于氨基酸组成的搜索) http://www.embl-heidelberg.de/aaa.html13. 序列搜索协议(集成模式搜索) /bsm/dbbrowser/protocol.html14. ProtoMap(SEISS-PROT中所有蛋白质的自动层次分类) http://www.protomap.cs.huji.ac.il/15. GenQuest(利用Fasta、Blast、Smith-Waterman方法在任意数据库中搜索) http://www.gdb.rog/Dan/gq/gq.form.html16. SSearch(对特定数据库的搜索) http://watson.genes.nig.ac.jp/homology/ssearch-e_help.html17. Peer Bork搜索列表(motif/模式序列谱搜索) http://www.embl-heidelberg.de/~bork/pattern.html18. PROSITE数据库搜索(搜索序列的功能位点) /searches/prosite.html19. PROWL(Skirball研究中心的蛋白质信息检索) /index.html序列和结构的两两比对1. 蛋白质两两比对(SIM) http://expasy.hcuge.ch/sprot/sim-prot.html2. LALNVIEW比对可视化观察程序ftp://expasy.hcuge.ch/pub/lalnview3. BCM搜索装置(两两序列比对) /seq-search/alignment.html4. DALI蛋白质三维结构比较/dali/5. DIALIGN(无间隙罚分的比对程序) http://www.gsf.de/biodv/dialign/html多重序列比对及系统进行树1. ClustalW(BCM的多重序列比对) /multi-align/multi-align.html2. PHYLIP(推测系统进行树的程序) /phylip.html3. 其它系统进行树程序,PHYLIP文档的汇编http://expasy.hcuge.ch/info/phylogeny.html4. 系统进行树分析程序(生命树列表) /tree/programs/programs.html5. 遗传分类学软件(Willi hennig协会提供的列表) /education.html6. 用于多重序列比对的BCM搜索装置/multi-align/multi-align.html7. AMAS(分析多重序列比对中的序列) /servers/amas_server.html8. 维也纳RNA二级结构软件包http://www.tbi.univie.ac.at/~ivo/RNA/四. 有代表性的预测服务器1. PHD蛋白质预测服务器,用于二级结构、水溶性以及跨膜片断的预测http://www.embl-heidelberg.de/predictprotein/predictprotein.html2. PhdThreader(利用逆折叠方法预测、识别折叠类) http://www.embl-heidelberg.de/predictprotein/phd_help.html3. PSIpred(蛋白质结构预测服务器) /psipred4. THREADER(戴维. 琼斯) /~jones/threader.html5. TMHMM(跨膜螺旋蛋白的预测) http://www.cbs.dtu.dk/services/TMHMM/6. 蛋白质结构分析,BMERC /protein-seq/protein-struct.html7. 蛋白质域和折叠预测的提交表http://genome.dkfz-heidelberg.de/nnga/def-query.html8. NNSSP(利用最近相邻法预测蛋白质的二级结构) /pss/pss.html9. Swiss-Model(基于知识的蛋白质自动同源建模服务器) http://www.expasy.ch/swissmod/SWISS-MODEL.html10. SSPRED(用多重序列比对进行二级结构预测) /jong/predict/sspred.html11. 法国IBCP的SOPM(自寻优化预测方法、二级结构) http://pbil.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_sopm.html12. TMAP(蛋白质跨膜片断的预测服务) http://www.embl-heidelberg.de/tmap/tmap_info.html13. TMpred(跨膜区域和方向的预测) /software/TMPRED_form.html14. MultPredict(多重序列比对的序列的二级结构) /zpred.html15. BCM搜索装置(蛋白质二级结构预测) /seq-search/struc-predict.html16. COILS(蛋白质的卷曲螺旋区域预测) /software/coils/COILS_doc.html17. Coiled Coils(卷曲螺旋) /depts/biol/units/coils/coilcoil.html18. Paircoil(氨基酸序列中的卷曲螺旋定位) /bab/webcoil.html19. PREDATOR(由单序列预测蛋白质二级结构) http://www.embl-heidelberg.de/argos/predator/predator_info.html20. EV A(蛋白质结构预测服务器的自动评估) /eva/五. 其他预测服务器1. SignalP (革兰氏阳性菌、革兰氏阴性菌和真核生物蛋白质的信号肽及剪切位点) http://www.cbs.dtu.dk/services/SignalP/2. PEDANT(蛋白质提取、描述及分析工具) http://pedant.mips.biochem.mpg.de/六. 分子生物学软件链接1. 生物信息学可视化工具/alan/VisSupp/2. EBI分子生物学软件档案/software/software.html3. BioCatalog /biocat/e-mail_Server_ANAL YSIS.html4. 生物学软件和数据库档案/Dan/softsearch/biol-links.html5. UC Santa Cruz的序列保守性HMM的SAM软件/research/compbio/sam.html七. 网上博士课程1. 生物计算课程资源列表:课程大纲http://www.techfak.uni-bielefeld.de/bcd/Curric/syllabi.html2. 生物序列分析和蛋白质建模的Ph.D课程http://www.cbs.dtu.dk/phdcourse/programme.html3. 分子科学虚拟学校/vsms/sbdd/4. EMBnet 生物计算指南http://biobase.dk/Embnetut/Universl/embnettu.html5. 蛋白质结构的合作课程/PPS/index.html6. 自然科学GNA虚拟学校http://www.techfak.uni-bielefeld.de/bcd/Vsns/index.html7. 分子生物学算法/education/courses/590bi。
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0079-6425工程技术1Y15.769 1062-7995工程技术1Y 4.702 0079-6727工程技术1Y 4.091 0079-6816工程技术1Y7.913 1364-0321工程技术1Y 4.842 1613-6810工程技术1Y 6.171 1744-683X工程技术1Y 4.869 0167-7799工程技术1Y 6.909 0924-2244工程技术1Y 4.051 1066-8888工程技术1Y 4.517 0001-1541工程技术2Y 1.955 0175-7598工程技术2Y 2.896 0009-2509工程技术2Y 2.136 0013-4686工程技术2Y 3.325 0308-8146工程技术2Y 3.146 0018-926X工程技术2Y 2.011 0018-9286工程技术2Y 2.556 0018-9448工程技术2Y 2.357 0018-9480工程技术2Y 2.076 1053-587X工程技术2Y 2.212 0888-5885工程技术2Y 1.758 0017-9310工程技术2Y 1.947 0002-7820工程技术2Y 1.944 0013-4651工程技术2Y 2.241 0376-7388工程技术2Y 3.203 0167-577X工程技术2Y 1.940 1359-6462工程技术2Y 2.949 0925-4005工程技术2Y 3.083 0257-8972工程技术2Y 1.793 0379-6779工程技术2Y 1.901 0040-6090工程技术2Y 1.727 0272-6963管理科学1Y 3.238 0025-1909管理科学1Y 2.227 0305-0483管理科学1Y 3.101 1059-1478管理科学1Y 2.080 0377-2217管理科学2Y 2.093 0001-4842化学1Y18.203 0108-7673化学化学-晶体1Y49.926 0002-5100化学1Y18.688 1433-7851化学1Y11.829 0066-426X化学1Y17.464 0161-4940化学1Y7.765 0009-2665化学1Y35.957 0306-0012化学1Y20.086 0010-8545化学1Y11.2251754-5692化学1Y8.500 0144-235X化学1Y 5.000 0002-7863化学1Y8.580 1389-5567化学1Y7.952 0265-0568化学1Y9.202 0079-6700化学1Y23.753 0167-5729化学1Y13.462 0165-9936化学1Y 6.546 0003-2700化学2Y 5.214 0022-3263化学2Y 4.219 1520-6106化学2Y 3.471 0743-7463化学2Y 3.898 0926-3373环境科学1Y 5.252 0003-0090环境科学1Y 4.133 1064-3389环境科学1Y7.091 1461-023X环境科学1Y10.318 0012-9615环境科学1Y 4.862 0012-9658环境科学1Y 4.411 0091-6765环境科学1Y 6.191 1462-2912环境科学1Y 4.909 0014-3820环境科学1Y 5.429 1540-9295环境科学1Y 6.922 1354-1013环境科学1Y 5.561 1466-822X环境科学1Y 5.913 1751-7362环境科学1Y 6.397 1352-2310环境科学2Y 3.139 0045-6535环境科学2Y 3.253 0013-936X环境科学2Y 4.630 0043-1354环境科学2Y 4.355 0065-2113农林科学1Y 3.800 0168-1923农林科学1Y 3.197 0261-1929农林科学1Y 1.580 1351-0754农林科学1Y 2.131 1467-2960农林科学1Y 4.489 1054-6006农林科学1Y 2.427 1050-4648农林科学1Y 2.892 1935-5130农林科学1Y 2.238 0016-7061农林科学1Y 2.461 1084-2020农林科学1Y 2.806 0021-8561农林科学1Y 2.469 0021-8812农林科学1Y 2.466 0022-0302农林科学1Y 2.463 1380-3743农林科学1Y 2.272 0960-3166农林科学1Y 2.161 0038-0717农林科学1Y 2.978 0361-5995农林科学1Y 2.179 0829-318X农林科学1Y 2.2920378-1135农林科学1Y 2.874 0928-4249农林科学1Y 3.579 0044-8486农林科学2Y 1.925 0706-652X农林科学2Y 1.951 0378-1127农林科学2Y 1.950 0003-1488农林科学2Y 1.714 0032-079X农林科学2Y 2.517 1526-5161社会科学1Y 4.000 0012-9682社会科学1Y 4.000 0304-4076社会科学2Y 1.902 0002-9297生物1Y12.303 0066-4154生物1Y29.875 1056-8700生物1Y18.955 1936-122X生物1Y19.304 1081-0706生物1Y19.571 1543-592X生物1Y8.190 0066-4170生物1Y11.271 0066-4197生物1Y13.235 1527-8204生物1Y11.568 0066-4227生物1Y12.804 0066-4286生物1Y11.212 1543-5008生物1Y23.460 0092-8674生物1Y31.152 1931-3128生物1Y13.021 1550-4131生物1Y17.350 1934-5909生物1Y23.563 1040-9238生物1Y10.216 0960-9822生物1Y10.992 0955-0674生物1Y14.153 0959-437X生物1Y8.987 1369-5266生物1Y10.333 0959-440X生物1Y9.344 1534-5807生物1Y13.363 0890-9369生物1Y12.075 1088-9051生物1Y11.342 0021-9525生物1Y9.575 1092-2172生物1Y12.585 1097-2765生物1Y14.608 1744-4292生物1Y12.125 1465-7392生物1Y19.527 1552-4450生物1Y16.058 1061-4036生物1Y34.284 1548-7091生物1Y16.874 1471-0056生物1Y27.822 1740-1526生物1Y17.644 1471-0072生物1Y42.198 1545-9985生物1Y12.2731040-4651生物1Y9.293 1544-9173生物1Y12.916 1553-7390生物1Y9.532 1553-7366生物1Y8.978 0163-7827生物1Y8.167 0033-5835生物1Y10.200 0968-0004生物1Y11.572 0962-8924生物1Y12.115 0169-5347生物1Y11.564 0168-9525生物1Y8.689 1360-1385生物1Y9.883 0099-2240生物2Y 3.686 0264-6021生物2Y 5.155 0006-3495生物2Y 4.390 0950-1991生物2Y7.194 0261-4189生物2Y8.993 0021-9193生物2Y 3.940 0021-9258生物2Y 5.328 0022-2836生物2Y 3.871 0270-7306生物2Y 6.057 0305-1048生物2Y7.479 0032-0889生物2Y 6.235 0001-5962数学1Y 2.619 0003-486X数学1Y 4.174 0090-5364数学1Y 3.185 0273-0979数学1Y 3.294 0010-3640数学1Y 2.657 1615-3375数学1Y 1.905 0020-9910数学1Y 2.794 0266-5611数学1Y 1.900 0894-0347数学1Y 3.411 0162-1459数学1Y 2.322 1369-7412数学1Y 3.473 0218-2025数学1Y 2.095 0025-5610数学1Y 2.048 0065-9266数学1Y 2.240 1540-3459数学1Y 2.198 0027-3171数学1Y 2.328 1468-1218数学1Y 2.381 0272-4332数学1Y 1.953 0036-1445数学1Y 3.391 0883-4237数学1Y 3.523 1070-5511数学1Y 3.153 0165-0114数学2Y 2.138 0377-0427数学2Y 1.292 0022-0396数学2Y 1.426 0022-247X数学2Y 1.2250362-546X数学2Y 1.487 0036-1429数学2Y 1.840 1064-8275数学2Y 1.595 0108-7673物理物理-晶体1Y49.926 0001-8732物理1Y19.632 0066-4189物理1Y9.353 0163-8998物理1Y11.964 1040-8436物理1Y 5.167 1126-6708物理1Y 6.019 1863-8880物理1Y 5.814 1433-8351物理1Y10.600 0277-7037物理1Y10.623 1749-4885物理1Y22.869 1745-2473物理1Y15.491 0370-1573物理1Y17.752 0031-9007物理1Y7.328 0079-6565物理1Y 6.742 0034-4885物理1Y11.444 0034-6861物理1Y33.145 0003-6951物理2Y 3.554 0021-9606物理2Y 3.093 1098-0121物理2Y 3.475 1550-7998物理2Y 4.922 0169-409X医学1Y11.957 0065-2776医学1Y7.725 0002-9165医学1Y 6.307 0002-9270医学1Y 6.012 0002-953X医学1Y12.522 1073-449X医学1Y10.689 1600-6135医学1Y 6.433 0003-4819医学1Y16.225 0364-5134医学1Y9.317 0003-4967医学1Y8.111 0003-4932医学1Y7.900 0732-0582医学1Y37.902 0066-4219医学1Y9.940 0147-006X医学1Y24.822 0199-9885医学1Y8.783 1553-4006医学1Y13.500 0362-1642医学1Y22.468 0066-4278医学1Y18.170 0066-4308医学1Y22.750 0163-7525医学1Y7.915 0003-990X医学1Y12.257 0003-9926医学1Y9.813 1079-5642医学1Y7.235 0004-3591医学1Y7.332。
赛普替尼 分子量
赛普替尼(Selpercatinib),其化学名为LOXO-292,是一种选择性RET抑制剂,用于治疗RET融合阳性的非小细胞肺癌和甲状腺癌等类型的癌症。
赛普替尼的分子式为C29H31N7O3,根据分子式计算其分子量如下:
碳(C)的原子量约为12.01,因此C29 = 29 * 12.01
氢(H)的原子量约为1.008,因此H31 = 31 * 1.008
氮(N)的原子量约为14.01,因此N7 = 7 * 14.01
氧(O)的原子量约为16.00,因此O3 = 3 * 16.00
分子量的计算公式为:
分子量= (C的数量×C的原子量) + (H的数量×H的原子量) + (N的数量×N的原子量) + (O的数量×O的原子量)
将上述数值代入计算:
分子量= (29 ×12.01) + (31 ×1.008) + (7 ×14.01) + (3 ×16.00)
分子量≈348.29 + 31.248 + 98.07 + 48.00
分子量≈525.608
所以,赛普替尼的分子量大约是525.61 g/mol。
这个计算是基于分子式中每种元素的原子量的标准值,实际分子量可能会有极小的变化,这取决于原子量的精确值。
美国 Gibco 最小必要基质 MEM 产品说明书
Product Information MINIMUM ESSENTIAL MEDIUM EAGLED-VALINE MODIFICATIONProduct Number M7395Storage Temperature 2-8°CProduct DescriptionMinimum Essential Medium (MEM), developed by Harry Eagle, is one of the most widely used of all synthetic cell culture media. Early attempts to cultivate normal mammalian fibroblasts and certain subtypes of HeLa cells revealed that they had specific nutritional requirements that could not be met by Eagle’s Basal Medium (BME). Subsequent studies using these and other cells in culture indicated that additions to BME could be made to aid growth of a wider variety of fastidious cells. MEM, which incorporates these modifications, includes higher concentrations of amino acids. MEM has been used for cultivation of a wide variety of cells grown in monolayers. Optional supplementation of non-essential amino acids to the formulations that incorporate either Hanks’ or Earle’s salts has broadened the usefulness of this medium. The formulation has been further modified by optional elimination of calcium to permit growth of cells in suspension culture.MINIMUM ESSENTIAL MEDIUM EAGLE, Product No. M 7395 is one of the cell culture media available from Sigma. The selection of a nutrient medium is strongly influenced by 1] type of cell, 2] type of culture [monolayer, suspension, clonal] and 3] degree of chemical definition necessary. It is important to review the literature for recommendations concerning medium, supplementation and physiological parameters required for a specific cell line.Components g/L Calcium Chloride•2H2O0.265 Magnesium Sulfate (anhydrous)0.09767 Potassium Chloride0.4 Sodium Chloride 6.8 Sodium Phosphate Monobasic0.122 (anhydrous)L-Arginine•HCl0.126L-Cystine•2HCl0.0313 L-Glutamine0.292L-Histidine•HCl•H2O0.042L-Isoleucine0.052L-Leucine0.052L-Lysine•HCl0.0725 L-Methionine0.015L-Phenylalanine0.032L-Threonine0.048L-Tryptophan0.01L-Tyrosine•2Na•2H2O0.0519D-Valine0.092 Choline Chloride0.001Folic Acid0.001myo-Inositol0.002 Niacinamide0.001D-Pantothenic Acid (hemicalcium)0.001 Pyridoxal•HCl0.001 Riboflavin0.0001 Thiamine•HCl0.001 Glucose 1.0 Phenol Red•Na0.011Precautions and DisclaimerREAGENTFor In Vitro Diagnostic UsePreparation InstructionsPowdered media are extremely hygroscopic and should be protected from atmospheric moisture. The entire contents of each package should be used immediately after opening. Preparing a concentrated solution of medium is not recommended as precipitates may form. Supplements can be added prior to filtration or introduced aseptically to sterile medium. The nature of the supplement may affect storage conditions and shelf life of the medium.1.Measure out 90% of final required volume ofwater. Water temperature should be 15-20°C.2.While gently stirring the water, add thepowdered medium. Stir until dissolved. Do NOTheat.3.Rinse original package with a small amount ofwater to remove all traces of powder. Add tosolution in step 2.4.To the solution in step 3, add 2.2 g sodiumbicarbonate or 29.3 ml of sodium bicarbonatesolution [7.5%w/v] for each liter of final volumeof medium being prepared. Stir until dissolved.5.While stirring, adjust the pH of the medium to0.1-0.3 pH units below the desired pH since itmay rise during filtration. The use of 1N HCl or1N NaOH is recommended.6.Add additional water to bring the solution tofinal volume.7.Sterilize immediately by filtration using amembrane with a porosity of 0.22 microns.8.Aseptically dispense medium into sterilecontainer.Storage/StabilityStore the dry powdered medium at 2-8°C under dry conditions and liquid medium at 2-8°C in the dark. Deterioration of the powdered medium may be recognized by any or all of the following: [1] color change, [2] granulation/clumping, [3] insolubility. Deterioration of the liquid medium may be recognized by any or all of the following: [1] pH change, [2] precipitate or particulate matter throughout the solution, [3] cloudy appearance [4] color change. The nature of supplements added may affect storage conditions and shelf life of the medium. Product label bears expiration date.ProcedureWater for tissue culture use [W-3500]Sodium Bicarbonate [S-5761] orSodium Bicarbonate Solution, 7.5% [S-8761]1N Hydrochloric Acid [H-9892]1N Sodium Hydroxide [S-2770]Medium additives as requiredProduct ProfileAppearance off-white powder Moisture content 2.0% Solubility clear solution at 1x concentrationpH at room temperature 5.8 ± 0.3 [without sodium bicarbonate]pH at room temperature 7.5 ± 0.3 [with sodium bicarbonate]Osmolality250 mOsm/kg H2O ± 5% [without sodium bicarbonate]Osmolality290 mOsm/kg H2O ± 5% [with sodium bicarbonate]Amino Acid Analysis Analysis has confirmedby HPLC that amino acids are present atconcentrations consistent withthe formula.Key Element Analysis Analysis has confirmed that by ICAP key elements are present atconcentrations consistent withthe formula.BIOLOGICAL PERFORMANCE CHARACTERISTICS Biological performance is assessed using an appropriate cell line(s). Growth studies are carried through 2 subculture generations. Cells are counted and growth is plotted as a logarithmic function of time in culture. Seeding efficiencies, doubling time, and final cell densities are determined. During the testing period cultures are examined microscopically for atypical morphology and evidence of cytotoxicity. Test results are available upon request.References1.Eagle, H. et al (1956) myo-Inositol as anEssential Growth Factor for Normal andMalignant Human Cells in Tissue Culture.J.Biol. Chem. 214, 845-847.2.Eagle, H.(1976) Media for Animal Cell Culture.Tissue Culture Association Manual. 3, 517-520.3.Eagle, H. (1959). Amino Acid Metabolism inMammalian Cell Cultures. Science. 130, 432-437.4.Eagle, H. (1955) Nutrition Needs of MammalianCells in Culture. Science. 122, 501.5.Gilbert, S.F. and Migeon, B.R. (1975) D-valineas a selective agent for normal human androdent epithelial cells in culture. Cell. 5, 11-17.7H027Sigma brand products are sold through Sigma-Aldrich, Inc.Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side ofthe invoice or packing slip.。
新型肿瘤标志物(PIVKAII)临床应用进展及评价
healthy liver
Chronic hepatitis
Cirrhosis
慢性炎症以及逐渐加深的肝脏损伤
Cancer (HCC)
Viral marker
Fibrosis marker
Tumor marker
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现有肝癌相关肿瘤标志物
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后又随之增加。血清甲胎蛋白的含量与异常凝血酶原水平基本不具相关性。
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Research design:
Song et al. (2002)
Tsai et al. (1997)
Tsai et al. (2003)
Hsia et al. (2007)
Hsia et al. (2007)
Cui et al. (2003)
Yoon et al. (2004)
Cutoff value 2.0 ng/ml
Sensitivity 51%
• Tumor-Derived Autoantibody (TAA)
Etc.
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Markers GPC3 GP73
TGF-β1
IGF-II IL-6 IL-10 GGT HCCR
References
Hippo et al. (2004)
Marrero et al. (2005)
益生菌对阿尔茨海默病作用的研究进展
益生菌对阿尔茨海默病作用的研究进展发布时间:2021-12-14T06:08:15.523Z 来源:《中国结合医学杂志》2021年12期作者:宋鑫萍1,2,李盛钰2,金清1[导读] 阿尔茨海默病已成为威胁全球老年人生命健康的主要疾病之一,患者数量逐年攀升,其护理的经济成本高,给全球经济造成重大挑战。
近年来研究显示,益生菌在适量使用时作为有益于宿主健康的微生物,在防治阿尔茨海默病方面具有积极影响,其作用机制可能通过调节肠道菌群,影响神经免疫系统,调控神经活性物质以及代谢产物,通过肠-脑轴影响该病发生和发展。
宋鑫萍1,2,李盛钰2,金清11.延边大学农学院,吉林延吉 1330022.吉林省农业科学院农产品加工研究所,吉林长春 130033摘要:阿尔茨海默病已成为威胁全球老年人生命健康的主要疾病之一,患者数量逐年攀升,其护理的经济成本高,给全球经济造成重大挑战。
近年来研究显示,益生菌在适量使用时作为有益于宿主健康的微生物,在防治阿尔茨海默病方面具有积极影响,其作用机制可能通过调节肠道菌群,影响神经免疫系统,调控神经活性物质以及代谢产物,通过肠-脑轴影响该病发生和发展。
本文综述了近几年来国内外益生菌对阿尔茨海默病的作用进展,以及其预防和治疗阿尔茨海默病的潜在作用机制。
关键词:益生菌;阿尔茨海默病;肠道菌群;机制Recent Progress in Research on Probiotics Effect on Alzheimer’s DiseaseSONG Xinping1,2,LI Shengyu2,JI Qing1*(1.College of Agricultural, Yanbian University, Yanji 133002,China)(2.Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Chanchun 130033, China)Abstract:Alzheimer’s disease has become one of the major diseases threatening the life and health of the global elderly. The number of patients is increasing year by year, and the economic cost of nursing is high, which poses a major challenge to the global economy. In recent years, studies have shown that probiotics, as microorganisms beneficial to the health of the host, have a positive impact on the prevention and treatment of Alzheimer’s disease. Its mechanism may be through regulating intestinal flora, affecting the nervous immune system, regulating the neuroactive substances and metabolites, and affecting the occurrence and development of the disease through thegut- brain axis. This paper reviews the progress of probiotics on Alzheimer’s disease at home and abroad in recent years, as well as its potential mechanism of prevention and treatment.Key words:probiotics; Alzheimer’s disease; gut microbiota; mechanism阿尔茨海默病(Alzheimer’s disease, AD),系中枢神经系统退行性疾病,属于老年期痴呆常见类型,临床特征主要包括:记忆力减退、认知功能障碍、行为改变、焦虑和抑郁等。
检测项目预约申请单
上海交通大学医学院实验动物科学部
检测项目预约申请单
申请日期:
文件编号: 生效日期:2012-12-1
申请单位(部门):
预约检测时间: 检测项目 ELISA检测 生理数据采集系统 血压测定 血常规指标(五分类) 血糖 ( )葡萄糖(GLU) ( )总蛋白(TP) ( )白蛋白(ALB) ( )总胆红素(BIL-T) 肝 ( )直接胆红素(BIL-D) 生 功 ( )碱性磷酸酶(ALP) 化 能 ( )甘油三酯+胆固醇(TG+CHOL) 指 ( )丙氨酸氨基转移酶(ALT) 标 ( )天冬氨酸氨基转移酶(AST) ( )γ -谷氨酰基转移酶(GGT) 肾 ( )尿酸(UA) 功 ( )肌酸激酶(CK) 能 ( )肌酐+尿素(CREA+UREA) 原位杂交 Tunel 组 组化 化 荧光 切 石蜡切片 片 冰切切片 HE 耗材(刀片/OCT/包埋)
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原发性醛固酮增多症(中英文
• 原醛症病人一般服用安体舒通1周后,尿 钾减少、血钾上升、血浆CO2结合力下 降,肌无力、四肢麻木等症状改善,夜 尿减少,约半数病人血压有下降趋势。
原醛的筛查
• 立,卧位的血ARR=ALDO/PRA。各种文 献对比值报道不一,>25可疑, > 50可能 性大。
• 如果同时运用下述标准:ALDO/PRA>30, ALDO>20ng/dl, 其诊断原醛的灵敏性为 90%,特异性为91% 。
原醛的确诊
FST
氟氢可的松0.1mg q6h,共4天 ➢测定立位ALDO>60pg/dl,立位PRA <1.0ng/ml ➢尿钠的排泄>3 mmol/kg/天 ➢血K正常。 ➢服药4天后10Am的血浆皮质醇必须低于7Am 的
皮质醇
盐负荷试验
• 静脉和口服 • 静脉:生理盐水2L,4小时内静注完,测
定血ALDO >5ng/dl,PA确诊。 • 口服:高钠饮食3天(300mmol钠/d),
测定24小时尿ALDO >10µg/d, PA确诊
盐负荷试验
• 高钠试验正常人及高血压病人血钾无明 显变化,原醛症患者血钾可降至3.5毫 摩尔/升以下
Schimenbach, Best Pract Res Clin Endocrinol Metab. 2006 Sep;20(3):369-84
机制
肾上腺皮质病变Aldo↑储NA排K 血容量↑ PRA↓
自主性
低K
BP↑
临床特点
1.BP↑ : 血容量↑,平滑肌内NA↑,Aldo增加血 管对NAR的反应. 最早最常见,病程进展, BP逐渐↑,轻中度.以DBP ↑为主 伴头晕,头痛.
type I) • FH type II (APA or IHA)
美国FDA批准首款基因疗法药物Roctavian_用于治疗重型血友病A
广东药科大学学报第39卷action of the ethanol-soluble extract from Tagetes lucida Cav.aerial parts and its main bioactive metabolite s[J].J Ethnopharmacol, 2021,266:113399.[7]ARJIN C,HONGSIBSONG S,PRINGPROA K,et al.Effectof ethanolic caesalpiniasappan fraction on in vitro antiviral activity against porcine reproductive and respiratory syndrome viru s[J].Vet Sci,2021,8(6):106.[8]GUO H,HE Y,BU C,et al.Antitumor and apoptotic effects of5-methoxypsoralen in U87MG human glioma cells and its effect on cell cycle,autophagy and PI3K/Akt signaling pathwa y[J].Arch Med Sci,2019,15(6):1530-1538.[9]KUMAR P P,KUMAR K T S,NAINITA M K,et al.Cerebro‐protective potential of hesperidin nanoparticles against bilateral common carotid artery occlusion reperfusion injury in rats and in silico approache s[J].Neurotox Res,2020,37(2):264-274. [10]刘心语.佛手质量标志物的研究[D].成都:西南交通大学,2021.[11]曹士政,赵登高,马燕燕,等.一测多评法同时测定不同产地佛手中6种化学成分的含量[J].中南药学,2022,20(5): 1167-1172.[12]王吉文,黄燕俊,胡倩倩,等.不同采收期及加工方法广佛手中浸出物、橙皮苷含量分析[J].海峡药学,2022,34(4): 54-57.[13]陈燕霞.岭南特色饮片制佛手生产工艺优化及质量标准研究[D].广州:广州中医药大学,2014.[14]周雷,李钢,苏哪锋.近红外技术(NIRS)在药物生产过程质量控制中的应用[J].广东化工,2021,48(1):60-61,56. [15]杨哲萱,周立红,章顺楠,等.NIRS技术在中药生产中的应用及其验证方法探讨[J].中草药,2013,44(10):1342-1348. [16]LAN Z,ZHANG Y,SUN Y,et al.A mid-level data fu‐sion approach for evaluating the internal and external changes determined by FT-NIR,electronic nose and color‐imeter in CurcumaeRhizoma processin g[J].J Pharm Biomed Anal,2020,188:113387.[17]李四海,陈建国,任国瑾.近红外光谱技术快速测定当归中藁本内酯含量[J].传感器与微系统,2017,36(12):114-117. [18]沈东旭.基于机器学习的近红外光谱波长选择方法研究及应用[D].重庆:重庆大学,2021.[19]李蕾蕾,黄洁燕,周文婷,等.近红外光谱法快速测定枇杷叶中齐墩果酸的含量[J].中国实验方剂学杂志,2014,20(5):86-89.[20]BARUD M,DABROWSKI W,SIWICKA-GIEROBA D,et al.Usefulness of cerebral oximetry in TBI by NIR S[J].J Clin Med,2021,10(13):2938.[21]WANG F,JIA B,SONG X,et al.Rapid identification ofPeucedanum praeruptorum Dunn and its adulterants by hand-held near-infrared spectroscop y[J].J AOAC Int,2022,105(3):928-933.[22]黎珊,高明,陈康,等.蒸制时间对佛手主要成分与抗氧化活性的影响[J].中成药,2015,37(4):821-824.(责任编辑:周鹏)美国FDA批准首款基因疗法药物Roctavian用于治疗重型血友病A美国FDA于2023年6月29日批准拜玛林制药公司(BioMarin Pharmaceutical Inc.)的基因治疗药物Roctavian 用于成人治疗重型血友病A。
中科院SCI分区目录
刊名简称 J AM CHEM SOC ANGEW CHEM INT EDIT ANAL CHEM CHEM REV ACCOUNTS CHEM RES COORDIN CHEM REV CHEM SOC REV ANNU REV PHYS CHEM PROG POLYM SCI TOP CURR CHEM ADV POLYM SCI SURF SCI REP CATAL REV CURR OPIN COLLOID IN ADV CATAL ADV ORGANOMET CHEM PROG SOLID STATE CH ALDRICHIM ACTA J ORG CHEM MACROMOLECULES CHEM COMMUN INORG CHEM J PHYS CHEM B LANGMUIR J CHROMATOGR A ORGANOMETALLICS DALTON T J CATAL ORG LETT CHEM-EUR J ELECTROPHORESIS J COMPUT CHEM CARBON RAPID COMMUN MASS SP CHEM RES TOXICOL J ANAL ATOM SPECTROM APPL CATAL B-ENVIRON MACROMOL RAPID COMM J AM SOC MASS SPECTR J PHYS CHEM REF DATA FARADAY DISCUSS J MASS SPECTROM ADV COLLOID INTERFAC BIOMACROMOLECULES TRAC-TREND ANAL CHEM ELECTROCHEM COMMUN J BIOL INORG CHEM ADV SYNTH CATAL ADV INORG CHEM CHEMPHYSCHEM GREEN CHEM J COMB CHEM PROG SURF SCI CRYST GROWTH DES
基于代谢组学探究托珠单抗治疗类风湿关节炎的应答反应演示稿件
托珠单抗在类风湿关节炎治疗中的应用
控制症状
托珠单抗能够快速控制类风湿关节炎的症状,如关节 疼痛、肿胀等,提高患者的生活质量。
延缓病情进展
长期使用托珠单抗可以延缓类风湿关节炎病情的进展 ,保护关节功能。
减少其他药物的使用
在一些情况下,使用托珠单抗可以减少患者对于其他 免疫抑制剂和止痛药的需求量。
03
基于代谢组学探究托珠单抗 治疗类风湿关节炎的应答反
应 汇报人:XXX
2024-01-05
• 引言 • 托珠单抗治疗类风湿关节炎的原理 • 基于代谢组学的应答反应分析 • 托珠单抗治疗类风湿关节炎的临床
效果 • 结论与展望
01
引言
研究背景
类风湿关节炎(RA)是一种慢性自身免疫性疾病,会导致关节炎症和关节破坏。托珠单抗是一种针对白细胞介素-6受体的生 物制剂,已被批准用于治疗RA。然而,不同患者对托珠单抗的应答反应存在差异,因此需要探究其应答机制。
02
托珠单抗治疗类风湿关节炎的长期疗效和安全性尚 需进一步观察和研究。
03
代谢组学技术仍有待进一步完善和提高,以提高研 究的可靠性和可重复性。
未来研究方向
需要进一步扩大样本量,对托珠单抗治疗类风湿关节炎的疗效进行更深入 的研究和分析。
需要深入研究托珠单抗治疗类风湿关节炎的作用机制和分子生物学基础, 为药物研发和优化提供理论支持。
代谢组学是一种研究生物体受刺激或扰动后代谢产物的变化,进而探究生物体代谢相关过程的学科。通过代谢组学的方法, 可以探究托珠单抗治疗RA过程中代谢产物的变化,从而深入了解其应答机制。
研究目的
• 本研究旨在通过代谢组学的方法 ,探究托珠单抗治疗RA过程中患 者体内代谢产物的变化,并分析 这些变化与临床应答反应之间的 关系,以期为优化RA的治疗提供 依据。
脑脊液降钙素基因相关肽
脑脊液降钙素基因相关肽文章目录*一、脑脊液降钙素基因相关肽的基本信息1. 定义2. 专科分类3. 检查分类4. 适用性别5. 是否空腹*二、脑脊液降钙素基因相关肽的正常值和临床意义1. 正常值2. 临床意义*三、脑脊液降钙素基因相关肽的检查过程及注意事项1. 检查过程2. 注意事项*四、脑脊液降钙素基因相关肽的相关疾病和症状1. 相关疾病2. 相关症状*五、脑脊液降钙素基因相关肽的不适宜人群和不良反应1. 不适宜人群2. 不良反应脑脊液降钙素基因相关肽的基本信息1、定义降钙素基因相关肽(CGRP)是一个由37个氨基酸组成的神经肽,广泛分布于中枢和外周神经系统,在心血管系统主要存在于支配心血管感觉或自主神经末梢中,为中枢和外周神经系统的重要递质。
其生物活性是通过与特异性受体结合后,激活腺苷酸环化酶使细胞内cAMP增高,经第二信使cAMP的中介而产生生物效应。
具有很强的血管扩张、心肌正性变力与变时作用,参与血糖的调节并能抑制脂质过氧化,保护多种组织细胞。
本实验是一种系列竞争反应放射免疫分析法,病人样本和抗降钙素抗体首先要经过预先温育,标记降钙素和病人样本中降钙素同时竞争抗体位点。
温育一定时间后,用PEG第二抗体来获得沉淀结合物。
最后,抗体结合物沉淀后进行计数,则病人样本的浓度从标准曲线上就能得到。
2、专科分类无3、检查分类脑脊液检查4、适用性别男女均适用5、是否空腹空腹脑脊液降钙素基因相关肽的正常值和临床意义1、正常值45±9pg/ml。
2、临床意义异常结果升高见于出血性脑血管病、缺血性脑血管病。
需要检测的人群出现对侧偏瘫(下肢重,上肢轻),强握反射,尿失禁,情感淡漠、意识模糊,痉挛性截瘫等症状人,特别是老人。
脑脊液降钙素基因相关肽的检查过程及注意事项1、检查过程患者侧卧于硬板床上,背部与桌面垂直,头部尽量向前胸屈曲,两手抱膝紧贴腹部,使躯干尽可能呈弓形;或由助手在术者对面用一手挽患者头部,另一手挽双下肢腘窝处并用力抱紧,使脊柱尽量后凸以增宽椎间隙,便于进针。
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MTHD / Visual CPSD-HL-01057-
MTHD / Visual CPSD-HL-01057-
MTHD / Visual CPSD-HL-01057-
MTHD / Visual CPSD-HL-01057-
MTHD / Visual CPSD-HL-01057-
MTHD / Visual
CPSD-HL-01057MTHD / Visual
All
As claimed
Report overall dimensions; shall meet label claims
1
(If applicable) (-0% / +5%).
Report overall height; shall meet label claims
STOOL OR BAR STOOL (V10)
Evaluation
* 16 CFR 1303 Lead content
FLAMMABILITY Flammability of solids
PHYSICAL CHARACTERISTICS Type of seat Dimensions - seat
All
- Report each packaging claim. - Each claim shall be evaluated in accordance with the cited
procedure.
Law label
CPSD-HL-01057MTHD / Visual
All
Must be included if it contains filling material
Shall have no loose component and unsecured fastening where rigidity is required
Welds shall be smoothly ground and free of pits and splatter
PERFORMANCE Actual use - functionality - not covered by other tests Seating - seat static load
*
Packaged product transit testing - if applicable
All samples shall be reviewed and tested to the appropriate
TRGT-HL-PTCL-09000US
-
requirements of protocol TRGT-HL-9000-US "Packaged Product Transit Testing".
Shall present uniform adhesion (wood)
Shall present no scratches, dents, cracks, marred or discolored surface
Shall have finished edges
Shall present proper and even adhesion
Shall have no burrs or sharp edges on any component
Shall have no components missing, malformed or fractured
Defects
CPSD-HL-01057MTHD / Visual
Shall have no hardware missing All
TARGET CORPORATION TEST PROTOCOL FOR TRGT - 03055 - US
STOOL OR BAR STOOL (V10)
BV Lab Number: Technician Name:
Test Date: Reviewed By/Date:
DPCI#:
Page 1 of 5
* Loading test - footrest
Seating - impact durability - single seater for seat height up to 29 in. Tilt resistance
Seating - back pull durability
Stability
CPSD-HL-01057MTHD / Visual
CPSD-HL-01056MTHD / Standard
measure CPSD-HL-01056MTHD / Standard
measure CPSD-HL-01057-
MTHD / Visual CPSD-HL-01056MTHD / Standard
All
Shall conform to claimed features
All
Shall conform to claimed features
All
Shall conform to claimed features
All
Components shall be even in color
BV Lab Number: Technician Name:
follow
Accuracy or adequacy of instructions layout
MTHD / Visual / CPSDHL-01058-MTHD /
1
Actual use
ANALYTICAL
TARGET CORPORATION TEST PROTOCOL FOR TRGT - 03055 - US
1
(If applicable) (-0% / +5%).
All
As claimed
Report overall density; shall meet label claims
1
(If applicable) (-0% / +5%).
All
As claimed
All
As claimed
All
Shall conform to claimed features
Test Date: Reviewed By/Date:
DPCI#:
Results
C: R: C: R:
C: R C: R: C: R: C: R C: R C: R C: R C: R C: R
Page 2 of 5 Rating
TARGET CORPORATION TEST PROTOCOL FOR TRGT - 03055 - US
All samples shall be reviewed against the requirements of
* California Proposition 65
TRGT-HL-PTCL-06572US
-
California Proposition 65 to determine if additional testing or labeling is required.
Target packaging and labeling requirements
Products in final retail packaging or open stock shall be
TRGT-HL-PTCL-09067US
-
evaluated to the Target Packaging and Labeling Requirements Protocol
*
Law label - bedding tag and California flammability tag
TRGT-GB-PTCL01990-US
Please See and Include the Supplemental Test Protocol of 1990
-
Law Label (Bedding Tag and California Flammability Label
Citation / Method
Consumer Product Safety Improvement Act of 2008 / 16 CFR 1303 / AOAC 974.02 (mod) /
CPSD-AN-00001MTHD
No. of Samples
1
Criteria
Shall not exceed 90 ppm (0.009% by weight) total lead. Compositing is allowed as follows:
Dimensions - height - seat Fabric type - seat Foam density - seat Type of backrest Leg type Leg height adjustment Type of seat - rotating or non-rotating Back - with or without Arm - with or without arm WORKMANSHIP Defects - material
- Lead in Surface Coating Requirement = 90 ppm - Max. = 2 materials - Must meet 45 ppm due to composite concentration
16 CFR 1500.44
1
Shall meet < 0.1 inches per second (horizontal burning).
STOOL OR BAR STOOL (V10)
BV Lab Number: Technician Name: