肿瘤浸润和转移生死的问题
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metastasis • Research work in my lab related to the above topic
Cancer is a major public health problem worldwide
The major technological breakthroughs and conceptual advances in cancer metastasis research
Routes of metastasis: lymphatic and/or blood vessels
Hematogenous metastasis
Int J Clin Exp Pathol. 2012; 5(7): 614–623
Metastatic patterns of ovarian cancer
Naora H, et al. Nat Rev Cancer, 2005; 5:355-66
Evolution of tumor metastasis
Klein CA. Science, 2008; 321(5897):1785-7
The invasion-metastasis cascade: multiple and complex
Trends in death rates
Cancer Statistics, 2015
Siegel RL, et al. CA Cancer J Clin, 2015; 65: 5-29
Tumor metastasis: responsible for over 90% of mortality from cancer
Fidler IJ. Nat Rev Cancer, 2003; 3: 453-8
Concept 3: Metastatic heterogeneity
• Metastasis is a Greek word meaning "displacement", from μετά, meta, "next", and στάσις, stasis, "placement"
Gupta GP, et al. Cell, 2006; Valastyan S, et al. Cell, 2011; Chaffer CL, et al. Science, 2011; Mehlen P, et al. Nat Rev Cancer, 2006
Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48
The major technological breakthroughs and conceptual advances in cancer metastasis research
Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48
Fidler IJ. Nat Rev Cancer, 2003; 3: 453-8
Concept 1: Inefficiency of the invasion-metastasis cascade
Valastyan S, et al. Cell, 2011; 147(2): 275-92; Chaffer CL, et al. Science, 2011;331(6024)ห้องสมุดไป่ตู้1559-64
• Metastasis, or metastatic disease, is the spread of a cancer or other disease from one organ or part to another not directly connected with it.
• The new occurrences of disease thus generated are referred to as metastases
Tumor invasion and metastasis: a question of life or death
生物医学研究院 (IBS) 及肿瘤研究所
Outline of the lecture
The basic concepts about tumor invasion and metastasis • The molecular mechanisms for tumor invasion and metastasis • The emerging therapeutic targets for tumor invasion and
Concept 2: Organ-specific metastasis
Schroeder A, et al. Nat Rev Cancer, 2011;12:39-50
Concept 2: Organ-specific metastasis
Valastyan S, et al. Cell, 2011; 147(2):275-92 Nguyen DX, et al. Nat Rev Cancer, 2009; 9: 274-84
metastasis • Research work in my lab related to the above topic
Outline of the lecture
The basic concepts about tumor invasion and metastasis • The molecular mechanisms for tumor invasion and metastasis • The emerging therapeutic targets for tumor invasion and
Nguyen DX, et al. Nat Rev Cancer, 2009; 9: 274-84
The seed and soil hypothesis
Stephen Paget: 1855 – 1926, an English surgeon
The seed and soil hypothesis
Cancer is a major public health problem worldwide
The major technological breakthroughs and conceptual advances in cancer metastasis research
Routes of metastasis: lymphatic and/or blood vessels
Hematogenous metastasis
Int J Clin Exp Pathol. 2012; 5(7): 614–623
Metastatic patterns of ovarian cancer
Naora H, et al. Nat Rev Cancer, 2005; 5:355-66
Evolution of tumor metastasis
Klein CA. Science, 2008; 321(5897):1785-7
The invasion-metastasis cascade: multiple and complex
Trends in death rates
Cancer Statistics, 2015
Siegel RL, et al. CA Cancer J Clin, 2015; 65: 5-29
Tumor metastasis: responsible for over 90% of mortality from cancer
Fidler IJ. Nat Rev Cancer, 2003; 3: 453-8
Concept 3: Metastatic heterogeneity
• Metastasis is a Greek word meaning "displacement", from μετά, meta, "next", and στάσις, stasis, "placement"
Gupta GP, et al. Cell, 2006; Valastyan S, et al. Cell, 2011; Chaffer CL, et al. Science, 2011; Mehlen P, et al. Nat Rev Cancer, 2006
Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48
The major technological breakthroughs and conceptual advances in cancer metastasis research
Sethi N, et al. Nat Rev Cancer, 2011; 11:735-48
Fidler IJ. Nat Rev Cancer, 2003; 3: 453-8
Concept 1: Inefficiency of the invasion-metastasis cascade
Valastyan S, et al. Cell, 2011; 147(2): 275-92; Chaffer CL, et al. Science, 2011;331(6024)ห้องสมุดไป่ตู้1559-64
• Metastasis, or metastatic disease, is the spread of a cancer or other disease from one organ or part to another not directly connected with it.
• The new occurrences of disease thus generated are referred to as metastases
Tumor invasion and metastasis: a question of life or death
生物医学研究院 (IBS) 及肿瘤研究所
Outline of the lecture
The basic concepts about tumor invasion and metastasis • The molecular mechanisms for tumor invasion and metastasis • The emerging therapeutic targets for tumor invasion and
Concept 2: Organ-specific metastasis
Schroeder A, et al. Nat Rev Cancer, 2011;12:39-50
Concept 2: Organ-specific metastasis
Valastyan S, et al. Cell, 2011; 147(2):275-92 Nguyen DX, et al. Nat Rev Cancer, 2009; 9: 274-84
metastasis • Research work in my lab related to the above topic
Outline of the lecture
The basic concepts about tumor invasion and metastasis • The molecular mechanisms for tumor invasion and metastasis • The emerging therapeutic targets for tumor invasion and
Nguyen DX, et al. Nat Rev Cancer, 2009; 9: 274-84
The seed and soil hypothesis
Stephen Paget: 1855 – 1926, an English surgeon
The seed and soil hypothesis