细菌耐药现状和耐药机制分析
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40
77
78
73
44 40
54
52
49
20
NA
0
泰I能mi 他啶Ceft舒a 普Cefp/ 噻M肟K826曲松Cefo匹t 肟 C特eft治r 特C美efi 庆大Pip丁/ 卡 T环ica丙r/
penem zidime Sulbact (MK) axime iaxone pime tazobact Clav
100 100
0 0 0 100
Cefi pime
8
72 71 79 71 70 63 70 100 87 95 68 100 33 38 100 67 90 100 100 63 100 83 40 60 25 67
100 100
0 100
0 100
Pip/ tazobact
16*
81 84 78 70 59 69 59 91 78 95 64 100 89 69 100 75 100 89 100 38 100 83 60 80 75 67
细菌耐药现状和耐药机制分析
倪语星
一、流行病学
2002年全国17家医院主要革兰阴性菌分布
POOL OF china, Gram-Negative isolates , N = 2013, Patients = 1749 Percentage susceptibility (NCCLS Breakpoints)
8 100
67 50 78
0 38 83 100 40 40
0 67
50 100
0 100
0 100
Ami kacin
16
81 88 84 73 74 23 68 91 87 86 64 100 28 15 100 82 70 89
0 63 100 100 80 80 75 67
100 100
0 100
408 399
100
55
64
50
Klebsiella pneumoniae
364 358
99
58
71
59
Acinetobacter baumanii
316 311
94
65
80
31
Enterobacter cloacae
150 148
96
43
63
35
Xanthomonas maltophilia
81 81
0 100
Cipro floxacin
1
57 25 63 67 59 43 48 70 65 36 68 65 17 31 100 67 50 67 38 25 83 100 60 40
0 67
100 100
0 0 0 0
ALL Tested on AB BioDisk E-Test MICs
2052
深
星汀
Genta micin
Ami kacin
Cipro floxacin
New NCCLS ESBL Bpts
革兰阴性菌主要耐药菌构成
Non Susceptible Isolates Distribution Pool Of China: Gram-Negative isolates , N = 2013 Pts = 1749
--
85
63
71
40
44
73
77
49
54
78
52
2002年全国17家医院革兰阴性菌敏感性
Percentage Susceptibility: Pool Of China Gram-Negative isolates , N = 2013 Pts = 1749
100
85
80
71 63 ercent 60 P
Species
bpt,mg/l->
Iso lates
Pat ients
Imi penem
4
Cefta zidime
8
Ceftaz Clav
8
Cefp/ Sulbact
16
MK826 (MK) 4
Cefot axime
8
Pseudomonas aeruginosa
412 403
62
75
67
15
Escherichia coli
22 22
100
59
59
55
Proteus mirabilis
20 20
100
100
95
95
Alcaligines spp.
18 18
83
61
94
17
Flavobacterium spp.
13 13
8
38
62
0
Serratia spp.
12 12
100
92
92
75
Serratia marcescens
2
78
81
35
Citrobacter freundii
44 44
98
43
64
41
Klebsiella spp.
23 22
100
70
96
70
Acinetobacter spp.
23 23
87
74
87
57
Morganella morganii
22 22
95
68
86
73
Enterobacter aerogenes
100 100
0 100
0 100
Ticar/ Clav
16*
49 29 55 66 32 72 27 65 70 64 45 100 61 31 67 67 60 78
0 25 100 67 40
0 25 67
50 100
0 100 100 100
Genta micin
4
60 37 71 63 44 17 41 83 70 45 55 75 17
1
1
100
0
100
0
Chryseomonas spp.
1
1
0
100
100
0
Proteus spp.
1
1
100
100
100
100
Ceftr iaxone
8
35 52 61 28 34 16 41 74 61 91 55 95 17
0 83 67 60 78 100 50 100 67 20 20
0 33
83
100
100
Citrobacter spp.
6
6
100
83
67
67
Acinetobacter calcoaceticus
5
5
100
40
60
20
Aeromonas spp.
5
Hale Waihona Puke Baidu
5
60
60
60
20
Unknown species
4
4
100
50
100
25
0
Achromobacter spp.
3
3
100
100
67
33
KLEBSIELLA PNEUMONINE ATCC 70
2
1
0
100
Salmonella spp.
2
2
100
100
100
100
Citrobacter diversus
1
1
100
100
100
100
Escherichia spp.
1
1
100
100
100
0
0
COMAMONAS ACIDOVORANS
12 12
100
75
75
67
Pseudomonas spp.
10 10
90
80
80
50
Klebsiella oxytoca
9
9
100
78
100
78
Pseudomonas cepacia
8
8
0
100
100
88
Enterobacter spp.
8
8
88
38
63
38
Proteus vulgaris
6
6
100
77
78
73
44 40
54
52
49
20
NA
0
泰I能mi 他啶Ceft舒a 普Cefp/ 噻M肟K826曲松Cefo匹t 肟 C特eft治r 特C美efi 庆大Pip丁/ 卡 T环ica丙r/
penem zidime Sulbact (MK) axime iaxone pime tazobact Clav
100 100
0 0 0 100
Cefi pime
8
72 71 79 71 70 63 70 100 87 95 68 100 33 38 100 67 90 100 100 63 100 83 40 60 25 67
100 100
0 100
0 100
Pip/ tazobact
16*
81 84 78 70 59 69 59 91 78 95 64 100 89 69 100 75 100 89 100 38 100 83 60 80 75 67
细菌耐药现状和耐药机制分析
倪语星
一、流行病学
2002年全国17家医院主要革兰阴性菌分布
POOL OF china, Gram-Negative isolates , N = 2013, Patients = 1749 Percentage susceptibility (NCCLS Breakpoints)
8 100
67 50 78
0 38 83 100 40 40
0 67
50 100
0 100
0 100
Ami kacin
16
81 88 84 73 74 23 68 91 87 86 64 100 28 15 100 82 70 89
0 63 100 100 80 80 75 67
100 100
0 100
408 399
100
55
64
50
Klebsiella pneumoniae
364 358
99
58
71
59
Acinetobacter baumanii
316 311
94
65
80
31
Enterobacter cloacae
150 148
96
43
63
35
Xanthomonas maltophilia
81 81
0 100
Cipro floxacin
1
57 25 63 67 59 43 48 70 65 36 68 65 17 31 100 67 50 67 38 25 83 100 60 40
0 67
100 100
0 0 0 0
ALL Tested on AB BioDisk E-Test MICs
2052
深
星汀
Genta micin
Ami kacin
Cipro floxacin
New NCCLS ESBL Bpts
革兰阴性菌主要耐药菌构成
Non Susceptible Isolates Distribution Pool Of China: Gram-Negative isolates , N = 2013 Pts = 1749
--
85
63
71
40
44
73
77
49
54
78
52
2002年全国17家医院革兰阴性菌敏感性
Percentage Susceptibility: Pool Of China Gram-Negative isolates , N = 2013 Pts = 1749
100
85
80
71 63 ercent 60 P
Species
bpt,mg/l->
Iso lates
Pat ients
Imi penem
4
Cefta zidime
8
Ceftaz Clav
8
Cefp/ Sulbact
16
MK826 (MK) 4
Cefot axime
8
Pseudomonas aeruginosa
412 403
62
75
67
15
Escherichia coli
22 22
100
59
59
55
Proteus mirabilis
20 20
100
100
95
95
Alcaligines spp.
18 18
83
61
94
17
Flavobacterium spp.
13 13
8
38
62
0
Serratia spp.
12 12
100
92
92
75
Serratia marcescens
2
78
81
35
Citrobacter freundii
44 44
98
43
64
41
Klebsiella spp.
23 22
100
70
96
70
Acinetobacter spp.
23 23
87
74
87
57
Morganella morganii
22 22
95
68
86
73
Enterobacter aerogenes
100 100
0 100
0 100
Ticar/ Clav
16*
49 29 55 66 32 72 27 65 70 64 45 100 61 31 67 67 60 78
0 25 100 67 40
0 25 67
50 100
0 100 100 100
Genta micin
4
60 37 71 63 44 17 41 83 70 45 55 75 17
1
1
100
0
100
0
Chryseomonas spp.
1
1
0
100
100
0
Proteus spp.
1
1
100
100
100
100
Ceftr iaxone
8
35 52 61 28 34 16 41 74 61 91 55 95 17
0 83 67 60 78 100 50 100 67 20 20
0 33
83
100
100
Citrobacter spp.
6
6
100
83
67
67
Acinetobacter calcoaceticus
5
5
100
40
60
20
Aeromonas spp.
5
Hale Waihona Puke Baidu
5
60
60
60
20
Unknown species
4
4
100
50
100
25
0
Achromobacter spp.
3
3
100
100
67
33
KLEBSIELLA PNEUMONINE ATCC 70
2
1
0
100
Salmonella spp.
2
2
100
100
100
100
Citrobacter diversus
1
1
100
100
100
100
Escherichia spp.
1
1
100
100
100
0
0
COMAMONAS ACIDOVORANS
12 12
100
75
75
67
Pseudomonas spp.
10 10
90
80
80
50
Klebsiella oxytoca
9
9
100
78
100
78
Pseudomonas cepacia
8
8
0
100
100
88
Enterobacter spp.
8
8
88
38
63
38
Proteus vulgaris
6
6
100