三丁酸甘油酯可以改善宫内发育迟缓仔猪脏器发育

三丁酸甘油酯营养干预可改善IUGR仔猪内脏器官发育Dietary tributyrin intervention ameliorates the development of internal

organs in IUGR piglets

1．IUGR的危害

The adverse effect of IUGR

子宫内发育迟缓（IUGR）通常指围产期的动物因受各种因素的影响，导致胎儿或其器官生长发育受阻，降低了仔猪出生时的质量和成活率，甚至会影响仔猪生长后期的发育（Longo等，2014）。猪IUGR的发生率高达20%，给生猪生产带来了巨大的损失（Wu等，2004）。

Intrauterine growth retardation(IUGR)usually refers to the retarded growth and development of the fetus or its inner organs during the perinatal period due to various factors, which not only reduces the birth quality and survival rate of piglets,but also negatively affected their growth and development after birth(Longo et al.,2014).The incidence of IUGR in pigs is as high as20%,which brings huge losses to the pig production(Wu et al.,2004).

2．三丁酸甘油酯对IUGR仔猪的应用效果

Effect of dietary tributyrin intervention on IUGR piglets

Li等（2015）、何等（2016）系统研究了三丁酸甘油酯营养干预对IUGR仔猪的应用效果。试验分为三个处理：正常组（NBW组）为正常仔猪饲喂基础人工乳，IUGR组为IUGR 仔猪饲喂基础人工乳，三丁酸甘油酯组（IT组）为IUGR仔猪饲喂基础人工乳+0.1%三丁酸甘油酯。研究结果如下：

Li et al.(2015)and He et al.(2016)have conducted several studies regarding the dietary tributyrin intervention on the IUGR piglets.Three treatments were included in the studies, including the normal group(NBW group,normal piglets+basic artificial milk),the IUGR group (IUGR piglets+basic artificial milk),and the tributyrin-fed group(IT group,IUGR piglets+ basic artificial milk+0.1%tributyrin).The results are as follows:

2.1三丁酸甘油酯促进IUGR仔猪的胰腺和肝脏发育

2.1Dietary tributyrin intervention improved the pancreas and liver development in IUGR piglets

研究发现，IUGR组乳猪的胰腺和肝脏的重量显著低于正常组；对IUGR仔猪采用三丁

酸甘油酯（TB）营养干预后，胰腺重量较IUGR组提高了31.03%(P<0.05)，肝脏重量较IUGR 组提高了52.32%(P<0.05)，与正常组相比均无显著差异。IUGR组仔猪的肝脏组织中央静脉和门管区充血较严重，采用三丁酸甘油酯（TB）营养干预后，则无上述变化。

Their results showed that the weights of pancreas and liver in the IUGR pigs were lower than that in the normal ones(P<0.05),while dietary tributyrin intervention on the IUGR pigs increased the weights of these organs by31.03%and52.32%when compared with those in the IUGR pigs consuming normal feed,respectively.The central vein and portal area of liver in the IUGR pigs were seriously congested,while no such pathologic changes were observed in response to dietary tributyrin intervention.

2.2三丁酸甘油酯改善IUGR仔猪的肠绒毛形态

2.2Dietary tributyrin intervention improved the intestinal villi morphology in the IUGR pigs

正常组IUGR三丁酸甘油酯

2.3三丁酸甘油酯缓解IUGR仔猪的肝脏充血症状

2.3Dietary tributyrin intervention ameliorated the liver congestion in IUGR piglets

正常组IUGR三丁酸甘油酯组

2.4三丁酸甘油酯提高IUGR仔猪胰腺酶的活力

2.4Dietary tributyrin intervention improved the pancreatic enzyme activity in IUGR piglets

IUGR组仔猪的胰蛋白酶、胰脂肪酶和胰淀粉酶的活性均显著低于正常组，对IUGR仔猪采用三丁酸甘油酯营养干预后，胰蛋白酶、胰脂肪酶和胰淀粉酶的活性分别提高了36.92%，